依达拉奉联合丁苯酞治疗急性脑梗死的效果
|
摘要
目的分析依达拉奉联合丁苯酞治疗急性脑梗死(ACI)的效果。方法选择本院收治的100例ACI患者为研究对象,根据患者入院先后顺序将其分成A组和B组,各50例。A组给予依达拉奉+丁苯酞治疗,B组给予丁苯酞单纯治疗。对比两组的临床疗效、治疗前后神经功能缺损程度、日常生活能力及血清因子水平。结果 A组的治疗总有效率显著高于B组(P<0.05)。治疗后,两组患者的NIHSS评分均降低,Barthel指数评分均升高,且A组优于B组(P<0.05)。治疗后,两组血清SOD水平均升高,MDA与CRP水平均降低,且A组优于B组(P<0.05)。结论为ACI患者行依达拉奉联合丁苯酞治疗可改善患者的脂质过氧化程度,降低其神经功能缺损程度,提高其生活能力,疗效良好。
Objective To analyze the effect of edaravone combined with butylphthalide on acute cerebral infarction(ACI). Methods One hundred ACI patients admitted in our hospital were selected as the research objects and divided into group A and group B according to the order of admission, with 50 cases in each group. The group A was treated with edaravone +butylphthalide, while the group B was treated with butylphthalide alone. The clinical efficacy, degree of neurological impairment, daily living ability and serum factor levels before and after treatment were compared between the two groups. Results The total effective rate of treatment in the group A was significantly higher than that in the group B(P<0.05). After treatment, the NIHSS scores of both groups decreased and Barthel index scores increased, and those of the group A were better than the group B(P<0.05). After treatment, the levels of serum SOD increased and the levels of MDA and CRP in both groups decreased, and those of the group A were better than the group B(P<0.05). Conclusion Edaravone combined with butylphthalide can improve the degree of lipid peroxidation, reduce the degree of neurological impairment and raise the viability in ACI patients, with good curative effect.
Objective To analyze the effect of edaravone combined with butylphthalide on acute cerebral infarction(ACI). Methods One hundred ACI patients admitted in our hospital were selected as the research objects and divided into group A and group B according to the order of admission, with 50 cases in each group. The group A was treated with edaravone +butylphthalide, while the group B was treated with butylphthalide alone. The clinical efficacy, degree of neurological impairment, daily living ability and serum factor levels before and after treatment were compared between the two groups. Results The total effective rate of treatment in the group A was significantly higher than that in the group B(P<0.05). After treatment, the NIHSS scores of both groups decreased and Barthel index scores increased, and those of the group A were better than the group B(P<0.05). After treatment, the levels of serum SOD increased and the levels of MDA and CRP in both groups decreased, and those of the group A were better than the group B(P<0.05). Conclusion Edaravone combined with butylphthalide can improve the degree of lipid peroxidation, reduce the degree of neurological impairment and raise the viability in ACI patients, with good curative effect.
引文
[1]李英华.丁苯酞氯化钠注射液联合依达拉奉治疗急性脑梗死的效果及安全性[J].国际医药卫生导报,2018,24(5):723-725.
[2]刘玉梅.丹红注射液治疗急性脑梗死的临床疗效和安全性观察[D].济南:山东大学,2014.
[3]王献胜,王伟,刘凤兰,等.依达拉奉联合丁苯酞对急性脑梗死患者的影响研究[J].实用心脑肺血管病杂志,2018,26(3):109-111.
[4]王绪飞,周井铎.研究依达拉奉与丁苯酞联合治疗急性脑梗死的疗效[J].中国继续医学教育,2018,10(1):106-107.
[5]刘西银,卜祎.依达拉奉联合丁苯酞氯化钠注射液治疗急性脑梗死疗效观察[J].中国保健营养,2017,27(33):28-29.
[6]王苗,邵丽,鲍俊杰,等.丁苯酞注射液联合依达拉奉治疗急性脑梗死的效果评价[J].中国继续医学教育,2017,9(33):95-96.
[7]秦向斐.丁苯酞注射液联合依达拉奉治疗急性脑梗死的临床疗效和安全性研究[J].北方药学,2018,15(6):150.
[8]高琦,黄玉雕,张忠波,等.丁苯酞注射液联合依达拉奉治疗急性脑梗死的疗效观察[J].中国实用医药,2017,12(21):129-130.
[2]刘玉梅.丹红注射液治疗急性脑梗死的临床疗效和安全性观察[D].济南:山东大学,2014.
[3]王献胜,王伟,刘凤兰,等.依达拉奉联合丁苯酞对急性脑梗死患者的影响研究[J].实用心脑肺血管病杂志,2018,26(3):109-111.
[4]王绪飞,周井铎.研究依达拉奉与丁苯酞联合治疗急性脑梗死的疗效[J].中国继续医学教育,2018,10(1):106-107.
[5]刘西银,卜祎.依达拉奉联合丁苯酞氯化钠注射液治疗急性脑梗死疗效观察[J].中国保健营养,2017,27(33):28-29.
[6]王苗,邵丽,鲍俊杰,等.丁苯酞注射液联合依达拉奉治疗急性脑梗死的效果评价[J].中国继续医学教育,2017,9(33):95-96.
[7]秦向斐.丁苯酞注射液联合依达拉奉治疗急性脑梗死的临床疗效和安全性研究[J].北方药学,2018,15(6):150.
[8]高琦,黄玉雕,张忠波,等.丁苯酞注射液联合依达拉奉治疗急性脑梗死的疗效观察[J].中国实用医药,2017,12(21):129-130.