浅谈奥沙利铂所致周围神经毒性的中医辨证论治
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摘要
目的:研究中医治疗奥沙利铂所致周围神经毒性的辨证分型和治疗法则。方法:根据患者使用奥沙利铂化疗后出现的不良反应的症状表现、舌苔脉象进行辨证,得出辨证结论,总结治疗原则。结果:奥沙利铂所致急慢性神经毒性中医分别从"寒"、从"虚"论治,以"温经通脉,益气养血""补气活血通络"为治疗大法。
Objective: To study syndrome differentiation type of TCM and therapeutics of peripheral neurotoxicity caused by oxaliplatin. Methods: According to the symptoms and signs of adverse reactions after chemotherapy with oxaliplatin and the pulse condition of tongue coating, the syndrome differentiation conclusion was drawn and the treatment principles were summarized. Results: The acute and chronic neurotoxicity caused by oxaliplatin was treated by traditional Chinese medicine from Han(寒) and Xu(虚), and the treatment method was Wenjing Tongmai( 温经通脉), Yiqi Yangxue(益气养血) and Buqi Huoxue Tongluo(补气活血通络).
Objective: To study syndrome differentiation type of TCM and therapeutics of peripheral neurotoxicity caused by oxaliplatin. Methods: According to the symptoms and signs of adverse reactions after chemotherapy with oxaliplatin and the pulse condition of tongue coating, the syndrome differentiation conclusion was drawn and the treatment principles were summarized. Results: The acute and chronic neurotoxicity caused by oxaliplatin was treated by traditional Chinese medicine from Han(寒) and Xu(虚), and the treatment method was Wenjing Tongmai( 温经通脉), Yiqi Yangxue(益气养血) and Buqi Huoxue Tongluo(补气活血通络).
引文
[1]陈小兵,吕慧芳,陈贝贝,等.奥沙利铂神经毒性机制及防治研究进展[J].中国医药科学,2012,2(03):38-40.
[2]曲卓慧,孟春,王耀辉.奥沙利铂神经毒性的机制及防治方法[J].中国全科医学,2008,11(02):139-141.
[3]曹梦苒,华海清,秦叔逵.神经节苷脂预防奥沙利铂周围神经毒性的研究[J].肿瘤防治研究,2014,41(04):387-390.
[4]谢建立,冯丽娟.神经节苷脂对结肠癌患者含奥沙利铂化疗方案致周围神经毒性的疗效观察[J].中国医院用药评价与分析,2017,17(11):1496-1498.
[5]魏晓晨,赵菁,朱立勤等.谷胱甘肽预防奥沙利铂致周围神经毒性疗效的系统评价[J].中国药房,2017,28(09):1216-1220.
[6]马金国,张冰,常晓静.奥沙利铂致神经毒性患者应用甲钴胺和谷胱甘肽治疗临床研究[J].中国实用神经疾病杂志,2015,18(23):77-79.
[7]赵姗姗,于丽,王海冀,等.不同剂量维生素C对奥沙利铂抗肿瘤效果的影响[J].齐鲁医学杂志,2016,31(03):262-265.
[8]赵发红,任志兵,温娟,等.中医诊治奥沙利铂致周围神经病变的思路与方法[J].中国中医药现代远程教育,2014,12(24):17-18.
[9]彭仁通.当归四逆汤合阳和汤防治奥沙利铂所致神经毒性疗效观察[J].中医临床研究,2015,7(12):88-90.
[10]魏晓晨,王慧,朱立勤,等.补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价[J].中国实验方剂学杂志,2016,22(22):186-190.
[11]黄海福.温针灸防治化疗神经毒性的临床观察[J].内蒙古中医药,2017,36(16):115-116.
[12]李智,易良杰.参附注射液对含奥沙利铂方案化疗引起的周围神经毒性的预防作用[J].中国医学创新,2016,13(07):87-90.
[13]李玲.中医治疗周围神经毒性探讨[J].中医研究,2014,27(08):10-12.
[14]秦宝宁,孙长岗.益气活血方防治奥沙利铂致大肠癌周围神经毒性疗效观察[J].山东中医杂志,2015,34(03):176-178.
[15]朱红丽,穆晓燕,张华平.参麦注射液在预防奥沙利铂所致周围神经毒性中的应用[J].中国实用神经疾病杂志,2013,16(11):36-38.
[16]陈勇,黄红霞.黄芪注射液联合弥可保防治奥沙利铂化疗所致神经毒性的效果[J].现代肿瘤医学,2018,26(08):1259-1262.
[17]郭梦圆.穴位贴敷联合益气活血方对奥沙利铂化疗所致神经毒性的影响[J].湖南中医杂志,2015,31(08):78-79.
[2]曲卓慧,孟春,王耀辉.奥沙利铂神经毒性的机制及防治方法[J].中国全科医学,2008,11(02):139-141.
[3]曹梦苒,华海清,秦叔逵.神经节苷脂预防奥沙利铂周围神经毒性的研究[J].肿瘤防治研究,2014,41(04):387-390.
[4]谢建立,冯丽娟.神经节苷脂对结肠癌患者含奥沙利铂化疗方案致周围神经毒性的疗效观察[J].中国医院用药评价与分析,2017,17(11):1496-1498.
[5]魏晓晨,赵菁,朱立勤等.谷胱甘肽预防奥沙利铂致周围神经毒性疗效的系统评价[J].中国药房,2017,28(09):1216-1220.
[6]马金国,张冰,常晓静.奥沙利铂致神经毒性患者应用甲钴胺和谷胱甘肽治疗临床研究[J].中国实用神经疾病杂志,2015,18(23):77-79.
[7]赵姗姗,于丽,王海冀,等.不同剂量维生素C对奥沙利铂抗肿瘤效果的影响[J].齐鲁医学杂志,2016,31(03):262-265.
[8]赵发红,任志兵,温娟,等.中医诊治奥沙利铂致周围神经病变的思路与方法[J].中国中医药现代远程教育,2014,12(24):17-18.
[9]彭仁通.当归四逆汤合阳和汤防治奥沙利铂所致神经毒性疗效观察[J].中医临床研究,2015,7(12):88-90.
[10]魏晓晨,王慧,朱立勤,等.补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价[J].中国实验方剂学杂志,2016,22(22):186-190.
[11]黄海福.温针灸防治化疗神经毒性的临床观察[J].内蒙古中医药,2017,36(16):115-116.
[12]李智,易良杰.参附注射液对含奥沙利铂方案化疗引起的周围神经毒性的预防作用[J].中国医学创新,2016,13(07):87-90.
[13]李玲.中医治疗周围神经毒性探讨[J].中医研究,2014,27(08):10-12.
[14]秦宝宁,孙长岗.益气活血方防治奥沙利铂致大肠癌周围神经毒性疗效观察[J].山东中医杂志,2015,34(03):176-178.
[15]朱红丽,穆晓燕,张华平.参麦注射液在预防奥沙利铂所致周围神经毒性中的应用[J].中国实用神经疾病杂志,2013,16(11):36-38.
[16]陈勇,黄红霞.黄芪注射液联合弥可保防治奥沙利铂化疗所致神经毒性的效果[J].现代肿瘤医学,2018,26(08):1259-1262.
[17]郭梦圆.穴位贴敷联合益气活血方对奥沙利铂化疗所致神经毒性的影响[J].湖南中医杂志,2015,31(08):78-79.