慢性阻塞性肺疾病急性加重与急性心肌梗死关系的研究进展
|
摘要
慢性阻塞性肺疾病和冠心病均是严重危害人类健康的常见病、多发病,二者病死率均较高。近期研究表明,慢性阻塞性肺疾病急性加重患者急性心肌梗死发生风险明显升高。本文主要综述了慢性阻塞性肺疾病并急性心肌梗死的流行病学、慢性阻塞性肺疾病急性加重引发急性心肌梗死的可能机制及其诊断、治疗等,以探讨慢性阻塞性肺疾病急性加重与急性心肌梗死的关系,提高临床慢性阻塞性肺疾病急性加重并急性心肌梗死的认识及诊治水平。
Both chronic obstructive pulmonary disease(COPD)and coronary heart disease(CHD)are common and frequently-occurring diseases that seriously endangering human health,moreover fatality rates of both COPD and CHD are relatively high. Recent studies have shown that,risk of acute myocardial infarction(AMI)significantly increases in patients with acute exacerbation of COPD. This paper mainly reviewed the epidemiology,possible mechanism,diagnosis and treatment of AMI in patients with acute exacerbation of COPD,to investigate the relationship between acute exacerbation of COPD and AMI,in order to improve the clinical acquaintance,diagnostic and therapeutic level of AMI in patients with acute exacerbation of COPD.
Both chronic obstructive pulmonary disease(COPD)and coronary heart disease(CHD)are common and frequently-occurring diseases that seriously endangering human health,moreover fatality rates of both COPD and CHD are relatively high. Recent studies have shown that,risk of acute myocardial infarction(AMI)significantly increases in patients with acute exacerbation of COPD. This paper mainly reviewed the epidemiology,possible mechanism,diagnosis and treatment of AMI in patients with acute exacerbation of COPD,to investigate the relationship between acute exacerbation of COPD and AMI,in order to improve the clinical acquaintance,diagnostic and therapeutic level of AMI in patients with acute exacerbation of COPD.
引文
[1]中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中国医学前沿杂志(电子版),2014,6(2):67-80.
[2]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2015,43(5):380-393.DOI:10.3760/cma.j.issn.0253-3758.2015.05.003.
[3]ROTHNIE K J,YAN R,SMEETH L,et al.Risk of myocardial infarction(MI)and death following MI in people with chronic obstructive pulmonary disease(COPD):a systematic review and meta-analysis[J].BMJ Open,2014,5(9):e007824.DOI:10.1136/bmjopen-2015-007824.
[4]黄若刚,段佳丽,焦淑芳,等.《2017年度卫生与人群健康状况报告》概述[J].首都公共卫生,2018,12(6):279-281.
[5]苏懿,王磊,张敏州.急性心肌梗死的流行病学研究进展[J].中西医结合心脑血管病杂志,2012,10(4):467-469.DOI:10.3969/j.issn.1672-1349.2012.04.045.
[6]MCALLISTER D A,MACLAY J D,MILLS N L,et al.Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD[J].Eur Respir J,2012,39(5):1097-1103.DOI:10.1183/09031936.00124811.
[7]肖建,杜春玲.慢性阻塞性肺疾病病因及发病机制研究进展[J].中国老年学杂志,2014,34(11):3191-3194.DOI:10.3969/j.issn.1005-9202.2014.11.142.
[8]王嘉慧,刘雪飞,韩秀.吸烟在冠心病发生发展中的作用机制研究进展[J].大连医科大学学报,2016,38(3):293-297.DOI:10.11724/jdmu.2016.03.20.
[9]DUONG M,ISLAM S,RANGARAJAN S,et al.Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1(PURE):an international,community-based cohort study[J].Lancet Glob health,2019,7(5):e613-e623.
[10]慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组.慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(草案)[J].国际呼吸杂志,2012,32(22):1681-1691.DOI:10.3760/cma.j.issn.1673-436X.2012.022.001.
[11]WEDZICHA J A,SEEMUNGAL T A,MACCALLUM P K,et al.Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6levels[J].Thromb Haemost,2000,84(2):210-215.
[12]MORGAN A D,ZAKERI R,QUINT J K.Defining the relationship between COPD and CVD:what are the implications for clinical practice?[J].Ther Adv Respir Dis,2018,12:175346581775052.DOI:10.1177/1753465817750524.
