穴位注射联合丹红注射液治疗对脊髓型颈椎病患者神经功能与生活质量的影响
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摘要
目的:分析穴位注射联合丹红注射液治疗对脊髓型颈椎病患者神经功能与生活质量的影响.方法:选取2014-01/2016-05河北省中医院骨伤一科收治的96例脊髓型颈椎病患者作为研究对象,将其随机分为对照组(n=48)和观察组(n=48).对照组患者在脊髓型颈椎病常规基础治疗上予以丹红注射液治疗,观察组患者在对照组基础上联合穴位注射治疗.治疗结束后比较两组患者的神经功能评分、生活质量、临床疗效及治疗过程中不良反应的发生情况.结果:两组患者治疗后JOA评分和40分法评分均较治疗前升高,且观察组升高程度更为明显,差异具有统计学意义(P<0.05);治疗后观察组患者生活总质量评分高于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(6.25%vs 10.42%),且均无严重不良反应发生.结论:穴位注射联合丹红注射液可较好地恢复脊髓型颈椎病患者的神经功能,提高其生活质量,且在治疗过程中无明显严重不良反应,可作为临床治疗脊髓型颈椎病的有效治疗方案.
AIM: To investigate the effect of point injection combined with Dan Hong Injection on the neurological function and life quality of patients with cervical spondylosis myelopathy.METHODS: A total of 96 cases of cervical spondylotic myelopathy admitted into Hebei Provincial Hospital of Traditional Chinese Medicine from January 2014 to May 2016 were selected and randomly divided into control group and observation group with 48 cases in each group. The patients in control group were treated by Danhong injection treatment based on cervical spondylotic myelopathy routine treatment. The patients in observation group were treated by point injection based on control group therapy. The neurological function score,quality of life,clinical effect and adverse reaction were observed and compared between two groups.RESULTS: The JOA score and 40 points score were higher than those before treatment in two groups and increased degree in the observation group was more obvious with statistically significant differences( P<0.05); After treatment,the total life quality score in the observation group was higher than that of the control group,with a statistically significant difference( P<0.05); The incidence of adverse reactions had no significant difference between the two groups( 6. 25% vs 10. 42%),and there were no serious adverse reactions. CONCLUSION: The neurological function and life quality of patients with cervical spondylotic myelopathy can be improved by point injection combined with Danhong injection. No obvious adverse reactions happen in the course of treatment. The therapy can be used as the effective treatment for patients with cervical spondylotic myelopathy.
AIM: To investigate the effect of point injection combined with Dan Hong Injection on the neurological function and life quality of patients with cervical spondylosis myelopathy.METHODS: A total of 96 cases of cervical spondylotic myelopathy admitted into Hebei Provincial Hospital of Traditional Chinese Medicine from January 2014 to May 2016 were selected and randomly divided into control group and observation group with 48 cases in each group. The patients in control group were treated by Danhong injection treatment based on cervical spondylotic myelopathy routine treatment. The patients in observation group were treated by point injection based on control group therapy. The neurological function score,quality of life,clinical effect and adverse reaction were observed and compared between two groups.RESULTS: The JOA score and 40 points score were higher than those before treatment in two groups and increased degree in the observation group was more obvious with statistically significant differences( P<0.05); After treatment,the total life quality score in the observation group was higher than that of the control group,with a statistically significant difference( P<0.05); The incidence of adverse reactions had no significant difference between the two groups( 6. 25% vs 10. 42%),and there were no serious adverse reactions. CONCLUSION: The neurological function and life quality of patients with cervical spondylotic myelopathy can be improved by point injection combined with Danhong injection. No obvious adverse reactions happen in the course of treatment. The therapy can be used as the effective treatment for patients with cervical spondylotic myelopathy.
引文
[1]Karadimas SK,Gatzounis G,Fehlings MG.Pathobiology of cervical spondylotic myelopathy[J].Eur Spine J,2015,24 Suppl 2:132-138.
[2]张一龙,陈仲强,孙宇,等.脊髓型颈椎病患者术后神经功能与生活质量的变化及其之间的相关性分析[J].中国脊柱脊髓杂志,2016,26(9):782-790.
[3]查华英.自拟足浴方、穴位按压联合丹红注射液治疗老年糖尿病性周围神经病变疗效观察[J].中国地方病防治杂志,2014(S1):101.
[4]马进,余能伟,武航海,等.丹红注射液对急性缺血性脑卒中患者神经功能及血液流变学的影响[J].中国实验方剂学杂志,2015,20(20):204-207.
[5]李玉伟,王海蛟,王义生,等.不同脊髓前方致压因素对后路手术治疗脊髓型颈椎病疗效的影响[J].中国修复重建外科杂志,2015,28(9):1099-1103.
