芳香开窍中药与血-视网膜屏障通透性相关研究进展
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摘要
常见的芳香开窍药石菖蒲、冰片、麝香等,能够芳香走窜、醒脑开窍、引药上行,带引其他药物直达病所,提高疗效。血-视网膜屏障是维持眼局部内环境稳定的重要结构,同时也是影响药物治疗作用的主要因素。分别从组织结构、中药药性和分子生物学改变三个方面进行说明和概括,总结以上几种芳香开窍药对血-视网膜屏障通透性改变的影响和作用机制,为芳香开窍中药的对于眼部疾病的治疗提供新的策略。参考文献32篇。
引文
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[17]肖傅文,赵瑞芝,胡巧红,等.引经药的历史沿革与现代实验研究进展[J].广东药学院学报,2016,32(1):123-125.
[18]刘超,刘敬霞,刘抒雯,等.芳香开窍药调控血脑屏障机制研究及脑病治疗[J].长春中医药大学报,2016,32(4):874-877.
[19]林群芳,黄培,田雪飞,等.麝香配伍乳香对大鼠前列腺上皮细胞紧密连接结构相关蛋白表达的影响[J].中华男科学杂志,2015,21(12):1110-1115.
[20]丁洁,张莹,巫悦,等.麝香、安息香和苏合香对血脑屏障脑区特异性开放作用及其机制[J].中国医院药学杂志,2015,35(4):279-282.
[21]姚洪武,王建,刘岩,等.麝香与冰片不同配比对急性脑缺血模型小鼠血脑屏障通透性的影响[J].成都中医药大学学报,2011,34(4):62-64,80.
[22]胡园,袁默,刘屏,等.石菖蒲对血脑屏障超微结构及通透性的影响[J].中国中药杂志,2009,34(3):349-351.
[23]吴珊,王凌.石菖蒲促进卡马西平透过血脑屏障的实验研究[J].福建医药杂志,2013,35(5):67-68,84.
[24]吴雪,欧阳丽娜,向大位,等.冰片及石菖蒲促进羟基红花黄色素A透过血脑屏障的实验研究[J].中草药,2011,42(4):734-737.
[25]吴启端,方永奇,李翎,等.石菖蒲醒脑开窍的有效部位筛选[J].时珍国医国药,2002,13(5):260-261.
[26]韩引秀,尹伟.冰片服用间隔时间对促血脑屏障开放程度的影响[J].赤峰学院学报（自然科学版）,2016,32(6):176-177.
[27]宋继科,毕宏生,郭俊国,等.冰片对盐酸青藤碱滴眼液角膜透过性的影响[J].时珍国医国药,2013,24(6):1321-1323.
[28]白昱旸,唐由之,梁丽娜,等.不同引经药干预对大鼠血-视网膜屏障claudin-5表达的影响[C].2014:61-62.
[29]吴超,李新民,张喜莲,等.开窍类中药增加血脑屏障通透性机制的研究进展[J].中国中医急症,2017,26(7):1220-1223.
[30]王利苹,奉建芳,胡凯莉,等.芳香开窍中药对血脑屏障通透性的调节作用及其机制研究进展[J].中国中药杂志,2014,39(6):949-954.
[31]RAN R J,ZHENG X Y,DU L P,et al.Upregulated inflammatory associated factors and blood-retinal barrier changes in the retina of type 2 diabetes mellitus model[J]Int J Ophthalmol,2016,9(11):1591-1597.
[32]张燕,彭绍民.血-视网膜外屏障发育的研究现状[J]中华眼底病杂志,2012,28(2):206-208.
[2]YESTE J,GARC I A-RAM I REZ M,ILLA X,et al.Acompartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood-retinal barrier[J].Lab Chip,2017,18(1):95-105.
[3]ZHANG Z,UCHIDA Y,HIRANO S,et al.Inner bloodretinal barrier dominantly expresses breast cancer resistance protein:comparative quantitative targeted absolute proteomics study of CNS barriers in pig[J].Mol Pharm,2017,14(11):3729-3738.
[4]PASCUAL-PASTO G,OLACIREGUI N G,OPEZZO J AW,et al.Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier[J].J Control Release,2017,264(10):34-44.
[5]纪娟,周安,张亚中,等.芳香开窍类中药促进药物体内吸收的研究进展[J].江西中医药大学学报,2016,28(2):106-109.
[6]ZHANG Y H,LI J,YANG W Z,et al.Mitochondrial expression and activity of P-glycoprotein under oxidative stress in outer blood-retinal barrier[J].Int J Ophthalmol,2017,10(7):1055-1063.
[7]QIAN Y W,LI C,JIANG A P,et al.HIV-1 gp120 glycoprotein interacting with dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin(DC-SIGN)down-regulates tight junction proteins to disrupt the blood retinal barrier and increase its permeability[J].J Biol Chem,2016,291(44):22977-22987.
