中药白及化学成分与药理活性研究进展
|
摘要
白及为兰科植物白及的干燥块茎,白及收敛止血,消肿生肌,主要用于咯血、吐血、外伤出血、疮疡肿毒、溃疡疼痛、汤火灼伤、皮肤皲裂等,疗效显著。研究显示,白及的化学成分主要包括联苄类、二氢菲类、联菲类、联菲醚类、菲并吡喃类、联苄葡萄糖苷类、甾体、三萜等。现代药理研究表明,白及药理活性主要包括抗菌、止血、抗肿瘤、抗溃疡、抗纤维化、抗氧化、促进伤口愈合等方面。白及用药历史悠久,其化学成分和药理活性得到不断深入研究,展现了其广阔的应用前景。本文综述了白及的化学成分与药理活性的研究进展,为白及相关的中药研究、新药开发、临床应用提供科学依据。
Bletilla striata is a perennial herb. The tubers of Bletilla striata were used to treat hemoptysis,hematemesis,trauma and bleeding,ulcers and swellings,ulcer and pains,burns,skin chapping,etc.based on the function of astringing to arrest bleeding and detumescence and tissue regeneration. Researches showed that bibenzyl,dihydrophenanthrene,blestriarene,dihy-drophenantropyrans,steroid,triterpenoids,sesquiterpenes have been isolated from Bletilla striata. Modern pharmacological research showed that the tubers of Bletilla striata have been widely used for antibacterial,hemostatic,antitumor,fight ulcer,anti-fibrosis,antioxidant,promoting wound healing,etc. Bletilla striata has a long history to treat diseases,and the chemical component and pharmacological activity of it has been studied deeply. In this article,new development of constituents and biological activities of Bletilla striata was reviewed and summarized for its further development and utilization.
Bletilla striata is a perennial herb. The tubers of Bletilla striata were used to treat hemoptysis,hematemesis,trauma and bleeding,ulcers and swellings,ulcer and pains,burns,skin chapping,etc.based on the function of astringing to arrest bleeding and detumescence and tissue regeneration. Researches showed that bibenzyl,dihydrophenanthrene,blestriarene,dihy-drophenantropyrans,steroid,triterpenoids,sesquiterpenes have been isolated from Bletilla striata. Modern pharmacological research showed that the tubers of Bletilla striata have been widely used for antibacterial,hemostatic,antitumor,fight ulcer,anti-fibrosis,antioxidant,promoting wound healing,etc. Bletilla striata has a long history to treat diseases,and the chemical component and pharmacological activity of it has been studied deeply. In this article,new development of constituents and biological activities of Bletilla striata was reviewed and summarized for its further development and utilization.
引文
[1]国家中医药管理局《中华本草》编委会.中华本草[M].上海:上海科学技术出版社,1999:8674.
[2]国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2010:95.
[3]Takagi S,Yamaki M,Inoue K.Antimicrobial agents from Bletilla striata[J].Phytochemistry,1983,22(4):1011-1015.
[4]Yamaki M,Kato T,Bai L,et al.Methylated stilbenoids from Bletilla striata[J].Phytochemistry,1991,30(8):2759-2760.
[5]Bai L,Kato T,Inoue K,et al.Stilbenoids from Bletilla striata[J].Phytochemistry,1993,33(6):1481-1483.
[6]Feng J,Zhang R,Zhao W.Novel bibenzyl derivatives from the tubers of Bletilla striata[J].Helvetica Chimica Acta,2008,91(3):520-525.
[7]韩广轩,王立新,顾正兵,等.中药白及中一新的联苄化合物[J].药学学报,2002,37(3):194-195.
[8]韩广轩,王立新,张卫东,等.中药白及的化学成分研究(I)[J].第二军医大学学报,2002,23(4):443-445.
[9]Yamaki M,Bai L,Inoue K,et al.Benzylphenanthrenes from Bletilla striata[J].Phytochemistry,1990,29(7):2285-2287.
[10]Yamaki M,Li B,Kato T,et al.Three dihydrophenanthropyrans from Bletilla striata[J].Phytochemistry,1993,32(2):427-430.
[11]Bai L,Yamaki M,Inoue K,et al.Blestrin A and B,bis(dihydrophenanthrene)ethers from Bletilla striata[J].Phytochemistry,1990,29(4):1259-1260.
[12]Yamaki M,Bai L,Inoue K,et al.Biphenanthrenes from Bletilla striata[J].Phytochemistry,1989,28(12):3503-3505.
