褐藻苷苔(Ecklonia cava)生物活性物质研究进展
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摘要
褐藻因含有丰富的生物活性物质及其具有的功能作用而成为科学家研究的热点。苷苔是一种广泛分布在韩国和日本海岸的褐藻,可以作为食物成分、动物饲料、肥料和药物,其含有丰富的褐藻多酚、岩藻聚糖硫酸酯、褐藻酸盐和色素等活性物质。论文综述了从苷苔中分离出的活性物质的功能活性,重点概括了褐藻多酚、岩藻聚糖硫酸酯的抗炎、抗氧化、抗糖尿病、抗凝血和抗肿瘤等活性,阐述了近年来苷苔活性物质的应用研究进展及现状,并展望了苷苔产业的发展,为苷苔活性物质进一步研究开发提供参考。
Brown seaweed is known as it contains an abundance of great potential bioactive compounds in the area of pharmaceuticals,food,and biomedical industries. Ecklonia cava is a brown seaweed widely distributed on the coasts of Korea and Japan which can be used as food ingredient,animal feed,fertilizer,and medicine. Ecklonia cava contains a variety of compounds including polyphenol,fucoidans,carotenoids,and phlorotannins. The paper reviewed the functional activities of active substances isolated from Ecklonia cava,focusing on the anti-inflammatory,anti-oxidation,anti-diabetic,anti-coagulant and anti-tumor activities of polyphenols and fucoidan.The research summarized the progress of current status and application of most active substances,and the development of Ecklonia cava industry was prospected,which provides a reference for the further research and development of Ecklonia cava active substances.
Brown seaweed is known as it contains an abundance of great potential bioactive compounds in the area of pharmaceuticals,food,and biomedical industries. Ecklonia cava is a brown seaweed widely distributed on the coasts of Korea and Japan which can be used as food ingredient,animal feed,fertilizer,and medicine. Ecklonia cava contains a variety of compounds including polyphenol,fucoidans,carotenoids,and phlorotannins. The paper reviewed the functional activities of active substances isolated from Ecklonia cava,focusing on the anti-inflammatory,anti-oxidation,anti-diabetic,anti-coagulant and anti-tumor activities of polyphenols and fucoidan.The research summarized the progress of current status and application of most active substances,and the development of Ecklonia cava industry was prospected,which provides a reference for the further research and development of Ecklonia cava active substances.
引文
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[24]Jiyi Janga,Bo-Ram Yea,Soo-Jin Heoa,et al.Photooxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes[J].Environ Toxicol Pharmacol,2012(34):926-934.
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[32]Seung-Hong Lee,Mi-Hwa Park,Sun-Joo Park,et al.Bioactive compounds extracted from Ecklonia cava by using enzymatic hydrolysis protects high glucose-induced damage in INS-1 pancreaticβ-cells[J].Appl Biochem Biotechnol,2012,167:1973-1985.
[33]Mi-Hwa,Soo-Jin,Pyo-Jam,et al.6,6'-Bieckol isolated from Ecklonia cava protects oxidative stress through inhibiting expression of ROS and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells[J].Appl Biochem Biotechnol,2014,174:632-643.
[34]Ji-Young Yoon,Hojung Choi,Hee-Sook Jun.The effect of phloroglucinol,a component of Ecklonia cava extract,on hepatic glucose production[J].Mar Drugs,2017,15(4):106.
[35]Chang-Suk,Haejin,Youngwan.Edible brown alga Ecklonia cava derived phlorotannin-induced anti-adipogenic activity in vitro[J].Journal of Food Biochemistry,2015,(39):1-10.
[36]Karadeniz F,Ahn B N,Kim J A,et al.Phlorotannins suppress adipogenesis in pre-adipocytes while enhancing osteoblastogenesis in pre-osteoblasts[J].Archives of Pharmacal Research,2015,38(12):2172-82.
