中药对心肌细胞钠离子通道的研究进展
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摘要
<正>离子通道在细胞的电活动过程中处于基础地位:既控制静息膜电位、动作电位和其他电信号的形成,还负责离子穿过分泌细胞和上皮细胞、调节细胞体积[1],在一定程度上决定机体能否正常运转。心肌细胞通过各离子通道调节跨膜离子的电位差来保持心脏的功能状态,一旦其形态、结构、泵和交换体的活动及细胞间耦联状态出现异常,易诱发各种心脏疾病,心律失常是其最常见的表现形式。分布于心肌细胞膜上的主要载体电流有:I N a,
引文
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[7]许正新,郑雪,朱磊.蛇床子素对大鼠心室肌细胞钠通道的影响[J].实用临床医药杂志,2016,20(7):1-5.
[8]袁春华,李树基,孙丽荣.蛇床子素对乳鼠心肌细胞钠通道的影响[J].数理医药学杂志,2011,24(3):286-9.
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[10]Peng L,Sun S,Xie LH,et al. Ginsenoside Re:pharmacological effects on cardiovascular system[J]. Cardiovascular Therapeutics,2012,30(4):e183-e188.
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[16]吕吉元,曹静,张明升,等.橙皮素对异丙基肾上腺素诱导大鼠心衰的保护作用[J].中西医结合心脑血管病杂志,2017,15(18):2241-4.
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[22]Liu M,Li S,Zhao S,et al. Studies on excretion kinetics of ten constituents in rat urine after oral administration of Shensong Yangxin Capsule by UPLC-MS/MS[J]. Biomedical Chromatography,2014,28(4):525-33.
[23]浦介麟,李宁,霍有平,等.通络药物对心肌细胞钠钙离子通道的影响[J].中华医学杂志,2007,87(14):995-8.
[24]Zhao Y,Gao F,Zhang Y,et al. Shensong Yangxin capsules prevent ischemic arrhythmias by prolonging action potentials and alleviating Ca2+overload[J]. Molecular Medicine Reports,2016,13(6):5185-92.
[25]Fan X,Wang C,Wang N,et al. Atrial-selective block of sodium channels by acehytisine in rabbit myocardium[J]. Journal of Pharmacological Sciences,2016,132(4).
[26]杨萌萌.盐酸关附甲素抗心律失常研究进展[J].心血管病学进展,2013,34(5):660-3.
[27]杨艳敏,浦介麟,丽英,等.盐酸关附甲素对豚鼠心室肌细胞膜钠通道的阻断作用[J].中华心律失常学杂志,2007,11(1):47-52.
[28]Jin SS,Guo Q,Xu J,et al. Antiarrhythmic ionic mechanism of Guanfu base A--Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs[J]. Chinese Journal of Natural Medicines,2015,13(5):361-7.
[29]侯月梅,欧阳松.晚钠电流阻滞剂与心律失常治疗[J].临床心血管病杂志,2016(9):873-7.
[30]郭继鸿.稳心颗粒:国际研究最新进展[J].临床心电学杂志,2015,24(1):51-64.
[31]Burashnikov A,Petroski A,Hu D,et al. Atrial-selective Inhibition of Sodium Channel Current by Wenxin Keli is Effective in Suppressing Atrial Fibrillation[J]. Heart Rhythm,2012,9(1):125-31.
[32] Xue X,Guo D,Sun H,et al. Wenxin Keli Suppresses Ventricular Triggered Arrhythmias via Selective Inhibition of Late Sodium Current[C]//2014中国医师协会中西医结合医师大会论文摘要集.2014:732-40.
[33]Hou JW,Li W,Guo K,et al. Antiarrhythmic Effects and Potential Mechanism of WenXin KeLi in Cardiac Purkinje Cells[J]. Heart Rhyth m,2015,13(4):973-82.
[34]徐惠梅,姜小刚,张文杰,等.安律胶囊对豚鼠心室肌细胞钠离子通道的影响[J].中华中医药杂志,2010(3):439-41.
[2]蒋卫民,唐蜀华.多离子通道阻断的抗心律失常中药研究探讨[J].中国中西医结合杂志,2011,31(6):858-60.
[3]Catterall WA. Voltage-gated sodium channels at 60:structure, function and pathophysiology[J]. Journal of Physiology,2012,590(Pt 11):2577.
[4]Chenizu Y,Shaw RM,Pitt GS,et al. Na+channel function,regulation,stru cture,trafficking and sequestration[J]. Journal of Physiology,2015,593(6):1347.
[5]Callahan T,Baranowski B. Managing newly diagnosed atrial fibrillation:rate, rhythm,and risk[J]. Cleveland Clinic Journal of Medicine,2011,78(4):258.
[6]Wang XY,Dong WP,Bi SH,et al. Protective effects of osthole against myocardial ischemia/reperfusion injury in rats[J]. International Journal of Molecular Medicine,2013,32(2):365.
[7]许正新,郑雪,朱磊.蛇床子素对大鼠心室肌细胞钠通道的影响[J].实用临床医药杂志,2016,20(7):1-5.
[8]袁春华,李树基,孙丽荣.蛇床子素对乳鼠心肌细胞钠通道的影响[J].数理医药学杂志,2011,24(3):286-9.
