呼吸道上皮细胞在牛肺炎发病机制中的作用
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摘要
牛肺炎的发病机制十分复杂,涉及到多种因素的综合作用。病毒感染、冷空气刺激、空气质量差、运输应激等均可损害呼吸道上皮细胞的防御系统,为细菌感染创造条件。致病因素可以影响呼吸道粘液分泌和纤毛功能;引起Toll样受体和Tim-1表达异常。在牛肺炎的发病机制中,NF-κB信号通路也具有重要作用。
The pathogenesis of bacterial pneumonia in cattle is very complicated, which involves many factors. Virus infection, cold air stimulation, poor air quality, transport stress and other factors can damage the respiratory epithelial cell defense system, so as to create conditions for the infection of bacterial pathogens. Pathogenic factors can affect mucus secretion and cilia function in the respiratory tract, also cause abnormal expression of Toll like receptors and Tim-1. NFkappa B signaling pathway also plays an important role in the pathogenesis of bovine pneumonia.
The pathogenesis of bacterial pneumonia in cattle is very complicated, which involves many factors. Virus infection, cold air stimulation, poor air quality, transport stress and other factors can damage the respiratory epithelial cell defense system, so as to create conditions for the infection of bacterial pathogens. Pathogenic factors can affect mucus secretion and cilia function in the respiratory tract, also cause abnormal expression of Toll like receptors and Tim-1. NFkappa B signaling pathway also plays an important role in the pathogenesis of bovine pneumonia.
引文
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[2]Sow FB,Gallup JM,Krishnan S,et al.Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs[J].Respiratory Research,2011,12(1):342-346
[3]Murphy TW,Cargill CF,Rutley DL,et al.Pig-shed air polluted by&alpha-haemolytic cocci and ammonia causes subclinical disease and production losses[J].Journal of the British Veterinary Association,2012,171(5):123-128
[4]Shen JC,Chen B,Cohen NA,et al.Keratinocyte chemoattractant(interleukin-8)regulation of sinonasal cilia function in a murine model.Int.Forum Allergy Rhinol.2,75-79[J].International Forum of Allergy&Rhinology,2012,2(1):75-79
[5]Jain R,Ray JM,Pan JH,et al.Sex Hormone-Dependent Regulation of Cilia Beat Frequency in Airway Epithelium[J].American Journal of Respiratory Cell&Molecular Biology,2012,46(4):446-453
[6]涂君平,王晓谦,蒋会会,等.猪肺炎支原体膜蛋白特点及其致病机制的研究进展[J].黑龙江畜牧兽医,2016(5):73-76
[7]邵文霞,叶青,王青青,等.肺炎支原体感染与儿童继发过敏的相关性研究[J].第二军医大学学报,2016,37(4):521-523
[8]Bürki S,Gaschen V,Stoffel MH,et al.Invasion and persistence of Mycoplasma bovis,in embryonic calf turbinate cells[J].Veterinary Research,2015,46(53):1-14
[9]Kong LC,Gao D,Jia BY,et al.Antimicrobial susceptibility and molecular characterization of macrolide resistance of Mycoplasma bovis isolates from multiple provinces in China[J].Journal of Veterinary Medical Science,2016,78(2):293-296
[10]樊青,颜萍,李培杰.不同类型支原体肺炎外周血TIM和TLR基因表达的变化及其意义[J].中国免疫学杂志,2016,32(4):546-552
[11]Rensetti D,Marin M,Quintana S,et al.Involvement of toll-like receptors 3 and 7/8 in the neuropathogenesis of bovine herpesvirus types 1 and 5[J].Research in Veterinary Science,2016,107:1-7
[12]Rodríguez F,González JF,Arbelo M,et al.Cytokine expression in lungs of calves spontaneously infected with Mycoplasma bovis[J].Veterinary Research Communications,2015,39(1):69-72
[13]Shivshankar P,Boyd AR,Saux CJL,et al.Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia[J].Aging Cell,2011,10(5):798-806
[14]Poole JA,Wyatt TA,Kielian T,et al.Toll-Like Receptor 2 Regulates Organic Dust-Induced Airway Inflammation[J].American Journal of Respiratory Cell&Molecular Biology,2011,45(4):711-719
[15]Vareille M,Kieninger E,Edwards MR,et al.The Airway Epithelium:Soldier in the Fight against Respiratory Viruses[J].Clinical Microbiology Reviews,2011,24(1):210-229
[16]Silva LFD,Sinani D,Jones C.ICP27 protein encoded by bovine herpesvirus type 1(bICP27)interferes with promoter activity of the bovine genes encoding beta interferon 1(IFN-β1)and IFN-β3[J].Virus Research,2012,169(1):162-168
[17]Zhu L,Yuan C,Huang L,et al.The activation of p38MAPK and JNK pathways in bovine herpesvirus 1 infected MDBK cells[J].Veterinary Research,2016,47(1):91-98
[18]Rückle A,Haasbach E,Julkunen I,et al.The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells[J].Journal of Virology,2012,86(18):10211-10217
[19]张金川,王志刚.铜绿假单胞菌感染引起TLR4活化导致NF-κB激活引起炎症反应[J].中国煤炭工业医学杂志,2013,16(8):1307-1308
[20]Negishi H,Yanai H,Nakajima A,et al.Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses[J].Nature Immunology,2012,13(7):659-666
[21]王云,黄升海,吴璇,等.呼吸道合胞病毒合并肺炎克雷伯菌感染所致肺炎与TLR4-NF-κB信号通路关系的初步研究[J].安徽医科大学学报,2015,50(9):1252-1258
[22]周敏.HMGB1-PTEN信号对脓毒症肺损伤调节性T细胞的影响及机制[D].合肥:安徽医科大学,2015
[23]Jamieson AM,Pasman L,Yu S,et al.Role of tissue protection in lethal respiratory viral-bacterial coinfection[J].Science,2013,340(6137):1230-1234
[24]Mcgill JL,Rusk RA,Mariana GM,et al.Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica[J].Plos One,2016,11(3):1-20
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[26]Hajishengallis G,Lambris JD.Microbial manipulation of receptor crosstalk in innate immunity[J].Nature Reviews Immunology,2011,11(3):187-200
[27]Kravchenko VV,Kaufmann GF,Mathison JC,et al.Modulation of gene expression via disruption of NF-kappa Bsignaling by a bacterial small molecule[J].Science,2008,321(5886):259-263
[28]方晓敏,赵为民,付言峰,等.猪支原体肺炎发生的品种敏感差异及分子基础[J].中国农业科学,2015(14):2839-2847
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