癫痫患者血清S100B蛋白水平与认知功能的相关性研究
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摘要
目的探讨癫痫患者血清S100B蛋白浓度与认知功能的相关性。方法对55例癫痫患者和33例健康对照者进行蒙特利尔认知功能量表(MoCA)测试,癫痫组依据MoCA得分分为癫痫认知障碍组(<26分)和癫痫非认知障碍组(≥26分),分别检测其血清S100B蛋白水平。结果健康对照组、癫痫非认知障碍组、癫痫认知障碍组的S100B蛋白浓度依次升高(P均<0. 05);癫痫认知障碍组S100B蛋白水平与延迟记忆(r=-0. 270,P <0. 05)和注意力(r=-0. 353,P <0. 05)得分呈负相关。结论癫痫患者血清S100B蛋白水平高于健康人,认知障碍的癫痫患者S100B水平与记忆力和注意力表现呈负相关。
Objective To explore the correlation between serum S100 B protein levels and cognitive function in epilepsy patients. Methods The Cognitive function of 55 patients with epilepsy and 33 healthy controls was tested by the Montreal Cognitive function scale( MoCA). According to MoCA scores,the epilepsy patients were divided into cognitive impairment epileptic group( < 26 points) and non-cognitive impairment epileptic group( > 26 points),then detect their serum S100 B protein levels. Results The concentration of S100 B protein in the group of healthy controls、non-cognitive impairment epileptic group and cognitive impairment epileptic group increased successively( all P < 0. 05). Serum S100 B protein level was negatively correlated with the score of delayed memory( r =-0. 270,P < 0. 05) and attention( r =-0. 353,P < 0. 05) in cognitive impairment epileptic group. Conclusion The serum S100 B protein level of epileptic patients was higher than that of healthy people,and was negatively correlated with delayed memory and attention.
Objective To explore the correlation between serum S100 B protein levels and cognitive function in epilepsy patients. Methods The Cognitive function of 55 patients with epilepsy and 33 healthy controls was tested by the Montreal Cognitive function scale( MoCA). According to MoCA scores,the epilepsy patients were divided into cognitive impairment epileptic group( < 26 points) and non-cognitive impairment epileptic group( > 26 points),then detect their serum S100 B protein levels. Results The concentration of S100 B protein in the group of healthy controls、non-cognitive impairment epileptic group and cognitive impairment epileptic group increased successively( all P < 0. 05). Serum S100 B protein level was negatively correlated with the score of delayed memory( r =-0. 270,P < 0. 05) and attention( r =-0. 353,P < 0. 05) in cognitive impairment epileptic group. Conclusion The serum S100 B protein level of epileptic patients was higher than that of healthy people,and was negatively correlated with delayed memory and attention.
引文
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[15]赵清,张晖,张桂,等. S100B及P300对颞叶癫痫患者记忆的评价[J].航空航天医学杂志,2017,28(9):1033-1035.
[16]Lydia AJ,Ali K,Flemming WB,et al. Alterations in pain responsiveness and serum biomarkers in juvenile myoclonic epilepsy:an age and gender-matched controlled pilot study[J]. Future Neurol,2016,11(1):33-46.
[17]Yetkin I,Shermatova K,Abuhandan M,et al. Evaluation of serum S-100B protein levels in patients with simple febrile convulsions[J]. J Pediatr Neurol,2016,14(3):102-104.
[18]魏志玄.大鼠癫痫模型脑脊液中S100B水平测定[J].中国医学工程,2014,22(1):20-23.
[19]Clasadonte J,Donq J,Hines DJ,et al. Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy[J]. Proc Natl Acad Sci,2013,110(43):17540-17545.
[20]Koh SX,Lee JK. S100B as a marker for brain damage and blood brain barrier disruption following exercise[J]. Sports Med,2014,44(3):369-385.
[21]Gorter JA,Van Vliet EA,Aronica E. Status epilepticus,blood-brain barrier disruption,inflammation,and epileptogenesis[J]. Epilepsy Behav,2015,49(8):13-16.
[22]Marchi N,Granata T,Ghosh C,et al. Blood-brain barrier dysfunction and epilepsy:pathophysiologic role and therapeutic approaches[J].Epilepsia,2012,53(11):1877-1886.
[23]阮学东,叶飞,邢海燕,等. S100B蛋白在癫痫患儿血清中的表达及其临床意义[J].中华全科医学,2014,12(8):1283-1285.
[24]Calik M,Abuhandan M,Sonmezler A,et al. Elevated serum S-100B levels in children with temporal lobe epilepsy[J]. Seizure,2013,22(2):99-102.
