不同时间服用盐酸达克罗宁胶浆对胃镜检查效果的影响
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摘要
目的:探讨不同时间服用盐酸达克罗宁胶浆对胃镜检查效果的影响。方法:2018年5月至8月,426例门诊胃镜检查患者,采用电脑随机化数字表等比例分为检查前5min组(A组)、检查前10min组(B组)和检查前15 min组(C组),比较分析各组插镜及麻醉效果、祛泡效果及安全性。结果:共420例患者完成检查,且检查中均未出现良反应。B组插镜及麻醉效果优于C组,差异有统计学意义(χ2=13.52,P=0.004)。B组祛泡效果优于A组(χ2=9.83,P=0.02)与C组(χ2=13.47,P=0.004),差异有统计学意义。结论:胃镜检查前10 min口服盐酸达克罗宁可提高插镜及麻醉效果和祛泡效果。
Objective: To explore the impact of opportunity of taking orally dyclonine hydrochloride mucilage on the performance of gastroscopy. Methods: A total of 426 patients who presented between May and August 2018 were randomly assigned into groups A, B, and C. Groups A, B, and C were instructed to taking orally dyclonine hydrochloride mucilage at 5, 10, and 15 min before gastroscopy, respectively. After completed all colonoscopies, the effect of gastroscopy insertion and anesthesia, antifoam effect and adverse events were evaluated. Results: A total of 420 outpatients completed the examination, and no adverse events were detected in the whole examination. Finally, we found that the effect of gastroscopy insertion and anesthesia in group B was superior tothat of group C(χ2=13.52, P=0.004), and antifoam effect in group B was also better than that of group A(χ2=9.83, P=0.02) and C(χ2=13.47, P=0.004). Conclusion: It is promising option to instruct patients undergoing gastroscopy taking orally dyclonine hydrochloride mucilage at 10 min before gastroscopy because this approach can improve the effect of gastroscopy insertion and anesthesia and antifoam effect.
Objective: To explore the impact of opportunity of taking orally dyclonine hydrochloride mucilage on the performance of gastroscopy. Methods: A total of 426 patients who presented between May and August 2018 were randomly assigned into groups A, B, and C. Groups A, B, and C were instructed to taking orally dyclonine hydrochloride mucilage at 5, 10, and 15 min before gastroscopy, respectively. After completed all colonoscopies, the effect of gastroscopy insertion and anesthesia, antifoam effect and adverse events were evaluated. Results: A total of 420 outpatients completed the examination, and no adverse events were detected in the whole examination. Finally, we found that the effect of gastroscopy insertion and anesthesia in group B was superior tothat of group C(χ2=13.52, P=0.004), and antifoam effect in group B was also better than that of group A(χ2=9.83, P=0.02) and C(χ2=13.47, P=0.004). Conclusion: It is promising option to instruct patients undergoing gastroscopy taking orally dyclonine hydrochloride mucilage at 10 min before gastroscopy because this approach can improve the effect of gastroscopy insertion and anesthesia and antifoam effect.
引文
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10.黄清华.比较口服达克罗宁胶浆与利多卡因胶浆在胃镜检查中的效果[J].今日健康,2014,13(10):322-323.HUANG Qinghua.Evaluation on e?ciency of dyclonine mucilagines and lidocaine mucilagines in gastroscopy[J].Journal of Today Health,2014,13(10):322-323.
11.王敬东.比较口服达克罗宁胶浆与利多卡因胶浆在胃镜检查中的应用效果[J].中国实用医刊,2014,41(21):63-65.WANG Jingdong.Evaluation on efficiency of dyclonine mucilagines and lidocaine mucilagines in gastroscopy[J].Chinese Journal of Practical Medicine,2014,41(21):63-65.
12.刘承统,刘志军.盐酸达克罗宁胶浆在上消化道内镜检查中的临床应用[J].中国基层医药,2007,14(2):203-204.LIU Chengtong,LIU Zhijun.Clinical application of hydrochloric dacionine mucilage on upper digestive tract endoscopy[J].Chinese Journal of Primary Medicine and Pharmacy,2007,14(2):203-204.
13.熊素萍.盐酸达克罗宁胶浆在胃镜检查前期准备中的应用评价[J].中国当代医药,2016,23(18):96-98.XIONG Suping.Application evaluation of dyclonine hydrochloride mucilage in pregastroscopy preparation[J].China Modern Medicine,2016,23(18):96-98.
14.李兴华.盐酸达克罗宁胶浆应用于上消化道内镜检查前期准备的效果观察[J].实用临床医药杂志,2012,16(5):102-104.LI Xinghua.Application of dyclonine hydrochloride mucilage for preparation of gastrointestinal endoscopy:clinical observation[J].Journal of Clinical Medicine in Practice,2012,16(5):102-104.
