肝片吸虫病药物治疗的研究进展
|
摘要
肝片吸虫是一种人畜共患的食源性寄生虫,主要寄生于哺乳动物的胆道中。肝片吸虫病多为散发,人感染该病的主要原因是误食了含有囊蚴的生菜或生水,感染后可引起肝脏损害、出血及肝实质变性,胆管增生或阻塞,虫体还可分泌具有溶血作用的毒素,对人体危害很大。目前,人畜感染该病后仍依赖于药物治疗,其治疗可追溯到20世纪60年代,但可用药物少且疗效有限,且药物也大多来源于兽药的转化。由于目前人体用药种类有限,耐药问题不断突出,近年来国内外也一直在研究兽药的人体转化、新型药物和新型给药方式。本文通过回顾国内外文献,综述了近10余年国内外对肝片吸虫病的药物治疗,并对这些药物的作用机制、疗效及优缺点进行了简述。
Fasciola hepatica is a zoonotic food borne parasite. To mammals, it is mainly parasite in bile duct.The disease is mostly sporadic. The main reason of human infection is eating raw lettuce or water, which contains metacercaria.If people are infected with it, hepatic lesion, hepatorrhagia, liver parenchyma degeneration and bile duct hyperplasia or obstruction could be found. It also can produce toxins which havehemolytic function. So, it has great harm to humankind. At present, people and animals are still dependent on drug therapy after infection. Its treatment can be traced back to the 60 s of last century.However,there are few available drugs after human infected in our country, and the curative effect is limited. Many drugs for human also come from the veterinary drugs conversion. At present, due to the limitation of the drug types for human, and the problem of drug resistance continue to emerge. Therefore, human transformation of veterinary drugs, new drugs and routes of medication have been studied both at home and abroad. This article summarizes the drug therapy for the disease and describes briefly the mechanisms, effects, advantages and disadvantages in recent ten years, by reviewing the literatures bothat home and abroad.
Fasciola hepatica is a zoonotic food borne parasite. To mammals, it is mainly parasite in bile duct.The disease is mostly sporadic. The main reason of human infection is eating raw lettuce or water, which contains metacercaria.If people are infected with it, hepatic lesion, hepatorrhagia, liver parenchyma degeneration and bile duct hyperplasia or obstruction could be found. It also can produce toxins which havehemolytic function. So, it has great harm to humankind. At present, people and animals are still dependent on drug therapy after infection. Its treatment can be traced back to the 60 s of last century.However,there are few available drugs after human infected in our country, and the curative effect is limited. Many drugs for human also come from the veterinary drugs conversion. At present, due to the limitation of the drug types for human, and the problem of drug resistance continue to emerge. Therefore, human transformation of veterinary drugs, new drugs and routes of medication have been studied both at home and abroad. This article summarizes the drug therapy for the disease and describes briefly the mechanisms, effects, advantages and disadvantages in recent ten years, by reviewing the literatures bothat home and abroad.
引文
[1]范本伦.近十年囊尾蚴病化学治疗药物研究进展[J].兽医科技杂志,1982(12):43-46.
[2]JAKOBSEN E,LANGE S C,ANDERSEN J V,et al.The inhibitors of soluble adenylate cyclase 2-OHE,KH7,and bithionol compromise mitochondrial ATP production by distinct mechanisms[J].Biochemical Pharmacology,2018,155:92-101.
[3]虞炳庆.在埃及应用硫氯酚(别丁)治疗确诊的片吸虫病[J].国际医学寄生虫病杂志,1989(4):180-181.
[4]吉田幸雄.片吸虫属寄生人体一例及用硫双二氯酚治疗[J].日本寄生虫学杂志,1975,23(3):116.
[5]何茜,胡文君,李行舟.硝唑尼特药理作用及临床应用的研究进展[J].沈阳药科大学学报,2015,32(4):321-330.
[6]ABDELRAHMAN M S.Testing the parasiticidal efficacy of fental(Nitazoxanide)[J].Alex J Vet Sci,1997,13:447-458.
[7]SAH R,KHADKA S,KHADKA M,et al.Human fascioliasis by Fasciola hepatica:the first case report in Nepal[J].BMC Res Notes,2017,10(1):439.
[8]FAVENNEC L,JAVE ORTIZ J,GARGALA G,et al.Double-blind,randomized,placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from northern Peru[J].Aliment Pharmacol Ther,2003,17(2):265-270.
[9]ZUMAQUERO-RíOS J L,SARRACENT-PéREZ J,ROJAS-GARCíA R,et al.Fascioliasis and intestinal parasitoses affecting schoolchildren in Atlixco,Puebla State,Mexico:epidemiology and treatment with nitazoxanide[J].PLoS Negl Trop Dis,2013,7(11):e2553.
