宁夏灵武地区中老年人群血清胃蛋白酶原水平与幽门螺杆菌感染的相关性分析
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摘要
目的分析宁夏灵武地区中老年人群血清胃蛋白酶原(PG)的分布情况,研究其与幽门螺杆菌(HP)感染的相关性。方法随机从灵武地区2017年-2018年45岁以上中老年健康体检人群中抽取1 310例,通过问卷调查的方式,结合体检资料对研究对象进行回顾性分析。空腹采集静脉血进行"胃功能四项"检测,分析胃蛋白酶原在不同性别、不同民族、不同居住地、不同年龄组人群中的差异以及与HP感染的关系。结果血清PGⅠ、PGⅡ、PGR以及HP在不同性别、不同年龄组、不同民族中差异均无统计学意义(P>0.05)。血清PGⅠ水平城镇比乡村显著升高,而PGⅡ水平城镇比乡村显著降低;血清PGⅠ、PGⅡ水平HP阳性组比HP阴性组明显升高,PGR指标HP阳性组比HP阴性组有明显降低,差异均有统计学意义(P<0.05)。结论灵武地区中老年人群的血清胃蛋白酶原水平与居住地等因素有关,且与HP感染有一定的相关性。
Objective To analyze the distribution of serum pepsinogen(PG) in middle-aged and elderly people in Lingwu area of Ningxia, and to study its correlation with Helicobacter pylori(HP) infection. Methods A total of 1 310 cases were randomly selected from the population aged 45 years old and above in Lingwu area from 2017 to 2018, and the subjects were analyzed retrospectively through questionnaires and physical examination data. The venous blood was collected on an empty stomach for "four stomach functions" test and the differences of pepsinogen in different sex, different nationalities, different residence, different age groups and the relationship with HP infection. Results There was no statistical significance on the differences in serum PGⅠ, PGⅡ, PGR and HP between different genders and among age groups and ethnic groups(P>0.05). The serum PGⅠ level was significantly higher than that in the rural areas, while the PGⅡ level in towns were significantly lower than that in the rural areas; the serum PGⅠ and PGⅡ levels were significantly higher in the HP-positive group than that in the HP-negative group, with the differences statistically significant(P<0.05). Conclusion The serum pepsinogen level in middle-aged and elderly people in Lingwu area is related to residence place and has a certain correlation with HP infection.
Objective To analyze the distribution of serum pepsinogen(PG) in middle-aged and elderly people in Lingwu area of Ningxia, and to study its correlation with Helicobacter pylori(HP) infection. Methods A total of 1 310 cases were randomly selected from the population aged 45 years old and above in Lingwu area from 2017 to 2018, and the subjects were analyzed retrospectively through questionnaires and physical examination data. The venous blood was collected on an empty stomach for "four stomach functions" test and the differences of pepsinogen in different sex, different nationalities, different residence, different age groups and the relationship with HP infection. Results There was no statistical significance on the differences in serum PGⅠ, PGⅡ, PGR and HP between different genders and among age groups and ethnic groups(P>0.05). The serum PGⅠ level was significantly higher than that in the rural areas, while the PGⅡ level in towns were significantly lower than that in the rural areas; the serum PGⅠ and PGⅡ levels were significantly higher in the HP-positive group than that in the HP-negative group, with the differences statistically significant(P<0.05). Conclusion The serum pepsinogen level in middle-aged and elderly people in Lingwu area is related to residence place and has a certain correlation with HP infection.
引文
[1] 褚美芬,叶爱青,吴怡春.血清胃蛋白酶原及幽门螺杆菌抗体在胃癌早期诊断中的意义[J].中国卫生检验杂志,2015,25(23):4063-4065.
[2] Senile K,Ozkan MB,Vural S,et al.The role of inflammation ingastric cancer[J].Adv Exp Med Biol,2014,816(2):235-257.
[3] 陶丽媛,冀子中,王玲珑,等.幽门螺杆菌感染对血清胃蛋白酶原诊断价值的影响[J].胃肠病学,2017,22(12):728-732.
[4] 叶火林.血清胃蛋白酶原与幽门螺杆菌免疫球蛋白 G抗体检测在胃癌及癌前病变筛查中的应用观察[J].中国医学工程,2016,24(9):19-21.
[5] 周月红,刘雄昌,吴德明,等.血清胃蛋白酶原和幽门螺旋杆菌Ig G抗体在胃癌患者中的表达及其意义[J].内科,2017,12(1):20-24.
[6] 裴正兵,俞继凤.“融入工作场景的 PBL 教学模式”在酒店管理本科教学的探讨[J].沈阳大学学报:社会科学版,2016,18(2):190-193.
[7] 朱琦,俞文,薛莱提·艾孜木,等.新疆维吾尔族、汉族胃癌血清胃蛋白酶原、胃泌素-17水平及其与幽门螺杆菌感染相关性的临床研究[J].肠病学,2016,21(6):348-352.
