解郁舒心丸联合西酞普兰治疗产后抑郁症的效果
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摘要
目的探究解郁舒心丸联合西酞普兰治疗产后抑郁症的效果。方法以2016年1月至2018年1月本院收治的89例产后抑郁症患者作为研究对象,随机分为观察组(n=45)和对照组(n=44),对照组给予西酞普兰治疗,观察组在此基础上加用解郁舒心丸给予治疗,连续治疗6周,统计对比两组治疗前后Edinburgh产后抑郁量表(EPDS)评分、汉密顿抑郁量表(HAMD)评分,并判定疗效;对比两组治疗前后血清雌二醇(E_2)、孕酮(P)、孤啡肽(OFQ)和5-羟色胺(5-HT)水平变化情况;观察记录两组不良反应发生情况。结果治疗后两组EPDS评分和HAMD评分均较治疗前降低,且观察组各评分明显低于对照组(P<0.05);观察组治疗有效率为93.33%,明显高于对照组的86.36%(P<0.05);治疗后两组E_2和5-HT水平均较治疗前升高,且观察组高于对照组(P<0.05);治疗后两组P和OFQ水平均较治疗前降低,且观察组低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义。结论解郁舒心丸联合西酞普兰治疗产后抑郁症的疗效优于单一使用西酞普兰治疗,不增加不良反应的发生,且对患者血清E_2、P、OFQ和5-HT水平的改善效果更为显著。
Objective To explore the effects of Jieyu Shuxin pill combined with citalopram on postpartum depression. Methods 89 cases of patients with postpartum depression who were admitted to the hospital from January 2016 to January 2018 were selected for the study and were randomly divided into observation group(n=45) and control group(n=44). Control group was given citalopram, and observation group was additionally given Jieyu Shuxin pill on the basis of this treatment, and they were continuously treated for 6 weeks. The Edinburgh Postpartum Depression Scale(EPDS) score and Hamilton Depression Scale(HAMD) score were counted and compared before and after treatment, and the efficacy was determined.The changes of levels of serum estradiol(E_2), progesterone(P), orphanin(OFQ) and 5-hydroxytryptamine(5-HT) were compared between the two groups before and after treatment. The occurrence of adverse reactions was observed and recorded in the two groups. Results After treatment, the scores of EPDS and HAMD in the two groups were lower than those before treatment, and the scores in observation group were significantly lower than those in control group(P<0.05). The effective rate of treatment in observation group was significantly higher than that in control group(93.33% vs 86.36%)(P<0.05). The levels of E_2 and 5-HT in the two groups were higher than those before treatment, and the levels in observation group were higher than those in control group(P<0.05). The levels of P and OFQ in the two groups were lower than those before treatment, and the levels in observation group were lower than those in control group(P<0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups. Conclusion Jieyu Shuxin pill combined with citalopram has better efficacy than single citalopram in the treatment of postpartum depression. And it does not increase the occurrence of adverse reactions, and it has significant improvement effects on the levels of serum E_2, P, OFQ and 5-HT.
Objective To explore the effects of Jieyu Shuxin pill combined with citalopram on postpartum depression. Methods 89 cases of patients with postpartum depression who were admitted to the hospital from January 2016 to January 2018 were selected for the study and were randomly divided into observation group(n=45) and control group(n=44). Control group was given citalopram, and observation group was additionally given Jieyu Shuxin pill on the basis of this treatment, and they were continuously treated for 6 weeks. The Edinburgh Postpartum Depression Scale(EPDS) score and Hamilton Depression Scale(HAMD) score were counted and compared before and after treatment, and the efficacy was determined.The changes of levels of serum estradiol(E_2), progesterone(P), orphanin(OFQ) and 5-hydroxytryptamine(5-HT) were compared between the two groups before and after treatment. The occurrence of adverse reactions was observed and recorded in the two groups. Results After treatment, the scores of EPDS and HAMD in the two groups were lower than those before treatment, and the scores in observation group were significantly lower than those in control group(P<0.05). The effective rate of treatment in observation group was significantly higher than that in control group(93.33% vs 86.36%)(P<0.05). The levels of E_2 and 5-HT in the two groups were higher than those before treatment, and the levels in observation group were higher than those in control group(P<0.05). The levels of P and OFQ in the two groups were lower than those before treatment, and the levels in observation group were lower than those in control group(P<0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups. Conclusion Jieyu Shuxin pill combined with citalopram has better efficacy than single citalopram in the treatment of postpartum depression. And it does not increase the occurrence of adverse reactions, and it has significant improvement effects on the levels of serum E_2, P, OFQ and 5-HT.
