磁共振T2*图在膝关节骨性关节炎诊断中的应用研究进展
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摘要
骨关节炎(OA)是由关节软骨"磨损"引起的进行性、退行性疾病,T2-star-mapping(T2*图)是一种相对较新的评估关节软骨组成的方法,与其他MR生理成像技术相比,T2*图具有成像速度快、图像分辨率高和能够进行各向同性三维(3D)软骨评估的优点,从而提供更大的空间分辨率和完整的关节面覆盖。这对早期发现OA和全面评估OA的进展至关重要。文章描述T2*图成像技术的原理,并对此技术在OA研究中的应用进展予以综述。
Osteoarthritis(OA) is a progressive and degenerative disease caused by wear and tear of articular cartilage. T2-star-mapping(T2 * map) is a relatively new method to evaluate the composition of articular cartilage. Compared with other MR physiological imaging techniques, T2* map has the advantages of fast imaging speed, high image resolution and isotropic three-dimensional(3 D) cartilage evaluation, thus providing greater value. Spatial resolution and complete articular coverage. This is essential for early detection of OA and for a comprehensive assessment of the progress of OA. This paper describes the principle of T2 * imaging technology and summarizes its application in OA research.
Osteoarthritis(OA) is a progressive and degenerative disease caused by wear and tear of articular cartilage. T2-star-mapping(T2 * map) is a relatively new method to evaluate the composition of articular cartilage. Compared with other MR physiological imaging techniques, T2* map has the advantages of fast imaging speed, high image resolution and isotropic three-dimensional(3 D) cartilage evaluation, thus providing greater value. Spatial resolution and complete articular coverage. This is essential for early detection of OA and for a comprehensive assessment of the progress of OA. This paper describes the principle of T2 * imaging technology and summarizes its application in OA research.
引文
[1]张晓贝,樊天佑,邱卫东.膝关节软骨的影像学检查进展[J].中国中西医结合影像学杂志,2015, 13(6):706-708. DOI:10.3969/j. issn. 1672-0512.2015.06.042.
[2] Hesper T, Hosalkar HS, Bittersohl D, et al. T2*mapping for articular cartilage assessment:principles, current applications, and future prospects[J]. Skeletal Radiology, 2014, 43(10):1429-1445. DOI:10.1007/s00256-014-1852-3.
[3]梁学恒,杨全,余洁,等.T2*mapping定量评估早期骨关节炎半月板与软骨的相关性[J].海南医学,2017,28(16):2631-2634. DOI:10.3969/j. issn. 1003-6350.2017.16.016.
[4]伍忠根,傅闽兰,李志国,等.微骨折术治疗膝关节软骨损伤修复效果-T2 star mapping评价研究[J].医学影像学杂志,2014,24(9):1599-1603. DOI:1006-9011(2014)09-1599-05.
[5]张新慧,于静红.骨性关节炎早期关节软骨损伤的MR研究进展[J].疑难病杂志,2016, 15(9):975-978.DOI:10. 3969/j.issn. 1671-6450.2016.09.026.
[6] Lota AS, Gatehouse PD, Mohiaddin RH. T2 mapping and T2*imaging in heart failure[J]. Heart Failure Reviews, 2017, 22(4):431-440. DOI:10.1007/s10741-017-9616-5.
[7] Mamisch TC, Hughes T, Mosher TJ, et al. T2 star relaxation times for assessment of articular cartilage at 3 T:a feasibility study[J].Skeletal Radiology, 2012, 41(3):287-292. DOI:10.1007/s00256-011-1171-x.
[8]高峰,张宗军,唐文伟,等.膝关节软骨磁共振T2及T2star弛豫时间图成像的初步研究[J].临床放射学杂志,2013, 32(9):1305-1310.
[9] Detiger SE, Holewijn RM, Hoogendoorn RJ, et al. MRI T2*mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model[J]. European spine journal,2015, 24(9):1935-1943. DOI:10.1007/s00586-014-3498-1.
[10]赵海南,姚伟武,姜铃霞,等.兔膝关节软骨退变的磁共振T2、T2*图成像定量测定[J].中国医学计算机成像杂志,2013, 19(4):385-389. DOI:1006.5741(2013). 04. 0385.05.
[11] Bittersohl B, Hosalkar HS, Sondern M, et al. Spectrum of T2*values in knee joint cartilage at 3 T:a cross-sectional analysis in asymptomatic young adult volunteers[J]. Skeletal Radiology, 2014,43(4):443-452. DOI:10.1007/s00256-013-1806-1.
[12] Newbould RD, Miller SR, Toms LD, et al. T2*measurement of the knee articular cartilage in osteoarthritis at 3T.[J]. Journal of Magnetic Resonance Imaging Jmri, 2012, 35(6):1422-1429. DOI:10.1002/jmri. 23598.