[10]钱科.吡喹酮抗血吸虫作用机制的研究进展[J].医学研究生学报,2013,26(9):979-983.
[11]KEISER J,ENGELS D,BüSCHER G,et al.Triclabendazole for the treatment of fascioliasis and paragonimiasis[J].Expert Opin Investig Drugs,2005,14(12):1513-1526.
[12]范东,李鹏,孙华,等.肝片吸虫感染所致肝脓肿的CT表现[J].中华放射学杂志,2006,40(2):191-194.
[13]黄仁刚,江南,杨兴祥,等.肝脏寄生虫感染48例临床分析[J].四川医学,2012,33(4):608-611.
[14]王斌,游潮,贺民,等.肝外肝片吸虫病1例及文献复习[J].华西医学,2007,22(1):56-57.
[15]黄正美,邢兰燕,范波,等.肝片吸虫病1例报告[J].中国热带医学,2006,6(9):1624.
[16]吴德智,马正,刘运锋,等.吡喹酮制剂的发展和应用[J].中国血吸虫病防治杂志,2013,25(2):194-196.
[17]ROSS F,HERNáNDEZ P,PORCAL W,et al.Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites[J].PLoS One,2012,7(4):e35033.
[18]李成应,焦伟丽,温锦芳.三氯苯达唑的国内外研究与应用现状[J].中国畜牧兽医文摘,2017,33(5):63-64.
[19]FLORES-RAMOS M,IBARRA-VELARDE F,JUNG-COOK H,et al.Novel triclabendazole prodrug:A highly water soluble alternative for the treatment of fasciolosis[J].Bioorg Med Chem Lett,2017,27(3):616-619.
[20]VILLEGAS F,ANGLES R,BARRIENTOS R,et al.Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano[J].PLoS Negl Trop Dis,2012,6(8):e1720.
[21]王艳波,魏如清,李六九,等.三氯苯达唑治疗肝片形吸虫病例报告[J].寄生虫病与感染性疾病,2015,13(2):110-111.
[22]ORTIZ P,SCARCELLA S,CERNA C,et al.Resistance of Fasciola hepatica against Triclabendazole in cattle in Cajamarca(Peru):a clinical trial and an in vivo efficacy test in sheep[J].Vet Parasitol,2013,195(1/2):118-121.
[23]CEBALLOS L,MORENO L,ALVAREZ L,et al.Unchanged triclabendazole kinetics after Co-administration with ivermectin and methimazole:failure of its therapeutic activity against triclabendazoleresistant liver flukes[J].BMC Veterinary Research,2010,6(1):8.
[24]BRENNAN G P,FAIRWEATHER I,TRUDGETT A,et al.Understanding triclabendazole resistance[J].Experimental and Molecular Pathology,2007,82(2):104-109.
[25]DEVINE C,BRENNAN G P,LANUSSE C E,et al.Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica[J].Parasitology,2011,138(2):224-236.
[26]孔繁瑶.家畜寄生虫学[M].北京:中国农业大学出版社,1981.
[27]张吉丽,司鸿飞,李冰,等.五氯柳胺的研究进展[J].中国兽药杂志,2015,49(11):65-69.
[28]ZIMMERMAN G L,WALLACE D H,SCHONS D J,et al.Efficacy of clorsulon against mature,naturally acquired Fasciola hepatica infections in cattle and sheep[J].Am J Vet Res,1986,47(8):1665-1667.
[29]靳家声.中国农业科学院兰州兽医研究所科学研究年报[C].1978,34-37.
[30]李伟.青海省部分地区藏羊肝片吸虫感染情况调查及药物驱虫试验[D].西宁:青海大学,2014.
[31]胡斌.新呋咱氮氧化物类NO供体药物合成及体外NO释放测试[D].石家庄:河北医科大学,2005.
[32]涂宏刚.喹喔啉类药物对哺乳动物细胞的遗传毒性研究[D].武汉:华中农业大学,2007.
[33]祝叶华.青蒿素研究进展[J].科技导报,2015,33(20):36-41.
[34]程思佳,符林春.青蒿素类药物治疗疟疾研究进展[J].中国热带医学,2018,18(7):670-681.
[35]茹炜炜,梁幼生.青蒿素类药物抗寄生虫作用研究进展[J].中国血吸虫病防治杂志,2006,18(1):78-80.
[36]李洪军,汪伟,梁幼生.双氢青蒿素抗寄生虫作用研究进展[J].中国血吸虫病防治杂志,2011,23(4):460-464.
[37]O′NEILL J F,JOHNSTON R C,HALFERTY L,et al.Disruption of spermatogenesis in the liver fluke,Fasciola hepatica by two artemisinin derivatives,artemether and artesunate[J].J Helminthol,2017,91(1):55-71.
[38]KEISER J,VENEZIANO V,RINALDI L,et al.Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep[J].Res Vet Sci,2010,88(1):107-110.
