参附注射液治疗慢性心力衰竭疗效观察
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摘要
目的:观察参附注射液治疗慢性心力衰竭的临床疗效。方法:将心力衰竭患者100例随机分为观察组和对照组各50例,对照组给予西医常规治疗,观察组在对照组治疗基础上加用参附注射液50 mL+5%葡萄糖注射液100 mL静脉滴注,1次/d,14天为1个疗程。比较2组患者临床疗效、心率、血压及左室射血分数(LVEF)、高敏C反应蛋白(hr-CRP)、B型利钠肽(BNP)。结果:总有效率观察组为96.0%,高于对照组的82.0%(P<0.05)。治疗后2组患者心率、收缩压、舒张压与治疗前相比均下降(P<0.05),但观察组下降程度与对照组比较差异不明显(P>0.05)。治疗后2组BNP、hr-CRP均较治疗前降低(P<0.05),LEVF和每分输出量增加(P<0.05),观察组改善程度优于对照组(P<0.05)。结论:参附注射液联合西医常规治疗能够改善气阴虚兼血瘀型慢性心力衰竭患者心脏功能,效果优于西医常规治疗。
Objective: To observe curative effects of ShenFu injection in treating chronic heart failure(CHF).Methods: A total of 100 patients were randomized into the observation group and the control group, 50 cases each group, the control group were given conventional therapy of Western medicine, and the observation group accepted intravenous dripping of ShenFu injection, 50 mL, and 5% glucose injection, 100 m L, once each day, 14 days were one course. To compare clinical effects, left ventricular ejection fraction(LVEF), high sensitivity C reactive protein(hs-CRP) and B type natriuretic peptide(BNP) between both groups. Results: Total effective rate of the observation group was 96.0%, higher than 82.0% of the control group(P<0.05). After treating, heart rate, systolic pressure and diastolic pressure lowered in both groups compared with before treating(P<0.05), the difference was insignificant when the decrease of the observation group was compared with that of the control group(P>0.05). BNP and hs-CRP of both groups decreased after treating compared with before treating(P<0.05), LVEF and output per minuter increased(P<0.05), the observation group was superior to the control group in the improvement(P<0.05). Conclusion: ShenFu injection based on conventional therapy of western medicine, its effects are superior to only conventional therapy of western medicine could improve cardiac function of CHF patients of Qi and Yin deficiency and blood stasis pattern.
Objective: To observe curative effects of ShenFu injection in treating chronic heart failure(CHF).Methods: A total of 100 patients were randomized into the observation group and the control group, 50 cases each group, the control group were given conventional therapy of Western medicine, and the observation group accepted intravenous dripping of ShenFu injection, 50 mL, and 5% glucose injection, 100 m L, once each day, 14 days were one course. To compare clinical effects, left ventricular ejection fraction(LVEF), high sensitivity C reactive protein(hs-CRP) and B type natriuretic peptide(BNP) between both groups. Results: Total effective rate of the observation group was 96.0%, higher than 82.0% of the control group(P<0.05). After treating, heart rate, systolic pressure and diastolic pressure lowered in both groups compared with before treating(P<0.05), the difference was insignificant when the decrease of the observation group was compared with that of the control group(P>0.05). BNP and hs-CRP of both groups decreased after treating compared with before treating(P<0.05), LVEF and output per minuter increased(P<0.05), the observation group was superior to the control group in the improvement(P<0.05). Conclusion: ShenFu injection based on conventional therapy of western medicine, its effects are superior to only conventional therapy of western medicine could improve cardiac function of CHF patients of Qi and Yin deficiency and blood stasis pattern.
引文
[1]严治涛,罗文利,黄金梅,等.不同剂量参附注射液治疗慢性心力衰竭的临床疗效观察[J].中华中医药杂志,2015,30(2):636-640.
[2]姚魁武,陈孟倩,刘甜甜,等.参附注射液辅助治疗对冠心病慢性心力衰竭患者生活质量及生存情况的影响[J].中医杂志,2016,57(24):2117-2120.
