空气污染与人类精子质量关系的分析研究
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摘要
空气污染会对人类生殖健康产生一定影响,特别是对精子质量在内的男性生殖健康的作用研究多有报告。但是空气污染中不同污染物成分(如PM_(10)、PM_(2.5)、O_3、SO_2、NO_2、CO、Vehicle Emission和PAHs等),与人类精子质量参数相关性和作用权重,及暴露时间敏感窗口(精子发生过程中不同发育周期)等问题尚未明确,需要具体分析研究。回顾现有的研究结果,总结分析空气污染对人类精子数量及质量影响的证据,为空气污染健康危害评价和预防提供科学数据支持。
There have been many reports on the impacts of air pollution on human reproductive health, especially on the male reproductive health, including sperm quality. However, the correlations of different pollutant components in air pollution(such as PM_(10), PM_(2.5), O_3, SO_2, NO_2, CO, Vehicle Emission, PAHs and etc.) with human sperm quality sensitive parameters, and the sensitive windows of exposure time(different developmental cycles during spermatogenesis) are not clear. Thus, specific analysis and research are needed. We reviewed the existing research result, summarized the evidences of the impact of air pollution on the quantity and quality of human sperm, and provided scientific data support for the assessment and prevention of air pollution health hazards.
There have been many reports on the impacts of air pollution on human reproductive health, especially on the male reproductive health, including sperm quality. However, the correlations of different pollutant components in air pollution(such as PM_(10), PM_(2.5), O_3, SO_2, NO_2, CO, Vehicle Emission, PAHs and etc.) with human sperm quality sensitive parameters, and the sensitive windows of exposure time(different developmental cycles during spermatogenesis) are not clear. Thus, specific analysis and research are needed. We reviewed the existing research result, summarized the evidences of the impact of air pollution on the quantity and quality of human sperm, and provided scientific data support for the assessment and prevention of air pollution health hazards.
引文
[1] Carlsen E,Giwercman A,Keiding N,et al.Evidence for decreasing quality of semen during past 50 years[J].BMJ,1992,305(6854):609-613.
[2] John Aitken R.Falling sperm counts twenty years on:where are we now?[J].Asian J Androl,2013,15(2):204-207.
[3] Sengupta P,Nwagha U,Dutta S,et al.Evidence for decreasing sperm count in African population from 1965 to 2015[J].Afr Health Sci,2017,17(2):418-427.
[4] Levine H,J?rgensen N,Martino-Andrade A,et al.Temporal trends in sperm count:a systematic review and meta-regression analysis[J].Hum Reprod Update,2017,23(6):646-659.
[5] Yuan HF,Shangguan HF,Zheng Y,et al.Decline in semen concentration of healthy Chinese adults:evidence from 9357 participants from 2010 to 2015[J].Asian J Androl,2018,20(4):379-384.
[6] Mahmud N,Sharmin E,Mamun MA,et al.Decline in semen parameters from 2000 to 2016 among Bangladeshi men attending a tertiary care hospital[J].Indian J Urol,2018,34(1):28-33.
[7] Afeiche M,Williams PL,Mendiola J,et al.Dairy food intake in relation to semen quality and reproductive hormone levels among physically active young men[J].Hum Reprod,2013,28(8):2265-2275.
[8] Jensen TK,Heitmann BL,Jensen MB,et al.High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population[J].Am J Clin Nutr,2013,97(2):411-418.
[9] Gollenberg AL,Liu F,Brazil C,et al.Semen quality in fertile men in relation to psychosocial stress[J].Fertil Steril,2010,93(4):1104-1111.
[10] Nordkap L,Jensen TK,Hansen ?M,et al.Psychological stress and testicular function:a cross-sectional study of 1,215 Danish men[J].Fertil Steril,2016,105(1):174-187.e2.
[11] Sharma R,Harlev A,Agarwal A,et al.Cigarette smoking and semen quality:a new meta-analysis examining the effect of the 2010 world health organization laboratory methods for the examination of human semen[J].Eur Urol,2016,70(4):635-645.
[12] Rehman S,Usman Z,Rehman S,et al.Endocrine disrupting chemicals and impact on male reproductive health[J].Transl Androl Urol,2018,7(3):490-503.
[13] Zhang MH,Zhang AD,Shi ZD,et al.Changes in levels of seminal nitric oxide synthase,macrophage migration inhibitory factor,sperm DNA integrity and caspase-3 in fertile men after scrotal heat stress[J].PLoS One,2015,10(10):e0141320.
