储存红细胞质量检测研究进展
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摘要
红细胞储存期的质量检测是判断红细胞储存期间质量变化的重要技术手段,主要包括红细胞的形态、功能、生化指标以及基础代谢研究。随着组学技术在输血医学领域的广泛应用,为储存红细胞的质量检测提供了新的研究方法和策略。本文将系统性地对红细胞储存期质量检测指标、检测方法和技术进行综述,归纳比较这些检测指标和检测方法的发展,为储存红细胞的临床使用和基础研究提供参考。
The quality detection of stored red blood cells(RBCs) is an important technique to determine the quality changes of RBCs during storage, including the morphology, function, biochemical indicators and basic metabolism of RBCs. In this paper, the quality indicators and detection methods or techniques of RBCs during storage will be systematically reviewed, summarized and compared in order to provide references for the clinical use and basic research of stored RBCs.
The quality detection of stored red blood cells(RBCs) is an important technique to determine the quality changes of RBCs during storage, including the morphology, function, biochemical indicators and basic metabolism of RBCs. In this paper, the quality indicators and detection methods or techniques of RBCs during storage will be systematically reviewed, summarized and compared in order to provide references for the clinical use and basic research of stored RBCs.
引文
[1] D′Alessandro A,Kriebardis AG,Rinalducci S,et al.An update on red blood cell storage lesions,as gleaned through biochemistry andomics technologies.Transfusion,2015;55(1):205-219.
[2] D′Alessandro A,Seghatchian J.Hitchhiker′s guide to the red cell storage galaxy:Omics technologies and the quality issue.Transfus Apher Sci,2017;56(2):248-253.
[3] Zimring JC.Established and theoretical factors to consider in assessing the red cell storage lesion..Blood,2015,125(14):2185-2190.
[4] Nemkov T,Hansen KC,Dumont LJ,et al.Metabolomics in transfusion medicine.Transfusion,2016 ,56(4):980-993.
[5] Spitalnik SL,Triulzi D,Devine DV,et al.2015 proceedings of the National Heart,Lung,and Blood Institute′s State of the Science in Transfusion Medicine symposium.Transfusion,2015;55(9):2282-2290.
[6] 孟强,宋敏,赵树铭,等.红细胞贮存损伤的生化和组学变化研究进展.临床输血与检验,2018,20(6):672-676.
[7] Prowse CV,de Korte D,Hess JR,van der Meer PF;Biomedical Excellence for Safer Transfusion (BEST) Collaborative.Commercially available blood storage containers.Vox Sang,2014,106(1):1-13.
[8] D′Alessandro A,Gray AD,Sczcepiorkowski ZM,et al.Red blood cell metabolic responses to refrigerated storage,rejuvenation,and frozen storage.Transfusion,2017,57(4):1019-1030.
[9] Dumont LJ,Baker S,Dumont DF,et al.Exploratory in vitro study of red blood cell storage containers formulated with an alternative plasticizer.Transfusion,2012,52(7):1439-1445.
[10] Bosman GJ,Werre JM,Willekens FL,et al.Erythrocyte ageing in vivo and in vitro:structural aspects and implications for transfusion.Transfus Med,2008,18(6):335-347.
[11] Glynn SA.The red blood cell storage lesion:a method to the madness.Transfusion,2010;50(6):1164-1169.
[12] 冯博,段澜,王景文,等.悬浮红细胞储存时间对制备的洗涤红细胞钾离子和游离血红蛋白含量的影响.中国输血杂志,2012,25(9):834-836.
[13] 王向明,王珏,甘佳,等.储存红细胞生化指标研究进展.中国输血杂志,2016,29(10):1203-1207.
[14] 赵燕.库存血液输注前血浆血红蛋白含量与显微镜下红细胞形态变化的研究.中国实用医药,2013,8(34):53-54.
[15] 王竹筠,滕本秀.ACD液保存的库存血红细胞变形性的变化.第三军医大学学报,2001,23(6):682-682.
[16] Nogueira D ,Rocha S ,Abreu E ,et al.Biochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion.Transfusion Medicine and Hemotherapy,2014,42(1):46-51.
[17] 中华人民共和国卫生部.全血及成分血质量要求.2012
[18] Food and Drug Administration.In:Proceedings from the 91st meeting of the blood products advisory committee.2008.
[19] Berezina TL,Zaets SB,Morgan C,et al.Influence of storage on red blood cell rheological properties.J Surg Res,2002,102(1):6-12.
[20] 魏少平,李柱,雷慧芬,等.客机运输对不同保存期悬浮红细胞质量影响的研究.中国输血杂志,2017,30(9):1000-1003.
