博落回主要功能成分及其在动物生产中的应用
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摘要
博落回[Macleaya cordata (willd.) R.Br.]又名"号筒杆",是罂粟科博落回属的多年生草本植物。博落回富含生物碱资源,其主要功能活性成分为血根碱、白屈菜红碱、原阿片碱、别隐品碱等异喹啉类生物碱,具有抗微生物、抗炎、抗氧化、杀虫、抗病毒、抗肿瘤等多种生物学活性。文章通过对博落回主要功能成分血根碱、白屈菜红碱、原阿片碱、别隐品碱等异喹啉类生物碱的抗微生物、抗炎、抗氧化、改善肠道健康等生物学活性及其在动物生产中的应用进行综述,以期为博落回功能成分的开发和应用提供参考。
Macleaya cordata(willd.) R.Br. is a perennial herb of Papaveraceae. Macleaya cordata isrich in alkaloid resources, and its main functional active components are Sanguine, Chelerythine, Protopine, Allocryptopine and other isoquinoline alkaloids. It has many biological activities, such as anti-microbial, anti-inflammatory, anti-oxidation, insecticidal, anti-virus, anti-tumor and so on. In this paper, we reviewed the main biological activities of these isoquinoline alkaloids and the application of alkaloids extracted from Macleaya cordata in the animal production. In order to provide a reference forthe development and application of the functional isoquinoline alkaloids.
Macleaya cordata(willd.) R.Br. is a perennial herb of Papaveraceae. Macleaya cordata isrich in alkaloid resources, and its main functional active components are Sanguine, Chelerythine, Protopine, Allocryptopine and other isoquinoline alkaloids. It has many biological activities, such as anti-microbial, anti-inflammatory, anti-oxidation, insecticidal, anti-virus, anti-tumor and so on. In this paper, we reviewed the main biological activities of these isoquinoline alkaloids and the application of alkaloids extracted from Macleaya cordata in the animal production. In order to provide a reference forthe development and application of the functional isoquinoline alkaloids.
引文
[1]European Commission.European Union Register of Feed Additives Pursuant to Regulation(EC)No 1831/2003[Z].2017-03-23.
[2]刘秀斌.基于同位素标记L-酪氨酸研究博落回中血根碱生源合成途径[D].湖南农业大学,2017.
[3]苏红,白华,骆延波,等.Sangrovit对临床多抗菌株的抑制作用及对肉鸡生长促进的饲养试验[J].饲料工业,2012,33(7):27-33.
[4]Kosina P,Gregorova J,Gruz J,et al.Phytochemical and antimicrobial characterization of Macleayacordata herb[J].Fitoterapia,2010,81(8):1006-1012.
[5]Cushnie T P T,Cushnie B,Lamb A J.Alkaloids:an overview of their antibacterial,antibiotic-enhancing and antivirulence activities[J].International Journal of Antimicrobial Agents,2014,44(5):377-386.
[6]王静慧,韩剑众,曲道峰.血根碱体外抑菌作用及其对细菌生物被膜的影响[J].中国畜牧杂志,2012(19):67-70.
[7]Beuria T K,Santra M K,Panda D.Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling[J].Biochemistry,2005,44(50):16584-16593.
[8]Obiang-Obounou B W,Kang O H,Choi J G,et al.The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus[J].The Journal of toxicological sciences,2011,36(3):277-283.
[9]Yang X J,Miao F,Yao Y,et al.In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic fungi[J].Molecules,2012,17(11):13026-13035.
[10]Lenfeld J,Kroutil M,Mar?álek E,et al.Antiinflammatory activity of quaternary benzophenanthridine alkaloids from Chelidonoum majus[J].Planta medica,1981,43(10):161-165.
[11]Baldwin Jr A S.The NF-κB and IκB proteins:new discoveries and insights[J].Annual review of immunology,1996,14(1):649-681.
[12]Chaturvedi M M,Kumar A,Darnay B G,et al.Sanguinarine(pseudochelerythrine)is a potent inhibitor of NF-κB activation,IκBαphosphorylation,and degradation[J].Journal of Biological Chemistry,1997,272(48):30129-30134.
[13]Khadem A,Soler L,Everaert N,et al.Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties[J].British journal of nutrition,2014,112(7):1110-1118.
