涎腺腺样囊性癌伴肺转移的治疗方案及预后
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摘要
涎腺腺样囊性癌(SACC)是口腔颌面部常见的恶性肿瘤之一,约占头颈部恶性肿瘤的3%～5%,最常发生于腭部小唾液腺及腮腺。该肿瘤浸润性强,呈现嗜神经侵袭、高血行性转移、低淋巴结转移等生物学特性,这些特性决定了其临床治疗的特殊性。SACC伴肺转移的系统性研究报道较为罕见,远期疗效不佳,治疗方案尚未达成共识。本综述的目的是回顾并总结SACC伴肺转移的治疗方案及预后,为其临床治疗提供依据。
Salivary adenoid cystic carcinoma(SACC) is a common malignant tumor in the oral and maxillofacial region and accounts for approximately 3%–5% of all head and neck carcinomas. SACC always occurs in the palatal salivary gland and parotid gland. The tumor has the characteristics of strong invasion, perineural invasion, high hematogenous metastasis,and low lymph node metastasis rate. The biological characteristics of SACC determine the specificity of clinical treatment.Thus far, few clinical trials have investigated the efficacy of systemic therapy owing to the rarity of SACC with lung metastasis.Moreover, long-term results are poor, and no consensus on standard treatment has been reached yet. This systematic review aims to provide a retrospective analysis of treatment options and prognosis for SACC with lung metastasis and evidence for future clinical treatment.
Salivary adenoid cystic carcinoma(SACC) is a common malignant tumor in the oral and maxillofacial region and accounts for approximately 3%–5% of all head and neck carcinomas. SACC always occurs in the palatal salivary gland and parotid gland. The tumor has the characteristics of strong invasion, perineural invasion, high hematogenous metastasis,and low lymph node metastasis rate. The biological characteristics of SACC determine the specificity of clinical treatment.Thus far, few clinical trials have investigated the efficacy of systemic therapy owing to the rarity of SACC with lung metastasis.Moreover, long-term results are poor, and no consensus on standard treatment has been reached yet. This systematic review aims to provide a retrospective analysis of treatment options and prognosis for SACC with lung metastasis and evidence for future clinical treatment.
引文
[1]Terhaard CH, Lubsen H, Van der Tweel I, et al. Salivary gland carcinoma:independent prognostic factors for locoregional control, distant metastases, and overall survival:results of the Dutch head and neck oncology cooperative group[J].Head Neck, 2004, 26(8):681-693.
[2]van der Wal JE, Becking AG, Snow GB, et al. Distant metastases of adenoid cystic carcinoma of the salivary glands and the value of diagnostic examinations during follow-up[J].Head Neck, 2002, 24(8):779-783.
[3]Dodd RL, Slevin NJ. Salivary gland adenoid cystic carcinoma:a review of chemotherapy and molecular therapies[J]. Oral Oncol, 2006, 42(8):759-769.
[4]Spiro RH. Salivary neoplasms:overview of a 35-year experience with 2 807 patients[J]. Head Neck Surg, 1986, 8(3):177-184.
[5]Gao M, Hao Y, Huang MX, et al. Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma[J]. Int J Oral Maxillofac Surg, 2013, 42(8):923-928.
[6]Matsuba HM, Spector GJ, Thawley SE, et al. Adenoid cystic salivary gland carcinoma. A histopathologic review of treatment failure patterns[J]. Cancer, 1986, 57(3):519-524.
[7]Hamper K, Lazar F, Dietel M, et al. Prognostic factors for adenoid cystic carcinoma of the head and neck:a retrospective evaluation of 96 cases[J]. J Oral Pathol Med, 1990, 19(3):101-107.
[8]da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, et al. Prognostic factors in head and neck adenoid cystic carcinoma[J]. Oral Oncol, 2006, 42(2):139-146.
[9]Bianchi B, Copelli C, Cocchi R, et al. Adenoid cystic carcinoma of intraoral minor salivary glands[J]. Oral Oncol, 2008,44(11):1026-1031.
[10]Bhayani MK, Yener M, El-Naggar A, et al. Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands[J]. Cancer, 2012, 118(11):2872-2878.