[21] Solheim BG,Hess JR.RBC metabolism and preservation;in Simon TL,Snyder EL,Solheim BG,et al (eds):Rossi′s principles of transfusion medicines,4th edn.Bethesda,MD,AABB Press,2009:54-68.
[22] Hess JR.Red cell changes during storage.Transfus Apheresis Sci,2010,43(1):51-59.
[23] Beutler E ,Blume KG ,Kaplan JC ,et al.International Committee for Standardization in Haematology:recommended methods for red-cell enzyme analysis.British Journal of Haematology,2010,35(2):331-340.
[24] 朱冠梅,马孔阜.用等速电泳法测定血中2,3-二磷酸甘油酸(2,3-DPG)的含量.色谱,1988,6(5):311-312.
[25] Rapoport S,Luebering J.Glycerate-2,3-diphosphatase.Journal of Biological Chemistry,1951,189(2):683-694.
[26] 王素玲,韩卫,何路军,等.去白悬浮红细胞储存过程中ATP、2,3-DPG含量变化与氧化应激的相关性分析.河北医科大学学报,2017,38(2):192-195.
[27] 李姝,张丽华,苏燕.代谢组学在红细胞存储损伤研究中的应用.中国输血杂志,2016,29(12):1413-1415.
[28] Fu X ,Felcyn JR ,Odem-Davis,Katherine,et al.Bioactive lipids accumulate in stored red blood cells despite leukoreduction:a targeted metabolomics study.Transfusion,2016,56(10):2560-2570.
[29] Rinalducci S,D′Amici GM,Blasi B,et al.Peroxiredoxin-2 as a candidate biomarker to test oxidative stress levels of stored red blood cells under blood bank conditions.Transfusion,2011,51(7):1439-1449.
[30] D′Alessandro A ,Amelio I ,Berkers CR ,et al.Metabolic effect of TAp63α:enhanced glycolysis and pentose phosphate pathway,resulting in increased antioxidant defense.Oncotarget,2014,5(17):7722-7733.
[31] Weisenhorn EM,Van′t Erve TJ,Riley NM,et al.Multi-omics evidence for inheritance of energy pathways in red blood cells.Molecular & Cellular Proteomics Mcp,2016,15(12):3614-3623.
[32] 武世文,文爱清.红细胞储存损伤的研究进展.中国输血杂志,2013,26(6):593-595.
[33] Hess JR.Measures of stored red blood cell quality.Vox Sang,2014,107(1):1-9.
[34] Sparrow RL.Time to revisit red blood cellad dative solutions and storage conditions:a role for "omics" analyses.Blood Transfus,2012,10( Suppl 2):s7-s11.
[35] 杨俊鸿,蒋玉林,刘一锋,等.脂肪血制备的去白细胞悬浮红细胞储存期代谢特性研究.中国实验血液学杂志,2018,26( 2):584-588.
[36] Angelo D′Alessandro,Nemkov T ,Reisz J ,et al.Omics markers of the red cell storage lesion and metabolic linkage.Blood transfusion,2017,15(2):137-144.
[2] D′Alessandro A,Seghatchian J.Hitchhiker′s guide to the red cell storage galaxy:Omics technologies and the quality issue.Transfus Apher Sci,2017;56(2):248-253.
[3] Zimring JC.Established and theoretical factors to consider in assessing the red cell storage lesion..Blood,2015,125(14):2185-2190.
[4] Nemkov T,Hansen KC,Dumont LJ,et al.Metabolomics in transfusion medicine.Transfusion,2016 ,56(4):980-993.
[5] Spitalnik SL,Triulzi D,Devine DV,et al.2015 proceedings of the National Heart,Lung,and Blood Institute′s State of the Science in Transfusion Medicine symposium.Transfusion,2015;55(9):2282-2290.
[6] 孟强,宋敏,赵树铭,等.红细胞贮存损伤的生化和组学变化研究进展.临床输血与检验,2018,20(6):672-676.
[7] Prowse CV,de Korte D,Hess JR,van der Meer PF;Biomedical Excellence for Safer Transfusion (BEST) Collaborative.Commercially available blood storage containers.Vox Sang,2014,106(1):1-13.
[8] D′Alessandro A,Gray AD,Sczcepiorkowski ZM,et al.Red blood cell metabolic responses to refrigerated storage,rejuvenation,and frozen storage.Transfusion,2017,57(4):1019-1030.
[9] Dumont LJ,Baker S,Dumont DF,et al.Exploratory in vitro study of red blood cell storage containers formulated with an alternative plasticizer.Transfusion,2012,52(7):1439-1445.