[6]Wang Y,Gao LN,Cui YL,et al.Protective effect of danhong injection on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice[J].Evid Based Complement Alternat Med,2014:153902.
[7]马慧.丹红注射液联合依达拉奉在脑梗死患者神经功能恢复中的临床研究[J].中药药理与临床,2015,30(4):284-286.
[8]陈士萍,王凯.丹红注射液对心力衰竭患者脑钠肽及心功能的影响[J].辽宁中医杂志,2016,58(9):1896-1897.
[9]史栋梁,史桂荣,孟庆良,等.中药内服联合穴位注射治疗神经根型颈椎病临床研究[J].中国中医基础医学杂志,2014,19(4):522-524.
[10]汪智文,姜为民,张宗余,等.椎间桥形固定颈部融合器与传统融合器联合钛板治疗脊髓型颈椎病的临床疗效比较[J].中华外科杂志,2014,52(6):425-430.
[11]仲伟涛,匡正达,叶启彬,等.颈椎后路单开门leverage钛板固定术治疗多节段脊髓型颈椎病的疗效研究[J].军事医学,2016,40(7):579-582.
[12]Boogaarts HD,Bartels RH.Prevalence of cervical spondylotic myelopathy[J].Eur Spine J,2015,24 Suppl 2:139-141.
[13]Zhao L,Wu Z.Effect of combination of acetyl cysteine and Dan Hong Injection on pulmonary function and serum levels of TNF-αand TGF-β1 in patients with TPF[J].海南医科大学学报:英文版,2016,22(23):20-23.
[14]王华仁,陈少文,杨焱鑫,等.两种颈前路术式治疗老年患者双节段脊髓型颈椎病的疗效比较[J].中国老年学杂志,2016,36(22):5668-5670.
[15]宗雅琪,雪原,赵莹,等.抑郁对脊髓型颈椎病后路减压手术预后的不良影响[J].中华骨科杂志,2015,35(8):854-858.
[2]张一龙,陈仲强,孙宇,等.脊髓型颈椎病患者术后神经功能与生活质量的变化及其之间的相关性分析[J].中国脊柱脊髓杂志,2016,26(9):782-790.
[3]查华英.自拟足浴方、穴位按压联合丹红注射液治疗老年糖尿病性周围神经病变疗效观察[J].中国地方病防治杂志,2014(S1):101.
[4]马进,余能伟,武航海,等.丹红注射液对急性缺血性脑卒中患者神经功能及血液流变学的影响[J].中国实验方剂学杂志,2015,20(20):204-207.
[5]李玉伟,王海蛟,王义生,等.不同脊髓前方致压因素对后路手术治疗脊髓型颈椎病疗效的影响[J].中国修复重建外科杂志,2015,28(9):1099-1103.
[6]Wang Y,Gao LN,Cui YL,et al.Protective effect of danhong injection on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice[J].Evid Based Complement Alternat Med,2014:153902.
[7]马慧.丹红注射液联合依达拉奉在脑梗死患者神经功能恢复中的临床研究[J].中药药理与临床,2015,30(4):284-286.
[8]陈士萍,王凯.丹红注射液对心力衰竭患者脑钠肽及心功能的影响[J].辽宁中医杂志,2016,58(9):1896-1897.
[9]史栋梁,史桂荣,孟庆良,等.中药内服联合穴位注射治疗神经根型颈椎病临床研究[J].中国中医基础医学杂志,2014,19(4):522-524.
[10]汪智文,姜为民,张宗余,等.椎间桥形固定颈部融合器与传统融合器联合钛板治疗脊髓型颈椎病的临床疗效比较[J].中华外科杂志,2014,52(6):425-430.
[11]仲伟涛,匡正达,叶启彬,等.颈椎后路单开门leverage钛板固定术治疗多节段脊髓型颈椎病的疗效研究[J].军事医学,2016,40(7):579-582.
[12]Boogaarts HD,Bartels RH.Prevalence of cervical spondylotic myelopathy[J].Eur Spine J,2015,24 Suppl 2:139-141.
[13]Zhao L,Wu Z.Effect of combination of acetyl cysteine and Dan Hong Injection on pulmonary function and serum levels of TNF-αand TGF-β1 in patients with TPF[J].海南医科大学学报:英文版,2016,22(23):20-23.
[14]王华仁,陈少文,杨焱鑫,等.两种颈前路术式治疗老年患者双节段脊髓型颈椎病的疗效比较[J].中国老年学杂志,2016,36(22):5668-5670.
[15]宗雅琪,雪原,赵莹,等.抑郁对脊髓型颈椎病后路减压手术预后的不良影响[J].中华骨科杂志,2015,35(8):854-858.