坤泰胶囊联合黄体酮胶囊治疗围绝经期综合征的疗效及对患者生活质量的影响
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摘要
目的:研究坤泰胶囊联合黄体酮胶囊治疗女性围绝经期综合征(MPS)的疗效及对患者生活质量的影响。方法:选取2016年1月—2017年1月我院收治的180例MPS患者,根据随机数字表法分为观察组和对照组,各90例,两组均给予戊酸雌二醇片(1 mg,qd)治疗,在此基础上观察组给予坤泰胶囊(2 g,tid)联合黄体酮胶囊(200 mg,qd)治疗,疗程为3个月。采用Kupperman评分和围绝经期生活质量量表(MENQOL)评定并比较两组治疗前后临床疗效及生活质量;比较两组治疗前后子宫内膜厚度变化情况。结果:观察组临床有效率为97.78%,高于对照组的84.44%,差异有统计学意义(P> 0.05);观察组临床症状评分明显低于对照组,差异有统计学意义(P <0.05);两组治疗后MENQOL量表各维度均明显降低,且观察组均低于对照组,差异有统计学意义(P <0.05);观察组子宫内膜厚度明显小于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较差异无统计学意义(P> 0.05)。结论:坤泰胶囊联合黄体酮胶囊治疗MPS的临床疗效显著,能有效提高患者生活质量,且安全性高。
Objective:To study the efficacy of kuntai capsules combined with progesterone capsules in the treatment of peri-menopausal syndrome(MPS) and their effect on patients' quality of life. Methods:180 patients with MPS admitted to our hospital from January 2016 to January 2017 were selected and randomly divided into an observation group and a control group, 90 cases each. The patients in the two groups were treated with estradiol valerate tablets(1 mg, qd). On the basis, the patients in the observation group were treated with kuntai capsules(2 g, tid) combined with progesterone capsules(200 mg, qd) for 3 months. The clinical efficacy and quality of life before and ofter treatment in the two groups were evaluated and compared by Kupperman scores and the menopause-specific quality of life questionnaire(MENQOL). The changes in endometrial thickness before and after treatment were compared between the two groups. Results:The clinical effective rate in the observation group was 97.78%, which was higher than 84.44% in the control group, and the difference was statistically signi?cant(P>0.05). The scores of clinical symptoms in the observation group were signi?cantly lower than those in the control group, and the difference was statistically signi?cant(P<0.05).After treatment, the MENQOL scales were significantly decreased in all dimensions, and the scales in the observation group were lower than those in the control group, with statistically signi?cant differences(P<0.05).The endometrial thickness in the observation group was significantly smaller than that in the control group,and the difference was statistically signi?cant(P<0.05). There was no statistically signi?cant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion:Kuntai capsules combined with progesterone capsules have significant clinical efficacy in the treatment of MPS, which can effectively improve the quality of life of the patients, and have high safety.
Objective:To study the efficacy of kuntai capsules combined with progesterone capsules in the treatment of peri-menopausal syndrome(MPS) and their effect on patients' quality of life. Methods:180 patients with MPS admitted to our hospital from January 2016 to January 2017 were selected and randomly divided into an observation group and a control group, 90 cases each. The patients in the two groups were treated with estradiol valerate tablets(1 mg, qd). On the basis, the patients in the observation group were treated with kuntai capsules(2 g, tid) combined with progesterone capsules(200 mg, qd) for 3 months. The clinical efficacy and quality of life before and ofter treatment in the two groups were evaluated and compared by Kupperman scores and the menopause-specific quality of life questionnaire(MENQOL). The changes in endometrial thickness before and after treatment were compared between the two groups. Results:The clinical effective rate in the observation group was 97.78%, which was higher than 84.44% in the control group, and the difference was statistically signi?cant(P>0.05). The scores of clinical symptoms in the observation group were signi?cantly lower than those in the control group, and the difference was statistically signi?cant(P<0.05).After treatment, the MENQOL scales were significantly decreased in all dimensions, and the scales in the observation group were lower than those in the control group, with statistically signi?cant differences(P<0.05).The endometrial thickness in the observation group was significantly smaller than that in the control group,and the difference was statistically signi?cant(P<0.05). There was no statistically signi?cant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion:Kuntai capsules combined with progesterone capsules have significant clinical efficacy in the treatment of MPS, which can effectively improve the quality of life of the patients, and have high safety.
