RNA表观遗传修饰及其在植物中的研究进展
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摘要
RNA转录后修饰是将新生RNA分子加工成为成熟产物的修饰过程,它已经成为表观遗传学研究的一个崭新领域,在生物体的生殖、生长和发育等生命活动过程中发挥着十分重要的作用。近年来,人们对RNA的6-甲基腺嘌呤(N~6-methyladenosine,m~6A)、5-甲基胞嘧啶(5-Methylcytosine,m~5C)以及假尿苷修饰(Pseudouridines,Ψ)等几种重要的RNA表观遗传修饰开展了广泛地研究。本文主要阐述了这几种RNA修饰的分布特征、形成机制以及检测方法,并着重总结了它们在植物生长发育中的功能与研究进展等,为今后系统开展RNA表观遗传学的研究提供理论参考。
The post-transcriptional RNA modification is a modification process that processes nascent RNA molecules into mature products. It represents an emerging research territory in epigenetic RNA modifications,which plays crucial roles in reproduction,growth and development by controlling gene express patterns. Recently,the post-transcriptional RNA modifications such as N6-methyladenosine( m6 A),5-methylcytosine( m5 C),and Pseudouridines( Ψ) have been widely studied. This review mainly focuses on the distribution characteristics,formation mechanism and detection methods of these RNA modifications,with special emphasis on the recent progress of its functions in the growth and development of plants,which provides valuable information for further study on the epigenetic RNA modifications in plants.
The post-transcriptional RNA modification is a modification process that processes nascent RNA molecules into mature products. It represents an emerging research territory in epigenetic RNA modifications,which plays crucial roles in reproduction,growth and development by controlling gene express patterns. Recently,the post-transcriptional RNA modifications such as N6-methyladenosine( m6 A),5-methylcytosine( m5 C),and Pseudouridines( Ψ) have been widely studied. This review mainly focuses on the distribution characteristics,formation mechanism and detection methods of these RNA modifications,with special emphasis on the recent progress of its functions in the growth and development of plants,which provides valuable information for further study on the epigenetic RNA modifications in plants.
引文
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