季节变化与产妇部分相关骨代谢指标的研究
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摘要
目的探讨季节变化对产妇骨代谢相关的部分血清检测指标,指导不同季节产妇膳食和钙的补充。方法选取2017年11月至2018年10月到云南省第三人民医院妇产科正常顺产的40例产妇进行骨代谢相关检测指标作为研究对象。40例产妇根据入院时间分为2组:2017年11月至2018年4月为冬春组(20例),2018年5月至2018年10月为夏秋组(20例);比较2组产妇产后36～42 d血清中25-羟基维生素D、骨钙素、血清钙含量。结果夏秋组和冬春组25-羟基维生素D (33.6±8.5和29.3±9.7) ng/m L、骨钙素(5.47±4.13和4.22±3.45) ng/m L,2项指标2个组比较差异有统计学意义(P <0.05);而血清钙(2.20±0.35)和(2.16±0.21) mmo L/L差异无统计学意义(P> 0.05)。结论常驻昆明本地的产妇夏秋组和冬春组产后36～42 d血清中25-羟基维生素D和骨钙素2项指标存在明显的季节性差异。
Objective To explore the serum bone metabolism indexes in parturient women related to seasonal changes, and to guide maternal diet and calcium supplementation in different seasons.Methods 40 parturients who were admitted in the department of obstetrics and gynecology of the third people's hospital of yunnan province from November 2017 to October 2018 were selected as subjects for the bone metabolism related indexesdetection.According to the time of admission, 40 parturient women were divided into two groups: winter and spring group(n =20) from November 2017 to April 2018, and summer and autumn group(n =20) from May 2018 to October 2018.The serum levels of 25-hydroxy vitamin D, osteocalcin and serum calcium in 36-42(d)postpartum of the 2 groups were compared. Results There were significant differences in 25-hydroxy vitamin D(33.64±8.51 and 28.32±9.78) ng/m L and osteocalcin(5.47±4.13 and 4.22±3.45) ng/m L between the two groups(P < 0.05).Meanwhile, there was no significant difference in serum calcium(2.20±0.35 and 2.16±0.21) mmo L/L(P > 0.05). Conclusion There were significant seasonal differences in serum levels of25-hydroxyvitamin D and osteocalcin between 36-42(d) postpartum in summer and autumn group and winter and spring group.
Objective To explore the serum bone metabolism indexes in parturient women related to seasonal changes, and to guide maternal diet and calcium supplementation in different seasons.Methods 40 parturients who were admitted in the department of obstetrics and gynecology of the third people's hospital of yunnan province from November 2017 to October 2018 were selected as subjects for the bone metabolism related indexesdetection.According to the time of admission, 40 parturient women were divided into two groups: winter and spring group(n =20) from November 2017 to April 2018, and summer and autumn group(n =20) from May 2018 to October 2018.The serum levels of 25-hydroxy vitamin D, osteocalcin and serum calcium in 36-42(d)postpartum of the 2 groups were compared. Results There were significant differences in 25-hydroxy vitamin D(33.64±8.51 and 28.32±9.78) ng/m L and osteocalcin(5.47±4.13 and 4.22±3.45) ng/m L between the two groups(P < 0.05).Meanwhile, there was no significant difference in serum calcium(2.20±0.35 and 2.16±0.21) mmo L/L(P > 0.05). Conclusion There were significant seasonal differences in serum levels of25-hydroxyvitamin D and osteocalcin between 36-42(d) postpartum in summer and autumn group and winter and spring group.
引文
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[12]金川云,胡建德.重型抑郁症患者血清维生素D水平的研究[J].中国健康心理学杂志,2017,25(11):1601-1604.
[13]张萌萌中国老年病学学会骨质疏松委员会骨代谢生化指标临床应用专家共识[J].中国骨质疏松杂志,2014,(20)11:1263-1271.
[2] BOLLAND M J,BACON C J,HORNE A M,et al.vitamin d insufficiency and health outcomes over 5 yin older women[J].Am J Clin Nutr,2010,91(1):82-89.
[3] CASHMAN K D,HILL T R,COTTER A A,et al. low vitamind status adversely affects bone health parameters in adolescents[J].Am J Clin Nutr,2008,87(4):1039-1044.
[4]连星烨,孟增东.不同地区光照量与人体维生素D水平及骨密度之间的关系[J].中国骨质疏松杂志,2012,18(2):183-187.
[5]褚西奏,周谰镇,黄飞.分娩妇女及新生儿血清骨钙素含量分析[J].第四军医大学学报,1997,18(2):175.
[6]张昕明,龚波,李海川,等.产后妇女全血钙和骨源性碱性磷酸酶(ABAP)活性的检测与分析[J].中国优生与遗传杂志,2009,17(10):75-76.
[7] FOO L H,ZHANG Q,ZHU K,et al.Relationship between vitamin D status,body composition and physical exercise of adolescent girls in Beijing[J].Osteoporos Int,2009,20(3):417-425.
[8] TSAI K S,HSU S H,CHENG J P,et a1vitamin dstores of urban women in taipei:effect on bone density and bone turnover,and seasonal variation[J]. Bone,1997,20(4):371-374.
[9]陈明慧,梁敏.维生素D、骨钙素与2型糖尿病患者胰岛功能相关性研究进展[J].广西医科大学学报,2017,34(7):1097-1099.
[10]ISSA C M.Vitamin D and Type 2 Diabetes Mellitus[J].Adv Exp Med Biol,2017,996(1):193-205.
[11] BROUWER-BROLSMA E M,DHONUKSHERUTTEN R,WIJNGAARDEN J,et al.Low vitamin D status is associated with more depressivesymptoms in Dutch older adults[J].Eur J Nutr,2016,55(4):1525-1534.
[12]金川云,胡建德.重型抑郁症患者血清维生素D水平的研究[J].中国健康心理学杂志,2017,25(11):1601-1604.
[13]张萌萌中国老年病学学会骨质疏松委员会骨代谢生化指标临床应用专家共识[J].中国骨质疏松杂志,2014,(20)11:1263-1271.
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