同型半胱氨酸与精神疾病的研究进展
|
摘要
精神疾病是一种慢性疾病,至今病因未明,本文回顾既往研究,对精神疾病患者血清同型半胱氨酸水平的变化进行整理及探讨。
引文
1.Phillips MR,Zhang JX,Song ZQ,et al.Prevalence,treatment,and associated disability of mentaldisorders in four provinces in China during 2001-05:an epidemiological survey[J].Lancet.2009,373(9680):2041-2053.
2.Charlson FJ,Charlson AJ,Cheng HG,et al.The burden of mental,neurological,and substance use disorders in China and India:a systematic analysis ofcommunity representative epidemiological studies[J].Lancet.2016,388(10042):376-389.
3.Allen NC,Bagade S,McQueen MB,et al.Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia:the SzGenedatabase[J].Nat Genet.2008,40(7):827-834.
4.Gao Q,Li Z,Jones P,et al.A Possible Role of the FKBP5Gene in Schizophrenia[J].Journal of Psychiatry and Brain Science,2016,1(5):2.
5.Van Dam F,Van Gool WA.Hyperhomocysteinemia and Alzheimer's disease:A systematic review[J].Arch GerontolGeriatr.2009,48(3):425-430.
6.Muntjewerff JW,Kahn RS,Blom HJ,et al.Homocysteine,methylenetetrahydrofolate reductase and risk of schizophrenia:a meta-analysis[J].Molecular psychiatry,2006,11(2):143-149.
7.Tiemeier H,van Tuijl HR,Hofman A,et al.Vitamin B12,folate,and homocysteine in depression:the Rotterdam Study[J].Am J Psychiatry,2002,159(12):2099-2101.
8.Clarke R,Smith AD,Jobst KA,et al.Folate,vitamin B12,and serum total homocysteine levels in confirmed Alzheimer disease[J].Arch Neurol.1998,55(11):1449-1455.
9.Kwok T,Lee J,Law CB,et al.A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people[J].ClinNutr.2011,30(3):297-302.
10.Muntjewerff JW,Kahn RS,Blom HJ,et al.Homocysteine,methylenetetrahydrofolate reductase and risk of schizophrenia:a meta-analysis[J].MolPsychiatry,2006,11(2):143-149.
11.Fan N,Tan Y,Yang F,et al.Effect of risperidone on serum homocysteine levels in first-episode,drug-naive patients with schizophrenia[J].Neurosci Lett.2017,650:168-173.
12.Levine J,Stahl Z,Sela BA,et al.Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia[J].Biol psychiatry,2006,60(3):265-269.
13.Bottiglieri T,Laundy M,Crellin R,et al.Homocysteine,folate,methylation,and monoamine metabolism in depression[J].J NeurolNeurosurg Psychiatry,2000,69(2):228-232.
14.de Koning EJ,van der Zwaluw NL,van Wijngaarden JP,et al.Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations:Additional Results from the B-PROOF Study,an RCT[J].Nutrients,2016,8(11).pii:E748.
15.Okereke OI,Cook NR,Albert CM,et al.Effect of longterm supplementation with folic acid and B vitamins on risk of depression in older women[J].Br J Psychiatry,2015,206(4):324-331.
16.Zhou SJ,Zhang LG,Chen HM,et al.Prevalence and clinical-demographic correlates of hyperhomocysteinemia in inpatients with bipolar disorder in a Han Chinese population[J].Psychiatry Res.2018,259:364-369.
17.Brown AS,Bottiglieri T,Schaefer CA,et al.Elevated prenatal homocysteine levels as a risk factor for schizophrenia[J].Arch Gen Psychiatry,2007,64(1):31-39.
18.Baydas G,Reiter RJ,Akbulut M,et al.Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3activation and by regulating pro-and anti-apoptotic protein levels[J].Neuroscience,2005,135(3):879-886.
19.陈景旭,陈红梅,李居艳,等.双相Ⅰ型障碍躁狂发作患者同型半胱氨酸水平及其影响因素[J].中华行为医学与脑科学杂志,2015,24(5):455-457.
