胱抑素C和β_2微球蛋白在2型糖尿病早期肾损害诊断中的意义
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摘要
目的分析胱抑素C和β2微球蛋白在2型糖尿病早期肾损害诊断中的意义。方法选择该院2014年1月—2015年1月收治的2型糖尿病患者100例,并选择同期健康体检者80例,对全部入选者的胱抑素C(Cysc)、β2微球蛋白(β2-MG)、尿素(Urea)、肌酐(Crea)进行检测,并对检测结果进行对比分析。结果糖尿病患者的胱抑素C和β2微球蛋白显著高于健康体检者,比较差异有统计学意义(P<0.05),而且在患者病情发展中胱抑素C和β2微球蛋白水平不断增高。结论在2型糖尿病早期肾损害诊断中,胱抑素C和β2微球蛋白具有非常重要的临床应用价值和参考价值。
Objective To analyze the cystatin C and β2-microglobulin significance in the diagnosis of type 2 diabetes in early nephropathy. Methods Select 100 cases of type 2 diabetes in our hospital from January 2014 to January 2015 were treated and choose healthy 80 cases over the same period, for all the selected candidates of cystatin C, β2-microglobulin, urea, creatinine detection, and the test results were analyzed. Results Diabetes cystatin C and β2-microglobulin was significantly higher than healthy controls, the difference was statistically significant( P<0.05), and in patients with disease progression in cystatin C and β2-microglobulin level continues increased. Conclusion Early diagnosis of diabetic nephropathy in type 2, and cystatin C and β2microglobulin has very important clinical value and reference value.
Objective To analyze the cystatin C and β2-microglobulin significance in the diagnosis of type 2 diabetes in early nephropathy. Methods Select 100 cases of type 2 diabetes in our hospital from January 2014 to January 2015 were treated and choose healthy 80 cases over the same period, for all the selected candidates of cystatin C, β2-microglobulin, urea, creatinine detection, and the test results were analyzed. Results Diabetes cystatin C and β2-microglobulin was significantly higher than healthy controls, the difference was statistically significant( P<0.05), and in patients with disease progression in cystatin C and β2-microglobulin level continues increased. Conclusion Early diagnosis of diabetic nephropathy in type 2, and cystatin C and β2microglobulin has very important clinical value and reference value.
引文
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[7]CHEN Ai-zhen,SUN Xiu-li.The Application of Cystatin C andβ2-microglobulin Detection in Renal Disease[J].Medical Reca pitulate,2009,17:2583-2586.
[2]柯振符.血清肌酐、胱抑素-C、尿素氮及尿β2-微球蛋白检测在2型糖尿病早期肾损伤中的价值[J].中国医药导报,2013,10(22):94-96.
[3]屠叶平.脂联素和胱抑素C在糖尿病肾病早期诊断中的临床意义[J].现代中西医结合杂志,2014,23(20):2191-2194.
[4]Filler G,Bokenkamp A,Hofmannw,et al.Cys C as a marker of GFR-history,Indications,and future research[J].Clin Biochem,2005,38(1):1-8.
[5]王谈昀,李军民,曾宪飞,等.血清胱抑素C与β2微球蛋白、尿微量清蛋白检测在2型糖尿病肾病早期诊断中的相关研究[J].现代检验医学杂志,2011,26(2):107-111.
[6]陈芳.胱抑素C(Cys C)和β2-微球蛋白(β2-MG)、视黄醇(RBP)、尿微量白蛋白(MA)、尿素氮(BUN)、肌酐(CR)对2型糖尿病肾病早期诊断价值[J].医学信息,2013(21):517.
[7]CHEN Ai-zhen,SUN Xiu-li.The Application of Cystatin C andβ2-microglobulin Detection in Renal Disease[J].Medical Reca pitulate,2009,17:2583-2586.