[14]Kantas D,Papatsiros V G,Tassis P D,et al.The effect of a natural feed additive(Macleaya cordata),containing sanguinarine,on the performance and health status of weaning pigs[J].Animal Science Journal,2015,86(1):92-98.
[15]Zhong M,Huang K,Zeng J,et al.Determination of contents of eight alkaloids in fruits of Macleaya cordata(Willd)R.Br.from different habitats and antioxidant activities of extracts[J].Journal of Central South University of Technology,2010,17(3):472-479.
[16]Li C M,Yang X Y,Zhong Y R,et al.Chemical composition,antioxidant and antimicrobial activity of the essential oil from the leaves of Macleaya cordata(Willd)R.Br.[J].Natural product research,2016,30(4):438-442.
[17]姚雯,杨天衡,刘学波.血根碱清除自由基及抑制生物大分子氧化的作用[J].食品科学,2014,35(9):137-141.
[18]Vrba J,Hrbá?J,UlrichováJ,et al.Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism[J].Chemico-biological interactions,2004,147(1):35-47.
[19]Zdarilova A,Vrublova E,Vostalova J,et al.Natural feed additive of Macleaya cordata:safety assessment in rats a 90-day feeding experiment[J].Food and Chemical Toxicology,2008,46(12):3721-3726.
[20]李杰,伍树松,熊兴耀,等.博落回生物碱对猪肠上皮细胞增殖的影响[J].动物营养学报,2014(6):1632-1637.
[21]Chen J,Kang B,Zhao Y,et al.Effects of natural dietary supplementation with Macleayacordata extract containing sanguinarine on growth performance and gut health of early-weaned piglets[J].Journal of animal physiology and animal nutrition,2018,102(6):1666-1674.
[22]Liu G,Guan G,Fang J,et al.Macleaya cordata extract decreased diarrhea score and enhanced intestinal barrier function in growing piglets[J].BioMed research international,2016:1-7.
[23]Huang P,Zhang Y,Xiao K,et al.The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids[J].Microbiome,2018,6(1):211.
[24]Goodarzi Boroojeni F,M?nner K,Zentek J.The impacts of Macleaya cordata extract and naringin inclusion in post-weaning piglet diets on performance,nutrient digestibility and intestinal histomorphology[J].Archives of animal nutrition,2018,72(3):178-189.
[25]陈家顺,康宝聚,曾建国,等.血根碱对断奶仔猪生长性能、肠道形态结构及小肠黏膜免疫功能的影响[J].动物营养学报,2018,30(5):1845-1853.
[26]Kosina P,Walterova D,UlrichováJ,et al.Sanguinarine and chelerythrine:assessment of safety on pigs in ninety days feeding experiment[J].Food and Chemical Toxicology,2004,42(1):85-91.
[27]Lee K W,Kim J S,Oh S T,et al.Effects of dietary sanguinarine on growth performance,relative organ weight,cecal microflora,serum cholesterol level and meat quality in broiler chickens[J].The Journal of Poultry Science,2015,52(1):15-22.
[28]Reansoi A,Ruangpanit Y,Attamangkune S.Effect of quaternary benzophenantridine and protopine alkaloids on growth response and gut health of broiler under hot climate management[C].Annual Conference Kasetsart,Bankok,Thailand,2015:36-41.
[29]Abudabos A M,Hussein E O S,Ali M H,et al.The effect of some natural alternative to antibiotics on growth and changes in intestinal histology in broiler exposed to Salmonella challenge[J].Poultry science,2019,98(3):1441-1446.
[30]Xue G D,Wu S B,Choct M,et al.Impact of a Macleaya cordata-derived alkaloid extract on necrotic enteritis in broilers[J].Poultry science,2017,96(10):3581-3585.
[31]Bavarsadi M,Mahdavi A H,Ansari-Mahyari S,et al.Effects of different levels of sanguinarine on antioxidant indices,immunological responses,ileal microbial counts and jejunal morphology of laying hens fed diets with different levels of crude protein[J].Journal of animal physiology and animal nutrition,2017,101(5):936-948.
[32]Liu G,Aguilar Y M,Zhang L,et al.Dietary supplementation with sanguinarine enhances serum metabolites and antibodies in growing pigs[J].Journal of Animal Science,2016,94(3):75-78.