15.迪丽达尔·阿布都热衣木,美丽克扎提·安扎尔,高峰.盐酸达克罗宁胶浆在胃镜检查术前准备应用的临床观察[J].临床消化病杂志,2011,23(5):302-303.Dilidaer·Abudureyimu,Meilikezhati·Anzhaer,GAO Feng.Application of dyclonine hydrochloride mucilage for preparation of gastrointestinal endoscopy:clinical observation[J].Chinese Journal of Clinical Gastroenterology,2011,23(5):302-303.
16.王翠华,吕芳,卢慧勤.盐酸达克罗宁胶浆在胃镜检查中的应用[J].现代医院,2014,14(6):40-41.WA NG Cui hua,LüFang,LU Huiqin.Ef fect of dyclonine hydrochloride mucilage in gastroscopy[J].Modern Hospital,2014,14(6):40-41.
17.王萍,高淑娟,郭雪艳.盐酸达克罗宁胶浆在上消化道内镜检查中的效果观察[J].吉林医学,2013,34(28):5847-5848.WANG Ping,GAO Shujuan,GUO Xueyan.Application of dyclonine hydrochloride mucilage for preparation of upper gastrointestinal endoscopy[J].Jilin Medical Journal,2013,34(28):5847-5848.
18.Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-E386.
19.辛磊,李兆申.二甲硅油在消化道内镜诊治中的应用[J].中华消化内镜杂志,2009,26(8):445-448.XIN Lei,LI Zhaoshen.Application of dimeticone in endoscopic diagnosis and treatment of digestive endoscopy[J].Chinese Journal of Digestive Endoscopy,2009,26(8):445-448.
20.郑晓梅,李兆申.盐酸达克罗宁胶(胃镜胶)的研制[J].第二军医大学学报,1993,14(3):295-297.ZHENG Xiaomei,LI Zhaoshen.Development of dyclonine glue(gastroscope glue)[J].Academic Journal of Second Military Medical University,1993,14(3):295-297.
2.李爱琴,金鹏,杨浪,等.链霉蛋白酶联合西甲硅油乳剂在胃镜检查术前准备中的应用价值[J].中华消化内镜杂志,2016,33(7):463-465.LI Aiqin,JIN Peng,YANG Lang,et al.Value of premedication of pronase and simethicone for upper gastrointestinal endoscopy[J].Chinese Journal of Digestive Endoscopy,2016,33(7):463-465.
3.吴嘉钏,方一,刘倩,等.无痛胃镜与常规胃镜检查的前瞻性对照研究[J].中华消化内镜杂志,2014,31(4):189-193.WU Jiachuan,FANG Yi,LIU Qian,et al.Sedated versus conventional upper gastrointestinal endoscopy:a prospective study on patient acceptability and satisfaction[J].Chinese Journal of Digestive Endoscopy,2014,31(4):189-193.
4.临床研究协作组.盐酸达克罗宁胶浆在上消化道内镜诊疗中麻醉润滑、祛泡效果的多中心、随机、对照研究[J].中华消化内镜杂志,2005,22(6):402-403.Clinical Research Collaboration Group.A multicenter,randomized controlled trial on the effect of dacronin hydrochloride on anesthesia lubrication and defoaming in upper gastrointestinal endoscopy[J].Chinese Journal of Digestive Endoscopy,2005,22(6):402-403.
5.安祯祥,王敏,蹇忠禄.盐酸达克罗宁胶浆与盐酸利多卡因胶浆复合静脉麻醉在胃镜检查中的对比研究[J].贵州医药,2016,40(3):280-281.AN Zhenxiang,WANG Min,JIAN Zhonglu.A comparative study of combined intravenous anesthesia with dacronin hydrochloride and lidocaine hydrochloride for gastroscopy[J].Guizhou Medical Journal,2016,40(3):280-281.
6.刘晓玲,韩杨,吴桂新.二甲硅油散在上消化道内镜诊治中的应用[J].中国内镜杂志,2016,22(6):44-46.LIU Xiaoling,HAN Yang,WU Guixin.Dimethicone power applied under endoscopy in examination of upper gastrointestinal tract[J].China Journal of Endoscopy,2016,22(6):44-46.
7.肖晓山,周代伟,戴航,等.异丙酚在胃肠镜检查治疗中应用分析[J].中华麻醉学杂志,2003,23(11):857-858.XIAO Xiaoshan,ZHOU Daiwei,DAI Hang,et al.Application of propofol in the practice of gastrointestinal endoscopy[J].Chinese Journal of Anesthesiology,2003,23(11):857-858.
