circRNA在肝癌中的研究进展
|
摘要
circRNA是一种新的内源性RNA,广泛存在于真核细胞中,参与转录或转录后基因表达调控,大部分属非编码RNA,是近几年RNA领域中的研究热点。circRNA主要通过拮抗miRNA来发挥"海绵作用"进而调控靶基因表达,与多种疾病有着密切联系,特别是在肿瘤中发挥重要作用。近年研究发现,circRNA对肝细胞肝癌(hepatocellular carcinoma,HCC)的发生、发展及转移具有重要调控作用。该文就circRNA与肝细胞肝癌关系的研究进展作一阐述。
Circular RNA is a novel class of endogenous non-coding RNAs,which is widespread in eukaryotic cell and the function is to regulate gene expression at the transcriptional or post-transcriptional level.Through miRNA sponge effect to regulate target gene expression,circRNA is closely related to a variety of disease,especially in tumors.Recent researches found that circRNA play an important role in regulating occurrence,development and metastasis of hepatocellular carcinoma(HCC).In this study,we review research progress about circRNA and HCC.
Circular RNA is a novel class of endogenous non-coding RNAs,which is widespread in eukaryotic cell and the function is to regulate gene expression at the transcriptional or post-transcriptional level.Through miRNA sponge effect to regulate target gene expression,circRNA is closely related to a variety of disease,especially in tumors.Recent researches found that circRNA play an important role in regulating occurrence,development and metastasis of hepatocellular carcinoma(HCC).In this study,we review research progress about circRNA and HCC.
引文
[1] Sanger HL,Klotz G,Riesner D,et al.Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures[J].Proc Natl Acad Sci USA,1976,73(11):3852-3856.
[2] Wang YM,Mo YZ,Gong ZJ,et al.Circular RNAs in human cancer[J].Molecular Cancer,2017,16(1):25-32.
[3] Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.
[4] Chen WQ,Zheng RS,Peter D,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[5] Sun HZ,Song YL,Wang XY.Effects of different anesthetic methods on cellular immune and neuroendocrine functions in patients with hepatocellular carcinoma before and after surgery[J].J Clin Lab Anal,2016,30(6):1175-1182.
[6] Suzuki H,Zuo Y,Wang J,et al.Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing[J].Nucleic Acids Res,2006,34(8):63-69.
[7] Suzuki H,Tsukahara T.A view of pre-mRNA splicing from RNase R resistant RNAs[J].Int J Mol Sci,2014,15(6):9331-9342.
[8] Jeck WR,Sorrentino JA,Wang K,et al.Circular RNAs are abundant,conserved,and associated with ALU repeats[J].RNA,2013,19(2):141-157.
[9] Lasda E,Parker R.Circular RNAs:Diversity of form and function[J].RNA,2014,20(12):1829-1842.
[10] Li Y,Zheng QP,Bao CY,et al.Circular RNA is enriched and stable in exosomes:A promising biomarker for cancer diagnosis[J].Cell Res,2015,25(8):981-984.
[11] Memczak S,Jens M,Elefsinioti A,et al.Circular RNAs are a large class of animal RNAs with regulatory potency[J].Nature,2013,495(7441):333-338.
[12] Zhang Y,Zhang XO,Chen T,et al.Circular intronic long non-coding RNAs[J].Molecular Cell,2013,51(6):792-806.
[13] Li ZY,Huang C,Bao C,et al.Exon-intron circular RNAs regulate transcription in the nucleus[J].Nature Structural & Molecular Biology,2015,22(3):256-264.
[14] Abdelmohsen K,Kuwano Y,Kim H,et al.Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress:Implications for cellular senescence[J].Biological Chemistry,2008,389(3):243-255.
[15] Pamudurti NR,Bartok O,Jens M,et al.Translation of circRNAs[J].Mol Cell,2017,66(1):9-21.
[16] Huang G,Li S,Yang N,et al.Recent progress in circular RNAs in human cancers[J].Cancer Lett,2017,404:8-18.
[17] Burd CE,Jeck WR,Liu Y,et al.Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk[J].PLoS Genet,2010,6(12):1001233-1001247.
[18] Guo W,Zhang J,Zhang D,et al.Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma[J]. Oncotarget,2017,8(29):48169-48177.
