消化性溃疡中医辨证分型与肠道菌群相关性的研究
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摘要
目的通过分析肠道菌群(intestinal flora,IF),研究消化性溃疡(peptic ulcer,PU)患者的中医证型特点,为临床治疗提供实验依据。方法随机选取我院消化性溃疡患者,对所有患者进行中医辨证分型与肠道菌群分析,对中医证型与其他结果的相关性进行统计学处理。结果四种PU证型患者肠道菌群多样性、相似性有差异,脾胃虚弱证组和胃阴不足PU患者相似性系数较一致,脾虚湿热证组和肝胃不和证相似性系数较一致。结论不同中医证型与消化性溃疡的肠道菌群存在显著相关性,因此可以为采取对症疗法对消化性溃疡患者提供重要临床资料。
Objective To study the characteristics of traditional Chinese medicine(TCM) syndromes in patients with peptic ulcer(PU) by analyzing the intestinal flora(IF), and provide experimental evidence for clinical treatment. Methods 245 cases of patients with PU were randomly selected. TCM syndrome differentiation and IF analysis were performed, and the correlation between TCM syndrome types and other results was statistically processed. Results The diversity and similarity of intestinal flora in patients with the four types of PU syndrome were different. The similarity coefficient of patients with spleen-stomach deficiency syndrome and gastric yin deficiency was consistent. The similarity coefficient between spleen-deficiency and dampheat syndrome group and liver-stomach syndrome was consistent. Conclusion There is a significant correlation between different TCM syndromes and IF of peptic ulcer, so it can provide important clinical data for patients with peptic ulcer.
Objective To study the characteristics of traditional Chinese medicine(TCM) syndromes in patients with peptic ulcer(PU) by analyzing the intestinal flora(IF), and provide experimental evidence for clinical treatment. Methods 245 cases of patients with PU were randomly selected. TCM syndrome differentiation and IF analysis were performed, and the correlation between TCM syndrome types and other results was statistically processed. Results The diversity and similarity of intestinal flora in patients with the four types of PU syndrome were different. The similarity coefficient of patients with spleen-stomach deficiency syndrome and gastric yin deficiency was consistent. The similarity coefficient between spleen-deficiency and dampheat syndrome group and liver-stomach syndrome was consistent. Conclusion There is a significant correlation between different TCM syndromes and IF of peptic ulcer, so it can provide important clinical data for patients with peptic ulcer.
引文
[1] Cho JH,Choi JS,Chun SW,et al.The IL-1B Genetic Polymorphism Is Associated with Aspirin-InducPUed PepticUlcers ina Korean Ethnic Group[J].Gut Liver,2016,10(3):362-368.
[2]杨菲,王济,王琦.过敏性疾病与肠道菌群失调的相关性及对过敏体质研究的启示[J].北京中医药大学学报,2015,38(8):509-514.
[3]彭勃.中西医临床消化病学[M].北京:中国医药科技出版社,1997:180-187.
[4]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,2004:6.
[5]唐琳,黄启阳,杨云生.消化性溃疡的检查方法及诊断标准[J].医学与哲学,2010,31(10):16-18.
[6] Farzaei MH,Abdollahi M,Rahimi R.Role of dietary polyp-henols in the management of peptic ulcer[J].World Journal ofGastroenterology Wjg,2015,21(21):6499.
[7] Sreide K,Thorsen K,Sreide JA.Strategies to improve theoutcome of emergency surgery for perforated peptic ulcer[J].British Journal of Surgery,2014,101(1):51-64.
[8]邵蕊,王莹,晋志高.中医治疗胃溃疡的研究进展[J].中医研究,2016,29(12):61-64.
[9]苏玉明,彭芃,孙世晓.中医治疗消化性溃疡的方法和思路[J].中医药信息,2006,23(3):26-27.
[10]叶瑜.中医药治疗消化性溃疡病研究进展[J].世界中西医结合杂志,2006(6):373-374.
[11]王海涛.复方玄连颗粒对无水乙醇诱导大鼠消化性溃疡愈合的影响[D].郑州:河南中医学院,2010:1-37.
[12]何善明,牛豫洁.辨证用药抗消化性溃疡复发的临床观察[J].广西中医药,2001,24(6):27-28.
[13]裘伟国,王丹.中医辨证治疗消化性溃疡212例的临床分析[J].内蒙古中医药,2012,31(1):13-14.
[2]杨菲,王济,王琦.过敏性疾病与肠道菌群失调的相关性及对过敏体质研究的启示[J].北京中医药大学学报,2015,38(8):509-514.
[3]彭勃.中西医临床消化病学[M].北京:中国医药科技出版社,1997:180-187.
[4]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,2004:6.
[5]唐琳,黄启阳,杨云生.消化性溃疡的检查方法及诊断标准[J].医学与哲学,2010,31(10):16-18.
[6] Farzaei MH,Abdollahi M,Rahimi R.Role of dietary polyp-henols in the management of peptic ulcer[J].World Journal ofGastroenterology Wjg,2015,21(21):6499.
[7] Sreide K,Thorsen K,Sreide JA.Strategies to improve theoutcome of emergency surgery for perforated peptic ulcer[J].British Journal of Surgery,2014,101(1):51-64.
[8]邵蕊,王莹,晋志高.中医治疗胃溃疡的研究进展[J].中医研究,2016,29(12):61-64.
[9]苏玉明,彭芃,孙世晓.中医治疗消化性溃疡的方法和思路[J].中医药信息,2006,23(3):26-27.
[10]叶瑜.中医药治疗消化性溃疡病研究进展[J].世界中西医结合杂志,2006(6):373-374.
[11]王海涛.复方玄连颗粒对无水乙醇诱导大鼠消化性溃疡愈合的影响[D].郑州:河南中医学院,2010:1-37.
[12]何善明,牛豫洁.辨证用药抗消化性溃疡复发的临床观察[J].广西中医药,2001,24(6):27-28.
[13]裘伟国,王丹.中医辨证治疗消化性溃疡212例的临床分析[J].内蒙古中医药,2012,31(1):13-14.