非那雄胺联合盐酸特拉唑嗪治疗前列腺增生伴急性尿潴留的疗效观察
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摘要
目的探讨非那雄胺联合盐酸特拉唑嗪治疗前列腺增生伴急性尿潴留的疗效。方法选取我院2013年1月至2018年9月收治的前列腺增生伴急性尿潴留患者89例,随机分为观察组(45例)与对照组(44例)。对照组采用盐酸特拉唑嗪治疗,观察组在对照组基础上采用非那雄胺治疗,比较两组的临床疗效、治疗前后的临床症状表现及不良反应情况。结果观察组的临床总有效率明显高于对照组(P <0.05)。治疗后,观察组的IPSS评分、前列腺体积、膀胱尿液残留量、血清前列腺肿瘤抗原指标低于对照组,最大排尿流速高于对照组(P均<0.05)。观察组的不良反应发生率低于对照组(P <0.05)。结论对前列腺增生伴急性尿潴留患者采用非那雄胺和盐酸特拉唑嗪治疗,效果更佳,且用药安全性较高,值得推广。
Objective To explore the curative effect of finasteride combined with terazosin hydrochloride in the treatment of benign prostatic hyperplasia complicated with acute urinary retention. Methods 89 cases of patients with benign prostatic hyperplasia complicated with acute urinary retention admitted to our hospital from January 2013 to September 2018 were selected and randomly divided into observation group(45 cases) and control group(44 cases). The control group was treated with terazosin hydrochloride, while the observation group was treated with finasteride on the basis of the control group. The clinical efficacy, clinical symptoms before and after treatment, and adverse reactions were compared between the two groups. Results The clinical total effective rate of the observation group was significantly higher than that of the control group(P <0.05). After treatment, the IPSS score, prostatic volume, bladder urine residue volume and serum prostate tumor antigen index of the observation group were lower than those of the control group, and the maximum urinary flow rate was higher than that of the control group(all P <0.05). The incidence of adverse reactions of the observation group was lower than that of the control group(P <0.05). Conclusions Finasteride combined with terazosin hydrochloride has better effect in the treatment of patients with benign prostatic hyperplasia complicated with acute urinary retentione, with higher safety of medication, which is worthy of promotion.
Objective To explore the curative effect of finasteride combined with terazosin hydrochloride in the treatment of benign prostatic hyperplasia complicated with acute urinary retention. Methods 89 cases of patients with benign prostatic hyperplasia complicated with acute urinary retention admitted to our hospital from January 2013 to September 2018 were selected and randomly divided into observation group(45 cases) and control group(44 cases). The control group was treated with terazosin hydrochloride, while the observation group was treated with finasteride on the basis of the control group. The clinical efficacy, clinical symptoms before and after treatment, and adverse reactions were compared between the two groups. Results The clinical total effective rate of the observation group was significantly higher than that of the control group(P <0.05). After treatment, the IPSS score, prostatic volume, bladder urine residue volume and serum prostate tumor antigen index of the observation group were lower than those of the control group, and the maximum urinary flow rate was higher than that of the control group(all P <0.05). The incidence of adverse reactions of the observation group was lower than that of the control group(P <0.05). Conclusions Finasteride combined with terazosin hydrochloride has better effect in the treatment of patients with benign prostatic hyperplasia complicated with acute urinary retentione, with higher safety of medication, which is worthy of promotion.
引文
[1]管斯斯,张文娟,刘玮,等.非那雄胺对老年良性前列腺增生合并原发性高血压患者炎症因子影响及临床疗效[J].重庆医学, 2018,47(35):4543-4545.
[2]庞聪,李涛,李季,等.温肾益气活血汤联合非那雄胺片治疗良性前列腺增生近期疗效观察[J].河北中医, 2018, 40(8):1196-1200.
[3]梁剑梅,赵冠耀,罗健玲,等.前列舒通胶囊联合非那雄胺治疗良性前列腺增生症的临床研究[J].中国性科学, 2018, 27(4):13-15.
[4]钱晓辉,黄河,申隆江,等.中断非那雄胺治疗对前列腺增生病情的影响[J].国际泌尿系统杂志, 2018, 38(1):35-38.
[5]田子阳,冯伟,朱元全,等.前列舒通胶囊联合非那雄胺对良性前列腺增生症的疗效观察[J].西部医学, 2018, 30(2):224-227.
[6]赵超群,王亚佟,邵林海.术前应用非那雄胺或苯甲酸雌二醇对预防TURP患者术中及术后出血的临床疗效[J].解放军医药杂志,2018, 30(12):61-64.
[7]李文威.赛洛多辛与非那雄胺治疗老年良性前列腺增生疗效比较[J].西南国防医药, 2017, 27(2):181-183.
[8]殷波,杨勇,孙菊元.非那雄胺与多沙唑嗪联合应用对老年良性前列腺增生夜尿症状的影响[J].解放军预防医学杂志, 2017, 35(7):793-795.
[2]庞聪,李涛,李季,等.温肾益气活血汤联合非那雄胺片治疗良性前列腺增生近期疗效观察[J].河北中医, 2018, 40(8):1196-1200.
[3]梁剑梅,赵冠耀,罗健玲,等.前列舒通胶囊联合非那雄胺治疗良性前列腺增生症的临床研究[J].中国性科学, 2018, 27(4):13-15.
[4]钱晓辉,黄河,申隆江,等.中断非那雄胺治疗对前列腺增生病情的影响[J].国际泌尿系统杂志, 2018, 38(1):35-38.
[5]田子阳,冯伟,朱元全,等.前列舒通胶囊联合非那雄胺对良性前列腺增生症的疗效观察[J].西部医学, 2018, 30(2):224-227.
[6]赵超群,王亚佟,邵林海.术前应用非那雄胺或苯甲酸雌二醇对预防TURP患者术中及术后出血的临床疗效[J].解放军医药杂志,2018, 30(12):61-64.
[7]李文威.赛洛多辛与非那雄胺治疗老年良性前列腺增生疗效比较[J].西南国防医药, 2017, 27(2):181-183.
[8]殷波,杨勇,孙菊元.非那雄胺与多沙唑嗪联合应用对老年良性前列腺增生夜尿症状的影响[J].解放军预防医学杂志, 2017, 35(7):793-795.