Ghrelin在哺乳动物免疫系统中的作用研究进展
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摘要
Ghrelin是一种具有多种生物学功能的生长激素释放肽,近年来其在哺乳动物免疫系统中的作用研究日益丰富,而在禽类免疫系统中的研究相对较少。论文就Ghrelin在调节哺乳动物淋巴细胞增殖、细胞因子分泌、炎症及组织损伤等方面的研究进展进行了综述,同时将禽类Ghrelin在免疫系统中的研究与之进行比较,为深入探索禽类Ghrelin在免疫系统中的功能及机制提供参考。
Ghrelin is a growth hormone releasing peptide with many biological functions.In recent years,its role in mammalian immune system has been increased,while few studies were performed in avian immune system.In this paper,the regulation of ghrelin on lymphocyte proliferation,cytokine secretion,inflammation and tissue injury were reviewed.Meanwhile,the comparison was made between the function of poultry ghrelin and mammal ghrelin in immune system.We hope that it will provide new ideas for the study of poultry ghrelin functions in immune system.
Ghrelin is a growth hormone releasing peptide with many biological functions.In recent years,its role in mammalian immune system has been increased,while few studies were performed in avian immune system.In this paper,the regulation of ghrelin on lymphocyte proliferation,cytokine secretion,inflammation and tissue injury were reviewed.Meanwhile,the comparison was made between the function of poultry ghrelin and mammal ghrelin in immune system.We hope that it will provide new ideas for the study of poultry ghrelin functions in immune system.
引文
[1] 唐丽,赵鹏伟,白瑞霞.ghrelin对人卵巢癌细胞株HO-8910增殖和凋亡的影响[J].南昌大学学报:医学版,2015(4):15-17.
[2] 刘婷宇,赵莹,王娇,等.禽类与哺乳类Ghrelin结构及功能研究进展[J].中国畜牧杂志,2018,54(2):21-25.
[3] 杨琼,刘进远,石凌霄.Ghrelin的研究进展及在仔猪上的应用前景[J].黑龙江畜牧兽医,2015(15):89-91.
[4] 杜娟,马瑜,陈芳,等.Ghrelin系统在炎症反应中的作用和研究进展[J].解剖科学进展,2017(5):518-521.
[5] 杨春艳,冯朝晖,杨萍,等.Ghrelin对AngⅡ诱导的心肌细胞凋亡的影响及机制[J].中国实验诊断学,2017,21(11):1982-1987.
[6] Baatar D,Patel K,Taub D D.The effects of ghrelin on inflammation and the immune system[J].Mol Cell Endocrinol,2011,340(1):44-58.
[7] Taub D D.Novel connections between the neuroendocrine and immune systems:the ghrelin immunoregulatory network[J].Vitam Horm,2007,77:325-346.
[8] 赵红光.Ghrelin对药物性肝损伤的作用及机制研究[D].吉林长春:吉林大学,2017.
[9] Wang W,Bansal S,Falk S,et al.Ghrelin protects mice against endotoxemia-induced acute kidney injury [J].Ajp Renal Physiol,2009,297:F1032-F1037.
[10] 张岩,马君贤,张金山.Ghrelin在类风湿关节炎中的研究进展[J].中国医药导报,2016,31(13):42-45.
[11] 郑海崇,曾勉,何婉媚,等.Ghrelin对脓毒症大鼠肺泡巨噬细胞炎症信号通路Akt、NF-κB和iNOS的影响[J].中山大学学报:医学科学版,2018(1):1-8.
[12] Dixit V D,Yang H,Cooper-Jenkins A,et al.Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression:implications for age-associated increases in inflammation[J].Blood,2009,113(21):5202-5205.
[13] 梅宗香.Ghrelin对岭南黄鸡细胞免疫功能的调节作用[D].广东广州:华南农业大学,2008.
[14] 李斌,曾勉,何婉媚,等.Ghrelin通过JNK信号通路抑制LPS诱导的肺泡巨噬细胞凋亡[J].中山大学学报:医学科学版,2015,36(2):181-188.
[15] Dixit V D,Yang H,Sun Y,et al.Ghrelin promotes thymopoiesis during aging[J].J Clin Invest,2007,117(10):2778-2790.
