麻醉药物与肿瘤转移
摘要
<正>肿瘤的发病率和死亡率仍居高不下,手术依然是实体肿瘤治疗的重要方法,然而绝大部分患者死于术后肿瘤的复发和转移。麻醉对肿瘤患者术后转移复发的关系尚存在争议~[1]。本文就近年来进行麻醉药物对肿瘤转移复发的影响等一系列研究作一综述。全身麻醉药对肿瘤转移的影响氟醚类吸入性麻醉药氟醚类吸入麻醉药能以时间依赖性的方式抑制癌细胞的增殖,并诱导这些细胞的晚期凋亡。但他们同时会对自然杀伤(NK)细胞和NK样细胞的细胞毒性有负面影响,如改变细胞因子
引文
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[15] Yoo S,Lee HB,Han W,et al.Total intravenous anesthesia versus inhalation anesthesia for breast cancer surgery:a retrospective cohort study.Anesthesiology ,2019,130(1):31-40.
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[19] Inada T,Kubo K,Kambara T,et al.Propofol inhibits cyclo-oxygenase activity in human monocytic THP-1 cells.Can J Anesth,2009,56(3):222-229.
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[25] Malsy M,Gebhardt K,Gruber M,et al.Effects of ketamine,s-ketamine,and MK 801 on proliferation,apoptosis,and necrosis in pancreatic cancer cells.BMC Anesthesiol,2015,15:111.
[26] D'Agostino G,Saporito A,Cecchinato V,et al.Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration.Br J Anaesth,2018,121(4):962-968.
[27] Zhou LW,Ding HL,Li MQ,et al.Effect of tramadol on perioperative immune function in patients undergoing gastric cancer surgeries.Anesth Essays Res,2015,7(1):54-57.
[28] Lucchinetti E,Awad AE,Rahman M,et al.Antiproliferative effects of local anesthetics on mesenchymal stemcells:potential implications for tumor spreading and wound healing.Anesthesiology,2012,116(4):841-856.
[29] Lirk P,Berger R,Hollmann MW,et al.Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro.Br J Anaesth,2012,109(2) :200-207.
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[31] 姬宁宁,夏明,花景煜,等.罗哌卡因对乳腺癌MDA-MB-231细胞生长、凋亡诱导和周期阻滞的影响.实用医学杂志,2017,33(21):3527-3530.
[32] Chamaraux-Tran TN,Piegeler T.The amide local anesthetic lidocaine in cancer surgery-potential antimetastatic effects and preservation of immune cell function?A narrative review.Front Med,2017,4:235.
[33] 许彦劼,夏明.非阿片类麻醉药与肿瘤转移的研究进展.医学研究生学报,2019,31(2):221-224.
[34] 夏明.吗啡与肿瘤转移:从实验室到临床//夏明,徐建国,段满林.吗啡与肿瘤转移—基础研究和临床试验.北京:人民卫生出版社,2017:1-3.
[2] Santamaria LB,Schifilliti D,La Torre D,et al.Drugs of anaesthesia and cancer.Surg Oncol,2010,19(2):63-81.
[3] Liang H,Gu MN,Yang CX,et al.Sevoflurane inhibits proliferation,induces apoptosis,and blocks cell cycle progression of lung carcinoma cells.Asian Pac J Cancer Prev,2011,12(12):3415-3420.
[4] Liang H,Gu M,Yang C,et al.Sevo?urane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway.J Anesth,2012,26(3):381-392.
[5] Liang H,Wang HB,Liu HZ,et al.The effects of combined treatment with sevoflurane and cisplatin on growth and invasion of human adenocarcinoma cell line A549.Biomed Pharmacother,2013,67(6):503-509.
[6] Müller-Edenborn B,Roth-Z'graggen B,Bartnicka K,et al.Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9.Anesthesiology,2012,117(2):293-301.
[7] Kawaraguchi Y,Horikawa YT,Murphy AN,et al.Volatile anesthetics protect cancer cells against tumor necrosis factor related apoptosis-inducing ligand-induced apoptosis via aveolins.Anesthesiology,2011,115(3):499-508.
[8] Pirbudak Cocelli L,Ugur MG,Karadasli H.Comparison of effects of low-flow sevoflurane and desflurane anesthesia on neutrophil and T-cell populations.Curr Ther Res Clin Exp,2012,73(1-2):41-51.
[9] Tavare AN,Perry NJ,Benzonana LL,et al.Cancer recurrence after surgery:direct and indirect effects of anesthetic agents.Int J Cancer,2012,130(6):1237-1250.
[10] Yuki K,Astrof NS,Bracken C,et al.Sevoflurane binds and allosterically blocks integrin lymphocyte functionassociated antigen-1.Anesthesiology,2010,113(3):600-609.