[14] Steinfeld JI.Atmospheric chemistry and physics:from air pollution to climate change[J].Environ:Sci Policy Sustain Dev,1998,40(7):26.
[15] World Health Organization.Household air pollution and health[EB/OL].(2018-05-08).http://www.who.int/mediacentre/factsheets/fs292/en/.
[16] Hammoud A,Carrell DM,Gibson M,et al.Decreased sperm motility is associated with air pollution in Salt Lake City[J].Fertil Steril,2010,93(6):1875-1879.
[17] Lao XQ,Zhang ZL,Lau AKH,et al.Exposure to ambient fine particulate matter and semen quality in Taiwan[J].Occup Environ Med,2018,75(2):148-154.
[18] Najafpour A,Aghaz F,Roshankhah S,et al.The effect of air dust pollution on semen quality and sperm parameters among infertile men in west of Iran[J].Aging Male,2018,doi:10.1080/13685538.2018.1482533.
[19] Mao H,Feng L,Yang WX.Environmental factors contributed to circannual rhythm of semen quality[J].Chronobiol Int,2017,34(3):411-425.
[20] Santi D,Magnani E,Michelangeli M,et al.Seasonal variation of semen parameters correlates with environmental temperature and air pollution:a big data analysis over 6 years[J].Environ Pollut,2018,235:806-813.
[21] Zhou NY,Jiang CT,Chen Q,et al.Exposures to atmospheric PM10 and PM10-2.5 affect male semen quality:results of MARHCS study[J].Environ Sci Technol,2018,52(3):1571-1584.
[22] 王笑臣,田晓佳,叶波,等.武汉市大气PM10暴露对精液质量的影响[J].中华预防医学杂志,2018,52(1):73-78.(In English:Wang XC,Tian XJ,Ye B,et al.The effect of ambient PM10 on sperm quality in Wuhan[J].Chin J Prev Med,2018,52(1):73-78.)
[23] Wu L,Jin L,Shi TM,et al.Association between ambient particulate matter exposure and semen quality in Wuhan,China[J].Environ Int,2017,98:219-228.
[24] Santi D,Vezzani S,Granata AR,et al.Sperm quality and environment:a retrospective,cohort study in a northern province of Italy[J].Environ Res,2016,150:144-153.
[25] Bosco L,Notari T,Ruvolo G,et al.Sperm DNA fragmentation:an early and reliable marker of air pollution[J].Environ Toxicol Pharmacol,2018,58:243-249.
[26] Hansen C,Luben TJ,Sacks JD,et al.The effect of ambient air pollution on sperm quality[J].Environ Health Perspect,2010,118(2):203-209.
[27] Liu YW,Zhou Y,Ma JX,et al.Inverse association between ambient sulfur dioxide exposure and semen quality in Wuhan,China[J].Environ Sci Technol,2017,51(21):12806-12814.
[28] Zhou NY,Cui ZH,Yang SM,et al.Air pollution and decreased semen quality:a comparative study of Chongqing urban and rural areas[J].Environ Pollut,2014,187:145-152.
[29] Radwan M,Jurewicz J,Polańska K,et al.Exposure to ambient air pollution-does it affect semen quality and the level of reproductive hormones?[J].Ann Hum Biol,2016,43(1):50-56.
[30] Farhat J,Farhat SCL,Braga ALF,et al.Ozone decreases sperm quality in systemic lupus erythematosus patients[J].Rev Bras Reumatol,2016,56(3):212-219.
[31] 田晓佳,王笑臣,叶波,等.武汉市臭氧暴露对男性精液质量的影响[J].中华预防医学杂志,2017,51(3):197-202.(In English:Tian XJ,Wang XC,Ye B,et al.The effects of exposure to ozone on sperm quality in Wuhan[J].Chin J Prev Med,2017,51(3):197-202.)
[32] Sokol RZ,Kraft P,Fowler IM,et al.Exposure to environmental ozone alters semen quality[J].Environ Health Perspect,2006,114(3):360-365.
[33] Lafuente R,García-Blàquez N,Jacquemin B,et al.Outdoor air pollution and sperm quality[J].Fertil Steril,2016,106(4):880-896.
[34] Boggia B,Carbone U,Farinaro E,et al.Effects of working posture and exposure to traffic pollutants on sperm quality[J].J Endocrinol Invest,2009,32(5):430-434.
[35] Jurewicz J,Radwan M,Sobala W,et al.The relationship between exposure to air pollution and sperm disomy[J].Environ Mol Mutagen,2015,56(1):50-59.
