帕罗西汀治疗卒中后抑郁、焦虑效果及对血清细胞因子水平影响
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摘要
目的分析帕罗西汀对脑卒中后焦虑抑郁患者负性情绪及血清细胞因子水平的影响。方法 111例脑卒中后焦虑抑郁患者采用随机数字表法分组,对照组55例给予盐酸舍曲林治疗,观察组56例使用帕罗西汀治疗,对比治疗后临床疗效、神经功能、焦虑抑郁情绪、血清细胞因子水平变化及安全性。结果观察组治疗后总有效率及5-HT水平高于对照组,NIHSS、HAMD、HAMA评分及Hcy、IL-1水平低于对照组(P<0.05);不良反应发生率8.93%低于对照组12.73%(P>0.05)。结论帕罗西汀较之舍曲林能更有效改善卒中后抑郁患者炎性因子失衡状态,改变神经生物学特性,促进神经递质传递及神经功能恢复,消除焦虑抑郁负性情绪,安全性高,效果确切。
Objective To analyze the changes of negative emotion and serum cytokine levels in patients with anxiety and depression after stroke using paroxetine. Methods A total of 111 patients with post-stroke anxiety and depression in our hospital were enrolled and divided in two groups by random number table.55 patients in the control group were treated with sertraline hydrochloride,and 56 patients in the observation group were treated with paroxetine. After treatment,clinical efficacy,neurological function,anxiety and depression Changes in mood,serum cytokine levels,and safety. Results The total effective rate and 5-HT level in the observation group were higher than those in the control group. The NIHSS,HAMD,HAMA scores and Hcy and IL-1 levels were lower than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 8.93%,which was lower than that in the control group. Group(12.73%,P>0.05). Conclusion Paroxetine can effectively improve the imbalance of inflammatory factors in patients with post-stroke depression,change neurobiological properties,promote neurotransmitter transmission and recovery of neurological function,eliminate negative emotions of anxiety and depression,and have high safety and effectiveness.
Objective To analyze the changes of negative emotion and serum cytokine levels in patients with anxiety and depression after stroke using paroxetine. Methods A total of 111 patients with post-stroke anxiety and depression in our hospital were enrolled and divided in two groups by random number table.55 patients in the control group were treated with sertraline hydrochloride,and 56 patients in the observation group were treated with paroxetine. After treatment,clinical efficacy,neurological function,anxiety and depression Changes in mood,serum cytokine levels,and safety. Results The total effective rate and 5-HT level in the observation group were higher than those in the control group. The NIHSS,HAMD,HAMA scores and Hcy and IL-1 levels were lower than those in the control group(P<0.05). The incidence of adverse reactions in the observation group was 8.93%,which was lower than that in the control group. Group(12.73%,P>0.05). Conclusion Paroxetine can effectively improve the imbalance of inflammatory factors in patients with post-stroke depression,change neurobiological properties,promote neurotransmitter transmission and recovery of neurological function,eliminate negative emotions of anxiety and depression,and have high safety and effectiveness.
引文
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9.宋雪云,董丽娜,甄雄严,等.尼麦角林、帕罗西汀联合心理疗法对缺血性脑卒中后抑郁患者抑郁情绪和炎症因子的影响[J].国际精神病学杂志,2018,45(3):508-510,518.
10.刘德芳,邓燕春,梁汝沛,等.养血清脑饮协定方联合盐酸帕罗西汀片治疗老年脑卒中后抑郁的临床效果及对血清5-HT、IL-1、Hcy水平的影响[J].陕西中医,2018,39(1):47-49.
11.王芳,蔺雪梅,史亚玲,等.帕罗西汀治疗卒中后抑郁/焦虑的疗效及安全性[J].药物评价研究,2017,40(9):1306-1309.
12.白维,刘阳,李尧.帕罗西汀与度洛西汀治疗脑卒中后抑郁的疗效观察[J].贵州医药,2018,42(4):441-442.
2.中华神经科学会,中华神经外科学会.脑卒中患者临床神经功能缺损程度评分标准[J].中华神经科杂志,1996,29(6):381-383.
3.中华医学会精神科分会.中国精神障碍分类与诊断标准[M].3版.济南:山东科学技术出版社,2001:87.
4.张明圆.精神科量表评定手册长沙[M].长沙:湖南科学技术出版社,1993:34-137.
5.许晓敬,贾阳娟,韩凝,等.NIHSS评分对急性脑梗死颅内大动脉闭塞的预测价值[J].脑与神经疾病杂志,2016,24(9):544-548.
6.邹琴,李其富,刘力源,等.缺血性脑卒中后抑郁的临床特点及相关因素分析[J].中国热带医学,2018,18(8):815-818.
7.吕敏,魏小利,袁媛,等.脑卒中伴不同程度抑郁患者的神经功能缺损、日常行为能力及认知功能分析[J].广西医科大学学报,2016,33(4):620-622.
8.李文涛,李志平,王胜,等.老年脑卒中患者血清炎症因子与焦虑抑郁程度相关性分析[J].国际精神病学杂志,2018,45(4):697-699,703.
9.宋雪云,董丽娜,甄雄严,等.尼麦角林、帕罗西汀联合心理疗法对缺血性脑卒中后抑郁患者抑郁情绪和炎症因子的影响[J].国际精神病学杂志,2018,45(3):508-510,518.
10.刘德芳,邓燕春,梁汝沛,等.养血清脑饮协定方联合盐酸帕罗西汀片治疗老年脑卒中后抑郁的临床效果及对血清5-HT、IL-1、Hcy水平的影响[J].陕西中医,2018,39(1):47-49.
11.王芳,蔺雪梅,史亚玲,等.帕罗西汀治疗卒中后抑郁/焦虑的疗效及安全性[J].药物评价研究,2017,40(9):1306-1309.
12.白维,刘阳,李尧.帕罗西汀与度洛西汀治疗脑卒中后抑郁的疗效观察[J].贵州医药,2018,42(4):441-442.