[11] Huitink JM,Heimerikxs M,Nieuwland M,et al.Volatile anesthetics modulate gene expression in breast and brain tumor cells.Anesth Analg,2010,111(6):1411-1415.
[12] Kawaraguchi Y,Horikawa YT,Murphy AN,et al.Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins.Anesthesiology,2011,115(3):499-508.
[13] Jun R,Gui-he Z,Xing-xing S,et al.Isoflurane enhances malignancy of head and neck squamous cell carcinoma cell lines:a preliminary study in vitro.Oral Oncol,2011,47(5):329-333.
[14] Schifilliti D,Mondello S,D'Arrigo MG,et al.Genotoxic effects of anesthetic agents:an update.Expert Opin Drug Saf,2011,10(6):891-899.
[15] Yoo S,Lee HB,Han W,et al.Total intravenous anesthesia versus inhalation anesthesia for breast cancer surgery:a retrospective cohort study.Anesthesiology ,2019,130(1):31-40.
[16] Du QH,Xu YB,Zhang MY,et al.Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κB activity.World J Gastroenterol,2013,19(33):5485-5492.
[17] Bajwa SJ,Anand S,Kaur G.Anesthesia and cancer recurrences:The current knowledge and evidence.J Cancer Res Ther,2015,11(3):528-534.
[18] Huang H,Benzonana LL,Zhao H,et al.Prostate Cancer cell malignancy via modulation of HIF-1α pathway with isoflurane and propofol alone and in combination.Br J Cancer,2014,111 (7):1338-1349.
[19] Inada T,Kubo K,Kambara T,et al.Propofol inhibits cyclo-oxygenase activity in human monocytic THP-1 cells.Can J Anesth,2009,56(3):222-229.
[20] Li R,Liu H,Dilger JP,et al.Effect of propofol on breast cancer cell,the immune system,and patient outcome.BMC Anesthesiology,2018,18(1):77.
[21] Melamed R,Bar-Yosef S,Shakhar G,et al.Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine,thiopental,and halothane,but not by propofol:mediating mechanisms and prophylactic measures.Anesth Analg,2003,97(5):1331-1339.
[22] Garib V,Lang K,Niggemann B,et al.Propofol-induced calcium signalling and actin reorganization within breast carcinoma cells.Eur J Anaesthesiol,2005,22(8):609-615.
[23] Forget P,Collet V,Lavand’homme P,et al.Does analgesia and condition influence immunity after surgery?Effects of fentanyl,ketamine and clonidine on natural killer activity at different ages.Eur J Anaesthesiol,2010,27(3):233-240.
[24] Ohta N,Ohashi Y,Fujino Y.Ketamine inhibits maturation of bone marrow-derived dendritic cells and priming of the Th1-type immune response.Anesth Analg,2009,109(3):793-800.
[25] Malsy M,Gebhardt K,Gruber M,et al.Effects of ketamine,s-ketamine,and MK 801 on proliferation,apoptosis,and necrosis in pancreatic cancer cells.BMC Anesthesiol,2015,15:111.
[26] D'Agostino G,Saporito A,Cecchinato V,et al.Lidocaine inhibits cytoskeletal remodelling and human breast cancer cell migration.Br J Anaesth,2018,121(4):962-968.
[27] Zhou LW,Ding HL,Li MQ,et al.Effect of tramadol on perioperative immune function in patients undergoing gastric cancer surgeries.Anesth Essays Res,2015,7(1):54-57.
[28] Lucchinetti E,Awad AE,Rahman M,et al.Antiproliferative effects of local anesthetics on mesenchymal stemcells:potential implications for tumor spreading and wound healing.Anesthesiology,2012,116(4):841-856.
[29] Lirk P,Berger R,Hollmann MW,et al.Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro.Br J Anaesth,2012,109(2) :200-207.
[30] 夏明,王少华,童建华,等.不同浓度罗哌卡因对乳腺癌MCF-7细胞增殖和细胞周期的作用研究.临床麻醉学杂志,2016,32(7):680-683.
[31] 姬宁宁,夏明,花景煜,等.罗哌卡因对乳腺癌MDA-MB-231细胞生长、凋亡诱导和周期阻滞的影响.实用医学杂志,2017,33(21):3527-3530.
[32] Chamaraux-Tran TN,Piegeler T.The amide local anesthetic lidocaine in cancer surgery-potential antimetastatic effects and preservation of immune cell function?A narrative review.Front Med,2017,4:235.
[33] 许彦劼,夏明.非阿片类麻醉药与肿瘤转移的研究进展.医学研究生学报,2019,31(2):221-224.
[34] 夏明.吗啡与肿瘤转移:从实验室到临床//夏明,徐建国,段满林.吗啡与肿瘤转移—基础研究和临床试验.北京:人民卫生出版社,2017:1-3.