[11]Kim KH, Sung MW, Chung PS, et al. Adenoid cystic carcinoma of the head and neck[J]. Arch Otolaryngol Head Neck Surg, 1994, 120(7):721-726.
[12]Huang M, Ma D, Sun K, et al. Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands[J].Int J Oral Maxillofac Surg, 1997, 26(6):435-439.
[13]Min R, Siyi L, Wenjun Y, et al. Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis:a preliminary study of 62 cases[J]. Int J Oral Maxillofac Surg, 2012,41(8):952-957.
[14]Umeda M, Nishimatsu N, Masago H, et al. Tumor-doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1999, 88(4):473-478.
[15]王佳峰,谭卓,邵岚,等.涎腺腺样囊性癌远处转移规律及其影响因素分析[J].肿瘤学杂志, 2017, 23(4):290-294.Wang JF, Tan Z, Shao L, et al. Analysis of distant metastasis of adenoid cystic carcinoma of the salivary gland and its influencing factors[J]. J Chin Oncolog, 2017, 23(4):290-294.
[16]Spiro RH. Distant metastasis in adenoid cystic carcinoma of salivary origin[J]. Am J Surg, 1997, 174(5):495-498.
[17]Sung MW, Kim KH, Kim JW, et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck[J]. Arch Otolaryngol Head Neck Surg, 2003, 129(11):1193-1197.
[18]Cohen AN, Damrose EJ, Huang RY, et al. Adenoid cystic carcinoma of the submandibular gland:a 35-year review[J].Otolaryngol Head Neck Surg, 2004, 131(6):994-1000.
[19]Todd TR. The surgical treatment of pulmonary metastases[J]. Chest, 1997, 112(4 Suppl):287S-290S.
[20]Rusch VW. Pulmonary metastasectomy. Current indications[J]. Chest, 1995, 107(6 Suppl):322S-331S.
[21]Perzin KH, Gullane P, Clairmont AC. Adenoid cystic carcinomas arising in salivary glands:a correlation of histologic features and clinical course[J]. Cancer, 1978, 42(1):265-282.
[22]Goldblatt LI, Ellis GL. Salivary gland tumors of the tongue.Analysis of 55 new cases and review of the literature[J].Cancer, 1987, 60(1):74-81.
[23]Eneroth CM, Hjertman L. Adenoid cystic carcinoma of the submandibular gland[J]. Laryngoscope, 1966, 76(10):1639-1661.
[24]Lee SY, Kim BH, Choi EC. Nineteen-year oncologic outcomes and the benefit of elective neck dissection in salivary gland adenoid cystic carcinoma[J]. Head Neck, 2014, 36(12):1796-1801.
[25]Spiro RH, Huvos AG, Strong EW. Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases[J].Am J Surg, 1974, 128(4):512-520.
[26]Osborn DA. Morphology and the natural history of cribriform adenocarcinoma(adenoid cystic carcinoma)[J]. J Clin Pathol, 1977, 30(3):195-205.
[27]Ju J, Li Y, Chai J, et al. The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis:a systematic review and meta-analysis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016, 122(6):691-701.
[28]Vrielinck LJ, Ostyn F, van Damme B, et al. The significance of perineural spread in adenoid cystic carcinoma of the major and minor salivary glands[J]. Int J Oral Maxillofac Surg,1988, 17(3):190-193.
[29]Kokemueller H, Eckardt A, Brachvogel P, et al. Adenoid cystic carcinoma of the head and neck—a 20 years experience[J]. Int J Oral Maxillofac Surg, 2004, 33(1):25-31.
[30]Amit MR, Binenbaum Y, Trejo-Leider L, et al. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck[J]. Head Neck, 2015, 37(7):1038-1045.
[31]Spiro RH, Huvos AG. Stage means more than grade in adenoid cystic carcinoma[J]. Am J Surg, 1992, 164(6):623-628.
[32]Sur RK, Donde B, Levin V, et al. Adenoid cystic carcinoma of the salivary glands:a review of 10 years[J]. Laryngoscope,1997, 107(9):1276-1280.