20.Bottiglieri T,Parnetti L,Arning E,et al.Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase(MTHFR)gene:a study in an Italian population with dementia[J].Mech Ageing Dev.2001,122(16):2013-2023.
2.Charlson FJ,Charlson AJ,Cheng HG,et al.The burden of mental,neurological,and substance use disorders in China and India:a systematic analysis ofcommunity representative epidemiological studies[J].Lancet.2016,388(10042):376-389.
3.Allen NC,Bagade S,McQueen MB,et al.Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia:the SzGenedatabase[J].Nat Genet.2008,40(7):827-834.
4.Gao Q,Li Z,Jones P,et al.A Possible Role of the FKBP5Gene in Schizophrenia[J].Journal of Psychiatry and Brain Science,2016,1(5):2.
5.Van Dam F,Van Gool WA.Hyperhomocysteinemia and Alzheimer's disease:A systematic review[J].Arch GerontolGeriatr.2009,48(3):425-430.
6.Muntjewerff JW,Kahn RS,Blom HJ,et al.Homocysteine,methylenetetrahydrofolate reductase and risk of schizophrenia:a meta-analysis[J].Molecular psychiatry,2006,11(2):143-149.
7.Tiemeier H,van Tuijl HR,Hofman A,et al.Vitamin B12,folate,and homocysteine in depression:the Rotterdam Study[J].Am J Psychiatry,2002,159(12):2099-2101.
8.Clarke R,Smith AD,Jobst KA,et al.Folate,vitamin B12,and serum total homocysteine levels in confirmed Alzheimer disease[J].Arch Neurol.1998,55(11):1449-1455.
9.Kwok T,Lee J,Law CB,et al.A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people[J].ClinNutr.2011,30(3):297-302.
10.Muntjewerff JW,Kahn RS,Blom HJ,et al.Homocysteine,methylenetetrahydrofolate reductase and risk of schizophrenia:a meta-analysis[J].MolPsychiatry,2006,11(2):143-149.
11.Fan N,Tan Y,Yang F,et al.Effect of risperidone on serum homocysteine levels in first-episode,drug-naive patients with schizophrenia[J].Neurosci Lett.2017,650:168-173.
12.Levine J,Stahl Z,Sela BA,et al.Homocysteine-reducing strategies improve symptoms in chronic schizophrenic patients with hyperhomocysteinemia[J].Biol psychiatry,2006,60(3):265-269.
13.Bottiglieri T,Laundy M,Crellin R,et al.Homocysteine,folate,methylation,and monoamine metabolism in depression[J].J NeurolNeurosurg Psychiatry,2000,69(2):228-232.
14.de Koning EJ,van der Zwaluw NL,van Wijngaarden JP,et al.Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations:Additional Results from the B-PROOF Study,an RCT[J].Nutrients,2016,8(11).pii:E748.
15.Okereke OI,Cook NR,Albert CM,et al.Effect of longterm supplementation with folic acid and B vitamins on risk of depression in older women[J].Br J Psychiatry,2015,206(4):324-331.
16.Zhou SJ,Zhang LG,Chen HM,et al.Prevalence and clinical-demographic correlates of hyperhomocysteinemia in inpatients with bipolar disorder in a Han Chinese population[J].Psychiatry Res.2018,259:364-369.
17.Brown AS,Bottiglieri T,Schaefer CA,et al.Elevated prenatal homocysteine levels as a risk factor for schizophrenia[J].Arch Gen Psychiatry,2007,64(1):31-39.
18.Baydas G,Reiter RJ,Akbulut M,et al.Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3activation and by regulating pro-and anti-apoptotic protein levels[J].Neuroscience,2005,135(3):879-886.
19.陈景旭,陈红梅,李居艳,等.双相Ⅰ型障碍躁狂发作患者同型半胱氨酸水平及其影响因素[J].中华行为医学与脑科学杂志,2015,24(5):455-457.
20.Bottiglieri T,Parnetti L,Arning E,et al.Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase(MTHFR)gene:a study in an Italian population with dementia[J].Mech Ageing Dev.2001,122(16):2013-2023.