[19] Yao ZC,Luo JY,Hu KP,et al.ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cellgrowth,migration,and invasion but through different signaling pathways[J].Mol Oncol,2017,11(4):422-437.
[20] Fu LY,Wu SD,Yao T,et al.Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance[J].J Clin Lab Anal,2018,32(2):22239-22245.
[21] Han D,Li JX,Wang HM,et al.Circular RNA circMTO1 acts asthe sponge of microRNA-9 to suppress hepatocellular carcinoma progression[J].Hepatology,2017,66(4):1151-1164.
[22] Zhu Q,Lu GY,Luo ZF,et al.CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis[J].Biochem Biophys Res Commun,2018,497(2):626-632.
[23] Shang XC,Li GZ,Liu H,et al.Comprehensive circular RNA profiling reveals that hsa_circ_0005075,a new circular RNA biomarker,is involved in hepatocellular carcinoma development[J].Medicine(Baltimore),2016,95(22):3811-3817.
[24] Jin H,Fang MF,Man ZR,et al.Circular RNA 001569 acts as an oncogene and correlates with aggressive characteristics in hepatocellular carcinoma[J].Int J Clin Exp Pathol,2017,10(3):2997-3005.
[25] Huang XY,Huang ZL,Xu YH,et al.Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma[J].Sci Rep,2017,7(1):5428-5439.
[26] Yu L,Gong XJ,Sun L,et al.The circular RNA Cdr1as act as an oncogene in hepatocellular carcinoma through targeting miR-7 expression[J].PLoS One,2016,11(7):1-10.
[27] Xu LL,Zhang M,Zheng XB,et al.The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma[J].J Cancer Res Clin Oncol,2017,143(1):17-27.
[28] Humphries B,Yang C.The microRNA-200 family:Small molecules with novel roles in cancer development,progression and therapy[J].Oncotarget,2015,6 (9):6472-6498.
[29] Qu SB,Liu ZC,Yang XS,et al.The emerging functions and roles of circular RNAs in cancer[J].Cancer Letters,2018,414:301-309.
[30] He J,Xie Q,Xu H,et al.Circular RNAs and cancer[J].Cancer Lett,2017,396:138-144.
[31] Li F,Zhang LY,Li W,et al.Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/beta-catenin pathway[J].Oncotarget,2015,6(8):6001-6013.
[32] Conn SJ,Pillman KA,Toubia J,et al.The RNA binding protein quaking regulates formation of circRNAs[J].Cell,2015,160(6):1125-1134.
[33] Fu LY,Chen QQ,Yao T,et al.Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcioma[J].Oncotarget,2017,8(27):43878-43888.
[34] Qin ML,Liu G,Huo XS,et al.Hsa_circ_0001649:A circular RNA and potential novel biomarker for hepatocelluar carcinoma[J].Cancer Biomark,2016,16(1):161-169.
[35] Fu LY,Yao T,Chen QQ,et al.Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma[J].Oncotarget,2017,8(35):58405-58416.
[2] Wang YM,Mo YZ,Gong ZJ,et al.Circular RNAs in human cancer[J].Molecular Cancer,2017,16(1):25-32.
[3] Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2012[J].CA Cancer J Clin,2015,65(2):87-108.
[4] Chen WQ,Zheng RS,Peter D,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[5] Sun HZ,Song YL,Wang XY.Effects of different anesthetic methods on cellular immune and neuroendocrine functions in patients with hepatocellular carcinoma before and after surgery[J].J Clin Lab Anal,2016,30(6):1175-1182.
[6] Suzuki H,Zuo Y,Wang J,et al.Characterization of RNase R-digested cellular RNA source that consists of lariat and circular RNAs from pre-mRNA splicing[J].Nucleic Acids Res,2006,34(8):63-69.
[7] Suzuki H,Tsukahara T.A view of pre-mRNA splicing from RNase R resistant RNAs[J].Int J Mol Sci,2014,15(6):9331-9342.
[8] Jeck WR,Sorrentino JA,Wang K,et al.Circular RNAs are abundant,conserved,and associated with ALU repeats[J].RNA,2013,19(2):141-157.
[9] Lasda E,Parker R.Circular RNAs:Diversity of form and function[J].RNA,2014,20(12):1829-1842.
[10] Li Y,Zheng QP,Bao CY,et al.Circular RNA is enriched and stable in exosomes:A promising biomarker for cancer diagnosis[J].Cell Res,2015,25(8):981-984.