[33]Conley J, Dingman DL. Adenoid cystic carcinoma in the head and neck(cylindroma)[J]. Arch Otolaryngol, 1974,100(2):81-90.
[34]Girard P, Baldeyrou P, Le Chevalier T, et al. Surgery for pulmonary metastases. Who are the 10-year survivors[J].Cancer, 1994, 74(10):2791-2797.
[35]Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy:prognostic analyses based on 5 206cases[J]. J Thorac Cardiovasc Surg, 1997, 113(1):37-49.
[36]Liu D, Labow DM, Dang N, et al. Pulmonary metastasectomy for head and neck cancers[J]. Ann Surg Oncol, 1999,6(6):572-578.
[37]Girelli L, Locati L, Galeone C, et al. Lung metastasectomy in adenoid cystic cancer:is it worth it[J]. Oral Oncol, 2017,65:114-118.
[38]Winter H, Meimarakis G, Hoffmann G, et al. Does surgical resection of pulmonary metastases of head and neck cancer improve survival[J]. Ann Surg Oncol, 2008, 15(10):2915-2926.
[39]Locati LD, Guzzo M, Bossi P, et al. Lung metastasectomy in adenoid cystic carcinoma(ACC)of salivary gland[J]. Oral Oncol, 2005, 41(9):890-894.
[40]Bobbio A, Copelli C, Ampollini L, et al. Lung metastasis resection of adenoid cystic carcinoma of salivary glands[J].Eur J Cardiothorac Surg, 2008, 33(5):790-793.
[41]Chen FS, Sonobe M, Sato K, et al. Pulmonary resection for metastatic head and neck cancer[J]. World J Surg, 2008, 32(8):1657-1662.
[42]Dillon PM, Chakraborty S, Moskaluk CA, et al. Adenoid cystic carcinoma:a review of recent advances, molecular targets, and clinical trials[J]. Head Neck, 2016, 38(4):620-627.
[43]Laurie SA, Ho AL, Fury MG, et al. Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands:a systematic review[J].Lancet Oncol, 2011, 12(8):815-824.
[44]Amit MR, Binenbaum Y, Sharma K, et al. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study[J]. Head Neck,2014, 36(7):998-1004.
[45]Rapidis AD,GivalosN,GakiopoulouH,etal. Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature[J]. Oral Oncol, 2005, 41(3):328-335.
[46]Coca-Pelaz A, Rodrigo JP, Bradley PJ, et al. Adenoid cystic carcinoma of the head and neck—an update[J]. Oral Oncol,2015, 51(7):652-661.
[47]Jiang Y, Feng X, Zheng L, et al. Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma[J]. Oncotarget, 2015, 6(28):25506-25519.
[48]Liu SL, Ye DX, Xu DL, et al. Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma[J]. Oncotarget, 2016, 7(18):25251-25263.
[49]Hu J, Li YN, Fang JH. Effect of ERK inhibitor on pulmonary metastasis of inoculated human adenoid cystic carcinoma cells in nude mice[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010, 109(1):117-123.
[50]Hu K, Li SL, Gan YH, et al. Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt[J]. Oral Oncol,2009, 45(2):156-163.
[51]Ding LC, She L, Zheng DL, et al. Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma[J]. Oncol Rep, 2010, 24(2):363-368.
[2]van der Wal JE, Becking AG, Snow GB, et al. Distant metastases of adenoid cystic carcinoma of the salivary glands and the value of diagnostic examinations during follow-up[J].Head Neck, 2002, 24(8):779-783.
[3]Dodd RL, Slevin NJ. Salivary gland adenoid cystic carcinoma:a review of chemotherapy and molecular therapies[J]. Oral Oncol, 2006, 42(8):759-769.
[4]Spiro RH. Salivary neoplasms:overview of a 35-year experience with 2 807 patients[J]. Head Neck Surg, 1986, 8(3):177-184.
[5]Gao M, Hao Y, Huang MX, et al. Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma[J]. Int J Oral Maxillofac Surg, 2013, 42(8):923-928.