[33]Artuso-Ponte V,Moeller S,Rajala-Schultz P,et al.Supplementation with quaternary benzo(c)phenanthridine alkaloids decreased salivary cortisol and Salmonella shedding in pigs after transportation to the slaughterhouse[J].Foodborne pathogens and disease,2015,12(11):891-897.
[34]Matulka R A,Dohms J.Effects of the Consumption of Macleayacordata Extract Preparation by Sows[J].Open Journal of Animal Sciences,2018,8(3):294.
[35]Moraes De J.Natural products with antischistosomal activity[J].Future medicinal chemistry,2015,7(6):801-820.
[36]芦程.血根碱杀灭指环虫机制及对金鱼免疫毒理研究[D].西北农林科技大学,2013.
[37]姚嘉赟,沈锦玉.博落回杀灭小瓜虫活性成分的研究[C].2010年中国水产学会学术年会论文摘要集.中国西安,中国水产学会,2011:252-252.
[38]Ali Y Korkut,Aysun Kop.Effect of Sangrovit?on the growth and performance of sea bass[J].The Iinternational Magazine for the Aquaculture Feed Industry,2012,6(6):28-29.
[39]Rawling M D,Merrifield D L,Davies S J.Preliminary assessment of dietary supplementation of Sangrovit?on red tilapia(Oreochromis niloticus)growth performance and health[J].Aquaculture,2009,294(1/2):118-122.
[40]Zhang R,Wang X W,Zhu J Y,et al.Dietary sanguinarine affected immune response,digestive enzyme activity and intestinal microbiota of Koi carp(cryprinus carpiod)[J].Aquaculture,2019,502:72-79.
[41]Imanpoor M R,Roohi Z.Effects of Sangrovit-supplemented diet on growth performance,blood biochemical parameters,survival and stress resistance to salinity in the C aspian roach(R utilusrutilus)fry[J].Aquaculture research,2016,47(9):2874-2880.
[42]Wang W,Dolan L C,Von Alvensleben S,et al.Safety of standardized Macleayacordata extract in an eighty-four-day dietary study in dairy cows[J].Journal of animal physiology and animal nutrition,2018,102(1):61-68.
[43]Estrada-Angulo A,Aguilar-Hernández A,Osuna-Pérez M,et al.Influence of quaternary benzophenantridine and protopine alkaloids on growth performance,dietary energy,carcass traits,visceral mass,and rumen health in finishing ewes under conditions of severe temperature-humidity index[J].Asian-Australasian journal of animal sciences,2016,29(5):652.
[44]Aguilar-Hernández J A,Urías-Estrada J D,López-Soto M A,et al.Evaluation of isoquinolinealkaloid supplementation levels on ruminal fermentation,characteristics of digestion,and microbial protein synthesis in steers fed a high-energy diet[J].Journal of Animal Science,2016,94(1):267-274.
[45]Michels A,Neumann M,Le?o G F M,et al.Isoquinoline alkaloids supplementation on performance and carcass traits of feedlot bulls[J].Asian-Australasian journal of animal sciences,2018,31(9):1474.
[2]刘秀斌.基于同位素标记L-酪氨酸研究博落回中血根碱生源合成途径[D].湖南农业大学,2017.
[3]苏红,白华,骆延波,等.Sangrovit对临床多抗菌株的抑制作用及对肉鸡生长促进的饲养试验[J].饲料工业,2012,33(7):27-33.
[4]Kosina P,Gregorova J,Gruz J,et al.Phytochemical and antimicrobial characterization of Macleayacordata herb[J].Fitoterapia,2010,81(8):1006-1012.
[5]Cushnie T P T,Cushnie B,Lamb A J.Alkaloids:an overview of their antibacterial,antibiotic-enhancing and antivirulence activities[J].International Journal of Antimicrobial Agents,2014,44(5):377-386.
[6]王静慧,韩剑众,曲道峰.血根碱体外抑菌作用及其对细菌生物被膜的影响[J].中国畜牧杂志,2012(19):67-70.
[7]Beuria T K,Santra M K,Panda D.Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling[J].Biochemistry,2005,44(50):16584-16593.
