全氟化合物在食品中的污染情况及检测方法研究进展
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摘要
全氟化合物以其优良的稳定性及表面活性作为加工助剂已被应用于多个领域,但它是一类多脏器毒性的环境污染物,具有持久性、生物积累性、难降解性等特点。本文综述了全氟辛酸和全氟辛烷磺酸等全氟化合物的危害、各国对其使用的限制和规定、各类食品中全氟化合物的污染情况和含量水平的差异,重点比较了不同测定全氟化合物方法的优劣,阐述了今后检测技术的发展方向,为我国开展食品中全氟化合物的风险评估及研究提供参考。
Due to the excellent stability and surfactivity of perfluorinated compounds,they have been used in many fields.However,they are a kind of environmental pollutants with multiple organ toxicity,which have the characteristics of persistence,bioaccumulation and hard degradation. The article mainly summarizes the harm of perfluorinated compounds such as perfluorooctanoic acid and perfluorooctane sulfonate,the domestic and international restrictions and regulations on them. The contamination levels of perfluorinated compounds in different kinds of food were also reviewed.The recent research progress on determination technology of perfluorinated compounds in food was introduced. The advantages and disadvantages of different determination methods are compared emphatically,and the development direction of detection technology in the future is expounded.The article would provide references for the risk assessment and studies on perfluorinated compounds in food.
Due to the excellent stability and surfactivity of perfluorinated compounds,they have been used in many fields.However,they are a kind of environmental pollutants with multiple organ toxicity,which have the characteristics of persistence,bioaccumulation and hard degradation. The article mainly summarizes the harm of perfluorinated compounds such as perfluorooctanoic acid and perfluorooctane sulfonate,the domestic and international restrictions and regulations on them. The contamination levels of perfluorinated compounds in different kinds of food were also reviewed.The recent research progress on determination technology of perfluorinated compounds in food was introduced. The advantages and disadvantages of different determination methods are compared emphatically,and the development direction of detection technology in the future is expounded.The article would provide references for the risk assessment and studies on perfluorinated compounds in food.
引文
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[3]李英春,李祺.氟化合物制备及应用[M].北京:化学工业出版社,2010:73-75.
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[10]Corsini E,Luebke R W,Germolec D R,et al.Perfluorinated compounds:Emerging POPs with potential immunotoxicity[J].Toxicology Letters,2014,230(2):263-270.
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[35]白润叶,张毅,肖陈责,等.中国部分主产区鸡肉中全氟化合物残留水平调查[J].食品安全质量检测学报,2016,7(2):730-740.
[36]王冬根,袁丽娟,张莉,等.江西省畜禽产品中全氟辛酸和全氟辛烷磺酸污染情况调查与分析[J].食品科学,2016,37(4):216-221.
[37]Yoo H,Guruge K S,Yamanaka N,et al.Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens(Gallus gallus)administered by subcutaneous implantation[J].Ecotoxicology and Environmental Safety,2009,72(1):26-36.
[38]赵玉乐,朱冬雪,黄宝勇,等.超高效液相色谱-串联质谱法测定蔬菜中15种全氟化合物[J].农产品质量与安全,2017,3:42-48.
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[41] Zafeiraki E,Costopoulou D,Vassiliadou I,et al.Determination of perfluorinated compounds(PFCs)in various foodstuff packaging materials used in the Greek market[J].Chemosphere,2014,94:169-176.
[42]Begley T H. PFAAs in food and migration from food packaging[J].Reproductive Toxicology,2012,33(4):591.
[43]Martin J W,Mabury S A,Solomon K R,et al.Progress toward understanding the bioaccumulation of perfluorinated alkyl acids[J]. Environmental Toxicology and Chemistry,2013,32(11):2421-2423.
[44]罗海英,蔡依军,冼燕萍,等.液相色谱-串联质谱法测定鱼肉中的七种全氟有机物[J].食品工业科技,2011(2):325-327.
[45]郭萌萌,国佼,吴海燕,等.通过式固相萃取液相色谱四极杆静电场轨道阱高分辨质谱快速筛查鱼肉中全氟化合物及其前体物质[J].分析化学,2016,44(10):1504-1513.
[46]王梦,王雨昕,杨琳,等.超高效液相色谱-质谱法测定鸡蛋中全氟烷酸和全氟磺酸前体物质[J].中华预防医学杂志,2016,50(5):439-444.
[47]郭萌萌,吴海燕,李兆新,等.超快速液相色谱-串联质谱法检测水产品中23中全氟烷基化合物[J].分析化学,2013,41(9):1322-1327.
[48]朱萍萍,岳振峰,郑宗坤,等.分散固相萃取结合高效液相色谱-串联质谱法测定羊肝中19种全氟烷基酸[J].色谱,2015,33(5):494-500.
[49]白文荟,刘金钏,颜朦朦,等.猪肉、猪肝中17种全氟烷基化合物的HPLC-MS-MS测定[J].色谱,2015,6(1):189-196.
[50]何建丽,彭涛,谢洁,等.高效液相色谱-串联质谱法测定动物肝脏中20种全氟烷基类化合物[J].分析化学,2015,43(1):40-48.
