硝苯地平控释片联合依那普利治疗高血压疗效的Meta分析
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摘要
目的系统评价硝苯地平控释片联合依那普利治疗高血压的疗效和安全性。方法检索PubMed、中国知网、维普及万方数据库中2000年至2018年发表的硝苯地平控释片联合依那普利治疗高血压相关文献,使用Jadad量表进行质量评价并通过Review Manager 5.3和Stata 11.0软件对纳入研究进行Meta分析。结果最终入选12篇研究,结果表明联合用药比单用依那普利疗效更好[OR=4.91,95%CI(3.32,7.26),P<0.00001],治疗前后舒张压和收缩压没有显著差异(P>0.05),安全性上联合组的表现也更好[OR=0.43,95%CI(0.26,0.69),P=0.0005]。结论本研究表明两种药物联合使用对高血压的疗效更好,安全性更高。
Objective: To assess the therapy efficacy and safety of enalapril combined with nifedipine for hypertension.Methods: Pubmed, CNKI, VIP and Wanfang Data were searched for combination of enalapril combined with nifedipine on hypertension during 2000-2018.Meta-analysis was performed by RevMan 5.3 and Stata software.Results: Twelve works in the literature were included in this study.Meta-analysis showed that there was a significant difference between experimental group and control group[OR=4.91,95%CI(3.32,7.26),P<0.00001].DBP and SBP had no significant difference between two groups. The difference of adverse effect was statistical between two groups[OR=0.43,95%CI(0.26,0.69),P=0.0005].Conclusion: Enalapril combined with nifedipine shows better efficacy and safety for hypertension.
Objective: To assess the therapy efficacy and safety of enalapril combined with nifedipine for hypertension.Methods: Pubmed, CNKI, VIP and Wanfang Data were searched for combination of enalapril combined with nifedipine on hypertension during 2000-2018.Meta-analysis was performed by RevMan 5.3 and Stata software.Results: Twelve works in the literature were included in this study.Meta-analysis showed that there was a significant difference between experimental group and control group[OR=4.91,95%CI(3.32,7.26),P<0.00001].DBP and SBP had no significant difference between two groups. The difference of adverse effect was statistical between two groups[OR=0.43,95%CI(0.26,0.69),P=0.0005].Conclusion: Enalapril combined with nifedipine shows better efficacy and safety for hypertension.
引文
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[18] 韦玉娟,杨连招,陈玲,等.社区老年高血压病病人睡眠质量与焦虑水平现况调查[J].护理研究,2018,32(9):1460-1463.
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[22] 李宁萍.钙拮抗剂治疗高血压比较研究进展[J].临床荟萃,2003,12(8):568.
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[24] 潘晓莉.高血压药物治疗的若干进展[J].中级医刊,2006,10(6):682.
[2] 梁秋华,吴笛,吴迪.南京市溧水区2013年和2016年高血压人群健康知晓率及行为变化分析[J].江苏卫生事业管理,2018,29(5):596-599.
[3] 孙宁玲,霍勇,王继光,等.难治性高血压诊断治疗中国专家共识[J].中华高血压杂志,2013,21(4):321-326.
[4] Juni P,Altman D G,Egger M.Systematic reviews in health care:assessing the quality of controlled clinical trials[J].BMJ,2001,323(7303):42-46.
[5] 张循明.硝苯地平控释片和依那普利联合治疗高血压病的疗效观察[J].临床医药文献电子杂志,2017,4(45):8869.
[6] 陈昌.马来酸依那普利联合硝苯地平控释片治疗原发性高血压疗效及安全性评价[J].吉林医学,2018,39(2):287-288.
[7] 梁必立,邢淑芳,蔡晶.硝苯地平控释片联用依那普利治疗老年高血压病85例疗效观察[J].卫生职业教育,2009,27(14):141-142.
[8] 王丽君.硝苯地平控释片与依那普利联合应用方案治疗原发性高血压的临床疗效观察[J].中国民康医学,2014,26(11):64-65.
[9] 吉岩忠,张意琪,王玉蛟.依那普利联合硝苯地平控释片治疗高血压病疗效观察[J].中国医学创新,2009,6(31):23-24.
[10] 王懋辉.依那普利联合硝苯地平控释片治疗高血压病疗效观察[J].实用中医药杂志,2015,31(3):249.
[11] 王晓玲.依那普利联合硝苯地平控释片治疗高血压疗效观察[J].临床合理用药杂志,2014,7(1):17-18.
[12] 黄成,郑福梅.依那普利联合硝苯地平控释片治疗社区高血压128例分析[J].北方药学,2017,14(7):160-161.
[13] 苗保霞,刘同宝.依那普利联合硝苯地平控释片治疗原发性高血压的疗效观察[J].中国医疗前沿,2013,8(23):36+114.
[14] 冯志琼.依那普利联合硝苯地平控释片治疗原发性高血压疗效观察[J].临床合理用药杂志,2012,5(7):1-2.
[15] 嵇爱平,罗义根.依那普利联合硝苯地平控释片治疗原发性高血压临床观察[J].首都食品与医药,2015,22(20):61-62.
[16] 陈秀华.依那普利联合硝苯地平控释片治疗高血压病的疗效观察[J].临床合理用药杂志,2012,5(13):77-78.
[17] 李云,杨鹏,吴寿岭.高血压危险因素研究进展[J].实用预防医学,2014,21(4):511-513+442.
[18] 韦玉娟,杨连招,陈玲,等.社区老年高血压病病人睡眠质量与焦虑水平现况调查[J].护理研究,2018,32(9):1460-1463.
[19] Eleftherohorinou H,Wright V,Hoggart C,et al.Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases[J].PLoS One,2009,4(11):e8068.
[20] 王兰香.高血压危险因素的防治[J].职业与健康,2013,29(16):2092-2094.
[21] 孙宁玲.降压治疗的升华血压管理//胡大一,马长生.心脏病学实践—2012[M].北京:人民卫生出版社,2012:51-54.
[22] 李宁萍.钙拮抗剂治疗高血压比较研究进展[J].临床荟萃,2003,12(8):568.
[23] 薛锦彤.实用心血管疾病诊疗手册[M].郑州:郑州大学出版社,2005.
[24] 潘晓莉.高血压药物治疗的若干进展[J].中级医刊,2006,10(6):682.