[8]Obiang-Obounou B W,Kang O H,Choi J G,et al.The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus[J].The Journal of toxicological sciences,2011,36(3):277-283.
[9]Yang X J,Miao F,Yao Y,et al.In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic fungi[J].Molecules,2012,17(11):13026-13035.
[10]Lenfeld J,Kroutil M,Mar?álek E,et al.Antiinflammatory activity of quaternary benzophenanthridine alkaloids from Chelidonoum majus[J].Planta medica,1981,43(10):161-165.
[11]Baldwin Jr A S.The NF-κB and IκB proteins:new discoveries and insights[J].Annual review of immunology,1996,14(1):649-681.
[12]Chaturvedi M M,Kumar A,Darnay B G,et al.Sanguinarine(pseudochelerythrine)is a potent inhibitor of NF-κB activation,IκBαphosphorylation,and degradation[J].Journal of Biological Chemistry,1997,272(48):30129-30134.
[13]Khadem A,Soler L,Everaert N,et al.Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties[J].British journal of nutrition,2014,112(7):1110-1118.
[14]Kantas D,Papatsiros V G,Tassis P D,et al.The effect of a natural feed additive(Macleaya cordata),containing sanguinarine,on the performance and health status of weaning pigs[J].Animal Science Journal,2015,86(1):92-98.
[15]Zhong M,Huang K,Zeng J,et al.Determination of contents of eight alkaloids in fruits of Macleaya cordata(Willd)R.Br.from different habitats and antioxidant activities of extracts[J].Journal of Central South University of Technology,2010,17(3):472-479.
[16]Li C M,Yang X Y,Zhong Y R,et al.Chemical composition,antioxidant and antimicrobial activity of the essential oil from the leaves of Macleaya cordata(Willd)R.Br.[J].Natural product research,2016,30(4):438-442.
[17]姚雯,杨天衡,刘学波.血根碱清除自由基及抑制生物大分子氧化的作用[J].食品科学,2014,35(9):137-141.
[18]Vrba J,Hrbá?J,UlrichováJ,et al.Sanguinarine is a potent inhibitor of oxidative burst in DMSO-differentiated HL-60 cells by a non-redox mechanism[J].Chemico-biological interactions,2004,147(1):35-47.
[19]Zdarilova A,Vrublova E,Vostalova J,et al.Natural feed additive of Macleaya cordata:safety assessment in rats a 90-day feeding experiment[J].Food and Chemical Toxicology,2008,46(12):3721-3726.
[20]李杰,伍树松,熊兴耀,等.博落回生物碱对猪肠上皮细胞增殖的影响[J].动物营养学报,2014(6):1632-1637.
[21]Chen J,Kang B,Zhao Y,et al.Effects of natural dietary supplementation with Macleayacordata extract containing sanguinarine on growth performance and gut health of early-weaned piglets[J].Journal of animal physiology and animal nutrition,2018,102(6):1666-1674.
[22]Liu G,Guan G,Fang J,et al.Macleaya cordata extract decreased diarrhea score and enhanced intestinal barrier function in growing piglets[J].BioMed research international,2016:1-7.
[23]Huang P,Zhang Y,Xiao K,et al.The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids[J].Microbiome,2018,6(1):211.
[24]Goodarzi Boroojeni F,M?nner K,Zentek J.The impacts of Macleaya cordata extract and naringin inclusion in post-weaning piglet diets on performance,nutrient digestibility and intestinal histomorphology[J].Archives of animal nutrition,2018,72(3):178-189.
[25]陈家顺,康宝聚,曾建国,等.血根碱对断奶仔猪生长性能、肠道形态结构及小肠黏膜免疫功能的影响[J].动物营养学报,2018,30(5):1845-1853.
[26]Kosina P,Walterova D,UlrichováJ,et al.Sanguinarine and chelerythrine:assessment of safety on pigs in ninety days feeding experiment[J].Food and Chemical Toxicology,2004,42(1):85-91.
[27]Lee K W,Kim J S,Oh S T,et al.Effects of dietary sanguinarine on growth performance,relative organ weight,cecal microflora,serum cholesterol level and meat quality in broiler chickens[J].The Journal of Poultry Science,2015,52(1):15-22.