[36] Wijesekara GU,Fernando DMS,Wijerathna S,et al.Environmental and occupational exposures as a cause of male infertility:a caveat[J].Ceylon Med J,2015,60(2):52-56.
[37] Guven A,Kayikci A,Cam K,et al.Alterations in semen parameters of toll collectors working at motorways:does diesel exposure induce detrimental effects on semen?[J].Andrologia,2008,40(6):346-351.
[38] Calogero AE,La Vignera S,Condorelli RA,et al.Environmental car exhaust pollution damages human sperm chromatin and DNA[J].J Endocrinol Invest,2011,34(6):e139-e143.
[39] Selevan SG,Borkovec L,Slott VL,et al.Semen quality and reproductive health of young Czech men exposed to seasonal air pollution[J].Environ Health Perspect,2000,108(9):887-894.
[40] Rubes J,Selevan SG,Evenson DP,et al.Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality[J].Hum Reprod,2005,20(10):2776-2783.
[41] Xia YK,Han Y,Zhu PF,et al.Relation between urinary metabolites of polycyclic aromatic hydrocarbons and human semen quality[J].Environ Sci Technol,2009,43(12):4567-4573.
[42] Jurewicz J,Radwan M,Sobala W,et al.Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality[J].Int J Occup Med Environ Health,2013,26(5):790-801.
[43] Radwan M,Jurewicz J,Sobala W,et al.Human sperm aneuploidy after exposure to polycyclic aromatic hydrocarbons[J].Reprod,Fertil Dev,2016,28(9):1376-1381.
[44] Yang P,Wang YX,Chen YJ,et al.Urinary polycyclic aromatic hydrocarbon metabolites and human semen quality in China[J].Environ Sci Technol,2017,51(2):958-967.
[45] Han X,Zhou NY,Cui ZH,et al.Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage:a population study in Chongqing,China[J].Environ Health Perspect,2011,119(5):652-657.
[46] Gaspari L,Chang SS,Santella RM,et al.Polycyclic aromatic hydrocarbon-DNA adducts in human sperm as a marker of DNA damage and infertility[J].Mutat Res/Genet Toxicol Environ Mutagen,2003,535(2):155-160.
[47] De Rosa M,Zarrilli S,Paesano L,et al.Traffic pollutants affect fertility in men[J].Hum Reprod,2003,18(5):1055-1061.
[48] Zhu QX,Gao ES,Pathak N,et al.Single or double semen samples:the dilemma in epidemiological studies on semen quality[J].Hum Reprod,2016,31(3):511-517.
[49] Hsu PC,Chen IY,Pan CH,et al.Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers[J].Int Arch Occup Environ Health,2006,79(5):349-356.
[50] Deng ZB,Chen F,Zhang MX,et al.Association between air pollution and sperm quality:a systematic review and meta-analysis[J].Environ Pollut,2016,208:663-669.
[51] rám RJ,Binková B,R?ssner P,et al.Adverse reproductive outcomes from exposure to environmental mutagens[J].Mutat Res/Fundam Mol Mech Mutagen,1999,428(1-2):203-215.
[52] Yoshida S,Sagai M,Oshio S,et al.Exposure to diesel exhaust affects the male reproductive system of mice[J].Int J Androl,1999,22(5):307-315.
[2] John Aitken R.Falling sperm counts twenty years on:where are we now?[J].Asian J Androl,2013,15(2):204-207.
[3] Sengupta P,Nwagha U,Dutta S,et al.Evidence for decreasing sperm count in African population from 1965 to 2015[J].Afr Health Sci,2017,17(2):418-427.
[4] Levine H,J?rgensen N,Martino-Andrade A,et al.Temporal trends in sperm count:a systematic review and meta-regression analysis[J].Hum Reprod Update,2017,23(6):646-659.
[5] Yuan HF,Shangguan HF,Zheng Y,et al.Decline in semen concentration of healthy Chinese adults:evidence from 9357 participants from 2010 to 2015[J].Asian J Androl,2018,20(4):379-384.
[6] Mahmud N,Sharmin E,Mamun MA,et al.Decline in semen parameters from 2000 to 2016 among Bangladeshi men attending a tertiary care hospital[J].Indian J Urol,2018,34(1):28-33.
[7] Afeiche M,Williams PL,Mendiola J,et al.Dairy food intake in relation to semen quality and reproductive hormone levels among physically active young men[J].Hum Reprod,2013,28(8):2265-2275.