[13]Bai L,Kato T,Inoue K,et al.Blestrianol A,B and C,biphenanthrenes from Bletilla striata[J].Phytochemistry,1991,30(8):2733-2735.
[14]Morita H,Koyama K,Sugimoto Y,et al.Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata[J].Bioorganic&medicinal chemistry letters,2005,15(4):1051-1054.
[15]Yamaki M,Bai L,Kato T,et al.Blespirol,a phenanthrene with a spirolactone ring from Bletilla striata[J].Phytochemistry,1993,33(6):1497-1498.
[16]Yamaki M,Kato T,Bai L,et al.Phenanthrene glucosides from Bletilla striata[J].Phytochemistry,1993,34(2):535-537.
[17]Sakuno E,Kamo T,Takemura T,et al.Contribution of militarine and dactylorhin A to the plant growth-inhibitory activity of a weed-suppressing orchid,Bletilla striata[J].Weed biology and management,2010,10(3):202-207.
[18]Wang Y,Liu D,Chen S,et al.A new glucomannan from Bletilla striata:Structural and anti-fibrosis effects[J].Fitoterapia,2014,(92):72-78.
[19]Park JE,Woo KW,Choi SU,et al.Two New Cytotoxic SpirostaneSteroidal Saponins from the Roots of Bletilla striata[J].Helvetica Chimica Acta,2014,97(1):56-63.
[20]韩广轩,王立新,王麦莉,等.中药白及化学成分的研究[J].药学实践杂志,2001,19(6):360-361.
[21]韩广轩,王立新,张卫东,等.中药白及化学成分研究(Ⅱ)[J].第二军医大学学报,2002,23(9):1029-1031.
[22]Saito N,Ku M,Tatsuzawa F,et al.Acylated cyanidin glycosides in the purple-red flowers of Bletilla striata[J].Phytochemistry,1995,40(5):1523-1529.
[23]Tatsuzawa F,Saito N,Shigihara A,et al.An Acylated Cyanidin3,7-diglucoside in the Bluish Flowers of Bletilla striata’Murasaki Shikibu’(Orchidaceae)[J].Journal of the Japanese Society for Horticultural Science,2010,79(2):215-220.
[24]Yamaki M,Honda C,KATO T,et al.The Steroids and Triterpenoids from Bletilla striata[J].Natural Medicine,1997,51(5):493.
[25]仰莲,彭成,杨雨婷,等.白及中1个新颖含氯甾体化合物[J].中草药,2015,46(3):325-328.
[26]王立新,韩广轩,舒莹,等.中药白及化学成分的研究[J].中国中药杂志,2001,26(10):691-692.
[27]彭芙,万峰,熊亮,等.白及不同提取部位抗耐甲氧西林金黄色葡萄球菌的体内外活性[J].中国实验方剂学杂志,2013,19(17):217-220.
[28]彭芙,万峰,熊亮,等.白及抑菌作用及其活性部位的初步研究[J].时珍国医国药,2013,24(5):1061-1063.
[29]吕迪,李伟平,潘平,等.白及块茎和须根抑菌作用的研究[J].中国实验方剂学杂志,2013,19(5):212-216.
[30]康庄,王和,李红芳,等.中药白及提取物介入治疗肺外淋巴结核的实验性研究[J].中国社区医师:医学专业,2011,(23):5-6.
[31]孙昕,范勇,杜钟珍,等.中药白芨凝胶经气道介入性治疗增殖型支气管结核的临床评价[J].中国内镜杂志,2006,12(8):832-835.
[32]Wang C,Sun J,Luo Y,et al.A polysaccharide isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro[J].Biotechnology letters,2006,28(8):539-543.
[33]Diao H,Li X,Chen J,et al.Bletilla striata Polysaccharide Stimulates Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression in Macrophages[J].Journal of bioscience and bioengineering,2008,105(2):85-89.
[34]Luo Y,Diao H,Xia S,et al.A physiologically active polysaccharide hydrogel promotes wound healing[J].Journal of Biomedical Materials Research Part A,2010,94(1):193-204.
[35]廖建中,王伟,罗永湘.白芨胶载高分子神经生长因子促进伤口的愈合(英文)[J].中国临床康复,2006,17:179-181,201.
[36]Liu B,Huang T,Yao C,et al.Novel wound dressing of non-woven fabric coated with genipin-crosslinked chitosan and bletilla striata herbal extract[J].J Med Biol Eng,2009,29(2):60-67.
[37]俞林花,聂绪强,潘会君,等.白及多糖对糖尿病溃疡创面愈合的作用研究[J].中国中药杂志,2011,36(11):1487-1491.