引文
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[3]王新,王轶蓉.女性围绝经期综合征中医治疗[J].辽宁中医药大学学报,2016,18(11):107-109.
[4]林莺,许金榜,范怀玲,等.针刺关元穴不同得气状态对绝经综合征Kuppermann评分影响的临床研究[J].针灸临床杂志,2017,33(5):42-45.
[5]刘真,阮祥燕,孟开,等.激素替代治疗改善绝经期妇女生存质量的效果评价研究[J].中国药学杂志,2017,52(8):690-695.
[6]Fontvieille A,Dionne IJ,Riesco E.Long-term exercise training and soy isoflavones to improve quality of life and climacteric symptoms[J].Climacteric,2017,20(3):233-239.
[7]李文娟,许良智,刘宏伟,等.坤泰胶囊与激素替代疗法对绝经早期妇女认知功能及心理状态影响的随机对照临床研究[J].中西医结合学报,2010,8(4):321-327.
[8]Buhling KJ,Daniels BV,Studnitz FS,et al.The use of complementary and alternative medicine by women transitioning through menopause in Germany:results of a survey of women aged 45-60 years[J].Complement Ther Med,2014,22(1):94-98.
[9]徐文君,高慧,李杨,等.和颜坤泰胶囊对卵巢早衰大鼠性激素水平和VEGF、bFGF mRNA表达的影响[J].重庆医学,2017,46(6):738-741.
[10]陈继明,高红艳,李沁.坤泰胶囊治疗围绝经期综合征患者30例临床观察[J].中医杂志,2015,56(3):231-234.
[11]栾燕秋,杨欣,彭向丽,等.坤泰胶囊治疗围绝经期妇女症状的随机双盲双模拟平行临床试验[J].中国临床药理学杂志,2004,20(6):452-455.
[12]刘泽星,薛薇,邓燕,等.阴道给药与肌内注射黄体酮对子宫内膜孕激素水平影响的研究[J].实用妇产科杂志2017,33(3):220-222.
[13]周莹,冯凤芝,金滢,等.子宫内膜增生并发子宫内膜癌的高危因素及预后分析[J].实用妇产科杂志,2016,32(11):826-829.
[2]吴飞.围绝经期综合征[J].中国社区医师,2004,20(7):16-17.
[3]王新,王轶蓉.女性围绝经期综合征中医治疗[J].辽宁中医药大学学报,2016,18(11):107-109.
[4]林莺,许金榜,范怀玲,等.针刺关元穴不同得气状态对绝经综合征Kuppermann评分影响的临床研究[J].针灸临床杂志,2017,33(5):42-45.
[5]刘真,阮祥燕,孟开,等.激素替代治疗改善绝经期妇女生存质量的效果评价研究[J].中国药学杂志,2017,52(8):690-695.
[6]Fontvieille A,Dionne IJ,Riesco E.Long-term exercise training and soy isoflavones to improve quality of life and climacteric symptoms[J].Climacteric,2017,20(3):233-239.
[7]李文娟,许良智,刘宏伟,等.坤泰胶囊与激素替代疗法对绝经早期妇女认知功能及心理状态影响的随机对照临床研究[J].中西医结合学报,2010,8(4):321-327.
[8]Buhling KJ,Daniels BV,Studnitz FS,et al.The use of complementary and alternative medicine by women transitioning through menopause in Germany:results of a survey of women aged 45-60 years[J].Complement Ther Med,2014,22(1):94-98.
[9]徐文君,高慧,李杨,等.和颜坤泰胶囊对卵巢早衰大鼠性激素水平和VEGF、bFGF mRNA表达的影响[J].重庆医学,2017,46(6):738-741.
[10]陈继明,高红艳,李沁.坤泰胶囊治疗围绝经期综合征患者30例临床观察[J].中医杂志,2015,56(3):231-234.
[11]栾燕秋,杨欣,彭向丽,等.坤泰胶囊治疗围绝经期妇女症状的随机双盲双模拟平行临床试验[J].中国临床药理学杂志,2004,20(6):452-455.
[12]刘泽星,薛薇,邓燕,等.阴道给药与肌内注射黄体酮对子宫内膜孕激素水平影响的研究[J].实用妇产科杂志2017,33(3):220-222.
[13]周莹,冯凤芝,金滢,等.子宫内膜增生并发子宫内膜癌的高危因素及预后分析[J].实用妇产科杂志,2016,32(11):826-829.
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