[8] 吴杰,骆骥才,张剑英,等.蛋白酶原在胃癌患者血清中变化的意义及其与幽门螺杆菌感染的相关性[J].中华全科医学,2017,15(6):1010-1012.
[9] 杜娟,席妍,郑珂,等.多种血清标志物联合检测在诊断老年胃癌患者中的意义[J].中国医药导报,2015,12(20):16-19.
[10] 黄钱珍.血清胃蛋白酶原及幽门螺杆菌抗体在胃癌早期诊断中的意义临床分析[J].系统医学,2017,2(1):92-96.
[11] 江唯波,陈淼,虞信维.血清胃蛋白酶原、CEA、CA199、CA724与胃泌素17联合检测在胃癌早期诊断中的应用价值分析[J].中国中西医结合消化杂志,2017,25(11):833-837.
[12] 钟华,吴雪艳,刘迪群.血清胃蛋白酶原Ⅰ、Ⅱ及比值联合 Hp抗体检测对早期胃癌的诊断价值[J].重庆医学,2017,46(6):821-823.
[13] 孙怡,康毅,刘天宇,等.胃蛋白酶原Ⅰ、Ⅱ水平与幽门螺杆菌感染相关性胃病的关系[J].医学综述,2016,22(12):2431-2437.
[14] 张曙云,陈渠通,葛晴川,等.幽门螺杆菌感染程度与胃蛋白酶原和胃癌相关肿瘤标志物的关系[J].国际检验医学杂志,2016,37(23):3299-3302.
[15] 周俊伟.幽门螺杆菌感染与胃癌的相关性[J].中华医院感染学杂志,2012,22(21):4799-4800.
[16] 李小萍,王俊先,王爱平,等.胃蛋白酶原水平与胃癌及胃溃疡的相关性分析[J].泰山医学院学报,2017,38(10):1117-1119.
[2] Senile K,Ozkan MB,Vural S,et al.The role of inflammation ingastric cancer[J].Adv Exp Med Biol,2014,816(2):235-257.
[3] 陶丽媛,冀子中,王玲珑,等.幽门螺杆菌感染对血清胃蛋白酶原诊断价值的影响[J].胃肠病学,2017,22(12):728-732.
[4] 叶火林.血清胃蛋白酶原与幽门螺杆菌免疫球蛋白 G抗体检测在胃癌及癌前病变筛查中的应用观察[J].中国医学工程,2016,24(9):19-21.
[5] 周月红,刘雄昌,吴德明,等.血清胃蛋白酶原和幽门螺旋杆菌Ig G抗体在胃癌患者中的表达及其意义[J].内科,2017,12(1):20-24.
[6] 裴正兵,俞继凤.“融入工作场景的 PBL 教学模式”在酒店管理本科教学的探讨[J].沈阳大学学报:社会科学版,2016,18(2):190-193.
[7] 朱琦,俞文,薛莱提·艾孜木,等.新疆维吾尔族、汉族胃癌血清胃蛋白酶原、胃泌素-17水平及其与幽门螺杆菌感染相关性的临床研究[J].肠病学,2016,21(6):348-352.
[8] 吴杰,骆骥才,张剑英,等.蛋白酶原在胃癌患者血清中变化的意义及其与幽门螺杆菌感染的相关性[J].中华全科医学,2017,15(6):1010-1012.
[9] 杜娟,席妍,郑珂,等.多种血清标志物联合检测在诊断老年胃癌患者中的意义[J].中国医药导报,2015,12(20):16-19.
[10] 黄钱珍.血清胃蛋白酶原及幽门螺杆菌抗体在胃癌早期诊断中的意义临床分析[J].系统医学,2017,2(1):92-96.
[11] 江唯波,陈淼,虞信维.血清胃蛋白酶原、CEA、CA199、CA724与胃泌素17联合检测在胃癌早期诊断中的应用价值分析[J].中国中西医结合消化杂志,2017,25(11):833-837.
[12] 钟华,吴雪艳,刘迪群.血清胃蛋白酶原Ⅰ、Ⅱ及比值联合 Hp抗体检测对早期胃癌的诊断价值[J].重庆医学,2017,46(6):821-823.
[13] 孙怡,康毅,刘天宇,等.胃蛋白酶原Ⅰ、Ⅱ水平与幽门螺杆菌感染相关性胃病的关系[J].医学综述,2016,22(12):2431-2437.
[14] 张曙云,陈渠通,葛晴川,等.幽门螺杆菌感染程度与胃蛋白酶原和胃癌相关肿瘤标志物的关系[J].国际检验医学杂志,2016,37(23):3299-3302.
[15] 周俊伟.幽门螺杆菌感染与胃癌的相关性[J].中华医院感染学杂志,2012,22(21):4799-4800.
[16] 李小萍,王俊先,王爱平,等.胃蛋白酶原水平与胃癌及胃溃疡的相关性分析[J].泰山医学院学报,2017,38(10):1117-1119.