P物质与犬术后急性疼痛强度关系
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摘要
P物质与术后疼痛密切相关,为了探究P物质与犬术后急性疼痛强度的关系,本试验基于比格犬术后急性疼痛模型,通过量表评分和P物质基因表达量比较研究犬术后急性疼痛强度。结果显示,试验组犬术后疼痛在1～24h期间明显高于假手术组(P<0.05),P物质基因表达量与量表评分对应良好,呈正相关。结果表明,P物质的基因表达量跟疼痛强度呈正相关,为犬术后疼痛的量化和科学干预奠定基础,对推进动物"疼痛最小化"有重要意义。
The substance P is closely relative to the postoperative pain.For exploring the relation between the P substance and the acute pain intensity after the surgery,comparing with the scale and gene expression of the P substance by building the model of acute pain after surgery in Beagle dogs.The experimental group postoperative pain is obviously more severe than the sham operation group(P<0.05)during the postoperative 24 h.There is good correspondence and positive correlation between the gene expression of the P substance and the postoperative pain.It lays a foundations of quantization and scientific intervention for animal"pain minimization"in postoperation.
The substance P is closely relative to the postoperative pain.For exploring the relation between the P substance and the acute pain intensity after the surgery,comparing with the scale and gene expression of the P substance by building the model of acute pain after surgery in Beagle dogs.The experimental group postoperative pain is obviously more severe than the sham operation group(P<0.05)during the postoperative 24 h.There is good correspondence and positive correlation between the gene expression of the P substance and the postoperative pain.It lays a foundations of quantization and scientific intervention for animal"pain minimization"in postoperation.
引文
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[2]GLENK L M.Current perspectives on therapy dog welfare in animal-assisted interventions[J].Animals(Basel),2017,7(2):326-334.
[3]远立国,熊惠军,贾坤,等.动物疼痛识别与评估研究进展[J].畜牧兽医学报,2014,45(10):1592-1599.
[4]LEE B,KIM K,AHN S,et al.Continuous wound infiltration system for postoperative pain management in gynecologic oncology patients[J].Arch Gynecol Obstet,2017,54(4):128-135.
[5]SPORER S M,ROGERS T.Postoperative pain management after primary total knee arthroplasty:the value of liposomal bupivacaine[J].J Arthrop,2016,31(11):2603-2607.
[6]WU X N,ZHANG T,QIAN N S,et al.Antinociceptive effects of endomorphin-2:suppression of substance P release in the inflammatory pain model rat[J].Neurochem Int,2015,82(10):1-9.
[7]DE AVILA E D,DE MOLON R S,DE GODOI G D,et al.Relationship between levels of neuropeptide substance P in periodontal disease and chronic pain:a literature review[J].J Invest Clin Dent,2014,5(2):91-97.
[8]LISOWSKA B,SIEWRUK K,LISOWSKI A.Substance P and acute pain in patients undergoing orthopedic surgery[J].PLoS One,2016,11(1):e146400.
[9]CASTEL D,WILLENTZ E,DORON O,et al.Characterization of a porcine model of post-operative pain[J].Eur J Pain,2014,18(4):496-505.
[10]AMIRMOHSENI S,SEGELCKE D,REICHL S,et al.Characterization of incisional and inflammatory pain in rats using functional tools of MRI[J].Neuroimage,2016,127(9):110-122.
[11]WANG S F,DONG C G,YANG X,et al.Upregulation of(C-X-C motif)ligand 13(CXCL13)attenuates morphine analgesia in rats with cancer-induced bone pain[J].Med Sci Monit,2016,22(29):4612-4622.
[12]CHEN Y W,TZENG J I,HUANG P C,et al.Therapeutic ultrasound suppresses neuropathic pain and upregulation of substance P and neurokinin-1receptor in rats after peripheral nerve injury[J].Ultrasound Med Biol,2015,41(1):143-150.
[13]SACERDOTE P,LEVRINI L.Peripheral mechanisms of dental pain:the role of substance P[J].Mediat Inflamm,2012,2012(10):951920.
[14]ETEMADI L,PETTERSSON L M,DANIELSEN N.UVB irradiation induces rapid changes in galanin,substance P and c-fos immunoreactivity in rat dorsal root ganglia and spinal cord[J].Peptides,2017,87(5):71-83.
[15]THORNTON E,VINK R.Substance P and its tachykinin NK1receptor:a novel neuroprotective target for Parkinson's disease[J].Neural Regen Res,2015,10(9):1403-1405.
[16]LAGERSTROM M C,ROGOZ K,ABRAHAMSENB,et al.A sensory subpopulation depends on vesicular glutamate transporter 2for mechanical pain,and together with substance P,inflammatory pain[J].Proc Natl Acad Sci USA,2011,108(14):5789-5794.
[17]LI R,QI F,ZHANG J,et al.Antinociceptive effects of dexmedetomidine via spinal substance P and CGRP[J].Transl Neurosci,2015,6(1):259-264.