8.田旭,刘晓玲,陈慧,等.达克罗宁与利多卡因用于胃镜检查前准备效果比较的Meta分析[J].中国循证医学杂志,2018,18(7):693-699.TIAN Xu,LIU Xiaoling,CHEN Hui,et al.E?cacy of dyclonine and lidocaine for preparation prior to gastroscopy:a meta-analysis[J].Chinese Journal of Evidence-based Medicine,2018,18(7):693-699.
9.王海燕,周新红,袁红,等.达克罗宁胶浆在上消化道内镜检查中的临床应用及体会[J].西南国防医药,2012,22(9):959-960.WANG Haiyan,ZHOU Xinhong,YUAN Hong,et al.Clinical application of dyclonine hydrochloride mucilage to superior gastrointestinal endoscopy and experiences[J].Medical Journal of National Defending Forces in Southwest China,2012,22(9):959-960.
10.黄清华.比较口服达克罗宁胶浆与利多卡因胶浆在胃镜检查中的效果[J].今日健康,2014,13(10):322-323.HUANG Qinghua.Evaluation on e?ciency of dyclonine mucilagines and lidocaine mucilagines in gastroscopy[J].Journal of Today Health,2014,13(10):322-323.
11.王敬东.比较口服达克罗宁胶浆与利多卡因胶浆在胃镜检查中的应用效果[J].中国实用医刊,2014,41(21):63-65.WANG Jingdong.Evaluation on efficiency of dyclonine mucilagines and lidocaine mucilagines in gastroscopy[J].Chinese Journal of Practical Medicine,2014,41(21):63-65.
12.刘承统,刘志军.盐酸达克罗宁胶浆在上消化道内镜检查中的临床应用[J].中国基层医药,2007,14(2):203-204.LIU Chengtong,LIU Zhijun.Clinical application of hydrochloric dacionine mucilage on upper digestive tract endoscopy[J].Chinese Journal of Primary Medicine and Pharmacy,2007,14(2):203-204.
13.熊素萍.盐酸达克罗宁胶浆在胃镜检查前期准备中的应用评价[J].中国当代医药,2016,23(18):96-98.XIONG Suping.Application evaluation of dyclonine hydrochloride mucilage in pregastroscopy preparation[J].China Modern Medicine,2016,23(18):96-98.
14.李兴华.盐酸达克罗宁胶浆应用于上消化道内镜检查前期准备的效果观察[J].实用临床医药杂志,2012,16(5):102-104.LI Xinghua.Application of dyclonine hydrochloride mucilage for preparation of gastrointestinal endoscopy:clinical observation[J].Journal of Clinical Medicine in Practice,2012,16(5):102-104.
15.迪丽达尔·阿布都热衣木,美丽克扎提·安扎尔,高峰.盐酸达克罗宁胶浆在胃镜检查术前准备应用的临床观察[J].临床消化病杂志,2011,23(5):302-303.Dilidaer·Abudureyimu,Meilikezhati·Anzhaer,GAO Feng.Application of dyclonine hydrochloride mucilage for preparation of gastrointestinal endoscopy:clinical observation[J].Chinese Journal of Clinical Gastroenterology,2011,23(5):302-303.
16.王翠华,吕芳,卢慧勤.盐酸达克罗宁胶浆在胃镜检查中的应用[J].现代医院,2014,14(6):40-41.WA NG Cui hua,LüFang,LU Huiqin.Ef fect of dyclonine hydrochloride mucilage in gastroscopy[J].Modern Hospital,2014,14(6):40-41.
17.王萍,高淑娟,郭雪艳.盐酸达克罗宁胶浆在上消化道内镜检查中的效果观察[J].吉林医学,2013,34(28):5847-5848.WANG Ping,GAO Shujuan,GUO Xueyan.Application of dyclonine hydrochloride mucilage for preparation of upper gastrointestinal endoscopy[J].Jilin Medical Journal,2013,34(28):5847-5848.
18.Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-E386.
19.辛磊,李兆申.二甲硅油在消化道内镜诊治中的应用[J].中华消化内镜杂志,2009,26(8):445-448.XIN Lei,LI Zhaoshen.Application of dimeticone in endoscopic diagnosis and treatment of digestive endoscopy[J].Chinese Journal of Digestive Endoscopy,2009,26(8):445-448.
20.郑晓梅,李兆申.盐酸达克罗宁胶(胃镜胶)的研制[J].第二军医大学学报,1993,14(3):295-297.ZHENG Xiaomei,LI Zhaoshen.Development of dyclonine glue(gastroscope glue)[J].Academic Journal of Second Military Medical University,1993,14(3):295-297.