臭氧治疗安全性和有效性的研究进展
摘要
臭氧是一种具有治疗作用的气体。但臭氧的分子结构不稳定,臭氧的治疗方法、使用浓度和剂量等缺乏规范化的指南,因而影响了臭氧治疗的安全性和有效性。本文对此进行了全面回顾,归纳总结了臭氧的理化性质、治疗作用和毒性作用及五种常用的治疗方法,这将有助于臭氧在疼痛疾病治疗中的深入研究与合理应用。
引文
[1]Smith NL, Wilson AL, Gandhi J, et al. Ozone therapy:an overview of pharmacodynamics, current research, and clinical utility[J]. Med Gas Res, 2017, 7(3):212-219.
[2]BabiorBernardM, TakeuchiCindy.Investigatingantibody-catalyzedozonegenerationbyhumanneutrophils[J]. Proc Natl Acad Sci USA, 2003, 100(6):3031-3034.
[3]Yu Y, Dong H, Yao S, et al. Protective Effects of AmbientOzoneonIncidenceandOutcomesofIschemic Stroke in Changzhou,China:A Time-Series Study[J]. Int J Environ Res Public Health, 2017, 14, 1610.
[4]Bocci V. Is it true that ozone is always toxic? The end of a dogma[J]. Toxicol Appl Pharmacol, 2006, 216(3):493-504.
[5]Zanardi I, Borrelli E, Valacchi G, et al. Ozone:A Multifaceted Molecule with Unexpected Therapeutic Activity[J]. Curr Med Chem, 2016, 23(4):304-314.
[6]KieranM,GavinE,JimS, et al.Percutaneous TreatmentofHerniatedLumbarDiscswithOzone:Investigation of the Mechanisms of Action[J]. J Vasc Interv Radiol, 2016, 27(8):1242-1250.
[7]CostanzoM,CisternaB,Vella A, etal.Lowozone concentrations stimulate cytoskeletal organization, mitochondrialactivityandnucleartranscription[J].EurJ Histochem, 2015, 59(2):2515.
[8]Hernandez-Zimbron LF, Rivas-Arancibia S. Oxidative stress caused by ozone exposure induces beta-amyloid1-42overproductionandmitochondrialaccumulation by activating the amyloidogenic pathway[J]. Neuroscience, 2015, 304:340-348.
[9]Francis M, Groves AM, Sun R, et al. CCR2 Regulates In?ammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure[J]. Toxicol Sci,2017, 155(2):474-484.
[10]Rumsey WL, Bolognese B, Davis AB, et al. Effects of airbornetoxicantsonpulmonaryfunctionandmitochondrial DNA damage in rodent lungs[J]. Mutagenesis, 2017, 32(3):343-353.
[11]BocciVelio.Theusefulnessofozonetreatmentin spinal pain[J]. Drug Design Development and Terapy,2015, 9:2677-2685.
[12]贾雅蕊,刘金锋.臭氧局部注射对急性软组织损伤的影响[J].中国疼痛医学杂志, 2015, 21(11):834-839.
[13]寇久社,吴涛,张润宁,等.不同质量浓度医用臭氧对兔骨骼肌损伤组织学与IL-6的影响[J].临床和实验医学杂志, 2017, 16(24):2415-2419.
[14]Lopes de Jesus CC, dos Santos FC, deJesus LMOB, et al.Comparison between intra articular ozone and placebo in the treatment of knee osteoarthritis:A randomized,double-blinded,placebo-controlledstudy[J].PLoS ONE, 2017, 12(7):e0179-185.
[15]Giombini A, Menotti F,Di Cesare A. Comparison between intrarticular injection of hyaluronic acid, oxygen ozone, and the combination of both in the treatment of knee osteoarthrosis[J]. J Biol Regul Homeost Agents,2016, 30(2):621-625.
[16]Raeissadat SA, Rayegani SM, Forogh B. Intra-articular ozone or hyaluronic acid injection:Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial[J]. J Pain Res, 2018, 11:111-117.
[17]文向萍.臭氧腔内注射治疗犬早期膝骨关节炎的最适低浓度.桂林医学院, 2014.
