无柄灵芝中1个新的杂萜类成分
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摘要
目的对无柄灵芝Ganodermaresinaceum子实体的化学成分进行研究,以期发现新的化合物。方法利用硅胶、MCI-GEL树脂及PR-HPLC等多种色谱技术进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果从云南瑞丽产无柄灵芝子实体中分离得到4个化合物,分别鉴定为无柄灵芝素F(1)、3β,7β,15β-三羟基-11,23-二酮基-羊毛脂-8,16-二烯-26-羧酸(2)、灵芝酸XL_2(3)和2,3-二氢-4(1H)-喹诺酮(4)。结论其中化合物1为1个新的杂萜类成分,命名为无柄灵芝素F。
Objective For the purpose of finding new agents, the chemical study on Ganoderma resinaceum was carried out. Methods The chemical constituents from the dried fruiting bodies of G. resinaceum were isolated by column chromatographic methods of silica gel, MCI-Gel resin, and high performance liquid chromatography. The structures were elucidated by spectroscopic methods, including extensive 1 D and 2 D NMR techniques. Results Four compounds including one new meroterpenoid were isolated from this fungus. Their structures were identified as ganoresinains F(1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid(2), ganoderic acid XL_2(3) and 2,3-dihydro-4(1 H)-quinolone(4). Conclusion Compound 1 is a new compound and named as ganoresinains F(1).
Objective For the purpose of finding new agents, the chemical study on Ganoderma resinaceum was carried out. Methods The chemical constituents from the dried fruiting bodies of G. resinaceum were isolated by column chromatographic methods of silica gel, MCI-Gel resin, and high performance liquid chromatography. The structures were elucidated by spectroscopic methods, including extensive 1 D and 2 D NMR techniques. Results Four compounds including one new meroterpenoid were isolated from this fungus. Their structures were identified as ganoresinains F(1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid(2), ganoderic acid XL_2(3) and 2,3-dihydro-4(1 H)-quinolone(4). Conclusion Compound 1 is a new compound and named as ganoresinains F(1).
引文
[1]Peng X R,Liu J Q,Wang C F,et al.Hepatoprotective effects of triterpenoids from Ganoderma cochlear[J].JNat Prod,2014,77(4):737-743.
[2]吕超田,姚向阳,孙程.灵芝主要活性物质及其药理作用研究进展[J].安徽农学通报,2011,17(1):50-51.
[3]彭惺蓉.无柄灵芝与反柄紫芝的化学成分及生物活性研究[D].昆明:云南农业大学,2012.
[4]于璐,姚铁,王萌,等.赤芝中1个新的三萜类化合物[J].中草药,2014,45(10):1363-1366.
[5]Ding P,Qiu J Y,Liang Y J.Chemical constituents of Ganoderma resinaceum[J].Chin Herb Med,2010,2(1):65-67.
[6]郭晓蕾,翟旭峰,王怀豫,等.不同产地灵芝(赤芝)的HPLC指纹图谱评价[J].中华中医药学刊,2011(12):2782-2784.
[7]Peng X,Qiu M.Meroterpenoids from Ganoderma species:A review of last five years[J].Nat Prod Bioprospect,2018,8(3):137-149.
[8]Al-Fatimi M,Wurster M,Kreisel H,et al.Antimicrobial,cytotoxic and antioxidant activity of selected basidiomycetes from Yemen[J].Die Pharmazie,2005,60(10):776-780.
[9]Luo Q,Wang X L,Di L,et al.Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum[J].Tetrahedron,2015,71(5):840-845.
[10]Luo Q,Tu Z C,Yang Z L,et al.Meroterpenoids from the fruiting bodies of Ganoderma theaecolum[J].Fitoterapia,2018,125:273-280.
[11]Hu L L,Ma Q Y,Huang S Z,et al.A new nortriterpenoid from the fruiting bodies of Ganoderma tropicum[J].JAsian Nat Prod Res,2013,15(4):357-362.
[12]Liu L Y,Chen H,Liu C,et al.Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities[J].Fitoterapia,2014,98:254-259.
[13]李丹丹,丁丽琴,杨灵,等.海蒿子含氮有机化学成分研究[J].中草药,2017,48(9):1735-1739.
[2]吕超田,姚向阳,孙程.灵芝主要活性物质及其药理作用研究进展[J].安徽农学通报,2011,17(1):50-51.
[3]彭惺蓉.无柄灵芝与反柄紫芝的化学成分及生物活性研究[D].昆明:云南农业大学,2012.
[4]于璐,姚铁,王萌,等.赤芝中1个新的三萜类化合物[J].中草药,2014,45(10):1363-1366.
[5]Ding P,Qiu J Y,Liang Y J.Chemical constituents of Ganoderma resinaceum[J].Chin Herb Med,2010,2(1):65-67.
[6]郭晓蕾,翟旭峰,王怀豫,等.不同产地灵芝(赤芝)的HPLC指纹图谱评价[J].中华中医药学刊,2011(12):2782-2784.
[7]Peng X,Qiu M.Meroterpenoids from Ganoderma species:A review of last five years[J].Nat Prod Bioprospect,2018,8(3):137-149.
[8]Al-Fatimi M,Wurster M,Kreisel H,et al.Antimicrobial,cytotoxic and antioxidant activity of selected basidiomycetes from Yemen[J].Die Pharmazie,2005,60(10):776-780.
[9]Luo Q,Wang X L,Di L,et al.Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum[J].Tetrahedron,2015,71(5):840-845.
[10]Luo Q,Tu Z C,Yang Z L,et al.Meroterpenoids from the fruiting bodies of Ganoderma theaecolum[J].Fitoterapia,2018,125:273-280.
[11]Hu L L,Ma Q Y,Huang S Z,et al.A new nortriterpenoid from the fruiting bodies of Ganoderma tropicum[J].JAsian Nat Prod Res,2013,15(4):357-362.
[12]Liu L Y,Chen H,Liu C,et al.Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities[J].Fitoterapia,2014,98:254-259.
[13]李丹丹,丁丽琴,杨灵,等.海蒿子含氮有机化学成分研究[J].中草药,2017,48(9):1735-1739.
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