[39]张燕萍,黄轶昕,洪青标,等.青蒿琥酯与吡喹酮联合应用早期治疗兔血吸虫病的实验观察[J].中国血吸虫病防治杂志,2003,15(3):192-194.
[40]汪少荣,吴雄飞,张志海,等.青蒿琥酯与吡喹酮联合应用治疗急性血吸虫病38例[J].中国血吸虫病防治杂志,2007,19(2):135.
[41]刘佳璐.苦瓜皂甙的提取纯化及功能性研究[D].太原:山西大学,2011.
[42]李健,张令文,闫恩志,等.苦瓜皂甙的研究进展[J].食品研究与开发,2005,26(3):21-24.
[43]张琳.黄酮类化合物与DNA及其组成碱基的相互作用研究[D].杭州:浙江大学,2005.
[44]PEREIRA C A J,OLIVEIRA L L S,COAGLIO A L,et al.Anti-helminthic activity of Momordica charantia L.against Fasciola hepatica eggs after twelve days of incubation in vitro[J].Vet Parasitol,2016,228:160-166.
[45]张杰,常义生,曾铖,等.生姜提取物中化学成分研究[J].安徽农业科学,2015,(25):287-288,290.
[46]MOAZENI M,KHADEMOLHOSEINI A A.Ovicidal effect of the methanolic extract of ginger(Zingiber officinale)on Fasciola hepatica eggs:an in vitro study[J].J Parasit Dis,2016,40(3):662-666.
[2]JAKOBSEN E,LANGE S C,ANDERSEN J V,et al.The inhibitors of soluble adenylate cyclase 2-OHE,KH7,and bithionol compromise mitochondrial ATP production by distinct mechanisms[J].Biochemical Pharmacology,2018,155:92-101.
[3]虞炳庆.在埃及应用硫氯酚(别丁)治疗确诊的片吸虫病[J].国际医学寄生虫病杂志,1989(4):180-181.
[4]吉田幸雄.片吸虫属寄生人体一例及用硫双二氯酚治疗[J].日本寄生虫学杂志,1975,23(3):116.
[5]何茜,胡文君,李行舟.硝唑尼特药理作用及临床应用的研究进展[J].沈阳药科大学学报,2015,32(4):321-330.
[6]ABDELRAHMAN M S.Testing the parasiticidal efficacy of fental(Nitazoxanide)[J].Alex J Vet Sci,1997,13:447-458.
[7]SAH R,KHADKA S,KHADKA M,et al.Human fascioliasis by Fasciola hepatica:the first case report in Nepal[J].BMC Res Notes,2017,10(1):439.
[8]FAVENNEC L,JAVE ORTIZ J,GARGALA G,et al.Double-blind,randomized,placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from northern Peru[J].Aliment Pharmacol Ther,2003,17(2):265-270.
[9]ZUMAQUERO-RíOS J L,SARRACENT-PéREZ J,ROJAS-GARCíA R,et al.Fascioliasis and intestinal parasitoses affecting schoolchildren in Atlixco,Puebla State,Mexico:epidemiology and treatment with nitazoxanide[J].PLoS Negl Trop Dis,2013,7(11):e2553.
[10]钱科.吡喹酮抗血吸虫作用机制的研究进展[J].医学研究生学报,2013,26(9):979-983.
[11]KEISER J,ENGELS D,BüSCHER G,et al.Triclabendazole for the treatment of fascioliasis and paragonimiasis[J].Expert Opin Investig Drugs,2005,14(12):1513-1526.
[12]范东,李鹏,孙华,等.肝片吸虫感染所致肝脓肿的CT表现[J].中华放射学杂志,2006,40(2):191-194.
[13]黄仁刚,江南,杨兴祥,等.肝脏寄生虫感染48例临床分析[J].四川医学,2012,33(4):608-611.
[14]王斌,游潮,贺民,等.肝外肝片吸虫病1例及文献复习[J].华西医学,2007,22(1):56-57.
[15]黄正美,邢兰燕,范波,等.肝片吸虫病1例报告[J].中国热带医学,2006,6(9):1624.
[16]吴德智,马正,刘运锋,等.吡喹酮制剂的发展和应用[J].中国血吸虫病防治杂志,2013,25(2):194-196.
[17]ROSS F,HERNáNDEZ P,PORCAL W,et al.Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites[J].PLoS One,2012,7(4):e35033.
[18]李成应,焦伟丽,温锦芳.三氯苯达唑的国内外研究与应用现状[J].中国畜牧兽医文摘,2017,33(5):63-64.
[19]FLORES-RAMOS M,IBARRA-VELARDE F,JUNG-COOK H,et al.Novel triclabendazole prodrug:A highly water soluble alternative for the treatment of fasciolosis[J].Bioorg Med Chem Lett,2017,27(3):616-619.
