一种基于弹性模量的颈动脉衰老模型及其应用
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摘要
心血管系统是人体最重要的循环系统,老龄化是心血管衰老的首要原因,随着年龄的增长,颈动脉血管弹性逐渐丧失,弹性模量逐渐变大,并且颈动脉内中膜厚度变厚。文中建立一种颈动脉衰老模型,该模型使用颈动脉弹性模量和内中膜厚度作为评估标志,通过分析增龄与颈动脉弹性模量、内中膜厚度之间的非线性关系,描述心血管随年龄增加所发生的衰老过程。仿真结果验证了颈动脉衰老模型的合理性和可行性,所描述的各年龄段下颈动脉内中膜厚度和弹性模量的变化规律与相关医学文献检测的数据是基本一致的,这表明用分段式方法表示增龄与内中膜厚度的关系是有效的。另外,颈动脉弹性模量是评价心血管衰老的一个客观指标,因而该模型可用于辅助分析心血管衰老和相关疾病的发生与发展过程,为多种衰老相关疾病的防治提供了新思路,开辟了新视野。
The cardiovascular system is the most important circulatory system in the human body. Aging is the first influencing factor of cardiovascular aging. The carotid vascular elasticity is gradually lost with age,the elastic modulus is gradually enlarged,and aging can also lead to thickening of the carotid intimamedia thickness. This paper establishes a model for carotid aging by using carotid elastic modulus and intima-media thickness as indicators to describe the cardiovascular aging process by analyzing the nonlinear relationship between age,and carotid elastic modulus and intima-media thickness. The simulation results verify the rationality and the feasibility of the carotid aging model. The changes of the intima-media thickness and elastic modulus of the lower carotid arteries for all ages are basically in agreement with the data of the relevant medical literatures. The segmented method indicates that the relationship between age and intima-media thickness is effective,and the carotid elastic modulus is an objective indicator for evaluating cardiovascular aging. Therefore,the model can be used to assist in the analysis of the occurrence and development of cardiovascular aging and related diseases.
The cardiovascular system is the most important circulatory system in the human body. Aging is the first influencing factor of cardiovascular aging. The carotid vascular elasticity is gradually lost with age,the elastic modulus is gradually enlarged,and aging can also lead to thickening of the carotid intimamedia thickness. This paper establishes a model for carotid aging by using carotid elastic modulus and intima-media thickness as indicators to describe the cardiovascular aging process by analyzing the nonlinear relationship between age,and carotid elastic modulus and intima-media thickness. The simulation results verify the rationality and the feasibility of the carotid aging model. The changes of the intima-media thickness and elastic modulus of the lower carotid arteries for all ages are basically in agreement with the data of the relevant medical literatures. The segmented method indicates that the relationship between age and intima-media thickness is effective,and the carotid elastic modulus is an objective indicator for evaluating cardiovascular aging. Therefore,the model can be used to assist in the analysis of the occurrence and development of cardiovascular aging and related diseases.
引文
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[2] TALAMINOS A,ROA L M,ALVAREZ A,et al. Computational hemodynamic model of the human cardiovascular system[J]. IFMBE Proceedings,2014,41:919-922.
[3] WU Wangyi,DAI Guohao,WEN Gongbi. The dynamic coupling of left ventricle and systemic arteries[J]. Applied Mathematics and Mechanics,1999,20(7):4-19.
[4]刘莹,殷艳飞,章德发,等.心血管系统电网络模型的脉动信号仿真分析[J].生物医学工程学杂志,2015,32(6):1207-1211.LIU Ying,YIN Yanfei,ZHANG Defa,et al. Simulation analysis of the pulse signal on the electricity network of cardiovascular system[J]. Journal of Biomedical Engineering,2015,32(6):1207-1211.(in Chinese)
[5] SCUTERI A,ORRU M,MORRELL C H,et al. Associations of large artery structure and function with adiposity:effects of age,gender,and hypertension[J]. Atherosclerosis,2012,221(1):189-197.
[6] JUONALA M,KAHONEN M,LAITINEN T,et al. Effect of age and sex on carotid intima-media thickness,elasticity and brachial endothelial function in healthy adults:the cardiovascular risk in young Finns study[J]. European Heart Journal,2008,29(9):1198.
[7] TAKATO T,YAMADA N,ASHIDA T. Effects of aging and sex on progression of carotid intima-media thickness:a retrospective 6-year follow-up study[J]. Geriatrics&Gerontology International,2008,8(3):172-179.
[8] ENGELEN L,FERREIRA I,STEHOUWER C D,et al. Reference intervals for common carotid intima-media thickness measured with echotracking:relation with risk factors[J].European Heart Journal,2013,34(30):2368-2380.
[9]张伟,谢玉环,姚月成,等.正常人脉压与颈动脉声像改变的相关性及其临床意义[J].中山大学学报(医学科学版),2006,27(S2):198-200.ZHANG Wei,XIE Yuhuan,YAO Yuecheng,et al. The correlation between normal pulse pressure and carotid artery sonographic changes and its clinical significance[J]. Journal of Sun Yat-Sen University(Medical Sciences),2006,27(S2):198-200.(in Chinese)
[10] CHANG W T,CHEN J S,HUNG Y K,et al. Characterization of aging-associated cardiac diastolic dysfunction[J].Plos One,2014,9(5):e97455.
[11] KIM S A,LEE K H,WON H Y,et al. Quantitative assessment of aortic elasticity with aging using velocity-vector imaging and its histologic correlation[J]. Arteriosclerosis Thrombosis and Vascular Biology,2013,33(6):1306-1312.
[12]许先进,董旭.颈动脉内膜中膜厚度的临床研究进展[J].中国动脉硬化杂志,2008,16(8):665-668.XU Xianjin,DONG Xu. Clinical research progress of carotid intima-media thickness[J]. Chinese Journal of Arteriosclerosis,2008,16(8):665-668.(in Chinese)
[13] UANGPAIROJ P,SHIBATA M. Evaluation of vascular wall elasticity of human digital arteries using alternating current-signal photoplethysmography[J]. Vascular Health and Risk Management,2013,2013:283-295.
[14]杜娟.颈动脉内中膜厚度与年龄关系的研究[D].泰安:泰山医学院,2011.DU Juan. A study on the relative of the carotid intimamedia thickness and the age[D]. Taian:Taishan Medical University,2011.(in Chinese)
[15]吴国强,赵耐青,沈霖霖,等.心血管变异性的中枢调节数学模型[J].生物物理学报,2001,17(3):504-512.WU Guoqiang,ZHAO Naiqing,SHEN Linlin,et al. A model of central regulation in cardiovascular variability[J]. Acta Biophysica Sinica,2001,17(3):504-512.(in Chinese)