[18]Xu F, Li BP. Therapeutic ef?cacy of ozone injection into the knee for the osteoarthritis patient along with oral celecoxib and glucosamine[J]. J Clini Diagnostic Res,2018, 11:UC01-UC03.
[19]Braidy N, Izadi M, Sureda A, et al. Therapeutic relevance of ozone therapy in degenerative diseases:Focus on diabetes and spinal pain[J]. J Cell Physiol, 2018, 233(4):2705-2714.
[20]王家双,魏星,包佳巾,等.臭氧介入综合治疗顽固性疱疹后神经痛5年随访研究[J].中国疼痛医学杂志, 2016, 22(1):34-40.
[21]胡永胜,张玉坤,黄卫民,等.不同浓度臭氧治疗椎间盘源性腰痛的疗效评价[J].中国疼痛医学杂志,2011, 17(11):697-699.
[22]ZhouNB,FuZJ,Sun T.Effectsofdifferentconcentrations of oxygen-ozone on rats'astrocytes in vitro[J].Neurosci Lett, 2008, 441(2):178-182.
[23]许维澄,林小雯,王群波,等.高浓度医用臭氧对大鼠运动功能和脊髓Bax、Bcl-2表达的影响[J].中国疼痛医学杂志, 2013, 19(2):95-97.
[24]Hüseyin Toman, U?ur?zdemir, Hasan Ali Kiraz, et al.Severeheadachefollowingozonetherapy:Pneumocephalus[J]. A?r?, 2017, 29(3):132-136.
[25]LambertoRe,GregorioMSánchez,NabilMawsouf.Clinical evidence of interaction with pain mediators[J].Saudi Med J, 2010, 31(12):1363-1367.
[26]槐洪波,朱彤,韩影.臭氧辅助治疗老年带状疱疹后神经痛的临床疗效分析[J].实用老年医学, 2016,30(12):1004-1006.
[27]Ceccherelli F, Gagliardi G, Faggian L, et al. Analgesic effect of subcutaneous administration of oxygen-ozone.A blind study in the rat on the modulation of the capsaicin-induced edema[J]. Acupunct Electrother Res, 1998,23N 3-4:171-184.
[28]Fuccio C, Luongo C, Capodanno P, et al. A single subcutaneousinjectionofozonepreventsallodyniaand decreasestheover-expressionofpro-inflammatory caspasesintheorbito-frontalcortexofneuropathic mice[J]. Eur J Pharmacol, 2009, 603:42-49.
[2]BabiorBernardM, TakeuchiCindy.Investigatingantibody-catalyzedozonegenerationbyhumanneutrophils[J]. Proc Natl Acad Sci USA, 2003, 100(6):3031-3034.
[3]Yu Y, Dong H, Yao S, et al. Protective Effects of AmbientOzoneonIncidenceandOutcomesofIschemic Stroke in Changzhou,China:A Time-Series Study[J]. Int J Environ Res Public Health, 2017, 14, 1610.
[4]Bocci V. Is it true that ozone is always toxic? The end of a dogma[J]. Toxicol Appl Pharmacol, 2006, 216(3):493-504.
[5]Zanardi I, Borrelli E, Valacchi G, et al. Ozone:A Multifaceted Molecule with Unexpected Therapeutic Activity[J]. Curr Med Chem, 2016, 23(4):304-314.
[6]KieranM,GavinE,JimS, et al.Percutaneous TreatmentofHerniatedLumbarDiscswithOzone:Investigation of the Mechanisms of Action[J]. J Vasc Interv Radiol, 2016, 27(8):1242-1250.
[7]CostanzoM,CisternaB,Vella A, etal.Lowozone concentrations stimulate cytoskeletal organization, mitochondrialactivityandnucleartranscription[J].EurJ Histochem, 2015, 59(2):2515.
[8]Hernandez-Zimbron LF, Rivas-Arancibia S. Oxidative stress caused by ozone exposure induces beta-amyloid1-42overproductionandmitochondrialaccumulation by activating the amyloidogenic pathway[J]. Neuroscience, 2015, 304:340-348.
[9]Francis M, Groves AM, Sun R, et al. CCR2 Regulates In?ammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure[J]. Toxicol Sci,2017, 155(2):474-484.