[8]XIE M S,ZHENG Y Z,HUANG L B.Infliximab relieves blood retinal barrier breakdown through the p38 MAPKpathway in a diabetic rat model[J].Int J Ophthalmol,2017,10(12):1824-1829.
[9]董蒙,陈松,段红涛,等.糖尿病大鼠血-视网膜屏障功能评估中伊文思蓝灌注视网膜铺片技术的改良和应用[J]中华实验眼科杂志,2015,33(7):606-609.
[10]CHE X,FAN X Q.Mechanism of blood-retinal barrier breakdown induced by HIV-1(Review)[J].Exp Ther Med,2014,7(4):768-772.
[11]陆萍.血-视网膜屏障的发育与大鼠硒性白内障形成的关系[J].国际眼科杂志,2017,17(12):2218-2221.
[12]马红婕,罗燕,王敏,等.紧密连接蛋白及神经胶质原纤维酸性蛋白在糖尿病大鼠视网膜的表达变化及其与血-视网膜屏障功能的关系[J].中华眼科杂志,2007,43(5):397-401.
[13]田蓉,刘秋慧,蔡萌,等.过表达Claudin-5增强体外培养的人视网膜微血管内皮细胞屏障功能[J].中山大学学报（医学科学版）,2014,35(5):695-701.
[14]CAMPBELL M,NGUYEN A T,KIANG A S,et al.An experimental platform for systemic drug delivery to the retina[J].Proc Natl Acad Sci USA,2009,106(42):17817-22.
[15]SAITOU M,FUJIMOTO K,DOI Y,et al.Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions[J].J Cell Biol,1998,141(2):397-408.
[16]曾绘域,沈强.芳香开窍药对血脑屏障通透性影响的研究进展[J].吉林中医药,2013,33(10):1390-1393.
[17]肖傅文,赵瑞芝,胡巧红,等.引经药的历史沿革与现代实验研究进展[J].广东药学院学报,2016,32(1):123-125.
[18]刘超,刘敬霞,刘抒雯,等.芳香开窍药调控血脑屏障机制研究及脑病治疗[J].长春中医药大学报,2016,32(4):874-877.
[19]林群芳,黄培,田雪飞,等.麝香配伍乳香对大鼠前列腺上皮细胞紧密连接结构相关蛋白表达的影响[J].中华男科学杂志,2015,21(12):1110-1115.
[20]丁洁,张莹,巫悦,等.麝香、安息香和苏合香对血脑屏障脑区特异性开放作用及其机制[J].中国医院药学杂志,2015,35(4):279-282.
[21]姚洪武,王建,刘岩,等.麝香与冰片不同配比对急性脑缺血模型小鼠血脑屏障通透性的影响[J].成都中医药大学学报,2011,34(4):62-64,80.
[22]胡园,袁默,刘屏,等.石菖蒲对血脑屏障超微结构及通透性的影响[J].中国中药杂志,2009,34(3):349-351.
[23]吴珊,王凌.石菖蒲促进卡马西平透过血脑屏障的实验研究[J].福建医药杂志,2013,35(5):67-68,84.
[24]吴雪,欧阳丽娜,向大位,等.冰片及石菖蒲促进羟基红花黄色素A透过血脑屏障的实验研究[J].中草药,2011,42(4):734-737.
[25]吴启端,方永奇,李翎,等.石菖蒲醒脑开窍的有效部位筛选[J].时珍国医国药,2002,13(5):260-261.
[26]韩引秀,尹伟.冰片服用间隔时间对促血脑屏障开放程度的影响[J].赤峰学院学报（自然科学版）,2016,32(6):176-177.
[27]宋继科,毕宏生,郭俊国,等.冰片对盐酸青藤碱滴眼液角膜透过性的影响[J].时珍国医国药,2013,24(6):1321-1323.
[28]白昱旸,唐由之,梁丽娜,等.不同引经药干预对大鼠血-视网膜屏障claudin-5表达的影响[C].2014:61-62.
[29]吴超,李新民,张喜莲,等.开窍类中药增加血脑屏障通透性机制的研究进展[J].中国中医急症,2017,26(7):1220-1223.
[30]王利苹,奉建芳,胡凯莉,等.芳香开窍中药对血脑屏障通透性的调节作用及其机制研究进展[J].中国中药杂志,2014,39(6):949-954.
[31]RAN R J,ZHENG X Y,DU L P,et al.Upregulated inflammatory associated factors and blood-retinal barrier changes in the retina of type 2 diabetes mellitus model[J]Int J Ophthalmol,2016,9(11):1591-1597.
[32]张燕,彭绍民.血-视网膜外屏障发育的研究现状[J]中华眼底病杂志,2012,28(2):206-208.