[38]左霞,常明泉,陶平德,等.白及在肿瘤治疗中的应用[J].中南药学,2015,1:58-60.
[39]祁波,王维云,陈士宗,等.肝癌白芨粉栓塞化疗与常规栓塞化疗的比较研究[J].肿瘤防治杂志,2005,11(4):405-406.
[40]王会轩.白芨硫酸钡食管造影在诊断原发性小细胞食管癌中的体会[J].中医临床研究,2011,3(16):114-115.
[41]刘文斌,尹彬祥,余朝骏.中药白及微粒与真丝线段栓塞子宫肌瘤的对比研究[J].中国中西医结合影像学杂志,2007,5(3):171-173.
[42]王丽凤,李伟平,沈一平,等.白及诱导HL-60细胞凋亡活性部位的筛选[J].中华中医药学刊,2012,30(12):2704-2706.
[43]陆雪芬.白及提取物对小鼠黑色素瘤B16细胞诱导凋亡作用的研究[J].中华中医药学刊,2013,31(7):1619-1621.
[44]车艳玲,刘松江.白及治疗小鼠移植性肝癌的研究[J].中医药信息,2008,(1):38-40.
[45]Jiang F,Li W,Huang Y,et al.Antioxidant,Antityrosinase and Antitumor Activity Comparison:The Potential Utilization of Fibrous Root Part of Bletilla striata(Thunb.)Reichb.f[J].Plo S one,2013,8(2):e58004.
[46]翁夏蒙,鲁光耀,王鸯妮,等.白及愈伤组织总酚含量测定及抗氧化作用研究[J].中药材,2013,(1):32-35.
[47]Dong L,Xia S,Luo Y,et al.Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-α[J].Journal of Controlled Release,2009,134(3):214-220.
[48]仇树林,王晓,李兵,等.白芨胶载重组人表皮生长因子对创面表皮细胞DNA含量及周期的影响[J].中国组织工程研究与临床康复,2007,11(1):63-66.
[49]Wu X,Xin M,Chen H,et al.Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis[J].Journal of pharmacy and pharmacology,2010,62(9):1152-1157.
[50]吕小波,黄春球,武正才,等.白及多糖对胃溃疡大鼠防治作用的实验研究[J].云南中医学院学报,2012,35(1):30-32.
[51]郑子春,沈洪,朱萱萱,等.黄柏,地榆,白及对溃疡性结肠炎大鼠组织中NF-κB和细胞因子表达的影响[J].中国中医急症,2010,(3):469-472.
[52]柯昌毅,赵春景.白及多糖对溃疡性结肠炎的作用研究[J].中国药房,2011,23:2132-2134.
[53]Wu J,Meng Y,Zou L,et al.Effects of diferent extracts from Bletilla colloid on hemostasis activity in mice[J].Journal of Pharmaceutical Practice,2011,29(3):206-207.
[54]陆波,徐亚敏,张汉明,等.白及不同提取部位对家兔血小板聚集的影响[J].解放军药学学报,2006,21(5):330-332.
[55]林卫红.白及雾化吸入治疗咯血症疗效观察[J].上海中医药杂志,2012,46(11):51-52.
[56]马世宏,金玲,王守香,等.中药白芨在牙膏中的应用研究[J].中国野生植物资源,2009,28(3):32-35.
[57]马世宏,金玲,揭邃,等.白芨-丹皮酚包合物在化妆品中的应用研究[J].日用化学品科学,2009,32(6):30-33.
[58]中华人民共和国卫生部.卫生部公布药食同源物品可用于保健食品物品名单[J].中医药学刊,2002,20(2):176.
[2]国家药典委员会.中华人民共和国药典(一部)[M].北京:中国医药科技出版社,2010:95.
[3]Takagi S,Yamaki M,Inoue K.Antimicrobial agents from Bletilla striata[J].Phytochemistry,1983,22(4):1011-1015.
[4]Yamaki M,Kato T,Bai L,et al.Methylated stilbenoids from Bletilla striata[J].Phytochemistry,1991,30(8):2759-2760.
[5]Bai L,Kato T,Inoue K,et al.Stilbenoids from Bletilla striata[J].Phytochemistry,1993,33(6):1481-1483.
[6]Feng J,Zhang R,Zhao W.Novel bibenzyl derivatives from the tubers of Bletilla striata[J].Helvetica Chimica Acta,2008,91(3):520-525.
[7]韩广轩,王立新,顾正兵,等.中药白及中一新的联苄化合物[J].药学学报,2002,37(3):194-195.