[16] 赵洁,张金山,李臻,等.Ghrelin在小鼠应激性胸腺萎缩中的表达及其意义[J].中国组织化学与细胞化学杂志,2009(4):472-472.
[17] 陈学清,王媛媛,刘思德,等.Ghrelin增强树突状细胞的免疫功能[J].现代消化及介入诊疗,2009,14(4):228-232,249.
[18] Koo G C,Huang C,Camacho R,et al.Immune enhancing effect of a growth hormone secretagogue[J].J Immunol,2001,166(6):4195-4201.
[19] 元艳.Ghrelin在天府肉鸭免疫器官内动态表达的研究[D].四川雅安:四川农业大学,2012.
[20] 崔晓婷,陈吉.Ghrelin与肝脏疾病关系的研究进展[J].世界最新医学信息文摘,2016(96):26-27.
[21] Iseri S O,Sener G,Saglam B,et al.Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats[J].Regul Peptides,2008,146(1-3):73-79.
[22] Gonzalez-Rey E,Chorny A,Delgado M.Therapeutic action of ghrelin in a mouse model of colitis[J].Gastroenterology,2006,130(6):1707-1720.
[23] 王旭垒,王雪,蒋维,等.Ghrelin拮抗LPS诱导的肝细胞损伤的保护作用[J].中国药理学通报,2013,29(4):486-490.
[24] Yang W L,Ma G,Zhou M,et al.Combined administration of human ghrelin and human growth hormone attenuates organ injury and improves survival in aged septic rats[J].Mol Med,2016,22(1):124-135.
[25] Deng B,Fang L,Chen X,et al.Effect of ghrelin on angiotensin Ⅱ induced human umbilicus vein endothelial cell oxidative stress and endothelial cell injury[J].J Central South University,2010,35(10):1037-1047.
[26] Ning S,Hui W,Li M,et al.Ghrelin attenuates brain injury in septic mice via PI3K/Akt signaling activation[J].Brain Res Bulletin,2016,124:278-285.
[27] Zhou M,Yang W L,Aziz M,et al.Therapeutic effect of human ghrelin and growth hormone:attenuation of immunosuppression in septic aged rats[J].Biochim Biophys Acta,2017,1863(10):1-45.
[28] 郑福,张珍,黎宗强.Ghrelin结构与生理功能的研究进展[J].黑龙江畜牧兽医,2015(19):77-80.
[29] Tang X,Tang G,Liang Z,et al.Effects of Ghrelin miRNA on inflammation and calcium pathway in pancreatic acinar cells of acute pancreatitis[J].Pancreas,2017,46(10):1305-1313.
[30] 王静,徐萍,杨志文,等.PI3K/AKT激动剂和抑制剂对巨噬细胞炎症反应的影响[J].胃肠病学,2017,22(2):82-86.
[31] Reis M D D S,Menezes C A D,Borbely K S C,et al.Resident murine macrophage migration and phagocytosis are modulated by growth hormone[J].Cell Biol Int,2018,42(5):615-623.
[2] 刘婷宇,赵莹,王娇,等.禽类与哺乳类Ghrelin结构及功能研究进展[J].中国畜牧杂志,2018,54(2):21-25.
[3] 杨琼,刘进远,石凌霄.Ghrelin的研究进展及在仔猪上的应用前景[J].黑龙江畜牧兽医,2015(15):89-91.
[4] 杜娟,马瑜,陈芳,等.Ghrelin系统在炎症反应中的作用和研究进展[J].解剖科学进展,2017(5):518-521.
[5] 杨春艳,冯朝晖,杨萍,等.Ghrelin对AngⅡ诱导的心肌细胞凋亡的影响及机制[J].中国实验诊断学,2017,21(11):1982-1987.
[6] Baatar D,Patel K,Taub D D.The effects of ghrelin on inflammation and the immune system[J].Mol Cell Endocrinol,2011,340(1):44-58.
[7] Taub D D.Novel connections between the neuroendocrine and immune systems:the ghrelin immunoregulatory network[J].Vitam Horm,2007,77:325-346.
[8] 赵红光.Ghrelin对药物性肝损伤的作用及机制研究[D].吉林长春:吉林大学,2017.