[28]Reansoi A,Ruangpanit Y,Attamangkune S.Effect of quaternary benzophenantridine and protopine alkaloids on growth response and gut health of broiler under hot climate management[C].Annual Conference Kasetsart,Bankok,Thailand,2015:36-41.
[29]Abudabos A M,Hussein E O S,Ali M H,et al.The effect of some natural alternative to antibiotics on growth and changes in intestinal histology in broiler exposed to Salmonella challenge[J].Poultry science,2019,98(3):1441-1446.
[30]Xue G D,Wu S B,Choct M,et al.Impact of a Macleaya cordata-derived alkaloid extract on necrotic enteritis in broilers[J].Poultry science,2017,96(10):3581-3585.
[31]Bavarsadi M,Mahdavi A H,Ansari-Mahyari S,et al.Effects of different levels of sanguinarine on antioxidant indices,immunological responses,ileal microbial counts and jejunal morphology of laying hens fed diets with different levels of crude protein[J].Journal of animal physiology and animal nutrition,2017,101(5):936-948.
[32]Liu G,Aguilar Y M,Zhang L,et al.Dietary supplementation with sanguinarine enhances serum metabolites and antibodies in growing pigs[J].Journal of Animal Science,2016,94(3):75-78.
[33]Artuso-Ponte V,Moeller S,Rajala-Schultz P,et al.Supplementation with quaternary benzo(c)phenanthridine alkaloids decreased salivary cortisol and Salmonella shedding in pigs after transportation to the slaughterhouse[J].Foodborne pathogens and disease,2015,12(11):891-897.
[34]Matulka R A,Dohms J.Effects of the Consumption of Macleayacordata Extract Preparation by Sows[J].Open Journal of Animal Sciences,2018,8(3):294.
[35]Moraes De J.Natural products with antischistosomal activity[J].Future medicinal chemistry,2015,7(6):801-820.
[36]芦程.血根碱杀灭指环虫机制及对金鱼免疫毒理研究[D].西北农林科技大学,2013.
[37]姚嘉赟,沈锦玉.博落回杀灭小瓜虫活性成分的研究[C].2010年中国水产学会学术年会论文摘要集.中国西安,中国水产学会,2011:252-252.
[38]Ali Y Korkut,Aysun Kop.Effect of Sangrovit?on the growth and performance of sea bass[J].The Iinternational Magazine for the Aquaculture Feed Industry,2012,6(6):28-29.
[39]Rawling M D,Merrifield D L,Davies S J.Preliminary assessment of dietary supplementation of Sangrovit?on red tilapia(Oreochromis niloticus)growth performance and health[J].Aquaculture,2009,294(1/2):118-122.
[40]Zhang R,Wang X W,Zhu J Y,et al.Dietary sanguinarine affected immune response,digestive enzyme activity and intestinal microbiota of Koi carp(cryprinus carpiod)[J].Aquaculture,2019,502:72-79.
[41]Imanpoor M R,Roohi Z.Effects of Sangrovit-supplemented diet on growth performance,blood biochemical parameters,survival and stress resistance to salinity in the C aspian roach(R utilusrutilus)fry[J].Aquaculture research,2016,47(9):2874-2880.
[42]Wang W,Dolan L C,Von Alvensleben S,et al.Safety of standardized Macleayacordata extract in an eighty-four-day dietary study in dairy cows[J].Journal of animal physiology and animal nutrition,2018,102(1):61-68.
[43]Estrada-Angulo A,Aguilar-Hernández A,Osuna-Pérez M,et al.Influence of quaternary benzophenantridine and protopine alkaloids on growth performance,dietary energy,carcass traits,visceral mass,and rumen health in finishing ewes under conditions of severe temperature-humidity index[J].Asian-Australasian journal of animal sciences,2016,29(5):652.
[44]Aguilar-Hernández J A,Urías-Estrada J D,López-Soto M A,et al.Evaluation of isoquinolinealkaloid supplementation levels on ruminal fermentation,characteristics of digestion,and microbial protein synthesis in steers fed a high-energy diet[J].Journal of Animal Science,2016,94(1):267-274.
[45]Michels A,Neumann M,Le?o G F M,et al.Isoquinoline alkaloids supplementation on performance and carcass traits of feedlot bulls[J].Asian-Australasian journal of animal sciences,2018,31(9):1474.