[8]韩广轩,王立新,张卫东,等.中药白及的化学成分研究(I)[J].第二军医大学学报,2002,23(4):443-445.
[9]Yamaki M,Bai L,Inoue K,et al.Benzylphenanthrenes from Bletilla striata[J].Phytochemistry,1990,29(7):2285-2287.
[10]Yamaki M,Li B,Kato T,et al.Three dihydrophenanthropyrans from Bletilla striata[J].Phytochemistry,1993,32(2):427-430.
[11]Bai L,Yamaki M,Inoue K,et al.Blestrin A and B,bis(dihydrophenanthrene)ethers from Bletilla striata[J].Phytochemistry,1990,29(4):1259-1260.
[12]Yamaki M,Bai L,Inoue K,et al.Biphenanthrenes from Bletilla striata[J].Phytochemistry,1989,28(12):3503-3505.
[13]Bai L,Kato T,Inoue K,et al.Blestrianol A,B and C,biphenanthrenes from Bletilla striata[J].Phytochemistry,1991,30(8):2733-2735.
[14]Morita H,Koyama K,Sugimoto Y,et al.Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata[J].Bioorganic&medicinal chemistry letters,2005,15(4):1051-1054.
[15]Yamaki M,Bai L,Kato T,et al.Blespirol,a phenanthrene with a spirolactone ring from Bletilla striata[J].Phytochemistry,1993,33(6):1497-1498.
[16]Yamaki M,Kato T,Bai L,et al.Phenanthrene glucosides from Bletilla striata[J].Phytochemistry,1993,34(2):535-537.
[17]Sakuno E,Kamo T,Takemura T,et al.Contribution of militarine and dactylorhin A to the plant growth-inhibitory activity of a weed-suppressing orchid,Bletilla striata[J].Weed biology and management,2010,10(3):202-207.
[18]Wang Y,Liu D,Chen S,et al.A new glucomannan from Bletilla striata:Structural and anti-fibrosis effects[J].Fitoterapia,2014,(92):72-78.
[19]Park JE,Woo KW,Choi SU,et al.Two New Cytotoxic SpirostaneSteroidal Saponins from the Roots of Bletilla striata[J].Helvetica Chimica Acta,2014,97(1):56-63.
[20]韩广轩,王立新,王麦莉,等.中药白及化学成分的研究[J].药学实践杂志,2001,19(6):360-361.
[21]韩广轩,王立新,张卫东,等.中药白及化学成分研究(Ⅱ)[J].第二军医大学学报,2002,23(9):1029-1031.
[22]Saito N,Ku M,Tatsuzawa F,et al.Acylated cyanidin glycosides in the purple-red flowers of Bletilla striata[J].Phytochemistry,1995,40(5):1523-1529.
[23]Tatsuzawa F,Saito N,Shigihara A,et al.An Acylated Cyanidin3,7-diglucoside in the Bluish Flowers of Bletilla striata’Murasaki Shikibu’(Orchidaceae)[J].Journal of the Japanese Society for Horticultural Science,2010,79(2):215-220.
[24]Yamaki M,Honda C,KATO T,et al.The Steroids and Triterpenoids from Bletilla striata[J].Natural Medicine,1997,51(5):493.
[25]仰莲,彭成,杨雨婷,等.白及中1个新颖含氯甾体化合物[J].中草药,2015,46(3):325-328.
[26]王立新,韩广轩,舒莹,等.中药白及化学成分的研究[J].中国中药杂志,2001,26(10):691-692.
[27]彭芙,万峰,熊亮,等.白及不同提取部位抗耐甲氧西林金黄色葡萄球菌的体内外活性[J].中国实验方剂学杂志,2013,19(17):217-220.
[28]彭芙,万峰,熊亮,等.白及抑菌作用及其活性部位的初步研究[J].时珍国医国药,2013,24(5):1061-1063.
[29]吕迪,李伟平,潘平,等.白及块茎和须根抑菌作用的研究[J].中国实验方剂学杂志,2013,19(5):212-216.
[30]康庄,王和,李红芳,等.中药白及提取物介入治疗肺外淋巴结核的实验性研究[J].中国社区医师:医学专业,2011,(23):5-6.
[31]孙昕,范勇,杜钟珍,等.中药白芨凝胶经气道介入性治疗增殖型支气管结核的临床评价[J].中国内镜杂志,2006,12(8):832-835.
[32]Wang C,Sun J,Luo Y,et al.A polysaccharide isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro[J].Biotechnology letters,2006,28(8):539-543.