[51]赵成哲,朱国华,刘劲松,等.气相色谱-质谱联用定性全氟羧酸丁基酯[J].广州化工,2012,40(4):67-68.
[52]张琼方,吴微,陈惠林,等.全氟化合物量子点荧光法检测[J].中国公共卫生,2012,28(11):1525-1526.
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[2]杨圣舒,刘美,张迪.地表水中典型全氟化合物的污染特性及降解机理研究[J].环境科学与管理,2017,42(3):39-42.
[3]李英春,李祺.氟化合物制备及应用[M].北京:化学工业出版社,2010:73-75.
[4]Xu J,Guo C S,Zhang Y,et al.Bioaccumulation and trophic transfer of perfluorinated compounds in a eutrophic freshwater food web[J].Environmental Pollution,2014,184(1):254-261.
[5]曹名,邵俊娟,高晓明,等.北京市昌平区市售乳制品及水果蔬菜中全氟化合物的含量及暴露评估[J].环境与健康杂志,2018,35(4):337-339.
[6]Sun R,Wu M H,Tang L,et al.Perfluorinated compounds in surface waters of Shanghai,China:Source analysis and risk assessment[J]. Ecotoxicology and Environmental Safety,2018,149:88-95.
[7]Fromme H,Tittlemier S A,Vlkel W,et al. Perfluorinated compounds-exposure assessment for the general population in western countries[J]. International Journal of Hygiene and Environmental Health,2009,212(3):239-270.
[8]Mandana G,Manhai L,Durita M R,et al. Polymorphism in xenobiotic and estrogen metabolizing genes, exposure to perfluorinated compounds and subsequent breast cancer risk:A nested case-control study in the Danish National Birth Cohort[J]. Environmental Research,2017,154:325-333.
[9]Surabhi S K,Kim B M,Hong Y C,et al.Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls[J].Environment International,2016,94:607-613.
[10]Corsini E,Luebke R W,Germolec D R,et al.Perfluorinated compounds:Emerging POPs with potential immunotoxicity[J].Toxicology Letters,2014,230(2):263-270.
[11]Zheng L,Dong G H,Jin Y H,et al. Immunotoxic changes associated with a 7-day oral exposure to perfluorooctane sulfonate(PFOS)in adult male C57BL/6 mice[J].Archives of Toxicology,2009,83(7):679-689.
[12]Cassone C G,Vongphachan V,Chiu S,et al.In ovo effects of perfluorohexane sulfonate and perfluorohexanoate on pipping success,development,mRNA expression and thyroid hormone levels in chicken embryos[J]. Toxicological Sciences,2012,127(1):216.
[13]张琦豪.母亲孕期全氟化合物暴露与0~1岁婴儿身心发育的相关研究[D].贵阳:贵阳医学院,2015.
[14]杨琳,李敬光.全氟化合物前体物质生物转化与毒性研究进展[J].环境化学,2015,34(4):649-655.
[15]Vestergren R,Cousins I. Tracking the pathways of human exposure to perfluorocarboxylates[J]. Environmental Science&Technology,2009,43(15):5565-5575.
[16]Chen S,Jiao X C,Gai N,et al.Perfluorinated compounds in soil,surface water and groundwater from rural areas in eastern China[J].Environment Pollution,2016,211:124-131.
[17]姚义鸣,赵洋洋,孙红文.天津市大气中全氟化合物挥发性前体物的分布和季节变化[J].环境化学,2016,35(7):1329-1336.
[18]European Food Safety Authority(EFSA). Perfluorooctane sulfonate(PFOS),perfluorooctanoic acid(PFOA)and their salts[M].EFSA J,2008,653(1):1-131.
[19]The European Commission. Commission Regulation(EU)2017/1000[OL].The European Commission,2017:2017-08-30.
[20]国家发展和改革委员会国家发展和改革委员会令2011年第9号[EB/OL].2011-03-27.
[21]Taves D R.Evidence that there are two forms of fluoride in human serum[J].Nature,1968,217(5133):1050-1051.
[22]Domingo J L,Jogsten I E,Eriksson U,et al.Human dietary exposure to perfluoroalkyl substances in Catalonia,Spain.Temporal trend[J].Food Chemistry,2012,135(3):1575-1582.
[23]Stahl L L,Snyder B D,Olsen A R,et al. Perfluorinated compounds in fish from U S urban rivers and the Great Lakes[J]. Science Total Environment,2014,499:185-195.
[24]European Food Safety Authority(EFSA).Perfluoroalkylated substances in food:Occurrence and dietary exposure[J].EFSA J,2012,10(6):2743.
[25]Bertin D,Labadie P,Ferrari B J D,et al.Potential exposure routes and accumulation kinetics for poly-and perfluorinated alkyl compounds for a freshwater amphipod:Gammarus spp.(Crustacea)[J].Chemosphere,2016,155:380-387.
[26]Vassiliadou I,Costopoulou D,Kalogeropoulos N,et al.Levels of perfluorinated compounds in raw and cooked Mediterranean finfish and shellfish[J].Chemosphere,2015,127:117-126.
