血清CYS-C与CRP在原发性高血压肾损害早期诊断中价值分析
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摘要
目的探讨原发性高血压肾损害患者应用血清CYS-S与CRP指标诊断作用。方法选择原发性高血压100例,均为本院2017年2月至2018年2月收治,设为观察组,并依据尿白蛋白排泄率(UAEP)按正常蛋白尿组40例,微量蛋白尿组35例,大量蛋白尿组25例划分;同期选择到院行健康体检的志愿者40例,设为对照组,分别检测血清CYS-C、CRP指标,对比观察组和对照组指标差异,明确单项检测或联合检测效果对比情况。结果观察组各组CYS-S、CRP检测值均高于对照组,差异具统计学意义(P<0.05)。观察组组内,微量蛋白尿组CYS-S、CRP均高于正常蛋白尿组,但低于大量蛋白尿组,差异均有统计学意义(P<0.05)。相较CYS-C、CRP单用对正常蛋白尿组、微量蛋白尿组检测,两项指标联用,敏感度均居更高水平,差异均有统计学意义(P<0.05)。结论针对临床收治的高血压肾损害患者,血清CYS-C、CRP均为重要检测指标,两项联用,可显著增强诊断敏感度,具非常积极的应用成效。
Objective To investigate the diagnostic value of serum CYS-S and CRP markers in patients with renal damage caused by essential hypertension. Methods 100 cases of primary hypertension were selected and treated in our hospital from February 2017 to February 2018 and set upas observation group. According to the urinary albumin excretion rate(UAEP), 40 cases of normal albuminuria group, 35 cases of microalbuminuriagroup and 25 cases of albuminuria group were divided, and 40 volunteers who were selected to the hospital for health examination in the same periodwere set as control. The serum CYS-C and CRP indexes were detected respectively, and the difference between the observation group and the controlgroup was compared. Results The values of CYS-S and CRP in the observation group were all higher than those in the control group, and the differ-ence was statistically significant(P<0.05). In the observation group, the levels of CYS-S and CRP in the microalbuminuria group were higher thanthose in the normal proteinuria group, but lower than those in the large proteinuria group, and the differences were statistically significant(P<0.05).Compared with CYS-C and CRP, the normal proteinuria group and the microalbuminuria group were detected. The sensitivity of the two indexes washigher, and the difference was statistically significant(P<0.05). Conclusion The serum CYS-C and CRP are important detection indexes for the patients with hypertension and renal damage. The two combined use can significantly enhance the diagnostic sensitivity and have a very positive effect.
Objective To investigate the diagnostic value of serum CYS-S and CRP markers in patients with renal damage caused by essential hypertension. Methods 100 cases of primary hypertension were selected and treated in our hospital from February 2017 to February 2018 and set upas observation group. According to the urinary albumin excretion rate(UAEP), 40 cases of normal albuminuria group, 35 cases of microalbuminuriagroup and 25 cases of albuminuria group were divided, and 40 volunteers who were selected to the hospital for health examination in the same periodwere set as control. The serum CYS-C and CRP indexes were detected respectively, and the difference between the observation group and the controlgroup was compared. Results The values of CYS-S and CRP in the observation group were all higher than those in the control group, and the differ-ence was statistically significant(P<0.05). In the observation group, the levels of CYS-S and CRP in the microalbuminuria group were higher thanthose in the normal proteinuria group, but lower than those in the large proteinuria group, and the differences were statistically significant(P<0.05).Compared with CYS-C and CRP, the normal proteinuria group and the microalbuminuria group were detected. The sensitivity of the two indexes washigher, and the difference was statistically significant(P<0.05). Conclusion The serum CYS-C and CRP are important detection indexes for the patients with hypertension and renal damage. The two combined use can significantly enhance the diagnostic sensitivity and have a very positive effect.
引文
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[10]李艳丽.血清Cys-C、CRP和Hcy联合检测对2型糖尿病肾病的诊断价值[J].当代医学,2018,24(2):13-15.
[2]沈恒山,高纯,沈红石,等.血清胱抑素C、超敏C反应蛋白和尿微量白蛋白对高血压患者早期肾功能损伤的诊断价值[J].山东医药,2012,52(1):57-58.
[3] Wu F, Dong XJ, Li YY, et al. Identification of phos-phorylated MYL12B as a potential plasma biomarkerfor septic acute kidney injury using a quantitativeproteomic approach[J]. Int J Clin Exp Pathol, 2015,8(11):14409-14416.
[4]张华,詹颉,苏宝凤,等.血清NGAL与肾功其他指标联合检测在原发性高血压肾病早期诊断中的应用[J].现代检验医学杂志,2016,31(4):54-57.
[5] Yun L, Xu R, Li G, et al. Homocysteine and theC677T Gene Polymorphism of Its Key Metabolic EnzymeMthfr Are Risk Factors of Early Renal Damage in Hy-pertension in a Chinese Han Population[J]. Medicine(Baltimore), 2015,94(52):2389.
[6]杜伙芬.尿微量蛋白与血清胱抑素C联合检测对高血压早期肾损害诊断的应用价值[J].临床合理用药,2015,8(6):4.
[7]彭俊华,张全华,赵勇,等.血清β2-MG, Cys-C及U-mALB在高血压肾损伤中的应用[J].现代检验医学杂志,2014,29(4):147-149.
[8] Wang Y, Cao X, Yang P, et al. Association of meta-bolic syndrome with serum cystatin C in people un-dergoing health examination[J]. Zhong Nan Da XueXue Bao Yi Xue Ban, 2015,40(7):742-747.
[9]候菲,缪洁萍,蔡红梅,等.原发性高血压患者血和尿中性粒细胞明胶酶相关脂质运载蛋白的改变及临床意义[J].首都医学大学学报,2016,34(4):605-608.
[10]李艳丽.血清Cys-C、CRP和Hcy联合检测对2型糖尿病肾病的诊断价值[J].当代医学,2018,24(2):13-15.