我国黄芪药理学研究的文献学分析
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摘要
目的:对我国黄芪研究现状进行全面梳理,以期为黄芪的进一步研究和学科的发展起到重要的指导作用。方法:通过中国知识基础设施工程检索相关黄芪药理学研究文献,运用文献计量学方法,从文献数量及增长规律、期刊分布规律、作者及影响力、研究机构、研究基金等方面对我国1980—2016年间黄芪药理学研究进行统计分析。结果:从20世纪90年代开始,我国黄芪药理学研究持续增长。目前黄芪生态学研究尚未形成较为稳定的核心作者群、研究人员偏少且分布范围较小,研究主题主要集中在几个领域,研究内容多停留在宏观方面,研究深度和广度均有待进一步提升。结论:黄芪研究者可根据本文分析结果,结合实际与自身特点,找到合适的研究路线。
Objective:To survey the study on Huangqi in China completely, and guide further study of Huangqi and the development of the subject. Methods: Pharmacological studies of Huangqi from 1980 to 2016 were statistically analyzed from the number of the papers, the increasing laws, distribution laws of the journals, author and impact, research institute, research fund and others using the methods of bibliometrics. Results: Since the beginning of 1990 s, pharmacological study of Huangqi increased gradually, but the number and quality needed to be lifted largely. Currently, ecological study of Huangqi didn′t form the stable core author group, there were few investigators and smaller distribution, the training of the investigator and the construction of research team were urgent, research subjects mainly focused in several fields, the research contents stayed in macroscopic aspect, the depth and width needed to be further improved. Conclusion:Huangqi investigator could find the appropriate research route according to the analysis results, combining the actual with personal features.
Objective:To survey the study on Huangqi in China completely, and guide further study of Huangqi and the development of the subject. Methods: Pharmacological studies of Huangqi from 1980 to 2016 were statistically analyzed from the number of the papers, the increasing laws, distribution laws of the journals, author and impact, research institute, research fund and others using the methods of bibliometrics. Results: Since the beginning of 1990 s, pharmacological study of Huangqi increased gradually, but the number and quality needed to be lifted largely. Currently, ecological study of Huangqi didn′t form the stable core author group, there were few investigators and smaller distribution, the training of the investigator and the construction of research team were urgent, research subjects mainly focused in several fields, the research contents stayed in macroscopic aspect, the depth and width needed to be further improved. Conclusion:Huangqi investigator could find the appropriate research route according to the analysis results, combining the actual with personal features.
引文
[1]国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2010:283-284.
[2]刘阿娜,赵文晓,巩丽丽,等.黄芪黄酮干预脾虚水湿不化大鼠血浆代谢组学研究[J].分析化学,2017,4(4):537-544.
[3]王玲丽,丰华玲,杨柯,等.黄芪生物学及化学成分研究进展[J].基因组学与应用生物学,2017,36(6):455-459.
[4]张亚洲,徐风,梁静,等.蒙古黄芪中异黄酮类化学成分研究[J].中国中药杂志,2012,37(21):3243-3247.
[5]赵文晓,崔宁,韩冰冰,等.黄芪及拆分组分对脾虚水湿不化模型大鼠的影响[J].山东中医药大学学报,2015,39(3):268-270.
[6]崔宁,赵文晓,季旭明,等.黄芪及其拆分组分对脾虚水湿不化大鼠肝脏功能的影响[J].中医药信息,2015,32(2):62-65.
[7]崔宁,赵文晓,季旭明,等.基于肝基因表达谱分析的黄芪及其拆分组分对脾虚水湿不化大鼠脂质代谢影响的机制研究[J].世界中医药,2015,10(12):1819-1823.
[8]巴金华,窦忠霞.黄芪总黄酮对科萨奇B3病毒感染心肌细胞内向整流钾电流的作用[J].中国分子心脏病学杂志,2013,3(1):412-414.
[9]庞歆桥,王婧,姚婷,等.黄芪甲苷通过调节细胞自噬增强贝伐单抗在肺癌细胞系A549中抗肿瘤作用机制的研究[J].临床与病理杂志,2016,6(3):220-225.
[10]曹艳,何利红,孙赟,等.黄芪甲苷对胃癌细胞SGC7901侵袭能力的影响及其机制探讨[J].陕西医学杂志,2015,44(6):656-659.
[11]褚兆苹,吴淑慧,刘文泰,等.黄芪多糖对甲流HA2蛋白真核表达载体免疫效果影响的研究[J].中国免疫学杂志,2016,9(2):189-192.
