益气活血汤联合小剂量雌激素治疗围绝经期功能性子宫出血疗效观察及对血清性激素水平的影响
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摘要
目的:观察益气活血汤联合小剂量雌激素治疗围绝经期功能性子宫出血的效果,以及对患者性激素水平的影响。方法:将收治的围绝经期功能性子宫出血92例随机分为对照组和观察组。对照组46例给予戊酸雌二醇及去氧孕烯炔雌醇治疗。观察组46例联用自拟益气活血汤。监测2组血清性激素水平,统计治疗结束后控制出血时间、完全止血时间、中医证候评分、不良反应、复发情况和疗效。结果:对照组总有效率为73.91%,观察组总有效率为91.30%,2组总有效率比较,差异有统计学意义(χ2=4.842,P=0.028 <0.05)。治疗后,2组各项性激素水平均降低,观察组性激素水平低于对照组,差异有统计学意义(P <0.05)。对照组控制出血时间为(34.18±5.20) h,完全止血时间为(46.79±6.80) h。观察组控制出血时间为(23.54±3.41) h,完全止血时间为(30.56±4.97) h,相比对照组减少,差异有统计学意义(P <0.05)。治疗后,观察组中医证候评分低于对照组,差异有统计学意义(P <0.05)。对照组不良反应发生率为19.57%、复发率为21.74%,观察组不良反应发生率为4.35%、复发率为4.35%,2组不良反应发生率和复发率比较,差异有统计学意义(χ2=5.060、6.133,P=0.024、0.012 <0.05)。结论:中药联合小剂量雌激素治疗围绝经期功能性子宫出血,通过调节性激素水平,可改善患者月经紊乱和出血症状。
Objective: To observe the effect of the therapy of Yiqi Huoxue tang combined with low-dose estrogen for perimenopausal dysfunctional uterine bleeding and its effect on the levels of sex hormones. Methods:A total of 92 cases of patients with perimenopausal dysfunctional uterine bleeding treated in our hospital were randomly divided into the control group and the observation group,46 cases in each group. The control group was treated with estradiol valerate as well as desogestrel and ethinyl estradiol,and the observation group was additionally treated with self-made Yiqi Huoxue tang. The levels of sex hormones in serum in the two groups were monitored,and the time of bleeding control,the time of complete hemostasis, the Chinese medicine syndrome scores, the adverse reactions, the recurrence and the curative effect after treatment were statistically analyzed. Results: The total effective rate was 73.91% in the control group and 91.30% in the observation group,the difference being significant(χ2=4.842,P = 0.028 < 0.05). After treatment,the levels of sex hormones in the two groups were decreased,and the levels in the observation group were lower than those in the control group,the difference being significant(P < 0.05). The time of bleeding control was(34.18±5.20) h and the time of complete hemostasis was(46.79±6.80) h in the control group. The time of bleeding control was(23.54±3.41) h and the time of complete hemostasis was(30.56 ±4.97) h in the observation group, which were decreased when compared with those in the control group, the difference being significant(P < 0.05). After treatment,the Chinese medicine syndrome score in the observation group was lower than that in the control group,the difference being significant(P < 0.05). The incidence of adverse reactions was 19.57%and the recurrence rate was 21.74% in the control group,and the incidence of adverse reactions was 4.35% and the recurrence rate was 4.35% in the observation group,the difference being significant(χ2=5.060,6.133,P=0.024,0.012<0.05). Conclusion:The therapy of Chinese medicine combined with low-dose estrogen for perimenopausal dysfunctional uterine bleeding can improve the symptoms of menstrual disorder and bleeding by regulating the levels of sex hormones.
Objective: To observe the effect of the therapy of Yiqi Huoxue tang combined with low-dose estrogen for perimenopausal dysfunctional uterine bleeding and its effect on the levels of sex hormones. Methods:A total of 92 cases of patients with perimenopausal dysfunctional uterine bleeding treated in our hospital were randomly divided into the control group and the observation group,46 cases in each group. The control group was treated with estradiol valerate as well as desogestrel and ethinyl estradiol,and the observation group was additionally treated with self-made Yiqi Huoxue tang. The levels of sex hormones in serum in the two groups were monitored,and the time of bleeding control,the time of complete hemostasis, the Chinese medicine syndrome scores, the adverse reactions, the recurrence and the curative effect after treatment were statistically analyzed. Results: The total effective rate was 73.91% in the control group and 91.30% in the observation group,the difference being significant(χ2=4.842,P = 0.028 < 0.05). After treatment,the levels of sex hormones in the two groups were decreased,and the levels in the observation group were lower than those in the control group,the difference being significant(P < 0.05). The time of bleeding control was(34.18±5.20) h and the time of complete hemostasis was(46.79±6.80) h in the control group. The time of bleeding control was(23.54±3.41) h and the time of complete hemostasis was(30.56 ±4.97) h in the observation group, which were decreased when compared with those in the control group, the difference being significant(P < 0.05). After treatment,the Chinese medicine syndrome score in the observation group was lower than that in the control group,the difference being significant(P < 0.05). The incidence of adverse reactions was 19.57%and the recurrence rate was 21.74% in the control group,and the incidence of adverse reactions was 4.35% and the recurrence rate was 4.35% in the observation group,the difference being significant(χ2=5.060,6.133,P=0.024,0.012<0.05). Conclusion:The therapy of Chinese medicine combined with low-dose estrogen for perimenopausal dysfunctional uterine bleeding can improve the symptoms of menstrual disorder and bleeding by regulating the levels of sex hormones.
引文
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[2]贾淑平.心理因素对宫腔镜手术治疗功能失调型子宫出血的影响[J].河北医学,2016,22(7):1208-1210.
[3]吕翠芬,陈晓辉.去氧孕烯炔雌醇片、米非司酮联合归脾丸治疗围绝经期功能性子宫出血疗效观察[J].现代中西医结合杂志,2017,26(35):3937-3939.
[4]高世华,李俊,张永丽,等.滋阴调经颗粒治疗肝肾阴虚型围绝经期功能性子宫出血的临床疗效[J].世界中医药,2017,12(9):2105-2108.
[5]赵冬梅,耿旭景,谭丽,等.多囊卵巢综合征个体化调整内分泌治疗疗效观察[J].郑州大学学报(医学版),2018,53(4):466-469.
[6]黄媛.益气健脾补血汤治疗围绝经期功能性子宫出血疗效研究[J].陕西中医,2018,39(2):211-213.