摘要
本研究,首次对蔷薇科蔷薇属植物光果金樱子进行化学成分研究。采用硅胶、凝胶、MCI等多种柱层析方法,并运用制备高效液相等现代天然产物手段对光果金樱子的降三萜类化学成分进行定向分离。结果从该植物中共分离出2个降三萜化合物,并通过质谱和核磁共振技术鉴定化合物为:红大戟酸A (1)、3-oxo-2,19a,22a-trihydroxy-24-nor-urs-1,4,12-trien-28-oic acid (2)。
This study is the first report about the chemical constituents from Rosa laevigata var. leiocapus. Kinds of column chromatographies such as silica gel,sephadex LH-20 gel and MCI, together with pre-HPLC were used to isolate and purify the nor-triterpene onstituents. The structures of the compounds were established by extensive analysis of mass spectrometric and NMR spectroscopic data, as a result, two nor-triterpenes were isolated and identified as knoxivalic acid A(1) and 3-oxo-2,19 a,22 a-trihydroxy-24-nor-urs-1,4,12-trien-28-oic acid(2).
引文
[1]王英强,陈邦余.广东植物新类群[J].热带亚热带植物学报,1995,3(1):29-33.
[2]赵峰,马丽,孙居锋,等.红大戟中的1个新降碳三萜[J].中草药,2014,45(1):28-30.
[3]Nareeboon P,Kraus W,Beifuss U,et al.Novel 24-nor-,24-nor-2,3-seco-,and 3,24-dinor-2,4-seco-ursane triterpenes from Diospyros decandra:evidences for ring A biosynthetic transformations[J].Tetrahedron,2006,62:5519-5526.
[4]Laghari AH,Memon S,Nelofar A,et al.Antifungal ursene-type triterpene from the roots of Alhagi camelorum[J].Helvetica Chimica Acta,2012,95(9):81556-1560.
[5]Li XH,Shen DD,Li N,et al.Bioactive triterpenoids from Symplocos chinensis[J].J Asian Nat Prod Res,2003,5(1):49-56.
[6]Zhao M,Zhang S,Fu L,et al.Taraxasterane-and ursane-type triterpenes from Nerium oleander and their biological activities[J].J Nat Prod,2006,69(8):1164-1167.
[7]Lin LP,Qu W,Liang JY.Triterpene saponins with XOD inhibitory activity from the roots of Ilex pubescens[J].Chin Chem Lett,2011,22(6):697-700.
[8]Viqa UA,Faryal VM.Nepetidone and nepedinol,two new triterpenoids from Nepeta Hindostana[J].J Nat Prod,1986,49:524-527.