[3]严治涛,罗文利,黄金梅,等.不同剂量参附注射液治疗慢性心力衰竭的临床疗效观察[J].中华中医药杂志,2015,30(2):636-640.
[4]周新强.参附注射液和香丹注射液联合治疗慢性心力衰竭患者疗效观察[J].中医临床研究,2016,8(27):49-50.
[5]王贤良,毛静远,崔小磊,等.基于病证结合的心力衰竭中医分期辨治方案集成研究[J].中医杂志,2013,54(6):475-477.
[6]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98-122.
[7]余莉,张鹏,刘鹏,等.冠心病慢性心力衰竭心脏指数、左室质量指数与中医证型的相关性研究[J].湖北中医药大学学报,2012,14(01):63-64.
[8]魏旭明,韩贝,焦全德,等.米力农治疗急性加重期慢性充血性心力衰竭疗效观察[J].新乡医学院学报,2019,36(1):56-59.
[9]郑军,刘金玲.中西医结合治疗气虚血瘀型慢性充血性心力衰竭37例[J].西部中医药,2011,24(12):62-64.
[10]张瑞娟,陆颖婷.益气健脾法在慢性心力衰竭治疗中的应用[J].中国中医急症,2017,26(7):1309-1311.
[11]赵嘉晶,曹飞,岳瑶函,等.慢性心力衰竭患者LDH与血浆BNP及中医证型相关性研究[J].西部中医药,2014,27(9):78-80.
[12]杨贵荣,杨长春.参附注射液在危重病中的应用进展[J].解放军药学学报,2017,33(3):259-261.
[13]章轶立,贾敏,谢雁鸣,等.参附注射液治疗缓慢性心律失常的有效性和安全性研究:随机对照试验的系统评价和Meta分析[J].北京中医药大学学报,2016,39(7):595-604.
[2]姚魁武,陈孟倩,刘甜甜,等.参附注射液辅助治疗对冠心病慢性心力衰竭患者生活质量及生存情况的影响[J].中医杂志,2016,57(24):2117-2120.
[3]严治涛,罗文利,黄金梅,等.不同剂量参附注射液治疗慢性心力衰竭的临床疗效观察[J].中华中医药杂志,2015,30(2):636-640.
[4]周新强.参附注射液和香丹注射液联合治疗慢性心力衰竭患者疗效观察[J].中医临床研究,2016,8(27):49-50.
[5]王贤良,毛静远,崔小磊,等.基于病证结合的心力衰竭中医分期辨治方案集成研究[J].中医杂志,2013,54(6):475-477.
[6]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98-122.
[7]余莉,张鹏,刘鹏,等.冠心病慢性心力衰竭心脏指数、左室质量指数与中医证型的相关性研究[J].湖北中医药大学学报,2012,14(01):63-64.
[8]魏旭明,韩贝,焦全德,等.米力农治疗急性加重期慢性充血性心力衰竭疗效观察[J].新乡医学院学报,2019,36(1):56-59.
[9]郑军,刘金玲.中西医结合治疗气虚血瘀型慢性充血性心力衰竭37例[J].西部中医药,2011,24(12):62-64.
[10]张瑞娟,陆颖婷.益气健脾法在慢性心力衰竭治疗中的应用[J].中国中医急症,2017,26(7):1309-1311.
[11]赵嘉晶,曹飞,岳瑶函,等.慢性心力衰竭患者LDH与血浆BNP及中医证型相关性研究[J].西部中医药,2014,27(9):78-80.
[12]杨贵荣,杨长春.参附注射液在危重病中的应用进展[J].解放军药学学报,2017,33(3):259-261.
[13]章轶立,贾敏,谢雁鸣,等.参附注射液治疗缓慢性心律失常的有效性和安全性研究:随机对照试验的系统评价和Meta分析[J].北京中医药大学学报,2016,39(7):595-604.