[9] Wang W,Bansal S,Falk S,et al.Ghrelin protects mice against endotoxemia-induced acute kidney injury [J].Ajp Renal Physiol,2009,297:F1032-F1037.
[10] 张岩,马君贤,张金山.Ghrelin在类风湿关节炎中的研究进展[J].中国医药导报,2016,31(13):42-45.
[11] 郑海崇,曾勉,何婉媚,等.Ghrelin对脓毒症大鼠肺泡巨噬细胞炎症信号通路Akt、NF-κB和iNOS的影响[J].中山大学学报:医学科学版,2018(1):1-8.
[12] Dixit V D,Yang H,Cooper-Jenkins A,et al.Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression:implications for age-associated increases in inflammation[J].Blood,2009,113(21):5202-5205.
[13] 梅宗香.Ghrelin对岭南黄鸡细胞免疫功能的调节作用[D].广东广州:华南农业大学,2008.
[14] 李斌,曾勉,何婉媚,等.Ghrelin通过JNK信号通路抑制LPS诱导的肺泡巨噬细胞凋亡[J].中山大学学报:医学科学版,2015,36(2):181-188.
[15] Dixit V D,Yang H,Sun Y,et al.Ghrelin promotes thymopoiesis during aging[J].J Clin Invest,2007,117(10):2778-2790.
[16] 赵洁,张金山,李臻,等.Ghrelin在小鼠应激性胸腺萎缩中的表达及其意义[J].中国组织化学与细胞化学杂志,2009(4):472-472.
[17] 陈学清,王媛媛,刘思德,等.Ghrelin增强树突状细胞的免疫功能[J].现代消化及介入诊疗,2009,14(4):228-232,249.
[18] Koo G C,Huang C,Camacho R,et al.Immune enhancing effect of a growth hormone secretagogue[J].J Immunol,2001,166(6):4195-4201.
[19] 元艳.Ghrelin在天府肉鸭免疫器官内动态表达的研究[D].四川雅安:四川农业大学,2012.
[20] 崔晓婷,陈吉.Ghrelin与肝脏疾病关系的研究进展[J].世界最新医学信息文摘,2016(96):26-27.
[21] Iseri S O,Sener G,Saglam B,et al.Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats[J].Regul Peptides,2008,146(1-3):73-79.
[22] Gonzalez-Rey E,Chorny A,Delgado M.Therapeutic action of ghrelin in a mouse model of colitis[J].Gastroenterology,2006,130(6):1707-1720.
[23] 王旭垒,王雪,蒋维,等.Ghrelin拮抗LPS诱导的肝细胞损伤的保护作用[J].中国药理学通报,2013,29(4):486-490.
[24] Yang W L,Ma G,Zhou M,et al.Combined administration of human ghrelin and human growth hormone attenuates organ injury and improves survival in aged septic rats[J].Mol Med,2016,22(1):124-135.
[25] Deng B,Fang L,Chen X,et al.Effect of ghrelin on angiotensin Ⅱ induced human umbilicus vein endothelial cell oxidative stress and endothelial cell injury[J].J Central South University,2010,35(10):1037-1047.
[26] Ning S,Hui W,Li M,et al.Ghrelin attenuates brain injury in septic mice via PI3K/Akt signaling activation[J].Brain Res Bulletin,2016,124:278-285.
[27] Zhou M,Yang W L,Aziz M,et al.Therapeutic effect of human ghrelin and growth hormone:attenuation of immunosuppression in septic aged rats[J].Biochim Biophys Acta,2017,1863(10):1-45.
[28] 郑福,张珍,黎宗强.Ghrelin结构与生理功能的研究进展[J].黑龙江畜牧兽医,2015(19):77-80.
[29] Tang X,Tang G,Liang Z,et al.Effects of Ghrelin miRNA on inflammation and calcium pathway in pancreatic acinar cells of acute pancreatitis[J].Pancreas,2017,46(10):1305-1313.
[30] 王静,徐萍,杨志文,等.PI3K/AKT激动剂和抑制剂对巨噬细胞炎症反应的影响[J].胃肠病学,2017,22(2):82-86.
[31] Reis M D D S,Menezes C A D,Borbely K S C,et al.Resident murine macrophage migration and phagocytosis are modulated by growth hormone[J].Cell Biol Int,2018,42(5):615-623.
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