[11] Memczak S,Jens M,Elefsinioti A,et al.Circular RNAs are a large class of animal RNAs with regulatory potency[J].Nature,2013,495(7441):333-338.
[12] Zhang Y,Zhang XO,Chen T,et al.Circular intronic long non-coding RNAs[J].Molecular Cell,2013,51(6):792-806.
[13] Li ZY,Huang C,Bao C,et al.Exon-intron circular RNAs regulate transcription in the nucleus[J].Nature Structural & Molecular Biology,2015,22(3):256-264.
[14] Abdelmohsen K,Kuwano Y,Kim H,et al.Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress:Implications for cellular senescence[J].Biological Chemistry,2008,389(3):243-255.
[15] Pamudurti NR,Bartok O,Jens M,et al.Translation of circRNAs[J].Mol Cell,2017,66(1):9-21.
[16] Huang G,Li S,Yang N,et al.Recent progress in circular RNAs in human cancers[J].Cancer Lett,2017,404:8-18.
[17] Burd CE,Jeck WR,Liu Y,et al.Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk[J].PLoS Genet,2010,6(12):1001233-1001247.
[18] Guo W,Zhang J,Zhang D,et al.Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma[J]. Oncotarget,2017,8(29):48169-48177.
[19] Yao ZC,Luo JY,Hu KP,et al.ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cellgrowth,migration,and invasion but through different signaling pathways[J].Mol Oncol,2017,11(4):422-437.
[20] Fu LY,Wu SD,Yao T,et al.Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance[J].J Clin Lab Anal,2018,32(2):22239-22245.
[21] Han D,Li JX,Wang HM,et al.Circular RNA circMTO1 acts asthe sponge of microRNA-9 to suppress hepatocellular carcinoma progression[J].Hepatology,2017,66(4):1151-1164.
[22] Zhu Q,Lu GY,Luo ZF,et al.CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis[J].Biochem Biophys Res Commun,2018,497(2):626-632.
[23] Shang XC,Li GZ,Liu H,et al.Comprehensive circular RNA profiling reveals that hsa_circ_0005075,a new circular RNA biomarker,is involved in hepatocellular carcinoma development[J].Medicine(Baltimore),2016,95(22):3811-3817.
[24] Jin H,Fang MF,Man ZR,et al.Circular RNA 001569 acts as an oncogene and correlates with aggressive characteristics in hepatocellular carcinoma[J].Int J Clin Exp Pathol,2017,10(3):2997-3005.
[25] Huang XY,Huang ZL,Xu YH,et al.Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma[J].Sci Rep,2017,7(1):5428-5439.
[26] Yu L,Gong XJ,Sun L,et al.The circular RNA Cdr1as act as an oncogene in hepatocellular carcinoma through targeting miR-7 expression[J].PLoS One,2016,11(7):1-10.
[27] Xu LL,Zhang M,Zheng XB,et al.The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma[J].J Cancer Res Clin Oncol,2017,143(1):17-27.
[28] Humphries B,Yang C.The microRNA-200 family:Small molecules with novel roles in cancer development,progression and therapy[J].Oncotarget,2015,6 (9):6472-6498.
[29] Qu SB,Liu ZC,Yang XS,et al.The emerging functions and roles of circular RNAs in cancer[J].Cancer Letters,2018,414:301-309.
[30] He J,Xie Q,Xu H,et al.Circular RNAs and cancer[J].Cancer Lett,2017,396:138-144.
[31] Li F,Zhang LY,Li W,et al.Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/beta-catenin pathway[J].Oncotarget,2015,6(8):6001-6013.
[32] Conn SJ,Pillman KA,Toubia J,et al.The RNA binding protein quaking regulates formation of circRNAs[J].Cell,2015,160(6):1125-1134.
[33] Fu LY,Chen QQ,Yao T,et al.Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcioma[J].Oncotarget,2017,8(27):43878-43888.
[34] Qin ML,Liu G,Huo XS,et al.Hsa_circ_0001649:A circular RNA and potential novel biomarker for hepatocelluar carcinoma[J].Cancer Biomark,2016,16(1):161-169.
[35] Fu LY,Yao T,Chen QQ,et al.Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma[J].Oncotarget,2017,8(35):58405-58416.