[13]寇博.核磁共振T2-star-mapping成像软骨定量分析在膝关节骨性关节炎诊断中的临床应用研究[D].银川:宁夏医科大学,2015.
[14] Wilusz RE, Johannah SA, Farshid G. The structure and function of the pericellular matrix of articular cartilage[J]. Matrix Biology,2014, 39:25-32. DOI:10.1016/j. matbio.2014.08.009.
[15]王可欣,许铖龙,于静红.DTI及T2弛豫时间图成像技术在膝关节骨性关节炎诊断中的应用研究进展[J].疑难病杂志,2017,16(11):1185-1188. DOI:10. 3969/j. issn. 1671-6450.2017.11.029.
[16]杨金永.磁共振T2-mapping成像对早期膝关节软骨损伤的诊断价值研究[J].医学影像学杂志,2010, 20(2):258-261. DOI:10.7666/d.y1786960.
[17]陈瑶,黄凤兰,马锦富.膝骨关节炎患者的关节稳定性研究进展[J].华西医学,2017,32(7):1097-1099.
[18] Robinson DL,Kersh ME,Walsh NC,et al. Mechanical propertiesof normal and osteoarthritic human articular cartilage[J]. Journal of Biomechanics, 2016, 61(8):96-109. DOI:10. 1016/j. jmbbm.2016.01.015.
[19] Tajika Y, Moue T, Ishikawa S, et al. Influence of periostin on synoviocytes in knee osteoarthritis[J]. Vivo, 2017, 31(1):69. DOI:10.21873/invivo. 11027.
[20] Bittersohl B, Miese FR, Hosalkar HS, et al. T2*mapping of hip joint cartilage in various histological grades of degeneration.[J].Osteoarthritis Cartilage, 2012, 20(7):653-660. DOI:10. 1016/j.joca. 2012.03.011.
[21]Bittersohl B, Miese F R, Hosalkar H S, et al. T2*mapping of acetabular and femoral hip joint cartilage at 3 T:a prospective controlled study.[J]. Investigative Radiology, 2012, 47(7):392.DOI:10.1097/RLI.0b013e3182518d57.
[22]白志刚,寇博,孙玺淳,等.核磁共振T2-star-mapping成像软骨定量分析在膝关节骨性关节炎诊断中的应用研究[J].宁夏医学杂志,2017,39(1):27-29. DOI:10. 13621/j. 1001-5949.2017.01.0027.
[23]石桥,冯飞,支丽萍,等.3.0 T磁共振.T2*定量分析评价膝关节骨性关节炎临床应用价值[J].中国CT和MRI杂志,2015,13(10):93-96. DOI:10.3969/j. issn. 1672-5131.2015.10.030.
[24]杨绿林.核磁共振T2-star-mapping成像软骨定量分析与γ-glutamyl carboxylase在膝骨性关节炎病情评估中的相关性研究[D].银川:宁夏医科大学,2016.
[25] Wang L, Regatte RR. Investigation of regional influence of magicangle effect on t2 in human articular cartilage with osteoarthritis at 3T[J]. Academic Radiology, 2015, 22(1):87-92. DOI:10. 1016/j. acra. 2014. 07. 015.
[26] Shao H, Pauli C, Li S, et al. Magic angle effect plays a major role in both Tlrho and T2 relaxation in articular cartilage.[J]. Osteoarthritis Cartilage, 2017, 25(12):2022. DOI:10. 1016/j. joca.2017.01.013.
[2] Hesper T, Hosalkar HS, Bittersohl D, et al. T2*mapping for articular cartilage assessment:principles, current applications, and future prospects[J]. Skeletal Radiology, 2014, 43(10):1429-1445. DOI:10.1007/s00256-014-1852-3.
[3]梁学恒,杨全,余洁,等.T2*mapping定量评估早期骨关节炎半月板与软骨的相关性[J].海南医学,2017,28(16):2631-2634. DOI:10.3969/j. issn. 1003-6350.2017.16.016.
[4]伍忠根,傅闽兰,李志国,等.微骨折术治疗膝关节软骨损伤修复效果-T2 star mapping评价研究[J].医学影像学杂志,2014,24(9):1599-1603. DOI:1006-9011(2014)09-1599-05.
[5]张新慧,于静红.骨性关节炎早期关节软骨损伤的MR研究进展[J].疑难病杂志,2016, 15(9):975-978.DOI:10. 3969/j.issn. 1671-6450.2016.09.026.
[6] Lota AS, Gatehouse PD, Mohiaddin RH. T2 mapping and T2*imaging in heart failure[J]. Heart Failure Reviews, 2017, 22(4):431-440. DOI:10.1007/s10741-017-9616-5.
[7] Mamisch TC, Hughes T, Mosher TJ, et al. T2 star relaxation times for assessment of articular cartilage at 3 T:a feasibility study[J].Skeletal Radiology, 2012, 41(3):287-292. DOI:10.1007/s00256-011-1171-x.