[33]Diao H,Li X,Chen J,et al.Bletilla striata Polysaccharide Stimulates Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression in Macrophages[J].Journal of bioscience and bioengineering,2008,105(2):85-89.
[34]Luo Y,Diao H,Xia S,et al.A physiologically active polysaccharide hydrogel promotes wound healing[J].Journal of Biomedical Materials Research Part A,2010,94(1):193-204.
[35]廖建中,王伟,罗永湘.白芨胶载高分子神经生长因子促进伤口的愈合(英文)[J].中国临床康复,2006,17:179-181,201.
[36]Liu B,Huang T,Yao C,et al.Novel wound dressing of non-woven fabric coated with genipin-crosslinked chitosan and bletilla striata herbal extract[J].J Med Biol Eng,2009,29(2):60-67.
[37]俞林花,聂绪强,潘会君,等.白及多糖对糖尿病溃疡创面愈合的作用研究[J].中国中药杂志,2011,36(11):1487-1491.
[38]左霞,常明泉,陶平德,等.白及在肿瘤治疗中的应用[J].中南药学,2015,1:58-60.
[39]祁波,王维云,陈士宗,等.肝癌白芨粉栓塞化疗与常规栓塞化疗的比较研究[J].肿瘤防治杂志,2005,11(4):405-406.
[40]王会轩.白芨硫酸钡食管造影在诊断原发性小细胞食管癌中的体会[J].中医临床研究,2011,3(16):114-115.
[41]刘文斌,尹彬祥,余朝骏.中药白及微粒与真丝线段栓塞子宫肌瘤的对比研究[J].中国中西医结合影像学杂志,2007,5(3):171-173.
[42]王丽凤,李伟平,沈一平,等.白及诱导HL-60细胞凋亡活性部位的筛选[J].中华中医药学刊,2012,30(12):2704-2706.
[43]陆雪芬.白及提取物对小鼠黑色素瘤B16细胞诱导凋亡作用的研究[J].中华中医药学刊,2013,31(7):1619-1621.
[44]车艳玲,刘松江.白及治疗小鼠移植性肝癌的研究[J].中医药信息,2008,(1):38-40.
[45]Jiang F,Li W,Huang Y,et al.Antioxidant,Antityrosinase and Antitumor Activity Comparison:The Potential Utilization of Fibrous Root Part of Bletilla striata(Thunb.)Reichb.f[J].Plo S one,2013,8(2):e58004.
[46]翁夏蒙,鲁光耀,王鸯妮,等.白及愈伤组织总酚含量测定及抗氧化作用研究[J].中药材,2013,(1):32-35.
[47]Dong L,Xia S,Luo Y,et al.Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-α[J].Journal of Controlled Release,2009,134(3):214-220.
[48]仇树林,王晓,李兵,等.白芨胶载重组人表皮生长因子对创面表皮细胞DNA含量及周期的影响[J].中国组织工程研究与临床康复,2007,11(1):63-66.
[49]Wu X,Xin M,Chen H,et al.Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis[J].Journal of pharmacy and pharmacology,2010,62(9):1152-1157.
[50]吕小波,黄春球,武正才,等.白及多糖对胃溃疡大鼠防治作用的实验研究[J].云南中医学院学报,2012,35(1):30-32.
[51]郑子春,沈洪,朱萱萱,等.黄柏,地榆,白及对溃疡性结肠炎大鼠组织中NF-κB和细胞因子表达的影响[J].中国中医急症,2010,(3):469-472.
[52]柯昌毅,赵春景.白及多糖对溃疡性结肠炎的作用研究[J].中国药房,2011,23:2132-2134.
[53]Wu J,Meng Y,Zou L,et al.Effects of diferent extracts from Bletilla colloid on hemostasis activity in mice[J].Journal of Pharmaceutical Practice,2011,29(3):206-207.
[54]陆波,徐亚敏,张汉明,等.白及不同提取部位对家兔血小板聚集的影响[J].解放军药学学报,2006,21(5):330-332.
[55]林卫红.白及雾化吸入治疗咯血症疗效观察[J].上海中医药杂志,2012,46(11):51-52.
[56]马世宏,金玲,王守香,等.中药白芨在牙膏中的应用研究[J].中国野生植物资源,2009,28(3):32-35.
[57]马世宏,金玲,揭邃,等.白芨-丹皮酚包合物在化妆品中的应用研究[J].日用化学品科学,2009,32(6):30-33.
[58]中华人民共和国卫生部.卫生部公布药食同源物品可用于保健食品物品名单[J].中医药学刊,2002,20(2):176.