栀子豉汤配伍规律研究

详细信息    查看全文 | 推荐本文 |

英文篇名：Study on the compatibilty rules of Zhizichi decoction 作者：李函阳 ; 曹文正 ; 高红梅 英文作者：LI Hanyang;CAO Wenzheng;GAO Hongmei;Changchun University of Chinese Medicine; 关键词：栀子豉汤 ; 配伍规律 ; 栀子苷 ; 总环烯醚萜苷 ; 含量测定 英文关键词：Zhizichi decoction;;compatibility rules;;geniposide;;total iridoid glycosides;;determination of content 中文刊名：CZXX 英文刊名：Journal of Changchun University of Chinese Medicine 机构：长春中医药大学; 出版日期：2018-10-10 出版单位：长春中医药大学学报 年：2018 期：v.34 基金：吉林省中医药科技项目“栀子豉汤配伍规律初探”(2018DZ08) 语种：中文; 页：CZXX201805021 页数：4 CN：05 ISSN：22-1375/R 分类号：77-79+108

摘要

目的测定不同配伍比例栀子豉汤中栀子苷、总环烯醚萜苷含量,考察不同比例配伍对栀子豉汤有效成分含量的影响。方法采用传统煎煮法制备不同配伍比例栀子豉汤;采用高效液相色谱法测定栀子苷含量、紫外分光光度法测定总环烯醚萜苷含量。结果栀子:淡豆豉(1:4)中栀子苷、总环烯醚萜苷含量最高。结论本研究进一步证明了栀子豉汤配伍比例的科学性,不同配伍比例的栀子豉汤中有效成分转移率有差别。
        Objective To determine the content of geniposide and total iridoid glycosides of Zhizichi decoction in different ratio of dosage, and to investigate the effect of different composition on the content of effective ingredients of Zhizichi decoction. Methods Using traditional boiling method to prepare different compositions of Zhizichidecoction; to determine geniposide and total iridoid glycosides by high performance liquid chromatography and UV Spectrophotometry. Results The content of geniposide and total iridoid glycosides in Gardenia jasminoides fruit: Fermented Soybean(1:4) is the highest. Conclusion Further proves the scientifi city of Zhizichi decoction in ratio of dosage, there is difference of the transfer rates of geniposide and total iridoid glycosides in different composition of Zhizichi decoction.

引文

[1]石景洋,张彦丽,张霄,等.栀子豉汤治疗抑郁证患者44例疗效观察[J].中国实验方剂学杂志,2012,18(18):316-318.
    [2]龙志敏.栀子豉汤体内外化学成分与药代动力学研究[D].沈阳:沈阳药科大学,2012.
    [3]张超云,谢东霞,毛秉豫,等.栀子豉汤治疗抑郁症有效部位的筛选研究[J].中华中医药学刊,2011,29(11):2493-2494.
    [4]CAI L,LI R,MENG G.Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis[J].European Neuropsychopharmacology,2015,25(8):1332-1341.
    [5]游伟良,平其能,孙敏捷,等.栀子苷的药理学研究新进展[J].药学进展,2012,36(4):158-162.
    [6]WANG,X.F.,ZHAO,X.,LONG,Z.M.Simultaneous quantification of sixteen bioactive constituents in Zhi-zichi decoction:Application to the optimization of Zhi-zi-chi decoction in ratio of dosage[J].Analytical Methods,2014,6(6):1868-1874.
    [7]韩燕.栀子豉汤的药效物质基础研究[D].福建:福建中医药大学,2015.
    [8]王虹玉,喇孝瑾,白素芬,等.正交试验法优选栀子豉汤的水提工艺[J].中国实验方剂学杂志,2012,18(22):36-38.
    [9]陈芳,董志,傅亚.栀子总环烯醚萜苷纯化工艺研究[J].激光杂志,2010,31(2):95-96.
    [10]吴亚超,赵万顺,张文生,等.栀子中栀子苷和绿原酸的提取工艺研究[J].天然产物研究与开发,2016,28(6):910-915.
    [11]林志坚.栀子苷提取工艺的优化[J].轻工科技,2014,30(5):32,61.
    [12]吴红娟,王清波,谭朝阳,等.不同来源栀子中栀子苷含量测定[J].湖南中医药大学学报,2010,30(5):35-37.
    [13]段启,庄义修,陈华师.HPLC法测定不同产地栀子中栀子苷含量[J].亚太传统医药,2009,5(6):20-21.
    [14]杨海玲,覃葆,宋永龙,等.不同炮制方法对栀子中栀子苷含量的影响[J].安徽农业科学,2011,39(32):19755-19757.
    [15]周婷婷,闻俊,佟典承,等.栀子总环烯醚萜苷含量的紫外分光光度法测定[J].时珍国医国药,2011,22(2):273-275.
    [16]王赟,李朝晖,华春.中药栀子总环烯醚萜苷的含量测定[J].安徽农业科学,2011,39(21):12859-12860.
    [17]蔡财军,张忠立,左月明,等.栀子环烯醚萜类化学成分研究[J].时珍国医国药,2013,24(2):342-343.
    [18]裴彩云,蔡艳,宋剑,等.10批栀子中环烯醚萜苷类成分含量测定[J].中国现代应用药学,2011,28(S1):1343-1345.
    [19]颜文强.历代中药度量衡演变考论[J].老子学刊,2016(1):137-144.
    [20]刘敏,郭明章,李宇航,等.仲景方中豆豉用药剂量研究[J].辽宁中医杂志,2010,37(11):2218-2219.
    [21]郭明章.仲景方用药剂量古今折算及配伍比例的研究[D].北京:北京中医药大学,2009.
    [22]翁恒,陈亦工.仲景方用药剂量古今折算与临床应用[J].南京中医药大学学报(社会科学版),2014,15(3):161-164.
    [23]孙燕,郭明章,李宇航.仲景方中以容量为计量单位的药物剂量折算研究[J].吉林中医药,2010,30(4):362-364.