Fe_3O_4/SiO_2复合磁性粒子的制备及其药物缓释行为
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摘要
目的:采用共沉淀法和溶剂热法制备Fe_3O_4纳米磁性粒子,对其药物控释性能进行检测。方法:以正硅酸乙酯(TEOS)为前驱体,采用Stober法,在乙醇/水溶液中,通过氨水催化水解硅醇盐,制得核壳式结构的Fe_3O_4/SiO_2复合磁性微球;以X射线衍射(XRD)、扫描电子显微镜(SEM)、Fourier红外光谱(FTIR)等手段表征样品的结构,研究复合材料的耐酸性、磁分离行为及对药物布洛芬的缓释行为。结果:SEM显示Fe_3O_4与Fe_3O_4/SiO_2粒子均为纳米颗粒,粒径分布基本均匀;与溶剂热法比较,共沉淀法制得的Fe_3O_4晶粒结晶度较好,XRD衍射峰强,SiO_2的包裹使得Fe_3O_4尖锐的特征衍射峰稍微下降,表明包覆过程没有破坏其晶体结构,Fe_3O_4/SiO_2样品谱图中出现了无定型SiO_2的衍射峰,红外谱图同样出现了无定型SiO_2的透射峰。结论:表面二氧化硅的包覆显著改善了四氧化三铁纳米粒子的耐酸性,磁分离实验表明二氧化硅的包裹减弱了Fe_3O_4的磁性,布洛芬缓释实验表明Fe_3O_4/SiO_2复合磁性微球具有较好的药物缓释效果。
Objective: Magnetic nanoparticles were synthesized via the coprcciptation and the solvothermal-method,and the control releasing for drug was investigaed. Method: Using tetraethyl orthosilicate( TEOS) as a precursor,the Fe_3O_4/SiO_2 composite microspheres were sunthesjzed via hydrolysis of silicon alkoxides catalyzed by ammonia in ethanol/water solution through a modified Stber method. The structure of the samples were investigated by X – ray diffraction( XRD),scanning electron microscopy( SEM),and Fourier transform infrared spectroscopy( FT-IR). Ibuprofen was chosen as a model drug to investigate the drug delivery behavior of magnetic composite. Result: The SEM revealed the size range of magnetic nanoparticles. In comparision with solvothermal mothod,the degree of crystallineity of coprccipitation method products Fe_3O_4 is higher,and the diffraction peak is stronger. The sharp diffraction peak of Fe_3O_4/SiO_2 indicated that the coating didn't destroy the structure of crystal. Sample Fe_3O_4/SiO_2 appeared amorphorous peak for SiO_2 in XRD and Fourier transform infrared spectrosco-py. Conclusion: The ability of acid resistance of Fe_3O_4 is enhanced with coating of SiO_2,but the magnetic performanc for Fe_3O_4 is reduced. The control releasing experiment of ibuprofen showed that the Fe_3O_4/SiO_2 has a significant effect on adsorption and releasing for drug.
Objective: Magnetic nanoparticles were synthesized via the coprcciptation and the solvothermal-method,and the control releasing for drug was investigaed. Method: Using tetraethyl orthosilicate( TEOS) as a precursor,the Fe_3O_4/SiO_2 composite microspheres were sunthesjzed via hydrolysis of silicon alkoxides catalyzed by ammonia in ethanol/water solution through a modified Stber method. The structure of the samples were investigated by X – ray diffraction( XRD),scanning electron microscopy( SEM),and Fourier transform infrared spectroscopy( FT-IR). Ibuprofen was chosen as a model drug to investigate the drug delivery behavior of magnetic composite. Result: The SEM revealed the size range of magnetic nanoparticles. In comparision with solvothermal mothod,the degree of crystallineity of coprccipitation method products Fe_3O_4 is higher,and the diffraction peak is stronger. The sharp diffraction peak of Fe_3O_4/SiO_2 indicated that the coating didn't destroy the structure of crystal. Sample Fe_3O_4/SiO_2 appeared amorphorous peak for SiO_2 in XRD and Fourier transform infrared spectrosco-py. Conclusion: The ability of acid resistance of Fe_3O_4 is enhanced with coating of SiO_2,but the magnetic performanc for Fe_3O_4 is reduced. The control releasing experiment of ibuprofen showed that the Fe_3O_4/SiO_2 has a significant effect on adsorption and releasing for drug.
引文
[1]Graepler F,Lauer U,Gregor M,et al.Magnetic cell sorting for parietal cell purification using a new monoclonal antibody without influence on cell function[J].J Biochem Biophys Meth,1998,36(2/3):143-155.
[2]Sieben S,Bergemann C,Lubbe A,et al.Comparison of different particles and methods for magnetic isolation of circulating tumor cells[J].J Magn Magn Mater,2001,225(1/2):175-179.