[37]Hyeon-Son Choi,Hui-Jeon Jeon,Ok-Hwan Lee,et al.Dieckol,a major phlorotannin in Ecklonia cava,suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice:Inhibition of early adipogenesis via cell-cycle arrest and AMPK activation[J].Mol Nutr Food Res,2015,(59):1458-1471.
[38]Li,Lee,Le,et al.Antiallergic effects of phlorotannins on histamine release via binding inhibittion between Ig E and Fce RI[J].Journal of Agricultural&Food Chemistry,2008,56(24):12073-12080.
[39]Shim,Le QT,Lee SH,et al.Ecklonia cava extract suppresses the high-affinity Ig E receptor,Fc RRI expression[J].Food&Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association,2009,47(3):555-560.
[40]Ahn G,Amagai Y,Matsuda A,et al.Dieckol,a phlorotannin of Ecklonia cava,suppresses Ig E-mediated mast cell activation and passive cutaneous anaphylactic reaction[J].Experimental Dermatology,2016,24(12):968-970.
[41]Quang-To Le,Yong Li,Zhong-Ji Qian,et al.Inhibitory effects of polyphenols isolated from marine alga Ecklonia cava on histamine release[J].Process Biochemistry,2009,44,168-176.
[42]Byoung Wook Choi,Hye Sook Lee,Hyeon-Cheol Shin,et al.Multifunctional activity of polyphenolic compounds associated with a potential for alzheimer’s disease therapy from Ecklonia cava[J].Phytotherapy Research,2015(29):549-553.
[43]Shin,Kim,Cho,et al.Enhancement of human hair growth using Ecklonia cava polyphenols[J].Annals of Dermatology,2016,28(1):15.
[44]Murat Artan,Yong Li,Fatih Karadeniz,et al.Anti-HIV-1activity of phloroglucinol derivative,6,6'-bieckol,from Ecklonia cava[J].Bioorg Med Chem,2008(16):7921-7926.
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[2]Ye Jin Jo,Yoon Sik Oh,Min Young Kim,et al.Transcriptiona responses in Ecklonia cava to short-term exposure to hyperthermal stess[J].Health Science and Springer,2016,8(2):181-188.
[3]Iwahashi Y,Inaba,Hushimi,et al.Ecological studies on Eisenia and Ecklonia in thecoast of Izu Peninsula-IV[J].The distribution and characteristicsof kelp stand,1979,13(10):75-82.
[4]Yukihiko S,Hideki A,Kazuyo M,et al.Morphometric study o Ecklonia cava sporophytes in two localities with differen temperature conditions.Phycological Research,2002,50:193-199.
[5]Hayashida F.Synecological studies of a brown alga,Ecklonia cava Kjellman,forming aquatic forest-II.On growth of Ecklonia cava[J].J Fac Mar Sci Technol Tokai Univ,1984,18:275-280.
[6]Kida,Maegawa M.Ecological studies on Eisenia bicyclis and Ecklonia cava community in the coastal areas of Kumanonada[J].The botanical magazine=Shokubutsu-gaku-zasshi,1982,10:57-69.
[7]Yong Li,Sang-Hoon Lee,Quang,et al.Anti-allergic effects o phlorotannins on histamine release via binding inhibition between Ig E and FcεRI[J].Agricultural And Food Chemistry,2008,56:12037-12080.
[8]Gin-Nae Ahn,Kil-Nam Kim,Seon-Heui Cha.Antioxidan activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage[J].European Food Research and Technology,2007,226(1-2):71-79.
[9]Hye-Jin Choi,Jung-Hwan Park,Bong Ho Lee,et al.Suppression of NF-κB by dieckol extracted from Ecklonia cava negatively regulates LPS induction of inducible nitric oxide synthase gene[J].Appl Biochem Biotechnol,2014,173:957-967.
[10]Yasantha Athukorala,Won-Kyo Jun,Thava Vasanthan,et al.An anticoagulative polysaccharide from an enzymatic hydrolysate of Ecklonia cava[J].Carbohydrate Polymers,2006,(66):184-191.