[27]Domingo J L,Ericson J I,PerellóG,et al.Human exposure to perfluorinated compounds in Catalonia,Spain:Contribution of drinking water and fish and shellfish[J]. Journal of Agricultural and Food Chemistry,2012,60(17):4408-4415.
[28]He XM,Ke D,Li AM,et al.Occurrence and assessment of perfluorinated compounds in fish from the Danjiangkou reservoir and Hanjiang river in China[J]. Food Chemistry,2015,174:180-187.
[29] Shi Y,Wang J,Pan Y,et al. Tissue distribution of perfluorinated compounds in farmed feshwater fish and human exposure by consumption[J]. Environmental Toxicology and Chemistry,2012,31(4):717-723.
[30]周殿芳,甘金华,吕磊,等.全氟烷基化合物在长江流域水产品中的分布研究[J].中国渔业质量与标准,2016,6(2):57-65.
[31]柳思帆,王铁宇,薛科社,等.北京水源地鱼体全氟化合物的暴露水平及其健康风险[J].生态毒理学报,2017,12(1):111-118.
[32]Kowalczyk J,Ehlers S,Oberhausen A,et al. Absorption,distribution,and milk secretion of the perfluoroalkyl acids PFBS,PFHx S,PFOS and PFOA by dairy cows fed naturally contaminated feed[J]. Journal of Agricultural and Food Chemistry,2013,61(12):2903-2912.
[33]杨琳,王梦,李敬光,等.18份市售牛奶中全氟化合物及其前体物质含量分析[J].中华预防医学杂志,2015,49(6):524-528.
[34]杨琳,于欣平,王梦,等.中国12个省份母乳中全氟化合物前体物质含量分析[J].中华预防医学杂志2015,49(6):529-535.
[35]白润叶,张毅,肖陈责,等.中国部分主产区鸡肉中全氟化合物残留水平调查[J].食品安全质量检测学报,2016,7(2):730-740.
[36]王冬根,袁丽娟,张莉,等.江西省畜禽产品中全氟辛酸和全氟辛烷磺酸污染情况调查与分析[J].食品科学,2016,37(4):216-221.
[37]Yoo H,Guruge K S,Yamanaka N,et al.Depuration kinetics and tissue disposition of PFOA and PFOS in white leghorn chickens(Gallus gallus)administered by subcutaneous implantation[J].Ecotoxicology and Environmental Safety,2009,72(1):26-36.
[38]赵玉乐,朱冬雪,黄宝勇,等.超高效液相色谱-串联质谱法测定蔬菜中15种全氟化合物[J].农产品质量与安全,2017,3:42-48.
[39]Ji K,Kim S,Kho Y,et al.Major perfluoroalkyl acid(PFAA)concentrations and influence of food consumption among the general population of Daegu,Korea[J]. Science of the Total Environment,2012,438(3):42-48.
[40]刘晓湾,张鸿,李静,等.中国沿海地区鸡蛋中全氟化合物污染水平及分布[J].食品科学,2016,37(4):191-196.
[41] Zafeiraki E,Costopoulou D,Vassiliadou I,et al.Determination of perfluorinated compounds(PFCs)in various foodstuff packaging materials used in the Greek market[J].Chemosphere,2014,94:169-176.
[42]Begley T H. PFAAs in food and migration from food packaging[J].Reproductive Toxicology,2012,33(4):591.
[43]Martin J W,Mabury S A,Solomon K R,et al.Progress toward understanding the bioaccumulation of perfluorinated alkyl acids[J]. Environmental Toxicology and Chemistry,2013,32(11):2421-2423.
[44]罗海英,蔡依军,冼燕萍,等.液相色谱-串联质谱法测定鱼肉中的七种全氟有机物[J].食品工业科技,2011(2):325-327.
[45]郭萌萌,国佼,吴海燕,等.通过式固相萃取液相色谱四极杆静电场轨道阱高分辨质谱快速筛查鱼肉中全氟化合物及其前体物质[J].分析化学,2016,44(10):1504-1513.
[46]王梦,王雨昕,杨琳,等.超高效液相色谱-质谱法测定鸡蛋中全氟烷酸和全氟磺酸前体物质[J].中华预防医学杂志,2016,50(5):439-444.
[47]郭萌萌,吴海燕,李兆新,等.超快速液相色谱-串联质谱法检测水产品中23中全氟烷基化合物[J].分析化学,2013,41(9):1322-1327.
[48]朱萍萍,岳振峰,郑宗坤,等.分散固相萃取结合高效液相色谱-串联质谱法测定羊肝中19种全氟烷基酸[J].色谱,2015,33(5):494-500.
[49]白文荟,刘金钏,颜朦朦,等.猪肉、猪肝中17种全氟烷基化合物的HPLC-MS-MS测定[J].色谱,2015,6(1):189-196.
[50]何建丽,彭涛,谢洁,等.高效液相色谱-串联质谱法测定动物肝脏中20种全氟烷基类化合物[J].分析化学,2015,43(1):40-48.
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