[10] Bosman GJ,Werre JM,Willekens FL,et al.Erythrocyte ageing in vivo and in vitro:structural aspects and implications for transfusion.Transfus Med,2008,18(6):335-347.
[11] Glynn SA.The red blood cell storage lesion:a method to the madness.Transfusion,2010;50(6):1164-1169.
[12] 冯博,段澜,王景文,等.悬浮红细胞储存时间对制备的洗涤红细胞钾离子和游离血红蛋白含量的影响.中国输血杂志,2012,25(9):834-836.
[13] 王向明,王珏,甘佳,等.储存红细胞生化指标研究进展.中国输血杂志,2016,29(10):1203-1207.
[14] 赵燕.库存血液输注前血浆血红蛋白含量与显微镜下红细胞形态变化的研究.中国实用医药,2013,8(34):53-54.
[15] 王竹筠,滕本秀.ACD液保存的库存血红细胞变形性的变化.第三军医大学学报,2001,23(6):682-682.
[16] Nogueira D ,Rocha S ,Abreu E ,et al.Biochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion.Transfusion Medicine and Hemotherapy,2014,42(1):46-51.
[17] 中华人民共和国卫生部.全血及成分血质量要求.2012
[18] Food and Drug Administration.In:Proceedings from the 91st meeting of the blood products advisory committee.2008.
[19] Berezina TL,Zaets SB,Morgan C,et al.Influence of storage on red blood cell rheological properties.J Surg Res,2002,102(1):6-12.
[20] 魏少平,李柱,雷慧芬,等.客机运输对不同保存期悬浮红细胞质量影响的研究.中国输血杂志,2017,30(9):1000-1003.
[21] Solheim BG,Hess JR.RBC metabolism and preservation;in Simon TL,Snyder EL,Solheim BG,et al (eds):Rossi′s principles of transfusion medicines,4th edn.Bethesda,MD,AABB Press,2009:54-68.
[22] Hess JR.Red cell changes during storage.Transfus Apheresis Sci,2010,43(1):51-59.
[23] Beutler E ,Blume KG ,Kaplan JC ,et al.International Committee for Standardization in Haematology:recommended methods for red-cell enzyme analysis.British Journal of Haematology,2010,35(2):331-340.
[24] 朱冠梅,马孔阜.用等速电泳法测定血中2,3-二磷酸甘油酸(2,3-DPG)的含量.色谱,1988,6(5):311-312.
[25] Rapoport S,Luebering J.Glycerate-2,3-diphosphatase.Journal of Biological Chemistry,1951,189(2):683-694.
[26] 王素玲,韩卫,何路军,等.去白悬浮红细胞储存过程中ATP、2,3-DPG含量变化与氧化应激的相关性分析.河北医科大学学报,2017,38(2):192-195.
[27] 李姝,张丽华,苏燕.代谢组学在红细胞存储损伤研究中的应用.中国输血杂志,2016,29(12):1413-1415.
[28] Fu X ,Felcyn JR ,Odem-Davis,Katherine,et al.Bioactive lipids accumulate in stored red blood cells despite leukoreduction:a targeted metabolomics study.Transfusion,2016,56(10):2560-2570.
[29] Rinalducci S,D′Amici GM,Blasi B,et al.Peroxiredoxin-2 as a candidate biomarker to test oxidative stress levels of stored red blood cells under blood bank conditions.Transfusion,2011,51(7):1439-1449.
[30] D′Alessandro A ,Amelio I ,Berkers CR ,et al.Metabolic effect of TAp63α:enhanced glycolysis and pentose phosphate pathway,resulting in increased antioxidant defense.Oncotarget,2014,5(17):7722-7733.
[31] Weisenhorn EM,Van′t Erve TJ,Riley NM,et al.Multi-omics evidence for inheritance of energy pathways in red blood cells.Molecular & Cellular Proteomics Mcp,2016,15(12):3614-3623.
[32] 武世文,文爱清.红细胞储存损伤的研究进展.中国输血杂志,2013,26(6):593-595.
[33] Hess JR.Measures of stored red blood cell quality.Vox Sang,2014,107(1):1-9.
[34] Sparrow RL.Time to revisit red blood cellad dative solutions and storage conditions:a role for "omics" analyses.Blood Transfus,2012,10( Suppl 2):s7-s11.
[35] 杨俊鸿,蒋玉林,刘一锋,等.脂肪血制备的去白细胞悬浮红细胞储存期代谢特性研究.中国实验血液学杂志,2018,26( 2):584-588.
[36] Angelo D′Alessandro,Nemkov T ,Reisz J ,et al.Omics markers of the red cell storage lesion and metabolic linkage.Blood transfusion,2017,15(2):137-144.