[12]王海芳,曹情雯,王娜娜,等.黄芪注射液和黄芪总皂苷注射液治疗冠心病心绞痛临床疗效的系统评价[J].云南中医学院学报,2017,40(1):22-27.
[13]雷心雨,黄怡婷,朱翠玲,等.黄茂总皂苷配伍雷公藤多苷抗炎镇痛作用[J].中医与临床,2015,6(6):29-31.
[14]胡清宇.黄芪总苷的提取及药理作用的研究[J].科技信息,2007,24(2):237-238.
[15]邹品文,赵春景,李攀,等.黄芪多糖抗S180肉瘤作用及其免疫调节的影响[J].遵义医学院学报,2012,5(1):17-20.
[16]张娟,陈建宗.黄芪甲苷体外抗乙型肝炎病毒的作用[J].第四军医大学学报,2007,28(4):2291-2293.
[17]裴文丽.黄芪多糖对2型糖尿病大鼠血清IL-1β、IL-6、IL-18的影响作用[J].中医临床研究,2016,2(8):10-13.
[18]钟灵,王振富,文德鉴.黄芪多糖抗衰老作用的实验研究[J].中国应用生理学杂志,2013,29(4):350-352.
[19]何文涓,袁志坚,何晓升.黄芪多糖的药理作用研究进展[J].中国生化药物杂志,2012,5(33):692-694.
[2]刘阿娜,赵文晓,巩丽丽,等.黄芪黄酮干预脾虚水湿不化大鼠血浆代谢组学研究[J].分析化学,2017,4(4):537-544.
[3]王玲丽,丰华玲,杨柯,等.黄芪生物学及化学成分研究进展[J].基因组学与应用生物学,2017,36(6):455-459.
[4]张亚洲,徐风,梁静,等.蒙古黄芪中异黄酮类化学成分研究[J].中国中药杂志,2012,37(21):3243-3247.
[5]赵文晓,崔宁,韩冰冰,等.黄芪及拆分组分对脾虚水湿不化模型大鼠的影响[J].山东中医药大学学报,2015,39(3):268-270.
[6]崔宁,赵文晓,季旭明,等.黄芪及其拆分组分对脾虚水湿不化大鼠肝脏功能的影响[J].中医药信息,2015,32(2):62-65.
[7]崔宁,赵文晓,季旭明,等.基于肝基因表达谱分析的黄芪及其拆分组分对脾虚水湿不化大鼠脂质代谢影响的机制研究[J].世界中医药,2015,10(12):1819-1823.
[8]巴金华,窦忠霞.黄芪总黄酮对科萨奇B3病毒感染心肌细胞内向整流钾电流的作用[J].中国分子心脏病学杂志,2013,3(1):412-414.
[9]庞歆桥,王婧,姚婷,等.黄芪甲苷通过调节细胞自噬增强贝伐单抗在肺癌细胞系A549中抗肿瘤作用机制的研究[J].临床与病理杂志,2016,6(3):220-225.
[10]曹艳,何利红,孙赟,等.黄芪甲苷对胃癌细胞SGC7901侵袭能力的影响及其机制探讨[J].陕西医学杂志,2015,44(6):656-659.
[11]褚兆苹,吴淑慧,刘文泰,等.黄芪多糖对甲流HA2蛋白真核表达载体免疫效果影响的研究[J].中国免疫学杂志,2016,9(2):189-192.
[12]王海芳,曹情雯,王娜娜,等.黄芪注射液和黄芪总皂苷注射液治疗冠心病心绞痛临床疗效的系统评价[J].云南中医学院学报,2017,40(1):22-27.
[13]雷心雨,黄怡婷,朱翠玲,等.黄茂总皂苷配伍雷公藤多苷抗炎镇痛作用[J].中医与临床,2015,6(6):29-31.
[14]胡清宇.黄芪总苷的提取及药理作用的研究[J].科技信息,2007,24(2):237-238.
[15]邹品文,赵春景,李攀,等.黄芪多糖抗S180肉瘤作用及其免疫调节的影响[J].遵义医学院学报,2012,5(1):17-20.
[16]张娟,陈建宗.黄芪甲苷体外抗乙型肝炎病毒的作用[J].第四军医大学学报,2007,28(4):2291-2293.
[17]裴文丽.黄芪多糖对2型糖尿病大鼠血清IL-1β、IL-6、IL-18的影响作用[J].中医临床研究,2016,2(8):10-13.
[18]钟灵,王振富,文德鉴.黄芪多糖抗衰老作用的实验研究[J].中国应用生理学杂志,2013,29(4):350-352.
[19]何文涓,袁志坚,何晓升.黄芪多糖的药理作用研究进展[J].中国生化药物杂志,2012,5(33):692-694.