皮下植入式化疗泵导向给药联合扶正抑瘤方治疗结直肠癌的临床研究
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摘要
目的探讨微创皮下植入式化疗泵导向给药联合扶正抑瘤方治疗中晚期结直肠癌的临床疗效。方法将60例中晚期结直肠癌患者随机分为研究组和对照组各30例,研究组采用皮下植入式化疗泵导向给药联合扶正抑瘤方治疗,对照组采用静脉化疗。21 d为1个疗程,2组均治疗6个疗程。统计2组近期疗效及不良反应发生情况,观察2组治疗前后肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)及白细胞计数情况。结果研究组近期总有效率和控制率分别为63. 33%和80. 00%,对照组近期总有效率和控制率分别为46. 67%和60. 00%,研究组近期疗效优于对照组(P <0. 05)。2组治疗后AFP、CEA水平均显著降低(P均<0. 05),且研究组均明显低于对照组(P均<0. 05)。2组治疗后白细胞计数检均较治疗前有所下降(P均<0. 05),但研究组下降幅度小于对照组(P <0. 05)。研究组不良反应发生率明显低于对照组(P <0. 05)。结论皮下动脉植入化疗泵导向给药联合扶正抑瘤方治疗结直肠癌患者近期疗效明显优于静脉化疗,且可增强患者免疫力,减轻化疗反应。
Objective It is to investigate the clinical efficacy of minimally invasive subcutaneous implantable chemotherapy pump-guided medication combined with Fuzheng Yiliu decoction on advanced colorectal cancer. Methods Sixty patients with advanced colorectal cancer were randomly divided into study group and control group,30 cases in each group.The study group was treated with subcutaneous implantable chemotherapy pump-directed medication combined with Fuzheng Yiliu decoction. The control group was treated with intravenous chemotherapy. 21 days as one treatment course,both groups were treated for 6 courses. The short-term effects and occurrence of adverse reactions of the two groups were statistically analyzed. The tumor markers alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA) and white blood cell count were observed before and after treatment. Results The recent total effective rate and control rate of the study group were 63. 33% and 80. 00%,respectively,those of the control group were 46. 67% and 60. 00%,respectively. The shortterm efficacy of the study group was better than that of the control group(P < 0. 05). The levels of AFP and CEA in the two groups were significantly decreased after treatment(P < 0. 05),and the levels in the study group was significantly lower than that in the control group(P < 0. 05). The white blood cell counts of the two groups were lower than those before treatment(P < 0. 05),but the decrease of the study group was less than that of the control group(P < 0. 05). The incidence of adverse reactions in the study group was significantly lower than that in the control group(P < 0. 05). Conclusion The short-term effect of subcutaneous artery implantation chemotherapy-guided medication combined with Fuzheng Yiliu decoction is significantly better than intravenous chemotherapy in the treatment of colorectal cancer patients,and can enhance the patient's immunity and reduce the chemotherapy response.
Objective It is to investigate the clinical efficacy of minimally invasive subcutaneous implantable chemotherapy pump-guided medication combined with Fuzheng Yiliu decoction on advanced colorectal cancer. Methods Sixty patients with advanced colorectal cancer were randomly divided into study group and control group,30 cases in each group.The study group was treated with subcutaneous implantable chemotherapy pump-directed medication combined with Fuzheng Yiliu decoction. The control group was treated with intravenous chemotherapy. 21 days as one treatment course,both groups were treated for 6 courses. The short-term effects and occurrence of adverse reactions of the two groups were statistically analyzed. The tumor markers alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA) and white blood cell count were observed before and after treatment. Results The recent total effective rate and control rate of the study group were 63. 33% and 80. 00%,respectively,those of the control group were 46. 67% and 60. 00%,respectively. The shortterm efficacy of the study group was better than that of the control group(P < 0. 05). The levels of AFP and CEA in the two groups were significantly decreased after treatment(P < 0. 05),and the levels in the study group was significantly lower than that in the control group(P < 0. 05). The white blood cell counts of the two groups were lower than those before treatment(P < 0. 05),but the decrease of the study group was less than that of the control group(P < 0. 05). The incidence of adverse reactions in the study group was significantly lower than that in the control group(P < 0. 05). Conclusion The short-term effect of subcutaneous artery implantation chemotherapy-guided medication combined with Fuzheng Yiliu decoction is significantly better than intravenous chemotherapy in the treatment of colorectal cancer patients,and can enhance the patient's immunity and reduce the chemotherapy response.
