外周血中性粒细胞/淋巴细胞比值(NLR)在卵巢癌中的研究进展
|
摘要
卵巢癌是一种比较常见的妇科恶性肿瘤,其死亡率位于妇科肿瘤之首位,主要原因在于大多数患者在就诊时就已经处于疾病晚期。中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)作为一种全身炎症反应的评价指标,近年来,关于NLR在卵巢癌诊断、病情判断及预后的预测中应用的研究越来越多,指出NLR在卵巢癌患者的中有一定的研究及应用价值,可以为卵巢癌患者的疾病诊断及预后预测提供新的思路。
Ovarian cancer is one of the most common gynecologic malignancies,and its mortality is at the top of gynecologic tumors. The main reason is that most of the patients are already in the advanced stage of the disease when they visit the clinic. Neutrophil and lymphocyte ratio is as a kind of systemic inflammatory response evaluation index,in recent years more and more research on NLR application predicts the severity and prognosis in the diagnosis of ovarian cancer,and points out that the NLR has a certain value of research and application in patients with ovarian cancer. So it can provide new ideas for the diagnosis and prognosis of disease the prediction of ovarian cancer patients.
Ovarian cancer is one of the most common gynecologic malignancies,and its mortality is at the top of gynecologic tumors. The main reason is that most of the patients are already in the advanced stage of the disease when they visit the clinic. Neutrophil and lymphocyte ratio is as a kind of systemic inflammatory response evaluation index,in recent years more and more research on NLR application predicts the severity and prognosis in the diagnosis of ovarian cancer,and points out that the NLR has a certain value of research and application in patients with ovarian cancer. So it can provide new ideas for the diagnosis and prognosis of disease the prediction of ovarian cancer patients.
引文
[1]SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2016[J].Cancer J Clin,2016,66(1):7.
[2]CHEN W,ZHENG R,BAADE P D,et al.Cancer statistics in China,2015[J].Cancer Journal for Clinicians,2016,66(2):115.
[3]BALKWILL F,ANTOVANI A.Inflammation and cancer:back to vir-chow[J].Lancet,001,57(9255):539-545.
[4]SHIMADA H,TAKIGUCHI N O,Soda H,et al.High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer[J].Gastric Cancer Official Journal of the International Gastric Cancer Association&the Japanese Gastric Cancer Association,2010,13(3):170.
[5]TOMITA M,SHIMIZU T,AYADE T,et al.Preoperative neutrophil to lymphocyte ratio as a prognostic predictor after curative resection for non-small cell lung cancer[J].Anticancer Research,2011,31(9):2995-2998.
[6]OZDEMIR Y,AKIN M L,SUCULLU I,et al.Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer[J].Asian Pacific Journal of Cancer Prevention Apjcp,2014,15(6):2647.
[7]YILDIRIM M,CENDEK B D,AVASAR A F.Differentiation between benignand malignant ovarian masses in the preoperative period using neu-trophil-to-lymphocyte and platelet-to-lymphocyte ratios[J].Mol Clin Oncol,2015,3(2):317-321.
[8]THAVARAMARA,PHALOPRAKARN C,TANGJITGAMOL S,et al.Role of neutrophil to lymphocyte ratio as a prognostic indicator for epithelial ovarian cancer[J].J Med Assoc Thai,2011,94(7):871-877.
[9]杜博,魏海峰,倪志强,等.CA125联合中性粒细胞与淋巴细胞比值对卵巢癌诊断及预后判断的意义[J].中国免疫学杂志,2014(12):1670-1671.
[10]WILLIAMS K A,LABIDIGALY S I,TERRY K L,et al.Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer[J].Gynecologic Oncology,2014,132(3):542.
[11]RUKA W,RUTKOWSKI P,KAMINSKA J,et al.Alterations of routine blood tests in adult patients with soft tissue sarcomas:relationships to cytokine serum levels and,prognostic significance[J].Annals of Oncology Official Journal of the European Society for Medical Oncology,2001,12(10):1423.
[12]陈欣,张国楠.早期子宫颈癌患者手术后外周血淋巴细胞计数变化的临床意义[J].中华妇产科杂志,2014,49(3):208-212.
[13]PARAMANATHAN A,SAXENA A,MORRIS D L.A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours[J].Surgical Oncology,2014,23(1):31-39.
[14]邹瑟音,夏勇,梁思宇,等.联合检测肿瘤标志物在卵巢癌诊断中的临床应用评价[J].检验医学与临床,2014(23):3316-3317.