[13]RIDKER P M.Role of inflammatory biomarkers in prediction of coronary heart disease[J].Lancet,2001,358(9286):946-948.DOI:10.1016/S0140-6736(01)06112-8.
[14]张运,张澄,张猛.动脉粥样硬化抗炎治疗的新时代[J].中华心血管病杂志,2018,46(5):332-337.DOI:10.3760/cma.j.issn.0253-3758.2018.05.002.
[15]黄元铸.心率与冠心病关系的研究进展[J].中华心血管病杂志,2006,34(6):574-576.DOI:10.3760/j:issn:0253-3758.2006.06.033.
[16]MACLAY J D,MCALLISTER D A,JOHNSTON S,et al.Increased platelet activation in patients with stable and acute exacerbation of COPD[J].Thorax,2011,66(9):769-774.DOI:10.1136/thx.2010.157529.
[17]PATEL A R,KOWLESSAR B S,DONALDSON G C,et al.Cardiovascular risk,myocardial injury,and exacerbations of chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2013,188(9):1091-1099.DOI:10.1164/rccm.201306-1170OC.
[18]RANJITH R,BINU T G,GEORGE V,et al.Aortic pulse wave velocity and its relationship with complexity of coronary artery disease based on SYNTAX score[J].Heart Asia,2014,6(1):109-115.DOI:10.1136/heartasia-2013-010492.
[19]ROTHNIE K J,CONNELL O,MüLLEROVáH,et al.Myocardial Infarction and Ischemic Stroke Following Exacerbations of Chronic Obstructive Pulmonary Disease[J].Ann Am Thorac Soc,2018,15(8):935-946.DOI:10.1513/AnnalsATS.201710-815OC.
[20]WANG W Q,HUANG H L,ZHU S,et al.High-Sensitivity Cardiac Troponin T in Patients with Acute Myocardial Infarction in Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Clin Lab,2015,61(8):1083-1093.
[21]PAVASINI R,BISCAGLIA S,D'ASCENZO F,et al.Antiplatelet Treatment Reduces All-Cause Mortality in COPD Patients:ASystematic Review and Meta-Analysis[J].COPD,2016,13(4):509-514.DOI:10.3109/15412555.2015.1099620.
[22]SCHWAMEIS R,PILS S,WEBER M,et al.Acetylic Salicylic Acid for the Treatment of Chronic Obstructive Pulmonary Disease:A Randomized,Double-Blind,Placebo-Controlled Trial[J].Pharmacology,2016,98(1/2):93-98.DOI:10.1159/000446349.
[23]STANBROOK M B.Review:cardioselective beta-blockers did not reduce respiratory function in chronic obstructive pulmonary disease[J].ACP J Club,2002,137(3):104.
[24]XIA N,WANG H,NIE X.Inhaled Long-Actingβ2-Agonists Do Not Increase Fatal Cardiovascular Adverse Events in COPD:A Meta-Analysis[J].PLoS One,2015,10(9):e0137904.DOI:10.1371/journal.pone.0137904.
[25]MORTENSEN E M,COPELAND L A,PUGH M J,et al.Impact of statins and ACE inhibitors on mortality after COPD exacerbations[J].Respir Res,2009,10(1):45.DOI:10.1186/1465-9921-10-45.
[2]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2015,43(5):380-393.DOI:10.3760/cma.j.issn.0253-3758.2015.05.003.
[3]ROTHNIE K J,YAN R,SMEETH L,et al.Risk of myocardial infarction(MI)and death following MI in people with chronic obstructive pulmonary disease(COPD):a systematic review and meta-analysis[J].BMJ Open,2014,5(9):e007824.DOI:10.1136/bmjopen-2015-007824.
[4]黄若刚,段佳丽,焦淑芳,等.《2017年度卫生与人群健康状况报告》概述[J].首都公共卫生,2018,12(6):279-281.
[5]苏懿,王磊,张敏州.急性心肌梗死的流行病学研究进展[J].中西医结合心脑血管病杂志,2012,10(4):467-469.DOI:10.3969/j.issn.1672-1349.2012.04.045.
[6]MCALLISTER D A,MACLAY J D,MILLS N L,et al.Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD[J].Eur Respir J,2012,39(5):1097-1103.DOI:10.1183/09031936.00124811.
[7]肖建,杜春玲.慢性阻塞性肺疾病病因及发病机制研究进展[J].中国老年学杂志,2014,34(11):3191-3194.DOI:10.3969/j.issn.1005-9202.2014.11.142.