[8] Jensen TK,Heitmann BL,Jensen MB,et al.High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population[J].Am J Clin Nutr,2013,97(2):411-418.
[9] Gollenberg AL,Liu F,Brazil C,et al.Semen quality in fertile men in relation to psychosocial stress[J].Fertil Steril,2010,93(4):1104-1111.
[10] Nordkap L,Jensen TK,Hansen ?M,et al.Psychological stress and testicular function:a cross-sectional study of 1,215 Danish men[J].Fertil Steril,2016,105(1):174-187.e2.
[11] Sharma R,Harlev A,Agarwal A,et al.Cigarette smoking and semen quality:a new meta-analysis examining the effect of the 2010 world health organization laboratory methods for the examination of human semen[J].Eur Urol,2016,70(4):635-645.
[12] Rehman S,Usman Z,Rehman S,et al.Endocrine disrupting chemicals and impact on male reproductive health[J].Transl Androl Urol,2018,7(3):490-503.
[13] Zhang MH,Zhang AD,Shi ZD,et al.Changes in levels of seminal nitric oxide synthase,macrophage migration inhibitory factor,sperm DNA integrity and caspase-3 in fertile men after scrotal heat stress[J].PLoS One,2015,10(10):e0141320.
[14] Steinfeld JI.Atmospheric chemistry and physics:from air pollution to climate change[J].Environ:Sci Policy Sustain Dev,1998,40(7):26.
[15] World Health Organization.Household air pollution and health[EB/OL].(2018-05-08).http://www.who.int/mediacentre/factsheets/fs292/en/.
[16] Hammoud A,Carrell DM,Gibson M,et al.Decreased sperm motility is associated with air pollution in Salt Lake City[J].Fertil Steril,2010,93(6):1875-1879.
[17] Lao XQ,Zhang ZL,Lau AKH,et al.Exposure to ambient fine particulate matter and semen quality in Taiwan[J].Occup Environ Med,2018,75(2):148-154.
[18] Najafpour A,Aghaz F,Roshankhah S,et al.The effect of air dust pollution on semen quality and sperm parameters among infertile men in west of Iran[J].Aging Male,2018,doi:10.1080/13685538.2018.1482533.
[19] Mao H,Feng L,Yang WX.Environmental factors contributed to circannual rhythm of semen quality[J].Chronobiol Int,2017,34(3):411-425.
[20] Santi D,Magnani E,Michelangeli M,et al.Seasonal variation of semen parameters correlates with environmental temperature and air pollution:a big data analysis over 6 years[J].Environ Pollut,2018,235:806-813.
[21] Zhou NY,Jiang CT,Chen Q,et al.Exposures to atmospheric PM10 and PM10-2.5 affect male semen quality:results of MARHCS study[J].Environ Sci Technol,2018,52(3):1571-1584.
[22] 王笑臣,田晓佳,叶波,等.武汉市大气PM10暴露对精液质量的影响[J].中华预防医学杂志,2018,52(1):73-78.(In English:Wang XC,Tian XJ,Ye B,et al.The effect of ambient PM10 on sperm quality in Wuhan[J].Chin J Prev Med,2018,52(1):73-78.)
[23] Wu L,Jin L,Shi TM,et al.Association between ambient particulate matter exposure and semen quality in Wuhan,China[J].Environ Int,2017,98:219-228.
[24] Santi D,Vezzani S,Granata AR,et al.Sperm quality and environment:a retrospective,cohort study in a northern province of Italy[J].Environ Res,2016,150:144-153.
[25] Bosco L,Notari T,Ruvolo G,et al.Sperm DNA fragmentation:an early and reliable marker of air pollution[J].Environ Toxicol Pharmacol,2018,58:243-249.
[26] Hansen C,Luben TJ,Sacks JD,et al.The effect of ambient air pollution on sperm quality[J].Environ Health Perspect,2010,118(2):203-209.
[27] Liu YW,Zhou Y,Ma JX,et al.Inverse association between ambient sulfur dioxide exposure and semen quality in Wuhan,China[J].Environ Sci Technol,2017,51(21):12806-12814.
[28] Zhou NY,Cui ZH,Yang SM,et al.Air pollution and decreased semen quality:a comparative study of Chongqing urban and rural areas[J].Environ Pollut,2014,187:145-152.
[29] Radwan M,Jurewicz J,Polańska K,et al.Exposure to ambient air pollution-does it affect semen quality and the level of reproductive hormones?[J].Ann Hum Biol,2016,43(1):50-56.