引文
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[12]金芝贵,金剑,肖忠革,等.女贞子的药理作用及其临床应用进展[J].药学服务与研究,2011,11(3):189-192
[13]梅雪,余刘勤,陈小云,等.何首乌化学成分和药理作用的研究进展[J].药物评价研究,2016,39(1):122-131
[14]刘屏,陈宜鸿,张志萍.鸡血藤对环磷酰胺、60钴照射后动物血象的影响[J].中药药理与临床,1998,14(3):25-26
[15]张军艳,邓显峰,张青梅,等.结直肠癌患者血清肿瘤标志物联合检测的临床意义[J].实用临床医药杂志,2015,19(5):60-63
[16]张馨元,李鸿立,白明,等.结直肠癌根治术后血清癌胚抗原变化趋势与患者预后的关系[J].山东医药,2015,55(14):64-66
[17]武春梅,蒋潮涌,吕先鱼,等.结直肠癌患者血清CEA、CA199水平与临床病理因素及预后的关系[J].中国医学创新,2012,9(29):38-39
[18]刘鸿章,段文都,周超熙,等.血清癌胚抗原、甲胎蛋白和低聚糖肿瘤相关糖类抗原的检测应用于结直肠癌肝转移的诊断[J].中日友好医院学报,2009,23(5):295-297
[19]李华,马箐,艾萍,等.中药预防肿瘤化疗后白细胞减少症随机对照试验的系统评价及Meta分析[J].中国中西医结合杂志,2015,35(2):157-166
[2]韩保卫,李朝辉,韩鸿彬,等.直肠癌根治术后早期经动脉介入局部化疗对肝转移的预防作用[J].中国老年学杂志,2013,33(18):4546-4547
[3] Eapen L,Stewart D,Collins J,et al. Effective bladder sparing therapy with intra-arterial cisplatin and radiotherapy for localized bladder cancer[J]. J Urol,2004,172:1276-1280
[4]陈秋美.埋入式化疗泵治疗晚期肝癌的观察与护理[J].现代中西医结合杂志,2005,14(7):954-955
[5]杨维竹,谢敬霞,江娜,等.经皮植入化疗泵动脉灌注化疗治疗恶性肿瘤[J].实用放射学杂志,2000,16(11):649-652
[6]高学敏.中药学[M].北京:中国中医药出版社,2002:503
[7]张燕,梁华平.黄芪多糖对烧伤小鼠细胞免疫功能的作用[J].中国药理学通报,1995,11(2):136-138
[8]刘裕,孙晓莉.黄芪对体外人胚肺二倍体成纤维细胞的抗衰老作用研究——Ⅱ.超微形态研究[J].首都医学院学报,1993,14(4):265-275
[9]董士丽,梁惠,李要轩.益气养阴灌肠汤治疗宫颈癌晚期放射性直肠炎临床观察[J].中医药临床杂志,2011,23(11):944-945
[10]王家葵,郑军,沈映君,等.太子参总提取物对环磷酰胺处理动物免疫功能及胸腺、脾脏核酸含量的影响[J].中药药理与临床,1996,12(6):12-18
[11]全淅强.白花蛇舌草及其有效组分对癌症的治疗作用[J].中医学报,2011,26(10):1155-1157
[12]金芝贵,金剑,肖忠革,等.女贞子的药理作用及其临床应用进展[J].药学服务与研究,2011,11(3):189-192
[13]梅雪,余刘勤,陈小云,等.何首乌化学成分和药理作用的研究进展[J].药物评价研究,2016,39(1):122-131
[14]刘屏,陈宜鸿,张志萍.鸡血藤对环磷酰胺、60钴照射后动物血象的影响[J].中药药理与临床,1998,14(3):25-26
[15]张军艳,邓显峰,张青梅,等.结直肠癌患者血清肿瘤标志物联合检测的临床意义[J].实用临床医药杂志,2015,19(5):60-63
[16]张馨元,李鸿立,白明,等.结直肠癌根治术后血清癌胚抗原变化趋势与患者预后的关系[J].山东医药,2015,55(14):64-66
[17]武春梅,蒋潮涌,吕先鱼,等.结直肠癌患者血清CEA、CA199水平与临床病理因素及预后的关系[J].中国医学创新,2012,9(29):38-39
[18]刘鸿章,段文都,周超熙,等.血清癌胚抗原、甲胎蛋白和低聚糖肿瘤相关糖类抗原的检测应用于结直肠癌肝转移的诊断[J].中日友好医院学报,2009,23(5):295-297
[19]李华,马箐,艾萍,等.中药预防肿瘤化疗后白细胞减少症随机对照试验的系统评价及Meta分析[J].中国中西医结合杂志,2015,35(2):157-166