[8]王嘉慧,刘雪飞,韩秀.吸烟在冠心病发生发展中的作用机制研究进展[J].大连医科大学学报,2016,38(3):293-297.DOI:10.11724/jdmu.2016.03.20.
[9]DUONG M,ISLAM S,RANGARAJAN S,et al.Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1(PURE):an international,community-based cohort study[J].Lancet Glob health,2019,7(5):e613-e623.
[10]慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组.慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(草案)[J].国际呼吸杂志,2012,32(22):1681-1691.DOI:10.3760/cma.j.issn.1673-436X.2012.022.001.
[11]WEDZICHA J A,SEEMUNGAL T A,MACCALLUM P K,et al.Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6levels[J].Thromb Haemost,2000,84(2):210-215.
[12]MORGAN A D,ZAKERI R,QUINT J K.Defining the relationship between COPD and CVD:what are the implications for clinical practice?[J].Ther Adv Respir Dis,2018,12:175346581775052.DOI:10.1177/1753465817750524.
[13]RIDKER P M.Role of inflammatory biomarkers in prediction of coronary heart disease[J].Lancet,2001,358(9286):946-948.DOI:10.1016/S0140-6736(01)06112-8.
[14]张运,张澄,张猛.动脉粥样硬化抗炎治疗的新时代[J].中华心血管病杂志,2018,46(5):332-337.DOI:10.3760/cma.j.issn.0253-3758.2018.05.002.
[15]黄元铸.心率与冠心病关系的研究进展[J].中华心血管病杂志,2006,34(6):574-576.DOI:10.3760/j:issn:0253-3758.2006.06.033.
[16]MACLAY J D,MCALLISTER D A,JOHNSTON S,et al.Increased platelet activation in patients with stable and acute exacerbation of COPD[J].Thorax,2011,66(9):769-774.DOI:10.1136/thx.2010.157529.
[17]PATEL A R,KOWLESSAR B S,DONALDSON G C,et al.Cardiovascular risk,myocardial injury,and exacerbations of chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2013,188(9):1091-1099.DOI:10.1164/rccm.201306-1170OC.
[18]RANJITH R,BINU T G,GEORGE V,et al.Aortic pulse wave velocity and its relationship with complexity of coronary artery disease based on SYNTAX score[J].Heart Asia,2014,6(1):109-115.DOI:10.1136/heartasia-2013-010492.
[19]ROTHNIE K J,CONNELL O,MüLLEROVáH,et al.Myocardial Infarction and Ischemic Stroke Following Exacerbations of Chronic Obstructive Pulmonary Disease[J].Ann Am Thorac Soc,2018,15(8):935-946.DOI:10.1513/AnnalsATS.201710-815OC.
[20]WANG W Q,HUANG H L,ZHU S,et al.High-Sensitivity Cardiac Troponin T in Patients with Acute Myocardial Infarction in Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Clin Lab,2015,61(8):1083-1093.
[21]PAVASINI R,BISCAGLIA S,D'ASCENZO F,et al.Antiplatelet Treatment Reduces All-Cause Mortality in COPD Patients:ASystematic Review and Meta-Analysis[J].COPD,2016,13(4):509-514.DOI:10.3109/15412555.2015.1099620.
[22]SCHWAMEIS R,PILS S,WEBER M,et al.Acetylic Salicylic Acid for the Treatment of Chronic Obstructive Pulmonary Disease:A Randomized,Double-Blind,Placebo-Controlled Trial[J].Pharmacology,2016,98(1/2):93-98.DOI:10.1159/000446349.
[23]STANBROOK M B.Review:cardioselective beta-blockers did not reduce respiratory function in chronic obstructive pulmonary disease[J].ACP J Club,2002,137(3):104.
[24]XIA N,WANG H,NIE X.Inhaled Long-Actingβ2-Agonists Do Not Increase Fatal Cardiovascular Adverse Events in COPD:A Meta-Analysis[J].PLoS One,2015,10(9):e0137904.DOI:10.1371/journal.pone.0137904.
[25]MORTENSEN E M,COPELAND L A,PUGH M J,et al.Impact of statins and ACE inhibitors on mortality after COPD exacerbations[J].Respir Res,2009,10(1):45.DOI:10.1186/1465-9921-10-45.