陇中消肿止痛合剂治疗骨筋膜室综合征临床研究
|
摘要
目的观察陇中消肿止痛合剂对骨筋膜室综合征(OCS)患者视觉模拟评分法(VAS)评分及相关实验室指标的影响。方法采用随机数字表法将100例OCS患者分为对照组和治疗组各50例。对照组予20%甘露醇250 mL,七叶皂苷钠20 mg+生理盐水250 mL,均每日1次,静脉滴注。治疗组在对照组基础上予陇中消肿止痛合剂,每次50 mL,每日3次,口服。均1周为1个疗程,连续治疗2个疗程。比较2组治疗前及治疗3、7、14 d VAS评分及血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、天冬氨酸氨基转移酶(AST)水平。结果与本组治疗前比较,2组治疗3、7、14 d VAS评分明显降低(P<0.05);2组治疗后比较,治疗组治疗3、7 d VAS评分明显低于对照组(P<0.05)。与本组治疗前比较,治疗3、7、14 d,2组血清CK、LDH、AST水平明显降低(P<0.01);2组治疗7、14 d比较,治疗组CK、LDH、AST水平改善明显优于对照组(P<0.05)。结论陇中消肿止痛合剂治疗OCS患者可有效止痛,降低患者血清CK、LDH、AST水平。
Objective To observe the effects of Longzhong Xiaozhong Zhitong Mixture on VAS score and related laboratory indicators in patients with osteofascial compartment syndrome(OCS). Methods Totally 100 patients with OCS were divided into two groups according to random number table method, with 50 cases in each group. The control group was given 20% mannitol 250 mL, sodium aescinate 20 mg + physiological saline 250 mL once daily,intravenously. On the basis of the control group, the treatment group was given Longzhong Xiaozhong Zhitong Mixture, 50 mL each time, 3 times a day, orally. One week was one treatment course, two courses successively. The VAS scores, serum creatine kinase(CK), lactate dehydrogenase(LDH), and glutamate aminotransferase(AST) levels were compared before treatment and at 3, 7, and 14 days of treatment. Results Compared with before treatment, the VAS scores of the two groups at 3, 7 and 14 days of treatment were significantly lower(P<0.05); After treatment, the VAS scores of the treatment group at 3 and 7 days of treatment were significantly lower than those of the control group(P<0.05). Compared with before treatment, the levels of serum CK, LDH and AST in the two groups significantly decreased 3, 7 and 14 day of treatment(P<0.01); Compared with the control group, the improvement of CK, LDH and AST levels in the treatment group was significantly better than those in the control group 7 and 14 day of treatment(P<0.05). Conclusion Longzhong Xiaozhong Zhitong Mixture is effective in relieving pain, reducing levels of CK, LDH and ASK in patients with OCS.
Objective To observe the effects of Longzhong Xiaozhong Zhitong Mixture on VAS score and related laboratory indicators in patients with osteofascial compartment syndrome(OCS). Methods Totally 100 patients with OCS were divided into two groups according to random number table method, with 50 cases in each group. The control group was given 20% mannitol 250 mL, sodium aescinate 20 mg + physiological saline 250 mL once daily,intravenously. On the basis of the control group, the treatment group was given Longzhong Xiaozhong Zhitong Mixture, 50 mL each time, 3 times a day, orally. One week was one treatment course, two courses successively. The VAS scores, serum creatine kinase(CK), lactate dehydrogenase(LDH), and glutamate aminotransferase(AST) levels were compared before treatment and at 3, 7, and 14 days of treatment. Results Compared with before treatment, the VAS scores of the two groups at 3, 7 and 14 days of treatment were significantly lower(P<0.05); After treatment, the VAS scores of the treatment group at 3 and 7 days of treatment were significantly lower than those of the control group(P<0.05). Compared with before treatment, the levels of serum CK, LDH and AST in the two groups significantly decreased 3, 7 and 14 day of treatment(P<0.01); Compared with the control group, the improvement of CK, LDH and AST levels in the treatment group was significantly better than those in the control group 7 and 14 day of treatment(P<0.05). Conclusion Longzhong Xiaozhong Zhitong Mixture is effective in relieving pain, reducing levels of CK, LDH and ASK in patients with OCS.
引文
[1]李盛华.消肿止痛合剂治疗下肢创伤早期肿痛146例总结[J].甘肃中医,2000,13(1):34.
[2]毕军伟,李盛华,米仲祥,等.陇中消肿止痛合剂的实验研究与临床应用[J].西部中医药,2016,29(4):51-53.
[3]刘红喜,毕军伟,米仲祥,等.陇中消定膏配合消肿止痛合剂治疗急性创伤性TFCC损伤的临床疗效观察[J].医学理论与实践,2017,30(12):1784-1786.
[4]张镛福.筋膜间室综合征[M].北京:人民卫生出版社,1986:269.
[5]RHEE H,BELYEA M,MAMMEN J.Visual analogue scale(VAS)as a monitoring tool for daily changes in asthma symptoms in adolescents:a prospective study[J].Allergy Asthma Clin Immunol,2017,13:24.
[6]BAUMFELD D,PEREIRA A L,CFG L,et al.Segmental decompressive fasciotomy for acute non-traumatic compartment syndrome in a professional soccer player:case report[J].Rev Bras Ortop,2018,53(2):244-247.
[7]冯宇,张睿,张玲,等.中小剂量地塞米松预防下肢急性创伤后软组织早期并发症的临床研究[J].组织工程与重建外科杂志,2017,13(1):29-33.
[8]BENIWAL R K,BANSAL A.Osteofascial compartment pressure measurement in closed limb injuries-Whitesides'technique revisited[J].J Clin Orthop Trauma,2016,7(4):225-228.