[20]VILLEGAS F,ANGLES R,BARRIENTOS R,et al.Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano[J].PLoS Negl Trop Dis,2012,6(8):e1720.
[21]王艳波,魏如清,李六九,等.三氯苯达唑治疗肝片形吸虫病例报告[J].寄生虫病与感染性疾病,2015,13(2):110-111.
[22]ORTIZ P,SCARCELLA S,CERNA C,et al.Resistance of Fasciola hepatica against Triclabendazole in cattle in Cajamarca(Peru):a clinical trial and an in vivo efficacy test in sheep[J].Vet Parasitol,2013,195(1/2):118-121.
[23]CEBALLOS L,MORENO L,ALVAREZ L,et al.Unchanged triclabendazole kinetics after Co-administration with ivermectin and methimazole:failure of its therapeutic activity against triclabendazoleresistant liver flukes[J].BMC Veterinary Research,2010,6(1):8.
[24]BRENNAN G P,FAIRWEATHER I,TRUDGETT A,et al.Understanding triclabendazole resistance[J].Experimental and Molecular Pathology,2007,82(2):104-109.
[25]DEVINE C,BRENNAN G P,LANUSSE C E,et al.Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica[J].Parasitology,2011,138(2):224-236.
[26]孔繁瑶.家畜寄生虫学[M].北京:中国农业大学出版社,1981.
[27]张吉丽,司鸿飞,李冰,等.五氯柳胺的研究进展[J].中国兽药杂志,2015,49(11):65-69.
[28]ZIMMERMAN G L,WALLACE D H,SCHONS D J,et al.Efficacy of clorsulon against mature,naturally acquired Fasciola hepatica infections in cattle and sheep[J].Am J Vet Res,1986,47(8):1665-1667.
[29]靳家声.中国农业科学院兰州兽医研究所科学研究年报[C].1978,34-37.
[30]李伟.青海省部分地区藏羊肝片吸虫感染情况调查及药物驱虫试验[D].西宁:青海大学,2014.
[31]胡斌.新呋咱氮氧化物类NO供体药物合成及体外NO释放测试[D].石家庄:河北医科大学,2005.
[32]涂宏刚.喹喔啉类药物对哺乳动物细胞的遗传毒性研究[D].武汉:华中农业大学,2007.
[33]祝叶华.青蒿素研究进展[J].科技导报,2015,33(20):36-41.
[34]程思佳,符林春.青蒿素类药物治疗疟疾研究进展[J].中国热带医学,2018,18(7):670-681.
[35]茹炜炜,梁幼生.青蒿素类药物抗寄生虫作用研究进展[J].中国血吸虫病防治杂志,2006,18(1):78-80.
[36]李洪军,汪伟,梁幼生.双氢青蒿素抗寄生虫作用研究进展[J].中国血吸虫病防治杂志,2011,23(4):460-464.
[37]O′NEILL J F,JOHNSTON R C,HALFERTY L,et al.Disruption of spermatogenesis in the liver fluke,Fasciola hepatica by two artemisinin derivatives,artemether and artesunate[J].J Helminthol,2017,91(1):55-71.
[38]KEISER J,VENEZIANO V,RINALDI L,et al.Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep[J].Res Vet Sci,2010,88(1):107-110.
[39]张燕萍,黄轶昕,洪青标,等.青蒿琥酯与吡喹酮联合应用早期治疗兔血吸虫病的实验观察[J].中国血吸虫病防治杂志,2003,15(3):192-194.
[40]汪少荣,吴雄飞,张志海,等.青蒿琥酯与吡喹酮联合应用治疗急性血吸虫病38例[J].中国血吸虫病防治杂志,2007,19(2):135.
[41]刘佳璐.苦瓜皂甙的提取纯化及功能性研究[D].太原:山西大学,2011.
[42]李健,张令文,闫恩志,等.苦瓜皂甙的研究进展[J].食品研究与开发,2005,26(3):21-24.
[43]张琳.黄酮类化合物与DNA及其组成碱基的相互作用研究[D].杭州:浙江大学,2005.
[44]PEREIRA C A J,OLIVEIRA L L S,COAGLIO A L,et al.Anti-helminthic activity of Momordica charantia L.against Fasciola hepatica eggs after twelve days of incubation in vitro[J].Vet Parasitol,2016,228:160-166.
[45]张杰,常义生,曾铖,等.生姜提取物中化学成分研究[J].安徽农业科学,2015,(25):287-288,290.
[46]MOAZENI M,KHADEMOLHOSEINI A A.Ovicidal effect of the methanolic extract of ginger(Zingiber officinale)on Fasciola hepatica eggs:an in vitro study[J].J Parasit Dis,2016,40(3):662-666.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |