色谱法分离手性药物研究进展
摘要
本文简述了色谱法手性分离的进展,并以每种色谱分离方法为线索,简要说明了每种方法的优缺点。
引文
[1]陈新滋,李月明.划时代的手性药物[J].中国处方药,2003,8(8):54-56.
[2]张怡评,洪专,方华,等.超临界流体色谱分离技术应用研究进展[J].中医药导报,2012,18(7):89-91.
[3]李阳,罗素琴,刘乐乐,等.手性药物的合成与拆分的研究进展[J].内蒙古医科大学学报,2014,36(1):74-78.
[4]Anon.FDA’s Policy Statement for the Development of New Stereoisomeric Drugs,U.S.Food and Drug Administration Guidance,Washington,DC,1992.
[5]Joshua D,Anjanette K,Preeti K,et al.Enantioselective separation on a naturally chiral surface[J].J.Am.Chem.Soc.,2004,126:14988-14994.
[6]丁徐中,黄金,王普.高效液相色谱法手性拆分N-叔丁氧羰基-3-羟基-1-金刚烷甘氨酸对映体[J],浙江工业大学学报,2015,43(3):298-301.
[7]程彪平,李来生,周仁丹,等.两种β-环糊精单臂键合固定相液相色谱法拆分三唑类手性农药[J],高等学校化学学报,2015,36(5):872-880.
[8]王嘉林,王斯坦.HP-β-CD手性添加剂反相高效液相色谱拆分盐酸帕洛诺司琼S,R异构体[J].中国药师,2015,18(2):237-240.
[9]郭佳莉,潘仲巍,李文杰.反相高效液相色谱手性柱前衍生化法分离DL-丙氨酸对映体[J].理化检验-化学分册,2015,51(3):875-876.
[10]孙嘉仪,邢玉平,宋佳新,等.毛细管电泳法分离4种手性药物对映体[J],沈阳药科大学学报,2015,3(3):199-203.
[11]Kuhn R,Steinmetz C,Bereuter T,et al.Enantiomeric separations in capillary zone electrophoresis using a chiral crown ether[J],J.Chromatogr.,1994,666,367-373.
[12]Armstrong D W,Rundlett K,ReidⅢG L.Use of a Macrocyclic Antibiotic,Rifamycin B,and Indirect Detection for the Resolution of Racemic Amino Alcohols by CE[J].Anal,Chem.,1994,66,1690-1695.
[13]王丙香,柴微波,唐安娜,等.涂层技术在毛细管电泳手性分离中的应用[J],色谱,2015,33(4):334~341.
[14]Rogan M M,Drake C D,Goodall D M,et al.Development of Chiral Separation by Capillary Electrophoresis[J].Anal.Biochem.,1993,208,343-345.
[15]Golkiewicz W,Ploak B.Relationship between capacity factors and mobile phase composition in thin layer ligand exchange chromatography of the enantiomers of some amino acids[J].J Planar Chromatogr Mod TCL,1994,7:453
[16]Bushan R,Reddy G P,Joshi S.TCL resolution of DL-amino acids on impreganted silica gel plates[J].J Planar Chromatogr Mod TCL,1994,7:126
[17]Peter A,Toth G.Chromatographic methods for the separation of enantiomers and epimers ofβ-alky amino acids and peptides containing them[J].Anal Chim Acta,1997,352:335
[18]朱全红,邓芹英,曾陇梅.手性药物的薄层色谱拆分[J].药物分析杂志.2002,22(2):155-158
[19]李娴,解新安.超临界流体的理化性质及应用[J].化学世界,2010,51(3):179-182.
[20]夏爽,袁圆,潘桂湘等.超临界液体色谱在手性药物拆分中的应用进展[J].中国实验方剂学杂志,2015,21(12):217-220.
[21]De Klerck K,Mangelings D,Vander Heyden Y,et al.Supercritical fluid chromatography for the enantioseparation of pharmaceuticals[J].J Pharmacent Biomed Anal,2012,69:77-92.
[22]缪叶龙,徐明仙,郑夏琼等.六种手性三唑类杀菌剂对映体的超临界流体色谱法分离[J].农药学学报.2015,17(4):432-438.
[23]罗英豪,超临界流体色谱法拆分萘普生对映体[J].中国药房,2015,26(34):4789-4791.
[2]张怡评,洪专,方华,等.超临界流体色谱分离技术应用研究进展[J].中医药导报,2012,18(7):89-91.
[3]李阳,罗素琴,刘乐乐,等.手性药物的合成与拆分的研究进展[J].内蒙古医科大学学报,2014,36(1):74-78.
[4]Anon.FDA’s Policy Statement for the Development of New Stereoisomeric Drugs,U.S.Food and Drug Administration Guidance,Washington,DC,1992.
[5]Joshua D,Anjanette K,Preeti K,et al.Enantioselective separation on a naturally chiral surface[J].J.Am.Chem.Soc.,2004,126:14988-14994.
[6]丁徐中,黄金,王普.高效液相色谱法手性拆分N-叔丁氧羰基-3-羟基-1-金刚烷甘氨酸对映体[J],浙江工业大学学报,2015,43(3):298-301.
[7]程彪平,李来生,周仁丹,等.两种β-环糊精单臂键合固定相液相色谱法拆分三唑类手性农药[J],高等学校化学学报,2015,36(5):872-880.
[8]王嘉林,王斯坦.HP-β-CD手性添加剂反相高效液相色谱拆分盐酸帕洛诺司琼S,R异构体[J].中国药师,2015,18(2):237-240.
[9]郭佳莉,潘仲巍,李文杰.反相高效液相色谱手性柱前衍生化法分离DL-丙氨酸对映体[J].理化检验-化学分册,2015,51(3):875-876.
[10]孙嘉仪,邢玉平,宋佳新,等.毛细管电泳法分离4种手性药物对映体[J],沈阳药科大学学报,2015,3(3):199-203.
[11]Kuhn R,Steinmetz C,Bereuter T,et al.Enantiomeric separations in capillary zone electrophoresis using a chiral crown ether[J],J.Chromatogr.,1994,666,367-373.
[12]Armstrong D W,Rundlett K,ReidⅢG L.Use of a Macrocyclic Antibiotic,Rifamycin B,and Indirect Detection for the Resolution of Racemic Amino Alcohols by CE[J].Anal,Chem.,1994,66,1690-1695.
[13]王丙香,柴微波,唐安娜,等.涂层技术在毛细管电泳手性分离中的应用[J],色谱,2015,33(4):334~341.
[14]Rogan M M,Drake C D,Goodall D M,et al.Development of Chiral Separation by Capillary Electrophoresis[J].Anal.Biochem.,1993,208,343-345.
[15]Golkiewicz W,Ploak B.Relationship between capacity factors and mobile phase composition in thin layer ligand exchange chromatography of the enantiomers of some amino acids[J].J Planar Chromatogr Mod TCL,1994,7:453
[16]Bushan R,Reddy G P,Joshi S.TCL resolution of DL-amino acids on impreganted silica gel plates[J].J Planar Chromatogr Mod TCL,1994,7:126
[17]Peter A,Toth G.Chromatographic methods for the separation of enantiomers and epimers ofβ-alky amino acids and peptides containing them[J].Anal Chim Acta,1997,352:335
[18]朱全红,邓芹英,曾陇梅.手性药物的薄层色谱拆分[J].药物分析杂志.2002,22(2):155-158
[19]李娴,解新安.超临界流体的理化性质及应用[J].化学世界,2010,51(3):179-182.
[20]夏爽,袁圆,潘桂湘等.超临界液体色谱在手性药物拆分中的应用进展[J].中国实验方剂学杂志,2015,21(12):217-220.
[21]De Klerck K,Mangelings D,Vander Heyden Y,et al.Supercritical fluid chromatography for the enantioseparation of pharmaceuticals[J].J Pharmacent Biomed Anal,2012,69:77-92.
[22]缪叶龙,徐明仙,郑夏琼等.六种手性三唑类杀菌剂对映体的超临界流体色谱法分离[J].农药学学报.2015,17(4):432-438.
[23]罗英豪,超临界流体色谱法拆分萘普生对映体[J].中国药房,2015,26(34):4789-4791.