[9]Ahern CA,Eastwood AL,Dougherty DA,et al. New insights into the therapeutic inhibition of voltage-gated sodium channels[J].Channels,2008,2(1):1-3.
[10]Peng L,Sun S,Xie LH,et al. Ginsenoside Re:pharmacological effects on cardiovascular system[J]. Cardiovascular Therapeutics,2012,30(4):e183-e188.
[11]刘建勋,孟红旭,姚明江.人参皂苷Re对大鼠心室肌细胞钠、钾离子通道的影响[J].世界中医药,2013,8(10):1147-9.
[12]Zhu L,Wei T,Gao J,et al. The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation[J]. Apoptosis,2015,20(11):1433-43.
[13]李映新,黄媛恒,谢剑.红景天苷体外灌流对大鼠心肌细胞膜钠通道电流的影响[J].山东医药,2016(7),31-3.
[14]徐锦文,王淑荣,凌霜,等.薯蓣皂苷现代药理学研究进展[J].中国药理学通报,2017,33(2):161-6.
[15]娄建石,刘静,吴红,等.薯蓣皂苷含药血清对大鼠心室肌细胞钠离子通道的影响[J].中草药,2014,45(16):2370-4.
[16]吕吉元,曹静,张明升,等.橙皮素对异丙基肾上腺素诱导大鼠心衰的保护作用[J].中西医结合心脑血管病杂志,2017,15(18):2241-4.
[17] Wang H,Wang HF,Zhang H,et al. Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes[J].中国药理学报,2016,37(12):1563-73.
[18]吴红金,杨继媛,吴德琳.甘草次酸对大鼠心室肌细胞钠离子通道电流的影响[J].中国中西医结合杂志,2012,32(7):944-7.
[19]Du Y,Zhang S,Wu H,et al. Glycyrretinic acid blocks cardiac sodium channels expressed in Xenopus, oocytes[J]. Journal of Ethnopharmacology,2009,125(2):318-23.
[20]Jiang XG,Jia JM,Ye-Shuang LI. Simultaneous Determination of Eight Bioactive Constituents in Shensong Yangxin Capsule by UPLC[J].Chinese Herbal Medicines,2013,5(3):212-6.
[21]Liu M,Zhao S,Wang Y,et al. Identification of Multiple Constituents in Chinese Medicinal Prescription Shensong Yangxin Capsule by UltraFast Liquid Chromatography Combined with Quadrupole Time-ofFlight Mass Spectrometry[J]. Journal of Chromatographic Science,2015,53(2):240-52.
[22]Liu M,Li S,Zhao S,et al. Studies on excretion kinetics of ten constituents in rat urine after oral administration of Shensong Yangxin Capsule by UPLC-MS/MS[J]. Biomedical Chromatography,2014,28(4):525-33.
[23]浦介麟,李宁,霍有平,等.通络药物对心肌细胞钠钙离子通道的影响[J].中华医学杂志,2007,87(14):995-8.
[24]Zhao Y,Gao F,Zhang Y,et al. Shensong Yangxin capsules prevent ischemic arrhythmias by prolonging action potentials and alleviating Ca2+overload[J]. Molecular Medicine Reports,2016,13(6):5185-92.
[25]Fan X,Wang C,Wang N,et al. Atrial-selective block of sodium channels by acehytisine in rabbit myocardium[J]. Journal of Pharmacological Sciences,2016,132(4).
[26]杨萌萌.盐酸关附甲素抗心律失常研究进展[J].心血管病学进展,2013,34(5):660-3.
[27]杨艳敏,浦介麟,丽英,等.盐酸关附甲素对豚鼠心室肌细胞膜钠通道的阻断作用[J].中华心律失常学杂志,2007,11(1):47-52.
[28]Jin SS,Guo Q,Xu J,et al. Antiarrhythmic ionic mechanism of Guanfu base A--Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs[J]. Chinese Journal of Natural Medicines,2015,13(5):361-7.
[29]侯月梅,欧阳松.晚钠电流阻滞剂与心律失常治疗[J].临床心血管病杂志,2016(9):873-7.
[30]郭继鸿.稳心颗粒:国际研究最新进展[J].临床心电学杂志,2015,24(1):51-64.
[31]Burashnikov A,Petroski A,Hu D,et al. Atrial-selective Inhibition of Sodium Channel Current by Wenxin Keli is Effective in Suppressing Atrial Fibrillation[J]. Heart Rhythm,2012,9(1):125-31.
[32] Xue X,Guo D,Sun H,et al. Wenxin Keli Suppresses Ventricular Triggered Arrhythmias via Selective Inhibition of Late Sodium Current[C]//2014中国医师协会中西医结合医师大会论文摘要集.2014:732-40.
[33]Hou JW,Li W,Guo K,et al. Antiarrhythmic Effects and Potential Mechanism of WenXin KeLi in Cardiac Purkinje Cells[J]. Heart Rhyth m,2015,13(4):973-82.
[34]徐惠梅,姜小刚,张文杰,等.安律胶囊对豚鼠心室肌细胞钠离子通道的影响[J].中华中医药杂志,2010(3):439-41.