[11]Ahn,Yang,Lee,et al.Dieckol isolated from the edible brown algae Ecklonia cava,induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth[J].Journal of cancer research&clinical oncology,2015,141(2):255-268.
[12]Koth,Yeon,Young,et al.Lipase inhibitory activity of ethyl acetate fraction from Ecklonia cava extracts[J].Biotechnology and Bioprocess Engineering,2012(17):739-745.
[13]Ginnae Ahn,Insun Hwang,Eunjin Park,et al.Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes[J].Marine Biotechnol,2008,10(2):278-289.
[14]杨会成,董士远,刘尊英,等.海藻中多酚类化学成分及其生物活性研究[J],中国海洋药物,2007,26(5):53-59.
[15]徐雅茹.褐藻多酚的抗氧化研究[D].宁波:宁波大学,2014.
[16]Bu H,Kim Y,Lee S,et al.Elastase and hyaluronidase inhibition activities of phlorotannins isolated from Ecklonia cava[J].Saengyak Hakhoechi,2006,37(2):92-96.
[17]Li Y,Qian Z J,Ryu B,et al.Chemical components and its antioxidant properties in vitro:An edible marine brown alga,Ecklonia cava Bioorg[J].Bioorg Med Chem,2009,17(5):1963-1973.
[18]Wijesekara,Young Yoon,Se-Kwon,et al.Phlorotannins from Ecklonia cava(Phaeophyceae):Biological activities and potential health benefits[J].International Union of Biochemistry and Molecular Biology,2010,36(6):408-414.
[19]Kang,Park,Hwang HJ,et al.Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors[J].Arch Pharm Res,2003,26(5):286-293.
[20]Kyoung Ah Kanga,Kyoung Hwa Leea,Sungwook Chaea,et al.Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells[J].FEBS Letters,2005,(579):6295-6304.
[21]Seung-Hong Lee,Seok-Chun Ko,Sung-Myung Kang.Antioxidative effect of Ecklonia cava dried by far infrared radiation drying[J].Food Sci Biotechnol,2010,19(1):129-135.
[22]Mun Young Chang,Song Yee Han,Hyeon-Cheol Shin,et al.Protective effect of a purified polyphenolic extract from Ecklonia cava against noise-induced hearing loss:Prevention of temporary threshold shift[J].International Journal of Pediatric Otorhinolaryngology,2016,87:178-184.
[23]Bo Mi Ryu,Byul-Nim Ahnb,Kyong-Hwa Kang,et al.Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2andcaspase pathway[J].Journal of Photochemistry&Photobiology Biology,2015(153):352-357.
[24]Jiyi Janga,Bo-Ram Yea,Soo-Jin Heoa,et al.Photooxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes[J].Environ Toxicol Pharmacol,2012(34):926-934.
[25]Hwang,Kim,Lee.Crude Ecklonia cava flake extracts attenuate inflammation through the regulation of TLR4 signaling pathway in LPS-induced RAW264.7 cells[J].Molecules,2017,22(5):777.
[26]Hye Kyung Kim.Role of ERK/MAPK signalling pathway in anti-inflammatory effects of Ecklonia cava in activated human mast cell line-1 cells[J].Asian Pacific Journal of Tropical Medicine,2014,7(9):703-708.
[27]Nalae Kang,Eui Jeong Han,Soo Yeon Park,et al.Inhibitory effects of Ecklonia cava ethanol extracts against TNF-α/IFN-γ-Induced inflammation in human keratinocytes[J].Journal of Aquatic Food Technology,2017,22(2):82-88.
[28]Eun-Kyung Kim,Yujiao Tang,Yon-Suk Kim,et al.First evidence that Ecklonia cava-derived dieckol attenuates MCF-7human breast carcinoma cell migration[J].Marine Drugs,2015,(13):1785-1797.
[29]Sadeeshkumar,Duraikannu,Ravichandran,et al.Modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes,cell proliferation,apoptosis,invasion and angiogenesis during NDEA-induced rat hepatocarcinogenesis[J].Molecular&Cellular Biochemistry,2017(4):1-10.
