MTHFR基因在高血压患者中的多态性分布及风险评估价值

详细信息    查看全文 | 推荐本文 |

英文篇名：Polymorphic distribution and risk assessment value of MTHFR gene in hypertensive patients 作者：程世亮 ; 戴永刚 ; 李萌 ; 刘新风 ; 王园 ; 孙厚科 英文作者：CHENG Shiliang;DAI Yonggang;LI Meng;LIU Xinfeng;WANG Yuan;SUN Houke;Department of Clinical Laboratory,Shandong Provincial Third Hospital;Department of Clinical Laboratory,Ji′nan Qilu Medical Laboratory; 关键词：MTHFR基因 ; H型高血压 ; 基因频率 ; 多态性分布 ; 风险评估 英文关键词：MTHFR gene;;H-type hypertension;;gene frequency;;polymorphic distribution;;risk assessment 中文刊名：JYYL 英文刊名：Laboratory Medicine and Clinic 机构：山东省立第三医院检验科;济南齐鲁医学检验所检验科; 出版日期：2019-07-25 出版单位：检验医学与临床 年：2019 期：v.16 基金：山东省济南市科学技术发展计划(201704022) 语种：中文; 页：JYYL201914007 页数：3 CN：14 ISSN：50-1167/R 分类号：30-31+35

摘要

目的分析MTHFR基因在高血压患者中的多态性分布及风险评估价值。方法将2016年9月至2017年9月山东省立第三医院收治的176例H型高血压患者纳入观察组,同期收治的160例原发性高血压患者纳入为对照组。检测所有研究对象MTHFR基因的分布,并通过Logistic回归分析C/T基因在机体内的表达频率与预后情况之间的相关性。结果两组患者C/T基因型频率及等位基因频率比较,差异均有统计学意义(χ~2=7.40,P=0.02;χ~2=13.77,P=0.00);同时,Logistic回归分析显示,C/T基因型频率与患者预后密切相关(回归系数=0.429,P=0.00)。结论 MTHFR基因在H型高血压患者中表达频率较高,并能有效预测高血压患者预后,具有较高的诊断价值,值得在临床推广应用。
        Objective To study the polymorphic distribution and risk assessment of MTHFR gene in patients with hypertension.Methods A total of 176 patients with H-type hypertension admitted to Shandong Provincial Third Hospital from September 2016 to September 2017 were enrolled as the observation group,and160 patients with common hypertension admitted to the same period were selected as the control group.The polymorphic distribution of MTHFR gene in all subjects was examined,and the correlation between the expression rate of C/T gene and prognosis was investigated by Logistic regression analysis.Results The difference between the C/T genotype frequency and allele frequencies were significant(χ~2=7.40,P=0.02;χ~2=13.77,P=0.00).At the same time,Logistic regression analysis showed that C/T gene expression level closely related to patients′prognosis(regression coefficient=0.429,P=0.00).Conclusion The MTHFR gene has a higher frequency in H-type hypertension and can effectively predict the prognosis of hypertension,which has a high diagnostic value and is worthy of clinical promotion.

引文

[1]中华医学会心血管病学分会高血压学组.H型高血压:同型半胱氨酸水平升高与高血压发生及控制的研究进展[J/CD].中国医学前沿杂志(电子版),2017,9(2):42-46.
    [2]吴旭华.补充叶酸对社区原发性高血压患者同型半胱氨酸的影响[D].合肥:安徽医科大学,2016.
    [3]唐岚,周礼清,王人佩,等.叶酸联合维生素B6对老年H型高血压患者高同型半胱氨酸血症的疗效观察[J].山西医药杂志,2016,45(4):445-447.
    [4]刘竞争,晁丹,陈燕,等.Hcy、FA、维生素B12水平及MTHFR基因多态性与脑梗死的相关性研究[J].检验医学与临床,2017,14(2):156-157.
    [5]孙宁玲,李建平,卢新政,等.H型高血压诊断标准依据解读[J].中华高血压杂志,2017,25(6):508-510.
    [6]李聪娜.亚甲基四氢叶酸还原酶C677T基因多态性及血清同型半胱氨酸浓度与原发性高血压病关系的临床研究[D].石家庄:河北医科大学,2016.
    [7]李琬.H型高血压与缺血性脑卒中的临床相关性研究[J].中国医药指南,2016,14(7):85-86.
    [8]赵艳红,刘涛.HSP27对Hcy诱导的血管内皮细胞损伤的保护作用及其机制研究[J].重庆医学,2018,47(7):892-895.
    [9]涂富莲,杜海林,陈涛,等.冠心病、高血压及冠心病合并高血压与Hcy临床相关性分析[J].中国继续医学教育,2016,8(14):24-26.
    [10]陈映慧,梁惠碧,周远青.MTHFR基因多态性和同型半胱氨酸在冠心病脑梗死和糖尿病中的分析[J].检验医学与临床,2016,13(A02):114-117.