引文
[1]王敦建,陈卓伟.加味疏肝解郁汤联合醒脑开窍针法治疗产后抑郁症临床研究[J].四川中医,2017,35(12):184-187.
[2]刁端忠.艾司西酞普兰联合疏肝解郁胶囊治疗抑郁症临床研究[J].精神医学杂志,2016,29(5):371-373.
[3]中华医学会精神科分会.中国精神障碍分类与诊断标准[M].3版.济南:山东科学技术出版社,2001:87-89.
[4]中华中医药学会.中医内科常见病诊疗指南.中医病症部分[M].中国中医药出版社,2008.
[5]罗曼,屈箫箫,李少源,等.耳穴迷走神经刺激治疗原发性失眠症及其情感障碍35例:病例系列研究[J].中国针灸,2017,37(3):269-273.
[6]伍娇娇,冯望德,伍振.信阳市某医院产后抑郁症调查现况及相关因素分析[J].中华疾病控制杂志,2016,20(1):96-98.
[7]时增科,梁学军,高存友.丹栀逍遥散联合电针及重复经颅磁刺激治疗产后抑郁症33例[J].辽宁中医杂志,2016,43(6):1220-1223.
[8]张玉红,张阳佳.产后抑郁症和性激素水平、神经递质之间的相关性分析[J].实用医学杂志,2018,34(4):621-623.
[9]陈宁贵,廖敏.解郁丸联合西酞普兰治疗难治性抑郁症的疗效及其对血清去甲肾上腺素和5-羟色胺及脑源性神经营养因子指标的影响研究[J].中国全科医学,2017,20(S2):338-340.
[10]孙素改,李春雷,王继花.解郁舒心丸联合西酞普兰治疗产后抑郁症临床研究[J].河北医药,2016,38(6):921-922.
[2]刁端忠.艾司西酞普兰联合疏肝解郁胶囊治疗抑郁症临床研究[J].精神医学杂志,2016,29(5):371-373.
[3]中华医学会精神科分会.中国精神障碍分类与诊断标准[M].3版.济南:山东科学技术出版社,2001:87-89.
[4]中华中医药学会.中医内科常见病诊疗指南.中医病症部分[M].中国中医药出版社,2008.
[5]罗曼,屈箫箫,李少源,等.耳穴迷走神经刺激治疗原发性失眠症及其情感障碍35例:病例系列研究[J].中国针灸,2017,37(3):269-273.
[6]伍娇娇,冯望德,伍振.信阳市某医院产后抑郁症调查现况及相关因素分析[J].中华疾病控制杂志,2016,20(1):96-98.
[7]时增科,梁学军,高存友.丹栀逍遥散联合电针及重复经颅磁刺激治疗产后抑郁症33例[J].辽宁中医杂志,2016,43(6):1220-1223.
[8]张玉红,张阳佳.产后抑郁症和性激素水平、神经递质之间的相关性分析[J].实用医学杂志,2018,34(4):621-623.
[9]陈宁贵,廖敏.解郁丸联合西酞普兰治疗难治性抑郁症的疗效及其对血清去甲肾上腺素和5-羟色胺及脑源性神经营养因子指标的影响研究[J].中国全科医学,2017,20(S2):338-340.
[10]孙素改,李春雷,王继花.解郁舒心丸联合西酞普兰治疗产后抑郁症临床研究[J].河北医药,2016,38(6):921-922.