[10]Rumsey WL, Bolognese B, Davis AB, et al. Effects of airbornetoxicantsonpulmonaryfunctionandmitochondrial DNA damage in rodent lungs[J]. Mutagenesis, 2017, 32(3):343-353.
[11]BocciVelio.Theusefulnessofozonetreatmentin spinal pain[J]. Drug Design Development and Terapy,2015, 9:2677-2685.
[12]贾雅蕊,刘金锋.臭氧局部注射对急性软组织损伤的影响[J].中国疼痛医学杂志, 2015, 21(11):834-839.
[13]寇久社,吴涛,张润宁,等.不同质量浓度医用臭氧对兔骨骼肌损伤组织学与IL-6的影响[J].临床和实验医学杂志, 2017, 16(24):2415-2419.
[14]Lopes de Jesus CC, dos Santos FC, deJesus LMOB, et al.Comparison between intra articular ozone and placebo in the treatment of knee osteoarthritis:A randomized,double-blinded,placebo-controlledstudy[J].PLoS ONE, 2017, 12(7):e0179-185.
[15]Giombini A, Menotti F,Di Cesare A. Comparison between intrarticular injection of hyaluronic acid, oxygen ozone, and the combination of both in the treatment of knee osteoarthrosis[J]. J Biol Regul Homeost Agents,2016, 30(2):621-625.
[16]Raeissadat SA, Rayegani SM, Forogh B. Intra-articular ozone or hyaluronic acid injection:Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial[J]. J Pain Res, 2018, 11:111-117.
[17]文向萍.臭氧腔内注射治疗犬早期膝骨关节炎的最适低浓度.桂林医学院, 2014.
[18]Xu F, Li BP. Therapeutic ef?cacy of ozone injection into the knee for the osteoarthritis patient along with oral celecoxib and glucosamine[J]. J Clini Diagnostic Res,2018, 11:UC01-UC03.
[19]Braidy N, Izadi M, Sureda A, et al. Therapeutic relevance of ozone therapy in degenerative diseases:Focus on diabetes and spinal pain[J]. J Cell Physiol, 2018, 233(4):2705-2714.
[20]王家双,魏星,包佳巾,等.臭氧介入综合治疗顽固性疱疹后神经痛5年随访研究[J].中国疼痛医学杂志, 2016, 22(1):34-40.
[21]胡永胜,张玉坤,黄卫民,等.不同浓度臭氧治疗椎间盘源性腰痛的疗效评价[J].中国疼痛医学杂志,2011, 17(11):697-699.
[22]ZhouNB,FuZJ,Sun T.Effectsofdifferentconcentrations of oxygen-ozone on rats'astrocytes in vitro[J].Neurosci Lett, 2008, 441(2):178-182.
[23]许维澄,林小雯,王群波,等.高浓度医用臭氧对大鼠运动功能和脊髓Bax、Bcl-2表达的影响[J].中国疼痛医学杂志, 2013, 19(2):95-97.
[24]Hüseyin Toman, U?ur?zdemir, Hasan Ali Kiraz, et al.Severeheadachefollowingozonetherapy:Pneumocephalus[J]. A?r?, 2017, 29(3):132-136.
[25]LambertoRe,GregorioMSánchez,NabilMawsouf.Clinical evidence of interaction with pain mediators[J].Saudi Med J, 2010, 31(12):1363-1367.
[26]槐洪波,朱彤,韩影.臭氧辅助治疗老年带状疱疹后神经痛的临床疗效分析[J].实用老年医学, 2016,30(12):1004-1006.
[27]Ceccherelli F, Gagliardi G, Faggian L, et al. Analgesic effect of subcutaneous administration of oxygen-ozone.A blind study in the rat on the modulation of the capsaicin-induced edema[J]. Acupunct Electrother Res, 1998,23N 3-4:171-184.
[28]Fuccio C, Luongo C, Capodanno P, et al. A single subcutaneousinjectionofozonepreventsallodyniaand decreasestheover-expressionofpro-inflammatory caspasesintheorbito-frontalcortexofneuropathic mice[J]. Eur J Pharmacol, 2009, 603:42-49.