清金化痰汤联合常规西药治疗痰热郁肺型AECOPD的临床价值
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摘要
目的分析中医辨证为痰热郁肺型慢性阻塞性肺疾病急性加重期患者在常规西药基础上加用中药清金化痰汤进行治疗的临床效果。方法选择在我院接受治疗的52例中医辨证为痰热郁肺型慢性阻塞性肺疾病急性加重期患者,以随机分组法分成对照组和治疗组,每组26例。对照组采用常规西药治疗;治疗组在常规西药基础上加用中药清金化痰汤进行治疗。结果治疗组患者病情药物控制总有效率达到92.3%(24/26),高于对照组的73.1%(19/26);药物不良反应发生率为3.8%,低于对照组的19.2%;治疗前后炎症因子水平的改善效果优于对照组;肺功能恢复正常时间和治疗总时间短于对照组。差异均有统计学意义(P<0.05)。结论中医辨证为痰热郁肺型慢性阻塞性肺疾病急性加重期患者在常规西药基础上加用中药清金化痰汤进行治疗,可以缩短病情控制时间,大幅度改善炎症反应程度,减少药物相关不良反应,使治疗效果得到显著性提升。
Objective To analyze the clinical effect of Qingjin Huatan decoction(QHD) in treating acute exacerbation chronic obstructive pulmonary disease(COPD) with phlegm-heat and blood stasis syndrome differentiation. Methods 52 patients with acute exacerbation COPD of phlegm-heat and blood stasis type were selected and randomly divided into control group and treatment group,with an average of 26 cases in each group. The control group was treated with conventional Western medicine, while the treatment group was treated with Qingjin Huatan decoction on the basis of conventional Western medicine. Results The total effective rate of drug control in the treatment group was 92.3%, which was higher than 73.1% in the control group; there was only one case of adverse drug reactions, which was less than 5 cases in the control group. The improvement effect of inflammatory factors before and after treatment in the treatment group was better than that in the control group. The recovery time of pulmonary function and the total treatment time in the treatment group were shorter than those in the control group. There was statistical significance( P <0.05).Conclusion The treatment of acute exacerbation COPD with TCM syndrome differentiation of phlegm-heat-stasis-lung syndrome by Qingjin Huatan decoction on the basis of conventional western medicine can shorten the time of disease control, greatly improve the degree of inflammatory reaction, reduce drug-related adverse reactions, and significantly improve the therapeutic effect.
Objective To analyze the clinical effect of Qingjin Huatan decoction(QHD) in treating acute exacerbation chronic obstructive pulmonary disease(COPD) with phlegm-heat and blood stasis syndrome differentiation. Methods 52 patients with acute exacerbation COPD of phlegm-heat and blood stasis type were selected and randomly divided into control group and treatment group,with an average of 26 cases in each group. The control group was treated with conventional Western medicine, while the treatment group was treated with Qingjin Huatan decoction on the basis of conventional Western medicine. Results The total effective rate of drug control in the treatment group was 92.3%, which was higher than 73.1% in the control group; there was only one case of adverse drug reactions, which was less than 5 cases in the control group. The improvement effect of inflammatory factors before and after treatment in the treatment group was better than that in the control group. The recovery time of pulmonary function and the total treatment time in the treatment group were shorter than those in the control group. There was statistical significance( P <0.05).Conclusion The treatment of acute exacerbation COPD with TCM syndrome differentiation of phlegm-heat-stasis-lung syndrome by Qingjin Huatan decoction on the basis of conventional western medicine can shorten the time of disease control, greatly improve the degree of inflammatory reaction, reduce drug-related adverse reactions, and significantly improve the therapeutic effect.
引文
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[2]黄晓群,高培阳,陈骏,等.温肾中药复方治疗慢性阻塞性肺疾病急性加重期疗效的系统评价[J].中国中医急症,2015,24(10):1713.
[3]付跃峰,刘清泉,蔡阳平,等. AECOPD呼吸衰竭中医证素、证候的分布及与胃肠功能障碍相关研究[J].世界中医药,2014,9(3):265.
[4]刘克琴,倪海滨,黄小菲.清金化痰汤治疗慢性阻塞性肺疾病急性加重期临床观察[J].中国中医急症,2013,22(11):1972-1973.
[5]杨晶,邝相如. IL-23、IL-17及IL-10变化与COPD及BODE指数的相关性研究[J].临床肺科杂志,2014,19(12):2 189.