[30]Hyun-Ah,Ji-Hyeok,Ji-Sook Hanc,et al.A phlorotannin constituent of Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice[J].Pharmaceutical Biology,2017,55(1):1149-1154.
[31]Lee Sang-Hoon,Karadeniz Fatih,Kim,et al.α-Glycosidase andα-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga Ecklonia cava[J].Journal of the Science of Food and Agriculture,2009,89(9):1552-1558.
[32]Seung-Hong Lee,Mi-Hwa Park,Sun-Joo Park,et al.Bioactive compounds extracted from Ecklonia cava by using enzymatic hydrolysis protects high glucose-induced damage in INS-1 pancreaticβ-cells[J].Appl Biochem Biotechnol,2012,167:1973-1985.
[33]Mi-Hwa,Soo-Jin,Pyo-Jam,et al.6,6'-Bieckol isolated from Ecklonia cava protects oxidative stress through inhibiting expression of ROS and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells[J].Appl Biochem Biotechnol,2014,174:632-643.
[34]Ji-Young Yoon,Hojung Choi,Hee-Sook Jun.The effect of phloroglucinol,a component of Ecklonia cava extract,on hepatic glucose production[J].Mar Drugs,2017,15(4):106.
[35]Chang-Suk,Haejin,Youngwan.Edible brown alga Ecklonia cava derived phlorotannin-induced anti-adipogenic activity in vitro[J].Journal of Food Biochemistry,2015,(39):1-10.
[36]Karadeniz F,Ahn B N,Kim J A,et al.Phlorotannins suppress adipogenesis in pre-adipocytes while enhancing osteoblastogenesis in pre-osteoblasts[J].Archives of Pharmacal Research,2015,38(12):2172-82.
[37]Hyeon-Son Choi,Hui-Jeon Jeon,Ok-Hwan Lee,et al.Dieckol,a major phlorotannin in Ecklonia cava,suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice:Inhibition of early adipogenesis via cell-cycle arrest and AMPK activation[J].Mol Nutr Food Res,2015,(59):1458-1471.
[38]Li,Lee,Le,et al.Antiallergic effects of phlorotannins on histamine release via binding inhibittion between Ig E and Fce RI[J].Journal of Agricultural&Food Chemistry,2008,56(24):12073-12080.
[39]Shim,Le QT,Lee SH,et al.Ecklonia cava extract suppresses the high-affinity Ig E receptor,Fc RRI expression[J].Food&Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association,2009,47(3):555-560.
[40]Ahn G,Amagai Y,Matsuda A,et al.Dieckol,a phlorotannin of Ecklonia cava,suppresses Ig E-mediated mast cell activation and passive cutaneous anaphylactic reaction[J].Experimental Dermatology,2016,24(12):968-970.
[41]Quang-To Le,Yong Li,Zhong-Ji Qian,et al.Inhibitory effects of polyphenols isolated from marine alga Ecklonia cava on histamine release[J].Process Biochemistry,2009,44,168-176.
[42]Byoung Wook Choi,Hye Sook Lee,Hyeon-Cheol Shin,et al.Multifunctional activity of polyphenolic compounds associated with a potential for alzheimer’s disease therapy from Ecklonia cava[J].Phytotherapy Research,2015(29):549-553.
[43]Shin,Kim,Cho,et al.Enhancement of human hair growth using Ecklonia cava polyphenols[J].Annals of Dermatology,2016,28(1):15.
[44]Murat Artan,Yong Li,Fatih Karadeniz,et al.Anti-HIV-1activity of phloroglucinol derivative,6,6'-bieckol,from Ecklonia cava[J].Bioorg Med Chem,2008(16):7921-7926.
[45]Chandía,Matsuhiro B.Characterization of a fucoidan from Lessonia vadosa(Phaeophyta)and its anticoagulant and elicitor properties[J].International Journal of Biological Macromolecules,2008,42(3):235-240.
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