[2]黄隽超,尚兰,张建新,等.阿尔茨海默病患者血清S100B蛋白和抗脑抗体浓度与认知功能关系[J].中国心理卫生杂志,2107,31(7):523-527.
[3]Hong W,Zhao M,Li HZ,et al. Higher plasma S100B concentrations in schizophrenia patients,and dependently associated with inflammatory marker[J]. Sci Rep,2016,6(6):27584.
[4]Wang F,Zou ZR,Yuan D,et al. Correlation between serum S100 beta protein levels and cognitivedysfunction in patients with cerebral small vessel disease:a case-control study[J]. Biosci Rep,2017,37(2):BSR20160446.
[5]Omidvar R,Hossein P,Kurosh G,et al. S100B:A new concept in neurocritical care[J]. Iran J Neurol,2017,16(2):83-89.
[6]Silva FP,Schmidt AP,Valentin LS,et al. S100B protein and neuronspecific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery:a prospective observational study[J]. Eur J Anaesthesiol,2016,33(9):681-689.
[7]Ji XL,Sun CL,Li XJ,et al. Baseline S100B protein as a potential predicator for postoperative cognitive dysfunction in elderly patients after hip joint replacement surgery[J]. Int J Clin Exp Pathol,2016,9(11):11911-11916.
[8]Chang CC,Lui CC,Lee CC,et al. Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy[J]. BMC Neurol,2012,12(3):15.
[9]Pitknen A,Lukasiuk K. Molecular Biomarkers of Epileptogenesis[J]. Neurotherapeutics,2011,5(5):629-633.
[10]Heidari K,Vafaee A,Rastekenari AM,et al. S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury Systematic review and meta-analysis[J]. Brain Inj,2015,29(10):1-12.
[11]Kacinski M,Budziszewska B,Lason W,et al. Level of S100B protein,neuron specific enolase,orexin A,adiponectin and insulin-like growth factor in serum of pediatric patients suffering from sleep disorders with or without epilepsy[J]. Pharmacol Rep,2012,64(6):1427-1433.
[12]De Vries HE,Kooij G,Frenkel D,et al. Inflammatory events at bloodbrain barrier in neuroinflammatory and neurodegenerative disorders:implications for clinical disease[J]. Epilepsia,2012,53(Suppl 6):45-52.
[13]Lu C,Li J,Sun W,et al. Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese:a casecontrol study[J]. Neurosci Lett,2010,484(2):139-142.
[14]Mikkonen K,Pekkala N,Pokka T,et al. S100B proteins in febrile seizures[J]. Seizure,2012,21(2):144-146.
[15]赵清,张晖,张桂,等. S100B及P300对颞叶癫痫患者记忆的评价[J].航空航天医学杂志,2017,28(9):1033-1035.
[16]Lydia AJ,Ali K,Flemming WB,et al. Alterations in pain responsiveness and serum biomarkers in juvenile myoclonic epilepsy:an age and gender-matched controlled pilot study[J]. Future Neurol,2016,11(1):33-46.
[17]Yetkin I,Shermatova K,Abuhandan M,et al. Evaluation of serum S-100B protein levels in patients with simple febrile convulsions[J]. J Pediatr Neurol,2016,14(3):102-104.
[18]魏志玄.大鼠癫痫模型脑脊液中S100B水平测定[J].中国医学工程,2014,22(1):20-23.
[19]Clasadonte J,Donq J,Hines DJ,et al. Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy[J]. Proc Natl Acad Sci,2013,110(43):17540-17545.
[20]Koh SX,Lee JK. S100B as a marker for brain damage and blood brain barrier disruption following exercise[J]. Sports Med,2014,44(3):369-385.
[21]Gorter JA,Van Vliet EA,Aronica E. Status epilepticus,blood-brain barrier disruption,inflammation,and epileptogenesis[J]. Epilepsy Behav,2015,49(8):13-16.
[22]Marchi N,Granata T,Ghosh C,et al. Blood-brain barrier dysfunction and epilepsy:pathophysiologic role and therapeutic approaches[J].Epilepsia,2012,53(11):1877-1886.
[23]阮学东,叶飞,邢海燕,等. S100B蛋白在癫痫患儿血清中的表达及其临床意义[J].中华全科医学,2014,12(8):1283-1285.
[24]Calik M,Abuhandan M,Sonmezler A,et al. Elevated serum S-100B levels in children with temporal lobe epilepsy[J]. Seizure,2013,22(2):99-102.