[9]郁啸云,赵佳盛,李瑾琰,等.桃红四物汤对早期骨筋膜室综合征模型家兔血CK、LDH、AST、SOD和MDA含量的影响[J].中医药导报,2015,21(22):9-13.
[10]彭智浩,缪杰佳,赵崇智,等.清热毒颗粒对骨筋膜室综合征切开减张术后CK、LDH、AST含量影响的临床观察[J].中国中医急症,2017,26(6):1069-1071.
[11]刘燚,沈海琦,夏永祥,等.动态检测CK、LDH、AST在骨筋膜室综合征早期诊断中的作用[J].临床骨科杂志,2009,12(3):336-339.
[12]王勇,黄宇宏,李兴利,等.18.4 mm橡皮弹生物致伤动物模型AST、ALP、CK、LDH-L的改变[J].国际检验医学杂志,2012,33(15):1828-1829,1831.
[13]时梦猇,刘燚,沈海琦,等.血清CK、CDH、AST检测在骨筋膜室综合征早期诊治中的应用观察[J].山东医药,2009,49(14):11-13.
[14]张绍文.消肿止痛合剂治疗创伤性炎症反应综合征的疗效观察[J].甘肃医药,2015,34(9):690-691.
[15]贾敏,秦巧红,陈玉龙,等.白芍总苷与赤芍总苷舒血管作用的比较及其物质基础研究[J].中药药理与临床,2018,34(5):69-74.
[16]韩淑娴,游云.三七总皂苷心脑血管药理作用及其溶血反应[J].中国中药杂志,2016,41(5):818-822.
[17]以敏,徐君毅,郝二伟,等.桃仁提取物抗血瘀证大鼠血栓形成的机制[J].中国实验方剂学杂志,2016,22(1):125-128.
[18]吴英花,张红英.桃仁乙醇提取物对小鼠移植性S180肿瘤的抑制作用[J].延边大学医学学报,2015,38(4):283-285.
[19]唐亚芳,杨岸新.中药川芎的有效成分及其药理作用研究[J].中国现代药物应用,2018,12(10):219-220.
[20]刘璇,高美风,孔毅.水蛭化学成分及药理作用的研究进展[J].药物生物技术,2017,24(1):76-80.
[2]毕军伟,李盛华,米仲祥,等.陇中消肿止痛合剂的实验研究与临床应用[J].西部中医药,2016,29(4):51-53.
[3]刘红喜,毕军伟,米仲祥,等.陇中消定膏配合消肿止痛合剂治疗急性创伤性TFCC损伤的临床疗效观察[J].医学理论与实践,2017,30(12):1784-1786.
[4]张镛福.筋膜间室综合征[M].北京:人民卫生出版社,1986:269.
[5]RHEE H,BELYEA M,MAMMEN J.Visual analogue scale(VAS)as a monitoring tool for daily changes in asthma symptoms in adolescents:a prospective study[J].Allergy Asthma Clin Immunol,2017,13:24.
[6]BAUMFELD D,PEREIRA A L,CFG L,et al.Segmental decompressive fasciotomy for acute non-traumatic compartment syndrome in a professional soccer player:case report[J].Rev Bras Ortop,2018,53(2):244-247.
[7]冯宇,张睿,张玲,等.中小剂量地塞米松预防下肢急性创伤后软组织早期并发症的临床研究[J].组织工程与重建外科杂志,2017,13(1):29-33.
[8]BENIWAL R K,BANSAL A.Osteofascial compartment pressure measurement in closed limb injuries-Whitesides'technique revisited[J].J Clin Orthop Trauma,2016,7(4):225-228.
[9]郁啸云,赵佳盛,李瑾琰,等.桃红四物汤对早期骨筋膜室综合征模型家兔血CK、LDH、AST、SOD和MDA含量的影响[J].中医药导报,2015,21(22):9-13.
[10]彭智浩,缪杰佳,赵崇智,等.清热毒颗粒对骨筋膜室综合征切开减张术后CK、LDH、AST含量影响的临床观察[J].中国中医急症,2017,26(6):1069-1071.
[11]刘燚,沈海琦,夏永祥,等.动态检测CK、LDH、AST在骨筋膜室综合征早期诊断中的作用[J].临床骨科杂志,2009,12(3):336-339.
[12]王勇,黄宇宏,李兴利,等.18.4 mm橡皮弹生物致伤动物模型AST、ALP、CK、LDH-L的改变[J].国际检验医学杂志,2012,33(15):1828-1829,1831.
[13]时梦猇,刘燚,沈海琦,等.血清CK、CDH、AST检测在骨筋膜室综合征早期诊治中的应用观察[J].山东医药,2009,49(14):11-13.
[14]张绍文.消肿止痛合剂治疗创伤性炎症反应综合征的疗效观察[J].甘肃医药,2015,34(9):690-691.
[15]贾敏,秦巧红,陈玉龙,等.白芍总苷与赤芍总苷舒血管作用的比较及其物质基础研究[J].中药药理与临床,2018,34(5):69-74.
[16]韩淑娴,游云.三七总皂苷心脑血管药理作用及其溶血反应[J].中国中药杂志,2016,41(5):818-822.
[17]以敏,徐君毅,郝二伟,等.桃仁提取物抗血瘀证大鼠血栓形成的机制[J].中国实验方剂学杂志,2016,22(1):125-128.
[18]吴英花,张红英.桃仁乙醇提取物对小鼠移植性S180肿瘤的抑制作用[J].延边大学医学学报,2015,38(4):283-285.
[19]唐亚芳,杨岸新.中药川芎的有效成分及其药理作用研究[J].中国现代药物应用,2018,12(10):219-220.
[20]刘璇,高美风,孔毅.水蛭化学成分及药理作用的研究进展[J].药物生物技术,2017,24(1):76-80.