[8]高峰,张宗军,唐文伟,等.膝关节软骨磁共振T2及T2star弛豫时间图成像的初步研究[J].临床放射学杂志,2013, 32(9):1305-1310.
[9] Detiger SE, Holewijn RM, Hoogendoorn RJ, et al. MRI T2*mapping correlates with biochemistry and histology in intervertebral disc degeneration in a large animal model[J]. European spine journal,2015, 24(9):1935-1943. DOI:10.1007/s00586-014-3498-1.
[10]赵海南,姚伟武,姜铃霞,等.兔膝关节软骨退变的磁共振T2、T2*图成像定量测定[J].中国医学计算机成像杂志,2013, 19(4):385-389. DOI:1006.5741(2013). 04. 0385.05.
[11] Bittersohl B, Hosalkar HS, Sondern M, et al. Spectrum of T2*values in knee joint cartilage at 3 T:a cross-sectional analysis in asymptomatic young adult volunteers[J]. Skeletal Radiology, 2014,43(4):443-452. DOI:10.1007/s00256-013-1806-1.
[12] Newbould RD, Miller SR, Toms LD, et al. T2*measurement of the knee articular cartilage in osteoarthritis at 3T.[J]. Journal of Magnetic Resonance Imaging Jmri, 2012, 35(6):1422-1429. DOI:10.1002/jmri. 23598.
[13]寇博.核磁共振T2-star-mapping成像软骨定量分析在膝关节骨性关节炎诊断中的临床应用研究[D].银川:宁夏医科大学,2015.
[14] Wilusz RE, Johannah SA, Farshid G. The structure and function of the pericellular matrix of articular cartilage[J]. Matrix Biology,2014, 39:25-32. DOI:10.1016/j. matbio.2014.08.009.
[15]王可欣,许铖龙,于静红.DTI及T2弛豫时间图成像技术在膝关节骨性关节炎诊断中的应用研究进展[J].疑难病杂志,2017,16(11):1185-1188. DOI:10. 3969/j. issn. 1671-6450.2017.11.029.
[16]杨金永.磁共振T2-mapping成像对早期膝关节软骨损伤的诊断价值研究[J].医学影像学杂志,2010, 20(2):258-261. DOI:10.7666/d.y1786960.
[17]陈瑶,黄凤兰,马锦富.膝骨关节炎患者的关节稳定性研究进展[J].华西医学,2017,32(7):1097-1099.
[18] Robinson DL,Kersh ME,Walsh NC,et al. Mechanical propertiesof normal and osteoarthritic human articular cartilage[J]. Journal of Biomechanics, 2016, 61(8):96-109. DOI:10. 1016/j. jmbbm.2016.01.015.
[19] Tajika Y, Moue T, Ishikawa S, et al. Influence of periostin on synoviocytes in knee osteoarthritis[J]. Vivo, 2017, 31(1):69. DOI:10.21873/invivo. 11027.
[20] Bittersohl B, Miese FR, Hosalkar HS, et al. T2*mapping of hip joint cartilage in various histological grades of degeneration.[J].Osteoarthritis Cartilage, 2012, 20(7):653-660. DOI:10. 1016/j.joca. 2012.03.011.
[21]Bittersohl B, Miese F R, Hosalkar H S, et al. T2*mapping of acetabular and femoral hip joint cartilage at 3 T:a prospective controlled study.[J]. Investigative Radiology, 2012, 47(7):392.DOI:10.1097/RLI.0b013e3182518d57.
[22]白志刚,寇博,孙玺淳,等.核磁共振T2-star-mapping成像软骨定量分析在膝关节骨性关节炎诊断中的应用研究[J].宁夏医学杂志,2017,39(1):27-29. DOI:10. 13621/j. 1001-5949.2017.01.0027.
[23]石桥,冯飞,支丽萍,等.3.0 T磁共振.T2*定量分析评价膝关节骨性关节炎临床应用价值[J].中国CT和MRI杂志,2015,13(10):93-96. DOI:10.3969/j. issn. 1672-5131.2015.10.030.
[24]杨绿林.核磁共振T2-star-mapping成像软骨定量分析与γ-glutamyl carboxylase在膝骨性关节炎病情评估中的相关性研究[D].银川:宁夏医科大学,2016.
[25] Wang L, Regatte RR. Investigation of regional influence of magicangle effect on t2 in human articular cartilage with osteoarthritis at 3T[J]. Academic Radiology, 2015, 22(1):87-92. DOI:10. 1016/j. acra. 2014. 07. 015.
[26] Shao H, Pauli C, Li S, et al. Magic angle effect plays a major role in both Tlrho and T2 relaxation in articular cartilage.[J]. Osteoarthritis Cartilage, 2017, 25(12):2022. DOI:10. 1016/j. joca.2017.01.013.
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