[3]Xuan S,Wang F,Lai J M,Sham K W,et al.Synthesis of biocompatible,mesoporous Fe3O4nano/microspheres with large surface area for magnetic resonance imaging and therapeutic applications[J].ACS Applied Materials&Interfaces,2011,3(2):237-244.
[4]张延琪.碳包覆磁性材料Fe3O4/C/Pd(O)的合成及其催化性能研究[J].安徽科技学院学报,2013,27(6):48-54.
[5]Tang Y,Liang S,Yu S,et al.Enhanced adsorption of humic acid on amine functionalized magnetic mesoporous composite microspheres[J].Colloids&Surfaces A Physicochemical&Engineering Aspects,2012,406(14):61-67.
[6]聂光庭,段泰炜,容建华,等.核壳型载药微球的制备及其释药性能研究[J].功能材料,2013,44(2):221-225.
[7]王士婷,陈文娟,王德平,等.Fe3O4@m-Si O2磁性纳米颗粒的制备及其药物缓释行为[J].硅酸盐学报,2013,41(3):281-287.
[8]丁志杰,郭雨,郭腾,等,介孔分子筛Ce-SBA-15催化合成乙酸正丁酯[J].安徽科技学院学报,2012,26(1):70-74.
[9]姚悦,汪徐春,陈俊明.镧掺杂介孔二氧化锰的制备及其电化学性能的研究[J].安徽科技学院学报,2015,29(4):51-56.
[10]陈成,贺玉成,杜治平,等.γ-Fe2O3/Si O2复合磁性纳米粒子制备与表征[J].磁性材料及器件,2014(45):21-24.
[11]辛铁军,张和鹏,马明亮,等.Fe3O4@Ti O2核壳磁性纳米材料的制备及表[J].功能材料,2014,45(1):1072-1077.
[12]熊珊,江向平,李菊梅,等.Fe3O4/Si O2核壳复合磁性微球的制备和表征[J].硅酸盐学报,2015,43(7):946-951.
[13]Wu P G,Zhu J H,Xu Z H.Template-assisted synthesis of mesoporous magnetic nanocomposite particles[J].Adv Funct Mater,2004,14(4):345–351.
[14]吴江渝,许谦,李竹,等.磁性二氧化硅纳米粒子的制备及性能[J].武汉工程大学学报,2014,36(7):43-47.
[2]Sieben S,Bergemann C,Lubbe A,et al.Comparison of different particles and methods for magnetic isolation of circulating tumor cells[J].J Magn Magn Mater,2001,225(1/2):175-179.
[3]Xuan S,Wang F,Lai J M,Sham K W,et al.Synthesis of biocompatible,mesoporous Fe3O4nano/microspheres with large surface area for magnetic resonance imaging and therapeutic applications[J].ACS Applied Materials&Interfaces,2011,3(2):237-244.
[4]张延琪.碳包覆磁性材料Fe3O4/C/Pd(O)的合成及其催化性能研究[J].安徽科技学院学报,2013,27(6):48-54.
[5]Tang Y,Liang S,Yu S,et al.Enhanced adsorption of humic acid on amine functionalized magnetic mesoporous composite microspheres[J].Colloids&Surfaces A Physicochemical&Engineering Aspects,2012,406(14):61-67.
[6]聂光庭,段泰炜,容建华,等.核壳型载药微球的制备及其释药性能研究[J].功能材料,2013,44(2):221-225.
[7]王士婷,陈文娟,王德平,等.Fe3O4@m-Si O2磁性纳米颗粒的制备及其药物缓释行为[J].硅酸盐学报,2013,41(3):281-287.
[8]丁志杰,郭雨,郭腾,等,介孔分子筛Ce-SBA-15催化合成乙酸正丁酯[J].安徽科技学院学报,2012,26(1):70-74.
[9]姚悦,汪徐春,陈俊明.镧掺杂介孔二氧化锰的制备及其电化学性能的研究[J].安徽科技学院学报,2015,29(4):51-56.
[10]陈成,贺玉成,杜治平,等.γ-Fe2O3/Si O2复合磁性纳米粒子制备与表征[J].磁性材料及器件,2014(45):21-24.
[11]辛铁军,张和鹏,马明亮,等.Fe3O4@Ti O2核壳磁性纳米材料的制备及表[J].功能材料,2014,45(1):1072-1077.
[12]熊珊,江向平,李菊梅,等.Fe3O4/Si O2核壳复合磁性微球的制备和表征[J].硅酸盐学报,2015,43(7):946-951.
[13]Wu P G,Zhu J H,Xu Z H.Template-assisted synthesis of mesoporous magnetic nanocomposite particles[J].Adv Funct Mater,2004,14(4):345–351.
[14]吴江渝,许谦,李竹,等.磁性二氧化硅纳米粒子的制备及性能[J].武汉工程大学学报,2014,36(7):43-47.
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