[30] Farhat J,Farhat SCL,Braga ALF,et al.Ozone decreases sperm quality in systemic lupus erythematosus patients[J].Rev Bras Reumatol,2016,56(3):212-219.
[31] 田晓佳,王笑臣,叶波,等.武汉市臭氧暴露对男性精液质量的影响[J].中华预防医学杂志,2017,51(3):197-202.(In English:Tian XJ,Wang XC,Ye B,et al.The effects of exposure to ozone on sperm quality in Wuhan[J].Chin J Prev Med,2017,51(3):197-202.)
[32] Sokol RZ,Kraft P,Fowler IM,et al.Exposure to environmental ozone alters semen quality[J].Environ Health Perspect,2006,114(3):360-365.
[33] Lafuente R,García-Blàquez N,Jacquemin B,et al.Outdoor air pollution and sperm quality[J].Fertil Steril,2016,106(4):880-896.
[34] Boggia B,Carbone U,Farinaro E,et al.Effects of working posture and exposure to traffic pollutants on sperm quality[J].J Endocrinol Invest,2009,32(5):430-434.
[35] Jurewicz J,Radwan M,Sobala W,et al.The relationship between exposure to air pollution and sperm disomy[J].Environ Mol Mutagen,2015,56(1):50-59.
[36] Wijesekara GU,Fernando DMS,Wijerathna S,et al.Environmental and occupational exposures as a cause of male infertility:a caveat[J].Ceylon Med J,2015,60(2):52-56.
[37] Guven A,Kayikci A,Cam K,et al.Alterations in semen parameters of toll collectors working at motorways:does diesel exposure induce detrimental effects on semen?[J].Andrologia,2008,40(6):346-351.
[38] Calogero AE,La Vignera S,Condorelli RA,et al.Environmental car exhaust pollution damages human sperm chromatin and DNA[J].J Endocrinol Invest,2011,34(6):e139-e143.
[39] Selevan SG,Borkovec L,Slott VL,et al.Semen quality and reproductive health of young Czech men exposed to seasonal air pollution[J].Environ Health Perspect,2000,108(9):887-894.
[40] Rubes J,Selevan SG,Evenson DP,et al.Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality[J].Hum Reprod,2005,20(10):2776-2783.
[41] Xia YK,Han Y,Zhu PF,et al.Relation between urinary metabolites of polycyclic aromatic hydrocarbons and human semen quality[J].Environ Sci Technol,2009,43(12):4567-4573.
[42] Jurewicz J,Radwan M,Sobala W,et al.Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality[J].Int J Occup Med Environ Health,2013,26(5):790-801.
[43] Radwan M,Jurewicz J,Sobala W,et al.Human sperm aneuploidy after exposure to polycyclic aromatic hydrocarbons[J].Reprod,Fertil Dev,2016,28(9):1376-1381.
[44] Yang P,Wang YX,Chen YJ,et al.Urinary polycyclic aromatic hydrocarbon metabolites and human semen quality in China[J].Environ Sci Technol,2017,51(2):958-967.
[45] Han X,Zhou NY,Cui ZH,et al.Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage:a population study in Chongqing,China[J].Environ Health Perspect,2011,119(5):652-657.
[46] Gaspari L,Chang SS,Santella RM,et al.Polycyclic aromatic hydrocarbon-DNA adducts in human sperm as a marker of DNA damage and infertility[J].Mutat Res/Genet Toxicol Environ Mutagen,2003,535(2):155-160.
[47] De Rosa M,Zarrilli S,Paesano L,et al.Traffic pollutants affect fertility in men[J].Hum Reprod,2003,18(5):1055-1061.
[48] Zhu QX,Gao ES,Pathak N,et al.Single or double semen samples:the dilemma in epidemiological studies on semen quality[J].Hum Reprod,2016,31(3):511-517.
[49] Hsu PC,Chen IY,Pan CH,et al.Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers[J].Int Arch Occup Environ Health,2006,79(5):349-356.
[50] Deng ZB,Chen F,Zhang MX,et al.Association between air pollution and sperm quality:a systematic review and meta-analysis[J].Environ Pollut,2016,208:663-669.
[51] rám RJ,Binková B,R?ssner P,et al.Adverse reproductive outcomes from exposure to environmental mutagens[J].Mutat Res/Fundam Mol Mech Mutagen,1999,428(1-2):203-215.
[52] Yoshida S,Sagai M,Oshio S,et al.Exposure to diesel exhaust affects the male reproductive system of mice[J].Int J Androl,1999,22(5):307-315.