[6]Matsuba HM, Spector GJ, Thawley SE, et al. Adenoid cystic salivary gland carcinoma. A histopathologic review of treatment failure patterns[J]. Cancer, 1986, 57(3):519-524.
[7]Hamper K, Lazar F, Dietel M, et al. Prognostic factors for adenoid cystic carcinoma of the head and neck:a retrospective evaluation of 96 cases[J]. J Oral Pathol Med, 1990, 19(3):101-107.
[8]da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, et al. Prognostic factors in head and neck adenoid cystic carcinoma[J]. Oral Oncol, 2006, 42(2):139-146.
[9]Bianchi B, Copelli C, Cocchi R, et al. Adenoid cystic carcinoma of intraoral minor salivary glands[J]. Oral Oncol, 2008,44(11):1026-1031.
[10]Bhayani MK, Yener M, El-Naggar A, et al. Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands[J]. Cancer, 2012, 118(11):2872-2878.
[11]Kim KH, Sung MW, Chung PS, et al. Adenoid cystic carcinoma of the head and neck[J]. Arch Otolaryngol Head Neck Surg, 1994, 120(7):721-726.
[12]Huang M, Ma D, Sun K, et al. Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands[J].Int J Oral Maxillofac Surg, 1997, 26(6):435-439.
[13]Min R, Siyi L, Wenjun Y, et al. Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis:a preliminary study of 62 cases[J]. Int J Oral Maxillofac Surg, 2012,41(8):952-957.
[14]Umeda M, Nishimatsu N, Masago H, et al. Tumor-doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1999, 88(4):473-478.
[15]王佳峰,谭卓,邵岚,等.涎腺腺样囊性癌远处转移规律及其影响因素分析[J].肿瘤学杂志, 2017, 23(4):290-294.Wang JF, Tan Z, Shao L, et al. Analysis of distant metastasis of adenoid cystic carcinoma of the salivary gland and its influencing factors[J]. J Chin Oncolog, 2017, 23(4):290-294.
[16]Spiro RH. Distant metastasis in adenoid cystic carcinoma of salivary origin[J]. Am J Surg, 1997, 174(5):495-498.
[17]Sung MW, Kim KH, Kim JW, et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck[J]. Arch Otolaryngol Head Neck Surg, 2003, 129(11):1193-1197.
[18]Cohen AN, Damrose EJ, Huang RY, et al. Adenoid cystic carcinoma of the submandibular gland:a 35-year review[J].Otolaryngol Head Neck Surg, 2004, 131(6):994-1000.
[19]Todd TR. The surgical treatment of pulmonary metastases[J]. Chest, 1997, 112(4 Suppl):287S-290S.
[20]Rusch VW. Pulmonary metastasectomy. Current indications[J]. Chest, 1995, 107(6 Suppl):322S-331S.
[21]Perzin KH, Gullane P, Clairmont AC. Adenoid cystic carcinomas arising in salivary glands:a correlation of histologic features and clinical course[J]. Cancer, 1978, 42(1):265-282.
[22]Goldblatt LI, Ellis GL. Salivary gland tumors of the tongue.Analysis of 55 new cases and review of the literature[J].Cancer, 1987, 60(1):74-81.
[23]Eneroth CM, Hjertman L. Adenoid cystic carcinoma of the submandibular gland[J]. Laryngoscope, 1966, 76(10):1639-1661.
[24]Lee SY, Kim BH, Choi EC. Nineteen-year oncologic outcomes and the benefit of elective neck dissection in salivary gland adenoid cystic carcinoma[J]. Head Neck, 2014, 36(12):1796-1801.
[25]Spiro RH, Huvos AG, Strong EW. Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases[J].Am J Surg, 1974, 128(4):512-520.
[26]Osborn DA. Morphology and the natural history of cribriform adenocarcinoma(adenoid cystic carcinoma)[J]. J Clin Pathol, 1977, 30(3):195-205.
[27]Ju J, Li Y, Chai J, et al. The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis:a systematic review and meta-analysis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016, 122(6):691-701.
[28]Vrielinck LJ, Ostyn F, van Damme B, et al. The significance of perineural spread in adenoid cystic carcinoma of the major and minor salivary glands[J]. Int J Oral Maxillofac Surg,1988, 17(3):190-193.