[15]CHO H,HUR H W,KIM S W,et al.Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment[J].Cancer Immunology Immunotherapy,2009,58(1):15-23.
[16]KIM H S,CHOI H Y,LEE M,et al.Systemic inflammatory response markers and CA-125 levels in ovarian clear cell carcinoma:Two center cohort study[J].Cancer Research&Treatment,2016,48(1):250.
[17]TOSOLINI M,IRILOVSKY A,LECNILK B,et al.Clinical impact of different classes of infiltrating T cytotoxic and helper cells(Th1,Th2,Treg,Th17)in patients with colorectal cancer[J].Cancer Res,2011,71(4):1263-1271.
[18]WANG Y,LIU P,XU Y,et al.Preoperative neutrophil-tolymphocyte ratio predicts response to first-line platinum-based chemotherapy and prognosis in serous ovarian cancer[J].Cancer Chemotherapy&Pharmacology,2015,75(2):255-262.
[2]CHEN W,ZHENG R,BAADE P D,et al.Cancer statistics in China,2015[J].Cancer Journal for Clinicians,2016,66(2):115.
[3]BALKWILL F,ANTOVANI A.Inflammation and cancer:back to vir-chow[J].Lancet,001,57(9255):539-545.
[4]SHIMADA H,TAKIGUCHI N O,Soda H,et al.High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer[J].Gastric Cancer Official Journal of the International Gastric Cancer Association&the Japanese Gastric Cancer Association,2010,13(3):170.
[5]TOMITA M,SHIMIZU T,AYADE T,et al.Preoperative neutrophil to lymphocyte ratio as a prognostic predictor after curative resection for non-small cell lung cancer[J].Anticancer Research,2011,31(9):2995-2998.
[6]OZDEMIR Y,AKIN M L,SUCULLU I,et al.Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer[J].Asian Pacific Journal of Cancer Prevention Apjcp,2014,15(6):2647.
[7]YILDIRIM M,CENDEK B D,AVASAR A F.Differentiation between benignand malignant ovarian masses in the preoperative period using neu-trophil-to-lymphocyte and platelet-to-lymphocyte ratios[J].Mol Clin Oncol,2015,3(2):317-321.
[8]THAVARAMARA,PHALOPRAKARN C,TANGJITGAMOL S,et al.Role of neutrophil to lymphocyte ratio as a prognostic indicator for epithelial ovarian cancer[J].J Med Assoc Thai,2011,94(7):871-877.
[9]杜博,魏海峰,倪志强,等.CA125联合中性粒细胞与淋巴细胞比值对卵巢癌诊断及预后判断的意义[J].中国免疫学杂志,2014(12):1670-1671.
[10]WILLIAMS K A,LABIDIGALY S I,TERRY K L,et al.Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer[J].Gynecologic Oncology,2014,132(3):542.
[11]RUKA W,RUTKOWSKI P,KAMINSKA J,et al.Alterations of routine blood tests in adult patients with soft tissue sarcomas:relationships to cytokine serum levels and,prognostic significance[J].Annals of Oncology Official Journal of the European Society for Medical Oncology,2001,12(10):1423.
[12]陈欣,张国楠.早期子宫颈癌患者手术后外周血淋巴细胞计数变化的临床意义[J].中华妇产科杂志,2014,49(3):208-212.
[13]PARAMANATHAN A,SAXENA A,MORRIS D L.A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours[J].Surgical Oncology,2014,23(1):31-39.
[14]邹瑟音,夏勇,梁思宇,等.联合检测肿瘤标志物在卵巢癌诊断中的临床应用评价[J].检验医学与临床,2014(23):3316-3317.
[15]CHO H,HUR H W,KIM S W,et al.Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment[J].Cancer Immunology Immunotherapy,2009,58(1):15-23.
[16]KIM H S,CHOI H Y,LEE M,et al.Systemic inflammatory response markers and CA-125 levels in ovarian clear cell carcinoma:Two center cohort study[J].Cancer Research&Treatment,2016,48(1):250.
[17]TOSOLINI M,IRILOVSKY A,LECNILK B,et al.Clinical impact of different classes of infiltrating T cytotoxic and helper cells(Th1,Th2,Treg,Th17)in patients with colorectal cancer[J].Cancer Res,2011,71(4):1263-1271.
[18]WANG Y,LIU P,XU Y,et al.Preoperative neutrophil-tolymphocyte ratio predicts response to first-line platinum-based chemotherapy and prognosis in serous ovarian cancer[J].Cancer Chemotherapy&Pharmacology,2015,75(2):255-262.