黄酒中不同物质对乙醇代谢的影响研究
|
摘要
乙醇作为酒类饮料中含量最高的物质,在酒类饮品导致的各类问题中都是最重要的影响因素。在本研究中,为研究黄酒易上头的问题,以乙醇作为研究目标,在SD大鼠模型中,通过共同摄入乙醇和黄酒中生物胺、高级醇和醛类物质,考察了不同物质对乙醇代谢的影响。结果显示,在考察的10种物质中,所有物质单独与乙醇共同摄入后都明显降低了SD大鼠血液中乙醇浓度。经药物代谢动力学模型分析后,10种物质中抑制乙醇代谢作用的物质由强到弱的顺序为:异丁醇>正丙醇>腐胺>尸胺>组胺>苯乙醇>乙醛>酪胺>5-HMF>异戊醇。因此,黄酒中含有的多种物质可能通过抑制乙醇代谢的作用达到促进黄酒上头、引起饮后舒适度问题的原因。
Ethanol is the component with the highest content in alcoholic beverages, and is the main cause of various social and alcohol-related disorders. In this study, the metabolism of ethanol in SD rats was investigated to understand the hangover mechanism of Huangjiu. The combined intake of ethanol and other compounds, including higher alcohols, biogenic amines and aldehyde compounds was carried out, and the effects of these compounds on ethanol metabolism were studied. The results showed that the blood ethanol concentrations in SD rats administrated with ethanol and other compounds were significantly reduced comparing with the control group. Meanwhile, pharmacokinetic analysis indicated that the order of ethanol-metabolism-inhibiting performance of the10 tested compounds was as follows: isobutanol > propyl alcohol > putrescine > cadaverine > histamine > phenethyl alcohol >acetaldehyde > tyramine > 5-HMF > isoamyl alcohol. In conclusion, Huangjiu hangover might be caused by the inhibitory effects of various compounds on ethanol metabolism, which finally led to discomfort.
Ethanol is the component with the highest content in alcoholic beverages, and is the main cause of various social and alcohol-related disorders. In this study, the metabolism of ethanol in SD rats was investigated to understand the hangover mechanism of Huangjiu. The combined intake of ethanol and other compounds, including higher alcohols, biogenic amines and aldehyde compounds was carried out, and the effects of these compounds on ethanol metabolism were studied. The results showed that the blood ethanol concentrations in SD rats administrated with ethanol and other compounds were significantly reduced comparing with the control group. Meanwhile, pharmacokinetic analysis indicated that the order of ethanol-metabolism-inhibiting performance of the10 tested compounds was as follows: isobutanol > propyl alcohol > putrescine > cadaverine > histamine > phenethyl alcohol >acetaldehyde > tyramine > 5-HMF > isoamyl alcohol. In conclusion, Huangjiu hangover might be caused by the inhibitory effects of various compounds on ethanol metabolism, which finally led to discomfort.
引文
[1]戈瑚瑚,倪莉.黄酒饮后产生上头上火的原因探究[J].食品与发酵工业,2010(8):136-139.
[2]KAIVOLA S,PARANTAINEN J,OSTERMAN T,et al.Hangover headache and prostaglandins:prophylactic treatment with tolfenamic acid[J].Cephalalgia,2010,3(1):31-36.
[3]COLLINS W E.Performance effects of alcohol intoxication and hangover at ground level and at simulated altitude[J].Aviation space&environmental medicine,1980,51(4):327.
[4]YESAVAGE J A,LEIRER V O.Hangover effects on aircraft pilots 14 hours after alcohol ingestion:a preliminary report[J].Am j psychiatry,1986,143(12):1546-1550.
[5]PENNING R,MCKINNEY A,BUS L D,et al.Measurement of alcohol hangover severity:development of the Alcohol Hangover Severity Scale(AHSS)[J].Psychopharmacology,2013,225(4):803-810.
[6]HISAKO H,WATARU F,YUTAKA H,et al.Effects of fusel oil on animal hangover models[J].Alcoholism clinical&experimental research,2010,27(S1):37S-41S.
[7]SWIFT R,DAVIDSON D.Alcohol hangover:mechanisms and mediators[J].Alcohol health research world,1998,22(1):54-60.
[2]KAIVOLA S,PARANTAINEN J,OSTERMAN T,et al.Hangover headache and prostaglandins:prophylactic treatment with tolfenamic acid[J].Cephalalgia,2010,3(1):31-36.
[3]COLLINS W E.Performance effects of alcohol intoxication and hangover at ground level and at simulated altitude[J].Aviation space&environmental medicine,1980,51(4):327.
[4]YESAVAGE J A,LEIRER V O.Hangover effects on aircraft pilots 14 hours after alcohol ingestion:a preliminary report[J].Am j psychiatry,1986,143(12):1546-1550.
[5]PENNING R,MCKINNEY A,BUS L D,et al.Measurement of alcohol hangover severity:development of the Alcohol Hangover Severity Scale(AHSS)[J].Psychopharmacology,2013,225(4):803-810.
[6]HISAKO H,WATARU F,YUTAKA H,et al.Effects of fusel oil on animal hangover models[J].Alcoholism clinical&experimental research,2010,27(S1):37S-41S.
[7]SWIFT R,DAVIDSON D.Alcohol hangover:mechanisms and mediators[J].Alcohol health research world,1998,22(1):54-60.