[29]Kokemueller H, Eckardt A, Brachvogel P, et al. Adenoid cystic carcinoma of the head and neck—a 20 years experience[J]. Int J Oral Maxillofac Surg, 2004, 33(1):25-31.
[30]Amit MR, Binenbaum Y, Trejo-Leider L, et al. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck[J]. Head Neck, 2015, 37(7):1038-1045.
[31]Spiro RH, Huvos AG. Stage means more than grade in adenoid cystic carcinoma[J]. Am J Surg, 1992, 164(6):623-628.
[32]Sur RK, Donde B, Levin V, et al. Adenoid cystic carcinoma of the salivary glands:a review of 10 years[J]. Laryngoscope,1997, 107(9):1276-1280.
[33]Conley J, Dingman DL. Adenoid cystic carcinoma in the head and neck(cylindroma)[J]. Arch Otolaryngol, 1974,100(2):81-90.
[34]Girard P, Baldeyrou P, Le Chevalier T, et al. Surgery for pulmonary metastases. Who are the 10-year survivors[J].Cancer, 1994, 74(10):2791-2797.
[35]Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy:prognostic analyses based on 5 206cases[J]. J Thorac Cardiovasc Surg, 1997, 113(1):37-49.
[36]Liu D, Labow DM, Dang N, et al. Pulmonary metastasectomy for head and neck cancers[J]. Ann Surg Oncol, 1999,6(6):572-578.
[37]Girelli L, Locati L, Galeone C, et al. Lung metastasectomy in adenoid cystic cancer:is it worth it[J]. Oral Oncol, 2017,65:114-118.
[38]Winter H, Meimarakis G, Hoffmann G, et al. Does surgical resection of pulmonary metastases of head and neck cancer improve survival[J]. Ann Surg Oncol, 2008, 15(10):2915-2926.
[39]Locati LD, Guzzo M, Bossi P, et al. Lung metastasectomy in adenoid cystic carcinoma(ACC)of salivary gland[J]. Oral Oncol, 2005, 41(9):890-894.
[40]Bobbio A, Copelli C, Ampollini L, et al. Lung metastasis resection of adenoid cystic carcinoma of salivary glands[J].Eur J Cardiothorac Surg, 2008, 33(5):790-793.
[41]Chen FS, Sonobe M, Sato K, et al. Pulmonary resection for metastatic head and neck cancer[J]. World J Surg, 2008, 32(8):1657-1662.
[42]Dillon PM, Chakraborty S, Moskaluk CA, et al. Adenoid cystic carcinoma:a review of recent advances, molecular targets, and clinical trials[J]. Head Neck, 2016, 38(4):620-627.
[43]Laurie SA, Ho AL, Fury MG, et al. Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands:a systematic review[J].Lancet Oncol, 2011, 12(8):815-824.
[44]Amit MR, Binenbaum Y, Sharma K, et al. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study[J]. Head Neck,2014, 36(7):998-1004.
[45]Rapidis AD,GivalosN,GakiopoulouH,etal. Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature[J]. Oral Oncol, 2005, 41(3):328-335.
[46]Coca-Pelaz A, Rodrigo JP, Bradley PJ, et al. Adenoid cystic carcinoma of the head and neck—an update[J]. Oral Oncol,2015, 51(7):652-661.
[47]Jiang Y, Feng X, Zheng L, et al. Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma[J]. Oncotarget, 2015, 6(28):25506-25519.
[48]Liu SL, Ye DX, Xu DL, et al. Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma[J]. Oncotarget, 2016, 7(18):25251-25263.
[49]Hu J, Li YN, Fang JH. Effect of ERK inhibitor on pulmonary metastasis of inoculated human adenoid cystic carcinoma cells in nude mice[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010, 109(1):117-123.
[50]Hu K, Li SL, Gan YH, et al. Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt[J]. Oral Oncol,2009, 45(2):156-163.
[51]Ding LC, She L, Zheng DL, et al. Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma[J]. Oncol Rep, 2010, 24(2):363-368.